The whipworm (Trichuris suis) secretes prostaglandin E2 to suppress proinflammatory properties in human dendritic cells

Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling

(2016) Marten A. Hoeksema et al.   FASEB JOURNAL

The neuroimmune guidance cue netrin-1 controls resolution programs and promotes liver regeneration

(2016) Martin Schlegel et al.   HEPATOLOGY

Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis

(2016) R. Duffin et al.   SCIENCE

Site-Specific Protein N- and O-Glycosylation Analysis by a C18-Porous Graphitized Carbon–Liquid Chromatography-Electrospray Ionization Mass Spectrometry Approach Using Pronase Treated Glycopeptides

(2015) Kathrin Stavenhagen et al.   ANALYTICAL CHEMISTRY

Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

(2015) Richard K. Grencis   Annual Review of Immunology

Trichuris suis soluble products induce Rab7b expression and limit TLR4 responses in human dendritic cells

(2015) E J Klaver et al.   GENES AND IMMUNITY

A parasitic helminth-derived peptide that targets the macrophage lysosome is a novel therapeutic option for autoimmune disease

(2015) Raquel Alvarado et al.   IMMUNOBIOLOGY

From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis

(2015) M A Pineda et al.   LUPUS

Clinical trials of helminth therapy in autoimmune diseases: rationale and findings

(2015) J. O. Fleming et al.   PARASITE IMMUNOLOGY

Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration

(2015) Y. Zhang et al.   SCIENCE

Trichuris suis induces human non-classical patrolling monocytes via the mannose receptor and PKC: implications for multiple sclerosis

(2015) Gijs Kooij et al.   Acta Neuropathologica Communications

Schistosoma mansoni Soluble Egg Antigens Induce Expression of the Negative Regulators SOCS1 and SHP1 in Human Dendritic Cells via Interaction with the Mannose Receptor

(2015) Elsenoor J. Klaver et al.   PLoS One

Therapeutic potential of larval excretory/secretory proteins of the pig whipwormTrichuris suisin allergic disease

(2014) F. Ebner et al.   ALLERGY

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

(2014) Romain A. Colas et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The helminth Trichuris suis suppresses TLR4-induced inflammatory responses in human macrophages

(2014) M K Ottow et al.   GENES AND IMMUNITY

Helminth Infections Decrease Host Susceptibility to Immune-Mediated Diseases

(2014) Joel V. Weinstock et al.   JOURNAL OF IMMUNOLOGY

Excreted/secreted Trichuris suis products reduce barrier function and suppress inflammatory cytokine production of intestinal epithelial cells

(2014) I.H. Hiemstra et al.   MOLECULAR IMMUNOLOGY

Pro-resolving lipid mediators are leads for resolution physiology

(2014) Charles N. Serhan   NATURE

Direct Anthelmintic Effects of Condensed Tannins from Diverse Plant Sources against Ascaris suum

(2014) Andrew R. Williams et al.   PLoS One

Trichuris suis and Oesophagostomum dentatum Show Different Sensitivity and Accumulation of Fenbendazole, Albendazole and Levamisole In Vitro

(2014) Tina V. A. Hansen et al.   PLoS Neglected Tropical Diseases

The Multiple Faces of Prostaglandin E2 G-Protein Coupled Receptor Signaling during the Dendritic Cell Life Cycle

(2013) Sandra De Keijzer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Role of PGE2 in the colonic motility: PGE2 generates and enhances spontaneous contractions of longitudinal smooth muscle in the rat colon

(2013) Yumiko Iizuka et al.   Journal of Physiological Sciences

PGE2 differentially regulates monocyte-derived dendritic cell cytokine responses depending on receptor usage (EP2/EP4)

(2013) Neil J. Poloso et al.   MOLECULAR IMMUNOLOGY

A Heterogeneous Mixture of F-Series Prostaglandins Promotes Sperm Guidance in the Caenorhabditis elegans Reproductive Tract

(2013) Hieu D. Hoang et al.   PLoS Genetics

Trichuris suis-induced modulation of human dendritic cell function is glycan-mediated

(2012) Elsenoor J. Klaver et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Soluble helminth products suppress clinical signs in murine experimental autoimmune encephalomyelitis and differentially modulate human dendritic cell activation

(2012) Loes M. Kuijk et al.   MOLECULAR IMMUNOLOGY

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Regulation of Immune Responses by Prostaglandin E2

(2011) P. Kalinski   JOURNAL OF IMMUNOLOGY

Symptoms after Ingestion of Pig Whipworm Trichuris suis Eggs in a Randomized Placebo-Controlled Double-Blind Clinical Trial

(2011) Peter Bager et al.   PLoS One

Helminths and dendritic cells: Sensing and regulating via pattern recognition receptors, Th2 and Treg responses

(2010) Bart Everts et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glycan gimmickry by parasitic helminths: A strategy for modulating the host immune response?

(2009) I. van Die et al.   GLYCOBIOLOGY

Modulation of host immune responses by helminth glycans

(2009) Donald A. Harn et al.   IMMUNOLOGICAL REVIEWS

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

(2009) Chengcan Yao et al.   NATURE MEDICINE

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

(2009) Y. Kihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA