Article
Multidisciplinary Sciences
Cheng-hui Yan, Hai-Wei Liu, Xiao-xiang Tian, Jiayin Li, Ye Ding, Yi Li, Zhu Mei, Ming-Hui Zou, Ya-ling Han
Summary: This study investigates the potential reasons for the inconsistent effects of fish oil (FO) in patients with cardiovascular disease. The findings suggest that AMP-activated protein kinase (AMPK) alpha 2 is necessary for the anti-inflammatory and anti-atherosclerotic effects of FO.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Akira Shikuma, Daisuke Kami, Ryotaro Maeda, Yosuke Suzuki, Arata Sano, Toshihiko Taya, Takehiro Ogata, Anne Konkel, Satoaki Matoba, Wolf-Hagen Schunck, Satoshi Gojo
Summary: EEQ-A exhibits potent anti-inflammatory and immunomodulatory properties, improving survival rate and reducing organ damage in sepsis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Roberta Cardim Lessa, Fabio de Abreu Alves, Erika Fortunati, Jun Lu
Summary: Oral mucositis (OM) is a painful condition caused by cancer treatments, impacting patients' quality of life and recovery. Current management strategies are insufficient, necessitating a search for new approaches. Utilizing ω-3 fatty acids to manage OM may be an effective strategy based on preliminary evidence.
Article
Nutrition & Dietetics
Xuefei Li, Zhengjie Lu, Yongjian Qi, Biao Chen, Bin Li
Summary: This study used the Mendelian randomization approach to explore the potential causal relationships between polyunsaturated fatty acids (PUFAs) and osteoarthritis (OA), and found that higher levels of omega-6 fatty acids may reduce the risk of knee OA and hip OA. These results highlight the importance of maintaining optimal levels of PUFAs, especially omega-6 fatty acids, in individuals with a genetic predisposition to OA.
Review
Biology
Salvatore Coniglio, Maria Shumskaya, Evros Vassiliou
Summary: Diet can have both positive and negative effects on human health, with omega-3 polyunsaturated fatty acids being overall beneficial. These fatty acids are primarily found in plant seeds and fish. Consuming omega-3 fatty acids can reduce inflammation and markers associated with certain diseases. This reduction in inflammation occurs through specific metabolic and biochemical changes. Overall, a diet high in omega-3 and low in omega-6 fats is considered favorable.
Article
Biochemistry & Molecular Biology
Elisabetta Del Duca, Anna Sansone, Mayla Sgrulletti, Federica Di Nolfo, Loredana Chini, Carla Ferreri, Viviana Moschese
Summary: Peanut allergy is a lifelong and potentially life-threatening disease that affects families and communities. A preliminary study explored the fatty-acid-based membrane lipidome profile of patients with angioedema and/or anaphylaxis after peanut ingestion. The study found significant differences in the levels of omega-6 and omega-3 fatty acids between allergic patients and healthy individuals, as well as a correlation between specific immunoglobulin E (IgE) levels and certain fatty acids. The results of this study suggest the need for larger screenings and further research to understand the molecular mechanisms and develop effective treatments for chronic allergic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Domenico Sergi, Juana Maria Sanz, Stefano Lazzer, Gloria Brombo, Giovanni Zuliani, Gianni Biolo, Bostjan Simunic, Rado Pisot, Edoardo Dalla Nora, Angelina Passaro
Summary: Dietary lipids play a crucial role in modulating metabolic inflammation, and interleukin 18 (IL-18) has been consistently linked to obesity and insulin resistance. This study aimed to assess if the quality of lipid intake affects IL-18 plasma levels and its implications on insulin resistance. The study confirmed that IL-18 is positively correlated with insulin resistance, and individuals with higher HOMA-IR levels displayed elevated IL-18 levels. The quality of dietary lipids, particularly the ratio between different fatty acids and the intake of omega-3, showed a negative correlation with IL-18 levels.
Article
Nutrition & Dietetics
Masayuki Okuda, Aya Fujiwara, Satoshi Sasaki
Summary: The study found that in Japanese youths, high intake of omega-6 polyunsaturated fatty acids was associated with low levels of low-density-lipoprotein cholesterol, while high intake of saturated fatty acids was associated with high levels of gamma-glutamyl transpeptidase, indicating a close relationship between dietary fatty acid composition and cardiometabolic risk.
Article
Cardiac & Cardiovascular Systems
Anthony D. Pisaniello, Peter J. Psaltis, Peta M. King, Ge Liu, Robert A. Gibson, Joanne Tm Tan, MyNgan Duong, Tracy Nguyen, Christina A. Bursill, Matthew Worthley, Stephen J. Nicholls, Belinda A. Di Bartolo
Summary: The study demonstrates that EPA supplementation is more effective than DHA in reducing acute and chronic vascular inflammation, providing a rationale for the cardiovascular benefit observed with high-dose omega-3 fatty acid administration.
Article
Pharmacology & Pharmacy
Yuting Ma, Guangdong Zhang, Zenggguang Kuang, Qian Xu, Tongtong Ye, Xue Li, Na Qu, Fang Han, Chengxia Kan, Xiaodong Sun
Summary: Empagliflozin (EMPA) therapy has been shown to improve non-alcoholic fatty liver disease (NAFLD) patients. This study investigated the functional implications of EMPA on the pathogenesis of NAFLD and identified the underlying molecular mechanisms. The results showed that EMPA treatment reversed liver damage by upregulating Sestrin2 and activating the AMPK-mTOR pathway, leading to the inhibition of lipogenesis and inflammation. These findings suggest that EMPA therapy could target Sestrin2 to alleviate lipogenesis and inflammation in obesity-related NAFLD.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Lingsi Zeng, Honggang Lv, Xubo Wang, Ranran Xue, Cong Zhou, Xia Liu, Hao Yu
Summary: Using Mendelian randomization (MR) analysis, this study found potential causal relationships between levels of fatty acids (FA) and the risk of depression. Specifically, oleic acid (OA) and alpha-linolenic acid (ALA) were identified as potential risk factors for depression, while adrenic acid and eicosapentaenoic acid (EPA) were found to be protective. These findings emphasize the importance of further research to investigate the underlying mechanisms that mediate the association between these fatty acids and depression risk.
FRONTIERS IN NUTRITION
(2022)
Article
Agriculture, Dairy & Animal Science
Anna Wyrostek, Katarzyna Czyz, Ewa Sokola-Wysoczanska, Bozena Patkowska-Sokola, Wieslaw Bielas
Summary: This study examined the effect of supplementation with ethyl esters of linseed oil on the fatty acid profile in blood serum, erythrocyte membranes, and hair sebum of healthy beagle dogs. The results showed that the supplementation decreased the content of saturated fatty acids and increased the level of beneficial unsaturated fatty acids, especially those from the omega-3 family.
Article
Geriatrics & Gerontology
Roxana Coras, Brian Pedersen, Rekha Narasimhan, Anahy Brandy, Lourdes Mateo, Agueda Prior-Espanol, Arthur Kavanaugh, Aaron M. Armando, Mohit Jain, Oswald Quehenberger, Melania Martinez-Morillo, Monica Guma
Summary: The study revealed that arthritis symptoms in older adults were related to disturbances in serum oxylipins, suggesting that certain oxylipins may be key effectors in arthritis in this population.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Editorial Material
Food Science & Technology
Emanuele Rinninella, Lara Costantini
Summary: The International Scientific Association for Probiotics and Prebiotics (ISAPP) considers polyunsaturated fatty acids (PUFAs) as candidate prebiotics, although there is a lack of complete scientific evidence. Recent partial evidence shows that metabolites of PUFAs can have important health effects in the host, supporting the concept of the prebiotic action of PUFAs.
Article
Endocrinology & Metabolism
Xianfeng Wang, Nancy L. Buechler, Barbara K. Yoza, Charles E. McCall, Vidula T. Vachharajani
Article
Endocrinology & Metabolism
Qiang Cao, Xin Cui, Rui Wu, Lin Zha, Xianfeng Wang, John S. Parks, Liqing Yu, Hang Shi, Bingzhong Xue
Review
Immunology
Vidula T. Vachharajani, Tiefu Liu, Xianfeng Wang, Jason J. Hoth, Barbara K. Yoza, Charles E. McCall
JOURNAL OF IMMUNOLOGY RESEARCH
(2016)
Article
Immunology
Nancy Buechler, Xianfeng Wang, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
JOURNAL OF IMMUNOLOGY RESEARCH
(2017)
Article
Endocrinology & Metabolism
Qiang Cao, Xianfeng Wang, Lin Jia, Ashis K. Mondal, Abdoulaye Diallo, Gregory A. Hawkins, Swapan K. Das, John S. Parks, Liqing Yu, Huidong Shi, Hang Shi, Bingzhong Xue
Article
Cell Biology
Xianfeng Wang, Nancy L. Buechler, David L. Long, Cristina M. Furdui, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
Review
Biochemistry & Molecular Biology
Xianfeng Wang, Nancy L. Buechler, Alan G. Woodruff, David L. Long, Manal Zabalawi, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Cell Biology
Vidula T. Vachharajani, Tiefu Liu, Candice M. Brown, Xianfeng Wang, Nancy L. Buechler, Jonathan David Wells, Barbara K. Yoza, Charles E. McCall
JOURNAL OF LEUKOCYTE BIOLOGY
(2014)
Article
Endocrinology & Metabolism
Xiaosong Yang, Xianfeng Wang, Dongxu Liu, Liqing Yu, Bingzhong Xue, Hang Shi
MOLECULAR ENDOCRINOLOGY
(2014)
Article
Multidisciplinary Sciences
Xianfeng Wang, Nancy L. Buechler, Ayana Martin, Jonathan Wells, Barbara Yoza, Charles E. McCall, Vidula Vachharajani
Article
Multidisciplinary Sciences
David Long, Hanzhi Wu, Allen W. Tsang, Leslie B. Poole, Barbara K. Yoza, Xianfeng Wang, Vidula Vachharajani, Cristina M. Furdui, Charles E. McCall
SCIENTIFIC REPORTS
(2017)
Article
Biotechnology & Applied Microbiology
Guo-dong Feng, Xiao-chang Xue, Mei-li Gao, Xian-feng Wang, Zhen Shu, Nan Mu, Yuan Gao, Zeng-lu Wang, Qiang Hao, Wei-na Li, Meng Li, Cun Zhang, Wei Zhang, Ying-qi Zhang
BIOMED RESEARCH INTERNATIONAL
(2014)
Article
Medicine, Research & Experimental
Xianfeng Wang, Qiang Cao, Liqing Yu, Huidong Shi, Bingzhong Xue, Hang Shi
Meeting Abstract
Endocrinology & Metabolism
Bingzhong Xue, Xianfeng Wang, Hang Shi
Article
Immunology
XianFeng Wang, Nancy L. Buechler, Barbara K. Yoza, Charles E. McCall, Vidula Vachharajani
JOURNAL OF INFLAMMATION RESEARCH
(2016)