标题
Targeting HECT-type E3 ligases - insights from catalysis, regulation and inhibitors
作者
关键词
-
出版物
FEBS LETTERS
Volume 591, Issue 17, Pages 2636-2647
出版商
Wiley
发表日期
2017-08-04
DOI
10.1002/1873-3468.12775
参考文献
相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。- Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase
- (2017) Michael E. French et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Tunable Brake for HECT Ubiquitin Ligases
- (2017) Zan Chen et al. MOLECULAR CELL
- A conformational switch regulates the ubiquitin ligase HUWE1
- (2017) Bodo Sander et al. eLife
- Drugging the undruggables: exploring the ubiquitin system for drug development
- (2016) Xiaodong Huang et al. CELL RESEARCH
- HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation
- (2016) Kevin B Myant et al. EMBO Molecular Medicine
- Molecular insights into RBR E3 ligase ubiquitin transfer mechanisms
- (2016) Katja K Dove et al. EMBO REPORTS
- Fine-tuning of ULK1 mRNA and protein levels is required for autophagy oscillation
- (2016) Francesca Nazio et al. JOURNAL OF CELL BIOLOGY
- System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
- (2016) Wei Zhang et al. MOLECULAR CELL
- Structural insights into the catalysis and regulation of E3 ubiquitin ligases
- (2016) Lori Buetow et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Deubiquitinase activity is required for the proteasomal degradation of misfolded cytosolic proteins upon heat-stress
- (2016) Nancy N. Fang et al. Nature Communications
- Assembly and structure of Lys33-linked polyubiquitin reveals distinct conformations
- (2015) Yosua Adi Kristariyanto et al. BIOCHEMICAL JOURNAL
- Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation
- (2015) Christopher Riling et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism
- (2015) Stefan G. Kathman et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Role of ubiquitin and the HPV E6 oncoprotein in E6AP-mediated ubiquitination
- (2015) Franziska Mortensen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- RBR E3 ubiquitin ligases: new structures, new insights, new questions
- (2014) Donald E. Spratt et al. BIOCHEMICAL JOURNAL
- Signaling through C2 domains: More than one lipid target
- (2014) Senena Corbalan-Garcia et al. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
- The Antiproliferative Response of Indole-3-Carbinol in Human Melanoma Cells Is Triggered by an Interaction with NEDD4-1 and Disruption of Wild-Type PTEN Degradation
- (2014) Ida Aronchik et al. MOLECULAR CANCER RESEARCH
- Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
- (2014) Paul A. DaRosa et al. NATURE
- Cargo recognition and trafficking in selective autophagy
- (2014) Alexandra Stolz et al. NATURE CELL BIOLOGY
- Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress
- (2014) Nancy N. Fang et al. NATURE CELL BIOLOGY
- New insights into ubiquitin E3 ligase mechanism
- (2014) Christopher E Berndsen et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Peptide and small molecule inhibitors of HECT-type ubiquitin ligases
- (2014) Thomas Mund et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Structural Basis of the Activation and Degradation Mechanisms of the E3 Ubiquitin Ligase Nedd4L
- (2014) Albert Escobedo et al. STRUCTURE
- Structural and Functional Framework for the Autoinhibition of Nedd4-Family Ubiquitin Ligases
- (2014) Sara Mari et al. STRUCTURE
- High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy
- (2014) M Rossi et al. Cell Death & Disease
- SUMO-targeted ubiquitin ligases
- (2013) Annie M. Sriramachandran et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Mammalian HECT ubiquitin-protein ligases: Biological and pathophysiological aspects
- (2013) Martin Scheffner et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- E6AP/UBE3A Ubiquitin Ligase Harbors Two E2∼ubiquitin Binding Sites
- (2013) Virginia P. Ronchi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structure of a ubiquitin-loaded HECT ligase reveals the molecular basis for catalytic priming
- (2013) Elena Maspero et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3
- (2013) Hari B Kamadurai et al. eLife
- Ubiquitin and Membrane Protein Turnover: From Cradle to Grave
- (2012) Jason A. MacGurn et al. Annual Review of Biochemistry
- The Ubiquitin Code
- (2012) David Komander et al. Annual Review of Biochemistry
- Signaling-mediated control of ubiquitin ligases in endocytosis
- (2012) Simona Polo BMC BIOLOGY
- Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide
- (2012) A Lopez-Girona et al. LEUKEMIA
- A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen
- (2012) Yi Sheng et al. MOLECULAR & CELLULAR PROTEOMICS
- Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases
- (2012) Jonathan N. Pruneda et al. MOLECULAR CELL
- Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
- (2012) Anna Plechanovová et al. NATURE
- Atypical ubiquitylation — the unexplored world of polyubiquitin beyond Lys48 and Lys63 linkages
- (2012) Yogesh Kulathu et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl
- (2012) Hao Dou et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1
- (2011) Harald W. Platta et al. BIOCHEMICAL JOURNAL
- Cereblon expression is required for the antimyeloma activity of lenalidomide and pomalidomide
- (2011) Y. X. Zhu et al. BLOOD
- The Mechanism of Linkage-Specific Ubiquitin Chain Elongation by a Single-Subunit E2
- (2011) Katherine E. Wickliffe et al. CELL
- Structure of the HECT:ubiquitin complex and its role in ubiquitin chain elongation
- (2011) Elena Maspero et al. EMBO REPORTS
- Physical and Functional Interaction of the HECT Ubiquitin-protein Ligases E6AP and HERC2
- (2011) Simone Kühnle et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Essential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate
- (2011) Anjanabha Saha et al. MOLECULAR CELL
- Ubiquitin ligase Nedd4 promotes -synuclein degradation by the endosomal-lysosomal pathway
- (2011) G. K. Tofaris et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Ubiquitin: Same Molecule, Different Degradation Pathways
- (2010) Michael J. Clague et al. CELL
- Calcium Activates Nedd4 E3 Ubiquitin Ligases by Releasing the C2 Domain-mediated Auto-inhibition
- (2010) Jian Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Ubiquitin signalling in DNA replication and repair
- (2010) Helle D. Ulrich et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Identification of a Primary Target of Thalidomide Teratogenicity
- (2010) T. Ito et al. SCIENCE
- Regulation of the RSP5 Ubiquitin Ligase by an Intrinsic Ubiquitin-binding Site
- (2009) Michael E. French et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Ubiquitin Binding Region of the Smurf HECT Domain Facilitates Polyubiquitylation and Binding of Ubiquitylated Substrates
- (2009) Abiodun A. Ogunjimi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Polyubiquitination by HECT E3s and the Determinants of Chain Type Specificity
- (2009) H. C. Kim et al. MOLECULAR AND CELLULAR BIOLOGY
- Nonproteolytic Functions of Ubiquitin in Cell Signaling
- (2009) Zhijian J. Chen et al. MOLECULAR CELL
- Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B∼Ubiquitin-HECTNEDD4L Complex
- (2009) Hari B. Kamadurai et al. MOLECULAR CELL
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays
- (2009) Avinash Persaud et al. Molecular Systems Biology
- Physiological functions of the HECT family of ubiquitin ligases
- (2009) Daniela Rotin et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain
- (2008) M. Christine Bruce et al. BIOCHEMICAL JOURNAL
- The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development
- (2008) Francesca Bernassola et al. CANCER CELL
- Ubiquitin in trafficking: The network at work
- (2008) Filippo Acconcia et al. EXPERIMENTAL CELL RESEARCH
- Targeting ubiquitin specific proteases for drug discovery
- (2007) Laurent Daviet et al. BIOCHIMIE
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