Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax and show no preference for Bak versus Bax

Bak Core and Latch Domains Separate during Activation, and Freed Core Domains Form Symmetric Homodimers

(2014) Jason M. Brouwer et al.   MOLECULAR CELL

Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein

(2014) J. M. Rogers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bax Crystal Structures Reveal How BH3 Domains Activate Bax and Nucleate Its Oligomerization to Induce Apoptosis

(2013) Peter E. Czabotar et al.   CELL

Resilience of death: intrinsic disorder in proteins involved in the programmed cell death

(2013) Z Peng et al.   CELL DEATH AND DIFFERENTIATION

Evaluation of the BH3-only Protein Puma as a Direct Bak Activator

(2013) Haiming Dai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights of tBid, the Caspase-8-activated Bid, and Its BH3Domain

(2013) Yu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BAK/BAX activation and cytochrome c release assays using isolated mitochondria

(2013) Thibaud T. Renault et al.   METHODS

BID Preferentially Activates BAK while BIM Preferentially Activates BAX, Affecting Chemotherapy Response

(2013) Kristopher A. Sarosiek et al.   MOLECULAR CELL

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy

(2013) Peter E. Czabotar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BID-induced structural changes in BAK promote apoptosis

(2013) Tudor Moldoveanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mechanisms of Action of Bcl-2 Family Proteins

(2013) A. Shamas-Din et al.   Cold Spring Harbor Perspectives in Biology

Bak apoptotic function is not directly regulated by phosphorylation

(2013) V H Tran et al.   Cell Death & Disease

BH3-only proteins are tail-anchored in the outer mitochondrial membrane and can initiate the activation of Bax

(2012) F Wilfling et al.   CELL DEATH AND DIFFERENTIATION

BH3-only proteins in apoptosis at a glance

(2012) L. Happo et al.   JOURNAL OF CELL SCIENCE

Dynamic Interaction of cBid with Detergents, Liposomes and Mitochondria

(2012) Stephanie Bleicken et al.   PLoS One

Can the analysis of BH3-only protein knockout mice clarify the issue of ‘direct versus indirect’ activation of Bax and Bak?

(2011) A Villunger et al.   CELL DEATH AND DIFFERENTIATION

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

(2011) Haiming Dai et al.   JOURNAL OF CELL BIOLOGY

A Unified Model of Mammalian BCL-2 Protein Family Interactions at the Mitochondria

(2011) Fabien Llambi et al.   MOLECULAR CELL

Intrinsic Order and Disorder in the Bcl-2 Member Harakiri: Insights into Its Proapoptotic Activity

(2011) Susana Barrera-Vilarmau et al.   PLoS One

Intrinsically Disordered Proteins in Bcl-2 Regulated Apoptosis

(2010) Gilles J. P. Rautureau et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Conformational Changes in BAK, a Pore-forming Proapoptotic Bcl-2 Family Member, upon Membrane Insertion and Direct Evidence for the Existence of BH3-BH3 Contact Interface in BAK Homo-oligomers

(2010) Kyoung Joon Oh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BH3 Domains other than Bim and Bid Can Directly Activate Bax/Bak

(2010) Han Du et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BID, BIM, and PUMA Are Essential for Activation of the BAX- and BAK-Dependent Cell Death Program

(2010) D. Ren et al.   SCIENCE

Mapping the Interaction of Pro-Apoptotic tBID with Pro-Survival BCL-XL

(2009) Yong Yao et al.   BIOCHEMISTRY

The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins

(2009) Delphine Mérino et al.   JOURNAL OF CELL BIOLOGY

Membrane promotes tBID interaction with BCLXL

(2009) Ana J García-Sáez et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

NF- B1 and c-Rel cooperate to promote the survival of TLR4-activated B cells by neutralizing Bim via distinct mechanisms

(2008) A. Banerjee et al.   BLOOD

ABT-263: A Potent and Orally Bioavailable Bcl-2 Family Inhibitor

(2008) C. Tse et al.   CANCER RESEARCH

Membrane Binding by tBid Initiates an Ordered Series of Events Culminating in Membrane Permeabilization by Bax

(2008) Jonathan F. Lovell et al.   CELL

BIM and tBID Are Not Mechanistically Equivalent When Assisting BAX to Permeabilize Bilayer Membranes

(2008) Oihana Terrones et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel BH3 ligand that selectively targets Mcl-1 reveals that apoptosis can proceed without Mcl-1 degradation

(2008) Erinna F. Lee et al.   JOURNAL OF CELL BIOLOGY

To Trigger Apoptosis, Bak Exposes Its BH3 Domain and Homodimerizes via BH3:Groove Interactions

(2008) Grant Dewson et al.   MOLECULAR CELL

Apoptosis is triggered when prosurvival Bcl-2 proteins cannot restrain Bax

(2008) J. I. Fletcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl-XL Inhibits Membrane Permeabilization by Competing with Bax

(2008) Lieven P Billen et al.   PLOS BIOLOGY

The BCL-2 protein family: opposing activities that mediate cell death

(2007) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY