Article
Biology
Lu Zhu, Qing Zhang, Ciro D. Cordeiro, Sudeep Banjade, Richa Sardana, Yuxin Mao, Scott D. Emr
Summary: The study reveals a novel ubiquitination modification implemented by Rsp5 adaptor proteins, which controls the recruitment and activity of Rsp5 to facilitate the turnover of membrane proteins.
Review
Pharmacology & Pharmacy
Xianyan Tian, Yifei Chen, Ziluo Peng, Qiong Lin, Aiqin Sun
Summary: This review addresses the oncogenic role of NEDD4 E3 ubiquitin ligase family in various malignancies by mediating ubiquitin dependent degradation processes. It also discusses the association of NEDD4 E3 ubiquitin ligases expression with cancer progression, the signaling pathways and molecular mechanisms involved, and potential therapeutic targeting of these ligases. The review provides a systematic summary of the latest research status of E3 ubiquitin ligases in the NEDD4 subfamily and suggests that they are promising targets for anti-cancer drug development.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sujitha Jayaprakash, Mangala Hegde, Bandari BharathwajChetty, Sosmitha Girisa, Mohammed S. Alqahtani, Mohamed Abbas, Gautam Sethi, Ajaikumar B. Kunnumakkara
Summary: Cancer is a deadly disease that is strongly related to genetic changes and post-translational modifications. The E3 ubiquitin ligases, particularly NEDD4, play a crucial role in regulating cellular processes by controlling protein degradation and substrate ubiquitination. NEDD4 has both tumor-suppressive and oncogenic roles in various malignancies. This review summarizes the function of NEDD4 in cancer development, including its role in cell survival, proliferation, autophagy, migration, invasion, metastasis, epithelial-mesenchymal transition, chemoresistance, and multiple signaling pathways. Additionally, the significance of NEDD4 as a potential target for cancer treatment is discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Shanez Haouari, Patrick Vourc'h, Mederic Jeanne, Sylviane Marouillat, Charlotte Veyrat-Durebex, Debora Lanznaster, Frederic Laumonnier, Philippe Corcia, Helene Blasco, Christian R. Andres
Summary: This article provides a review on the roles of the 9 proteins of the HECT E3 ligase NEDD4 subfamily in the development and function of neurons in the central nervous system. These proteins are involved in the regulation of neurodevelopmental and neurodegenerative diseases and contribute to a better understanding of neuronal function and dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Sungmin Nam, Bo Ri Seo, Alexander J. Najibi, Stephanie L. McNamara, David J. Mooney
Summary: The mechanically active gel-elastomer-nitinol tissue adhesive (MAGENTA) presented in this study generates and delivers muscle-contraction-mimicking stimulation to target tissue. MAGENTA treatment increases muscle size and strength, preventing muscle atrophy.
Article
Biochemistry & Molecular Biology
Weaam Mohamed, Andreas D. Schenk, Georg Kempf, Simone Cavadini, Anja Basters, Alessandro Potenza, Wassim Abdul Rahman, Julius Rabl, Kurt Reichermeier, Nicolas H. Thomae
Summary: The study focuses on the structure and mechanism of the CRL4(DCAF1) ligase, identifying a novel mechanism by which unneddylated and substrate-free CUL4 ligases can be maintained in an inactive state.
Review
Immunology
Yosuke Asano, Yoshinori Matsumoto, Jun Wada, Robert Rottapel
Summary: This article summarizes the role of E3 ubiquitin ligases in bone metabolism, the immune system, and inflammation. It also highlights the connection between E3 ubiquitin ligase and the rare disease cherubism, emphasizing the importance of E3 ubiquitin ligases in human disorders.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Chibuzo Sampson, Qiuping Wang, Wuxiyar Otkur, Haifeng Zhao, Yun Lu, Xiaolong Liu, Hai-long Piao
Summary: Ubiquitination, an important post-translational modification, is crucial for maintaining cellular protein homeostasis. E3 ubiquitin ligases are the most influential enzymes in the ubiquitination process and play a significant role in cancer hallmarks. The specificity of E3 ligases and their involvement in cancer hallmarks have led to the development of compounds that target them for cancer therapy. This review highlights the role of E3 ligases in cancer hallmarks and summarizes the application and significance of targeting E3 ligases as potential cancer therapy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Emma I. Kane, Donald E. Spratt
Summary: Ankyrin repeat (AR) domains are the most common repetitive structure in eukaryotic proteins, mediating specific protein-protein interactions and recognizing a variety of intracellular substrates. Proteins with AR domains play crucial roles in biological processes and their dysfunction is linked to neurological diseases and disorders. Understanding the structure and mechanism of key AR-containing proteins can provide insights into how they support ubiquitylation and subsequent signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Likai Ji, Yan Wang, Liying Zhou, Juan Lu, Siwen Bao, Quan Shen, Xiaochun Wang, Yuwei Liu, Wen Zhang
Summary: The outbreaks caused by RNA and DNA viruses pose serious threats to human health. Understanding the mechanisms of different members of the E3s families that mediate the RLR and cGAS-STING pathways can help prevent and treat virus-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Fengguang Zhai, Jingyun Li, Meng Ye, Xiaofeng Jin
Summary: CUL3 is a scaffold protein that forms ubiquitin ligases with the substrate recognition adaptor and RING-finger protein 1. Through non-degradative ubiquitination, CUL3-E3 ligases play crucial roles in cell cycle regulation, protein transportation, and tumorigenesis.
Review
Biochemistry & Molecular Biology
Rui Zhang, Shaoqing Shi
Summary: HECT-type E3 ubiquitin ligases play a vital role in controlling protein function and stability, and members of the NEDD4 family have critical roles in dysregulation of autophagy in cancer cells. This review focuses on the role of NEDD4 E3 ligases in defective autophagy in cancer cells, discussing their function, substrates, and signaling pathways, providing a basis for cancer treatment through modulation of these ligases.
MOLECULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Stephanie Diaz, Kankan Wang, Benita Sjogren, Xing Liu
Summary: Maintenance of protein homeostasis is crucial for eukaryotic biology, and the ubiquitin-proteasome system (UPS) plays an important role in the pathogenesis of cardiovascular diseases. Recent research has found that cullin-RING ubiquitin ligases (CRLs), an essential component of UPS, have significant physiological and pathological functions in the cardiovascular system.
Review
Immunology
Min Zou, Qi-Shan Zeng, Jiao Nie, Jia-Hui Yang, Zhen-Yi Luo, Hua-Tian Gan
Summary: Inflammatory bowel disease (IBD) is a complex disorder involving genetic susceptibility, gut microbiota imbalance, mucosal immune disorder, and environmental factors. Recent studies have shown associations between ubiquitination and deubiquitination in the pathogenesis of IBD, highlighting the importance of these post-translational modifications in inflammation development and potential targeted therapeutics for IBD.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Long Mu, Zhibin Han, Shengkun Yu, Aowen Wang, Dongjiang Chen, Sijia Kong, Yifei Gu, Lin Xu, Axiang Liu, Ruohan Sun, Yu Long
Summary: ASB3 is aberrantly expressed in various tumors, particularly in GBM, and is significantly correlated with patient prognosis, TMB, MSI, and immune cell infiltration. In GBM, ASB3 expression is negatively associated with Tregs, cancer-associated fibroblasts, and oncogenetic signaling pathways. Overexpression of ASB3 reduces the proportion of Tregs in TILs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jing Wei, Guanzhen Yu, Genbao Shao, Aiqin Sun, Miao Chen, Wannian Yang, Qiong Lin
Article
Cell Biology
Qiong Lin, Qian Dai, Hongxia Meng, Aiqin Sun, Jing Wei, Ke Peng, Chandra Childress, Miao Chen, Genbao Shao, Wannian Yang
JOURNAL OF CELL SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Genbao Shao, Ranran Wang, Aiqin Sun, Jing Wei, Ke Peng, Qian Dai, Wannian Yang, Qiong Lin
Article
Biochemistry & Molecular Biology
Qiong Lin, Jian Wang, Chandra Childress, Marius Sudol, David J. Carey, Wannian Yang
MOLECULAR AND CELLULAR BIOLOGY
(2010)
Article
Biochemistry & Molecular Biology
Yixin Jin, Yang Liu, Qiong Lin, Jieli Li, Joseph E. Druso, Marc A. Antonyak, Cynthia J. Meininger, Shenyuan L. Zhang, David E. Dostal, Jun-Lin Guan, Richard A. Cerione, Xu Peng
MOLECULAR AND CELLULAR BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Aiqin Sun, Guanzhen Yu, Xiaoyan Dou, Xiaowei Yan, Wannian Yang, Qiong Lin
Article
Cell Biology
Xu Peng, Qiong Lin, Yang Liu, Yixin Jin, Joseph E. Druso, Marc A. Antonyak, Jun-Lin Guan, Richard A. Cerione
Article
Cell Biology
Aiqin Sun, Jing Wei, Chandra Childress, John H. Shaw, Ke Peng, Genbao Shao, Wannian Yang, Qiong Lin
