Phosphoinositide 3-kinase inhibition restores neutrophil accuracy in the elderly: toward targeted treatments for immunosenescence

The Cell Polarity Protein mInsc Regulates Neutrophil Chemotaxis via a Noncanonical G Protein Signaling Pathway

(2013) Sachiko Kamakura et al.   DEVELOPMENTAL CELL

The WD40 protein Morg1 facilitates Par6–aPKC binding to Crb3 for apical identity in epithelial cells

(2013) Junya Hayase et al.   JOURNAL OF CELL BIOLOGY

Reduced Neutrophil Chemotaxis and Infiltration Contributes to Delayed Resolution of Cutaneous Wound Infection with Advanced Age

(2013) A. L. Brubaker et al.   JOURNAL OF IMMUNOLOGY

Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study

(2012) Joanna Collerton et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Functional Redundancy of Class I Phosphoinositide 3-Kinase (PI3K) Isoforms in Signaling Growth Factor-Mediated Human Neutrophil Survival

(2012) Jatinder K. Juss et al.   PLoS One

Regulation of Neutrophil Senescence by MicroRNAs

(2011) Jon R. Ward et al.   PLoS One

The fibrinogen cleavage product A -Val360, a specific marker of neutrophil elastase activity in vivo

(2011) R. I. Carter et al.   THORAX

Phosphoinositide-3 Kinase γ Activity Contributes to Sepsis and Organ Damage by Altering Neutrophil Recruitment

(2010) Erica L. Martin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Phosphatidylinositol 3-kinase-  inhibitor CAL-101 shows promising preclinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals

(2010) S. E. M. Herman et al.   BLOOD

Age-Related Inflammation: the Contribution of Different Organs, Tissues and Systems. How to Face it for Therapeutic Approaches

(2010) E. Cevenini et al.   CURRENT PHARMACEUTICAL DESIGN

Differential Regulation of Protrusion and Polarity by PI(3)K during Neutrophil Motility in Live Zebrafish

(2010) Sa Kan Yoo et al.   DEVELOPMENTAL CELL

The paradox of the neutrophilˈs role in tissue injury

(2010) George B. Segel et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Disruption of PKB signaling restores polarity to cells lacking tumor suppressor PTEN

(2010) Ming Tang et al.   MOLECULAR BIOLOGY OF THE CELL

An Improved Chamber for Direct Visualisation of Chemotaxis

(2010) Andrew J. Muinonen-Martin et al.   PLoS One

Inflammatory Markers and Longitudinal Lung Function Decline in the Elderly

(2008) R. Jiang et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury

(2008) A. Murat Kaynar et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

PI3K accelerates, but is not required for, neutrophil chemotaxis to fMLP

(2008) B. Heit et al.   JOURNAL OF CELL SCIENCE

Inter-relationships between inflammatory markers in patients with stable COPD with bronchitis: intra-patient and inter-patient variability

(2007) E Sapey et al.   THORAX