Article
Parasitology
Tokio Hoshina, Tatsuya Sakurai, Hidetoshi Ichimura, Kenji Ishiwata, Shitan En, Takahiro Yamada, Lee Kwangyole, Akihiro Shimizu, Koji Hase, Hirotaka Kanuka
Summary: The study demonstrated that healthy Japanese individuals tolerated all doses of TSO without any severe adverse events. However, mild to moderate abdominal symptoms were observed in some participants, and higher doses of TSO led to elevated eosinophil count. Close follow-up is recommended for sustainable medicinal use of TSO in Japan.
PARASITOLOGY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Si-Chun Gu, Qing Ye, Chang-De Wang, Shao-Rong Zhao, Jie Zhou, Chen Gao, Yu Zhang, Zhen-Guo Liu, Can-Xing Yuan
Summary: Pingchan granule (PCG) has a long-lasting and extensive symptomatic efficacy for both motor and non-motor symptoms of Parkinson's disease (PD) with good tolerance.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Integrative & Complementary Medicine
Si-chun Gu, Jie Zhou, Qing Ye, Can-xing Yuan
Summary: The study demonstrated that treatment with Pingchan Granule significantly improved depressive symptoms in Parkinson's disease patients, as well as motor and other non-motor symptoms.
JOURNAL OF INTEGRATIVE MEDICINE-JIM
(2021)
Article
Nutrition & Dietetics
Asako Sato, Akika Fukawa-Nagira, Toshihiro Sashihara, Juergen Schrezenmeir
Summary: This study found that Lactobacillus paragasseri OLL2809 has a significant effect in reducing stress and managing menstrual symptoms in women, leading to an improved quality of life.
Article
Nutrition & Dietetics
Choongsung Yoo, Dante Xing, Drew Gonzalez, Victoria Jenkins, Kay Nottingham, Broderick Dickerson, Megan Leonard, Joungbo Ko, Mark Faries, Wesley Kephart, Martin Purpura, Ralf Jaeger, Shawn D. Wells, Ryan Sowinski, Christopher J. Rasmussen, Richard B. Kreider
Summary: The study suggests that acute ingestion of paraxanthine may affect some measures of short-term memory, reasoning, and response time to cognitive challenges, and help sustain attention.
Article
Food Science & Technology
Alvaro Lopez-Samanes, Juan Jose Ramos-Alvarez, Francisco Miguel-Tobal, Sofia Gaos, Pablo Jodra, Raquel Arranz-Munoz, Raul Dominguez, Juan Jose Montoya
Summary: This study explored the acute ingestion of beetroot juice in female rugby players. The results showed that beetroot juice ingestion may improve neuromuscular performance, while no differences were found in sprint, agility, isometric handgrip strength, and endurance performance.
Article
Nutrition & Dietetics
Naoki Azuma, Takashi Mawatari, Yasuo Saito, Masashi Tsukamoto, Masatoshi Sampei, Yoshitaka Iwama
Summary: This study confirms that intake of GCL2505 and inulin can improve cognitive function by improving the intestinal environment and alleviating inflammation. The randomized, double-blind, placebo-controlled study shows significant improvements in the neurocognitive index domain, overall attention, cognitive flexibility, and executive function after 12 weeks of consumption.
Article
Plant Sciences
Lih-Lian Chen, Yuh-Chiang Shen, Chih-Chun Ke, Zuha Imtiyaz, Hui- Chen, Chin-Hsien Chang, Mei-Hsien Lee
Summary: The study indicates that treatment with cinnamon patch may be an effective and safe complementary therapy for overactive bladder (OAB), leading to significant improvements in OAB symptoms.
Article
Nutrition & Dietetics
David Briskey, Phillippa Ebelt, Amanda Rao
Summary: The study suggests that Palmitoylethanolamide (PEA) can alleviate allergic rhinitis symptoms, reduce histamine and inflammatory markers. However, there was no significant difference in allergy symptom scores throughout the treatment period, but a subgroup analysis showed a significant reduction in scores for participants with higher baseline symptom scores in the PEA group.
Article
Microbiology
Yohei Sakai, Hiroshi Ochi, Miyuki Tanaka
Summary: Oral administration of a low dose of lactulose increases the abundance of Bifidobacterium in the large intestine. The percentage of Bifidobacterium significantly increases 2 days after starting lactulose ingestion, and the difference continues to widen over the 2-week intervention period. After cessation of lactulose ingestion, the percentage of Bifidobacterium returns to its original level.
Article
Neurosciences
Mahmoud S. Abdallah, Esraa M. Mosalam, Ahmed Hassan, Ahmed N. Ramadan, Hend Omara-Reda, Abdel-Aziz A. Zidan, Waad A. Samman, Eman El-Berri
Summary: This study aimed to investigate the effectiveness and safety of pentoxifylline as an adjuvant to risperidone in mitigating the negative symptoms in patients with chronic schizophrenia. The results showed that pentoxifylline adjunctive therapy had a significant effect in reducing PANSS-negative subscale scores, PANSS general psychopathology subscale scores, and PANSS total scores. Furthermore, it also led to an increase in cAMP serum level and a decrease in TNF-alpha and IL-6 serum levels.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Seyed Ahmad Hosseini, Zainab Shateri, Farhad Abolnezhadian, Elham Maraghi, Maryam Haddadzadeh Shoushtari, Marzie Zilaee
Summary: This study aimed to investigate the effects of pomegranate supplementation on clinical symptoms and blood cell counts in patients with allergic asthma. The findings showed that pomegranate extract improved clinical symptoms and reduced eosinophil, basophil, and neutrophil counts in allergic asthma patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Monique Michels, Emily Corneo, Luana Cucker, Carla Sasso Simon, Gabriel Fernandes Alves de Jesus, Carolina Michels, Kristian Madeira, Ana Paula Voytena, Marina Rossetto, Fernanda Ramlov, Danusa de Castro Damasio, Felipe Dal-Pizzol
Summary: This study evaluated the efficacy of Bifidobacterium lactis CCT 7858 in preventing antibiotic-related diarrhea and improving gastrointestinal symptoms. The results showed that this strain can reduce diarrhea and gastrointestinal symptoms.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Psychiatry
Federico Cavanna, Stephanie Muller, Laura Alethia de la Fuente, Federico Zamberlan, Matias Palmucci, Lucie Janeckova, Martin Kuchar, Carla Pallavicini, Enzo Tagliazucchi
Summary: The use of low sub-perceptual doses of psychedelics, known as microdosing, has become popular in recent years. However, there is a lack of placebo-controlled studies on microdosing and its effects. A new study recruited individuals who were starting to microdose with psilocybin mushrooms and found that it had noticeable subjective effects and altered EEG rhythms, but without evidence to support enhanced well-being, creativity and cognitive function.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Michael Schaefer, Kurt Zimmermann, Paul Enck
Summary: Placebos can have effects on clinical symptoms even without deception. This study compared the efficacy of open-label placebos, double-blind placebos, and treatment as usual in relieving seasonal allergic symptoms, and found that open-label placebos were more effective. The COVID-19 pandemic also had an impact on allergic symptoms and the effects of open-label placebos.
SCIENTIFIC REPORTS
(2023)
Letter
Allergy
Lars H. Blom, Ewa A. Bartko, Thea K. R. Moller, Lars K. Poulsen, Bettina M. Jensen
Article
Infectious Diseases
Christian Holm Hansen, Nikolaj Ulrik Friis, Peter Bager, Marc Stegger, Jannik Fonager, Anders Fomsgaard, Mie Agermose Gram, Lasse Engbo Christiansen, Steen Ethelberg, Rebecca Legarth, Tyra Grove Krause, Henrik Ullum, Palle Valentiner-Branth
Summary: Through a study in Denmark, we found that previous infection can provide up to 92.7% protection against SARS-CoV-2 omicron subvariant BA.5 and reduce the risk of hospitalization. The vaccine protection against BA.5 infection is similar to or slightly weaker than that against BA.2 infection. BA.5 infections are associated with an increased risk of hospitalization compared with BA.2 infections.
LANCET INFECTIOUS DISEASES
(2023)
Article
Psychiatry
Marie-Louise H. Rasmussen, Gry J. Poulsen, Poul Videbech, Jan Wohlfahrt, Mads Melbye
Summary: Previous research suggests that women with endocrine disease may have an increased risk of postpartum depression (PPD) due to their sensitivity to hormonal fluctuations. This nationwide cohort study aimed to investigate the association between endocrine disease history and PPD risk. The study included 888,989 deliveries and found that women with endocrine disease history had a 42% higher risk of PPD compared to those without. Interestingly, women with a history of PPD also had a 50% higher risk of endocrine disease. These findings highlight the importance of monitoring and providing support for pregnant women with endocrine disease to prevent and address PPD.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Letter
Allergy
Ewa A. A. Bartko, Jesper Elberling, Lars K. K. Poulsen, Bettina M. M. Jensen
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Endocrinology & Metabolism
Arvid Engstroem, Viktor Wintzell, Mads Melbye, Anders Hviid, Bjoern Eliasson, Soffia Gudbjoernsdottir, Kristian Hveem, Christian Jonasson, Henrik Svanstroem, Bjoern Pasternak, Peter Ueda
Summary: Using nationwide registers data from Denmark, Norway, and Sweden, this study demonstrates an association between the use of SGLT2 inhibitors and the risk of new-onset atrial fibrillation. Compared to GLP-1 receptor agonists, SGLT2 inhibitors are associated with a modestly reduced risk of new-onset atrial fibrillation.
Article
Medicine, General & Internal
Anders Husby, Jan Wohlfahrt, Mads Melbye
Summary: A Danish study found that there is a link between gestational age at birth and cognitive outcomes. Children born before 34 weeks showed lower academic performance in language and mathematics, while those born between 34-39 weeks did not differ significantly from full-term babies. This study provides important insights into the development of preterm babies.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Letter
Allergy
Victor Lendal, Sara Fransson, Holger Mosbech, Jonas Bredtoft Boel, Natasha Kahlhofen, Lars H. Blom, Lars K. Poulsen, Lene H. Garvey
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Letter
Allergy
Sara Fransson, Jonas Bredtoft Boel, Anne Holm, Natasha Kahlhofen, Janni Hjortlund, Holger F. Mosbech, Lars K. Poulsen, Susanne Reventlow, Lene H. Garvey
CLINICAL AND EXPERIMENTAL ALLERGY
(2023)
Article
Allergy
Sara Fransson, Christina Monnerup Damving, Jonas Bredtoft Boel, Magnus Arpi, Ida Gjorup Skinhoj, Jens Otto Jarlov, Holger F. Mosbech, Lars K. Poulsen, Lene H. Garvey
Summary: This study investigated the proportion of patients with penicillin allergy labels in a Danish hospital and classified them into no risk, low risk, and high-risk categories based on guidelines. The results showed that 10% of inpatients had a penicillin allergy label, and 17% of them could potentially have their label removed without allergy testing.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Pol Sole-Navais, Christopher Flatley, Valgerdur L. Steinthorsdottir, Marc Vaudel, Julius Juodakis, Jing Chen, Triin Laisk, Abigail C. LaBella, David Westergaard, Jonas Bacelis, Ben Brumpton, Line Skotte, Maria Borges, Oyvind A. Helgeland, Anubha Mahajan, Matthias N. Wielscher, Frederick P. Lin, Catherine Briggs, Carol Wang, Gunn-Helen E. Moen, Robin R. Beaumont, Jonathan Bradfield, Abin A. Abraham, Gudmar Thorleifsson, Maiken Gabrielsen, Sisse Ostrowski, Dominika Modzelewska, Ellen M. Nohr, Elina Hypponen, Amit M. Srivastava, Octavious Talbot, Catherine Allard, Scott Williams, Ramkumar Menon, Beverley Shields, Gardar Sveinbjornsson, Huan B. Xu, Mads F. Melbye, William Lowe, Luigi Bouchard, Emily I. Oken, Ole I. Pedersen, Daniel T. Gudbjartsson, Christian Erikstrup, Erik Sorensen, Rolv Lie, Kari Teramo, Mikko T. Hallman, Thorhildur Juliusdottir, Hakon Hakonarson, Henrik L. Ullum, Andrew Hattersley, Line Sletner, Mario Merialdi, Sheryl Rifas-Shiman, Thora Steingrimsdottir, Denise A. Scholtens, Christine H. Power, Jane West, Mette A. Nyegaard, John Capra, Anne Skogholt, Per Magnus, Ole E. Andreassen, Unnur Thorsteinsdottir, Struan F. A. M. Grant, Elisabeth Qvigstad, Craig I. Pennell, Marie-France A. Hivert, Geoffrey M. Hayes, Marjo-Riitta Jarvelin, Mark I. McCarthy, Deborah Lawlor, Henriette Nielsen, Reedik Maegi, Antonis Rokas, Kristian Hveem, Kari J. Stefansson, Bjarke M. Feenstra, Pal Njolstad, Louis Muglia, Rachel Freathy, Stefan Johanson, Ge Zhang, Bo Jacobsson
Summary: The study conducted a meta-analysis and identified genetic variants associated with gestational duration and preterm delivery. It revealed the importance of maternal alleles in influencing gestational duration and the complex relationship between gestational duration and birth weight. The study also identified antagonistic pleiotropy, where maternal alleles that increase gestational duration have negative effects on birth weight.
Article
Allergy
Stephanie Dramburg, Christiane Hilger, Alexandra F. Santos, Leticia de las Vecillas, Rob C. Aalberse, Nathalie Acevedo, Lorenz Aglas, Friedrich Altmann, Karla L. Arruda, Riccardo Asero, Barbara Ballmer-Weber, Domingo Barber, Kirsten Beyer, Tilo Biedermann, Maria Beatrice Bilo, Simon Blank, Philipp P. Bosshard, Heimo Breiteneder, Helen A. Brough, Merima Bublin, Dianne Campbell, Luis Caraballo, Jean Christoph Caubet, Giorgio Celi, Martin D. Chapman, Maksymilian Chruszcz, Adnan Custovic, Rebecca Czolk, Janet Davies, Nikolaos Douladiris, Bernadette Eberlein, Motohiro Ebisawa, Anna Ehlers, Philippe Eigenmann, Gabriele Gadermaier, Mattia Giovannini, Francisca Gomez, Rebecca Grohman, Carole Guillet, Christine Hafner, Robert G. Hamilton, Michael Hauser, Thomas Hawranek, Hans Juergen Hoffmann, Thomas Holzhauser, Tomona Iizuka, Alain Jacquet, Thilo Jakob, Bente Janssen-Weets, Uta Jappe, Marek Jutel, Tanja Kalic, Sandip Kamath, Sabine Kespohl, Joerg Kleine-Tebbe, Edward Knol, Andre Knulst, Jon R. Konradsen, Peter Korosec, Annette Kuehn, Gideon Lack, Thuy-My Le, Andreas Lopata, Olga Luengo, Mika Maekelae, Alessandro Maria Marra, Clare Mills, Martine Morisset, Antonella Muraro, Anna Nowak-Wegrzyn, Roni Nugraha, Markus Ollert, Kati Palosuo, Elide Anna Pastorello, Sarita Ulhas Patil, Thomas Platts-Mills, Anna Pomes, Pascal Poncet, Ekaterina Potapova, Lars K. Poulsen, Christian Radauer, Suzana Radulovic, Monika Raulf, Pierre Rouge, Joaquin Sastre, Sakura Sato, Enrico Scala, Johannes M. Schmid, Peter Schmid-Grendelmeier, Denise Schrama, Helene Senechal, Claudia Traidl-Hoffmann, Marcela Valverde-Monge, Marianne van Hage, Ronald van Ree, Kitty Verhoeckx, Stefan Vieths, Magnus Wickman, Josefina Zakzuk, Paolo M. Matricardi, Karin Hoffmann-Sommergruber
Summary: Since the discovery of IgE as a mediator of allergic diseases, our knowledge about its immunological mechanisms has greatly increased. Innovations in bioscience and technology have facilitated the production of well-defined molecules for component-resolved diagnosis, allowing personalized management of allergic diseases. The Molecular Allergology User's Guide 2.0 provides updated information on allergen molecules, their clinical relevance, and diagnostic algorithms, serving as a valuable resource for clinicians and scientists.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Victoria de Knegt, Paula Hedley, Gitte N. Hedermann, Casper Wilstrup, Marie Baekvad-Hansen, Ida Thagaard, Henrik M. Hjalgrim, Jorgen Kanters, Mads Melbye, David Hougaard, Anders Hviid, Lone Krebs, Morten Breindahl, Ulrik Lausten-Thomsen, Michael Christiansen
Summary: A nationwide COVID-19 lockdown in Denmark resulted in a reduced prevalence of extremely preterm or extremely low birthweight births. This study aimed to investigate the impact of the lockdown on term birthweights in Denmark. The findings showed a small but significant increase in birthweight during the lockdown period, primarily driven by an increase in birthweight in gestational weeks 40 and 41. Additionally, the proportion of infants with a large-for-gestational-age (LGA) increased during the lockdown.
Article
Allergy
Alexandra F. Santos, Carmen Riggioni, Ioana Agache, Cezmi A. Akdis, Mubeccel Akdis, Alberto Alvarez-Perea, Montserrat Alvaro-Lozano, Barbara Ballmer-Weber, Simona Barni, Kirsten Beyer, Carsten Bindslev-Jensen, Helen A. Brough, Betul Buyuktiryaki, Derek Chu, Stefano Del Giacco, Audrey Dunn-Galvin, Bernadette Eberlein, Motohiro Ebisawa, Philippe Eigenmann, Thomas Eiwegger, Mary Feeney, Montserrat Fernandez-Rivas, Helen R. Fisher, David M. Fleischer, Mattia Giovannini, Claudia Gray, Karin Hoffmann-Sommergruber, Susanne Halken, Jonathan O'B. Hourihane, Christina J. Jones, Marek Jutel, Edward Knol, George N. Konstantinou, Gideon Lack, Susanne Lau, Andreina Marques Mejias, Mary Jane Marchisotto, Rosan Meyer, Charlotte G. Mortz, Beatriz Moya, Antonella Muraro, Caroline Nilsson, Lucila Camargo Lopes de Oliveira, Liam O'Mahony, Nikolaos G. Papadopoulos, Kirsten Perrett, Rachel L. Peters, Marcia Podesta, Lars K. Poulsen, Graham Roberts, Hugh A. Sampson, Juergen Schwarze, Peter Smith, Elizabeth Huiwen Tham, Eva Untersmayr, Ronald Van Ree, Carina Venter, Brian P. Vickery, Berber Vlieg-Boerstra, Thomas Werfel, Margitta Worm, George Du Toit, Isabel Skypala
Summary: This guideline from the European Academy of Allergy and Clinical Immunology provides recommendations for diagnosing IgE-mediated food allergy, including clinical history, tests for determining IgE sensitization, and the use of oral food challenges for confirmation.
Article
Allergy
Lars H. Blom, Lasse B. Schmidt, Claus R. Johnsen, Jesper Elberling, Lars K. Poulsen, Lene H. Garvey
Article
Cardiac & Cardiovascular Systems
Niklas Worm Andersson, Giulia Corn, Tine Lovso Dohlmann, Mads Melbye, Jan Wohlfahrt, Marie Lund
Summary: Reducing LDL cholesterol through lipid-lowering therapy has been shown to effectively lower the risk of cardiovascular disease in individuals under 70 years old, but the evidence is less clear for older individuals. This study compared the clinical effectiveness of lowering LDL cholesterol through lipid-lowering therapy for primary prevention of cardiovascular disease in older and younger individuals, and found that the risk reduction effect was similar between the two age groups.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)