Review
Cell Biology
Sabrina Ceeraz, Charlotte R. Thompson, Richard Beatson, Ernest H. Choy
Summary: T regulatory cell therapy offers a new approach for treating autoimmune diseases and transplantation. CD8(+) Treg cells, particularly the CD8(+)CD28(-) subset, have been shown to be effective in preclinical models, although their impaired functionality in disease limits their effectiveness in immunosuppression. The review focuses on harnessing CD8(+) Treg cell therapy in clinical settings to aid current treatments for autoimmune and inflammatory conditions.
Review
Pharmacology & Pharmacy
Yang Yang, Pere Santamaria
Summary: In the past two decades, research on nanoparticle/microparticle-based compounds for treating autoimmune diseases has experienced explosive growth. Compounds have been evaluated using a variety of materials with different shapes, sizes, surface chemistries, and structures, incorporating various active pharmaceutical ingredients. These compounds can be categorized into four groups based on their intended mechanisms of action.
ADVANCED DRUG DELIVERY REVIEWS
(2021)
Review
Immunology
Qi Ke, Ashley Nicole Greenawalt, Veera Manukonda, Xingqi Ji, Roland Michael Tisch
Summary: Inflammasome molecules are receptors that trigger proinflammatory responses against microbial infections. Dysregulation of inflammasome activity has been associated with chronic inflammation and autoimmune diseases. Inflammasome activation affects both innate and adaptive immune effectors as well as resident cells in target tissues, contributing to autoimmune responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Zhineng Wang, Ying Sun, Wenbo Yao, Qian Ba, Hui Wang
Summary: Cadmium, a biologically non-essential heavy metal, widely present in the environment and foods, is mainly known for its immunotoxicity, which includes modulation of immune cell activity, induction of immune responses, and alteration of antibody production.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Brett E. Phillips, Yesica Garciafigueroa, Carl Engman, Wen Liu, Yiwei Wang, Robert J. Lakomy, Wilson S. Meng, Massimo Trucco, Nick Giannoukakis
Summary: The study demonstrated that using the RA + TGF beta 1 microparticle formulation could effectively prevent hyperglycemia in non-obese diabetic mice with mid-stage active islet-selective autoimmunity. The preventive effects did not seem to be mediated by increased numbers of regulatory T-lymphocytes inside the pancreatic lymph nodes, but rather by a mild increase in the frequency of regulatory B-lymphocytes inside the mesenteric lymph nodes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Elena Gianchecchi, Domenico V. Delfino, Alessandra Fierabracci
Summary: Autoimmune diseases have a multifactorial pathogenesis and the involvement of natural killer (NK) cells has been highlighted in shaping immune responses. Aberrant number and functionality of NK cells have been reported in various autoimmune disorders, indicating their potential as markers for disease activity and therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Maorun Zhang, Junmin Song, Weitang Yuan, Wei Zhang, Zhenqiang Sun
Summary: RNA methylation is a widely existing RNA modification in eukaryotes and prokaryotes, affecting various aspects of RNA such as splicing, nucleation, stability, and immunogenicity. It plays a role in many physiological and pathological processes, particularly in the immune system. Through regulating RNA immunogenicity and innate immune components, RNA methylation influences the innate immunity of the body.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Feifei Qiu, Junfeng Liu, Xiumei Mo, Huazhen Liu, Yuchao Chen, Zhenhua Dai
Summary: Artemisinin and its derivatives, traditionally used as antimalarial drugs, have shown promising therapeutic effects on inflammation and autoimmune disorders. Recent studies have highlighted the immunomodulatory potential of ARTs, paving the way for future clinical trials in treating immune-based disorders, particularly autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Catherine Sabatel, Fabrice Bureau
Summary: Respiratory mucosal surfaces are continuously exposed to innocuous non-self antigens and pathogen-associated molecular patterns (PAMPs). Despite the potential for immune responses, there are regulatory mechanisms in the lung that tightly control immune homeostasis and prevent the development of aberrant immune responses. Understanding these mechanisms could lead to the development of new therapeutic strategies for lung diseases like asthma.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Mohan Liu, Zhongyan Wang, Dandan Feng, Yuna Shang, Xinxin Li, Jianfeng Liu, Chen Li, Zhimou Yang
Summary: The tetrapeptide hydrogel Nap-G(d)F(d)F(d)Y exhibits promising potential in vaccine development and has been found to have significant therapeutic effects on type 1 diabetes by enhancing the population and function of T regulatory cells, thereby reducing inflammatory responses in the immune system.
Review
Medicine, General & Internal
Devaki Pilapitiya, Adam K. Wheatley, Hyon-Xhi Tan
Summary: Currently approved COVID-19 vaccines administered parenterally induce robust systemic humoral and cellular responses, but their effectiveness in preventing breakthrough infection and/or transmission is limited due to poor immunity at the respiratory mucosa. Therefore, there is considerable interest in developing mucosal vaccines that elicit localized immune responses for better protection at the site of virus entry. This review explores mucosal immunity, evaluates studies on the efficacy of mucosal immunity conferred by vaccination or respiratory infection, discusses ongoing clinical trials of mucosal vaccines, and assesses challenges and prospects for mucosal vaccine development.
Article
Allergy
Franziska Roth-Walter, Ian M. Adcock, Cristina Benito-Villalvilla, Rodolfo Bianchini, Leif Bjermer, Onur Boyman, Gaetano Caramori, Luigi Cari, Kian Fan Chung, Zuzana Diamant, Ibon Eguiluz-Gracia, Edward F. Knol, Antonios Kolios, Francesca Levi-Schaffer, Giuseppe Nocentini, Oscar Palomares, Frank Redegeld, Betty Van Esch, Cristiana Stellato
Summary: Therapeutic advances using targeted biologicals and small-molecule drugs have achieved significant success in treating chronic inflammatory and autoimmune diseases, especially for some severe, treatment-resistant forms. T cell-based therapies aim to cure diseases by delivering engineered specific cytotoxic or regulatory T cells, revolutionizing the field of oncology and offering potential curative options for immune-driven disorders.
Article
Immunology
Amanda D. Caulfield, Maiya Callender, Eric T. Harvill
Summary: Bordetella pertussis is the causative agent of whooping cough, a severe respiratory disease with high morbidity and mortality in infants and young children. Current vaccines do not provide long-lasting immunity and cannot prevent subclinical infection or transmission. Research limitations and potent immunomodulation by the bacterium have hindered efforts to generate robust mucosal immunity. New directions and methods are needed to fill critical gaps in understanding host-pathogen dynamics and to develop novel vaccines that can halt the circulation of Bordetella pertussis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Neurosciences
Maria M. Sirufo, Lina M. Magnanimi, Lia Ginaldi, Massimo De Martinis
Summary: There is a reciprocal association between anorexia nervosa and autoimmune diseases based on shared immunopathological mechanisms. Factors such as the influence of gut microbiota, disrupted gut-brain communication, and disrupted T cell tolerance and autoantibodies may play important roles in the pathogenesis of anorexia nervosa.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Immunology
Wen Jie Yeoh, Philippe Krebs
Summary: The review summarizes the current knowledge of the phosphoinositide phosphatase SHIP1 and its role in regulating innate immune cells. It also discusses the development of small-molecule agonists and antagonists targeting SHIP1, and explores the potential use of SHIP1 modulation in immune therapies for human diseases with unmet medical needs.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
