Influence of protein fold stability on immunogenicity and its implications for vaccine design

Follicular Helper T Cells

(2016) Carola G. Vinuesa et al.   Annual Review of Immunology

Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2

(2016) Hitomi Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

MAESTROweb: a web server for structure-based protein stability prediction

(2016) Josef Laimer et al.   BIOINFORMATICS

Fold stability during endolysosomal acidification is a key factor for allergenicity and immunogenicity of the major birch pollen allergen

(2016) Yoan Machado et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A Randomized, Controlled, Observer-Blinded Phase 1 Study of the Safety and Immunogenicity of a Respiratory Syncytial Virus Vaccine With or Without Alum Adjuvant

(2016) Joanne M. Langley et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Ricin Subunit Antigens With Enhanced Capacity to Elicit Toxin-Neutralizing Antibody Responses in Mice

(2016) Newton Wahome et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

(2016) M Gordon Joyce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Present Yourself! By MHC Class I and MHC Class II Molecules

(2016) Kenneth L. Rock et al.   TRENDS IN IMMUNOLOGY

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV

(2016) M Gordon Joyce et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation

(2016) Nicholas van Panhuys   Frontiers in Immunology

MAESTRO - multi agent stability prediction upon point mutations

(2015) Josef Laimer et al.   BMC BIOINFORMATICS

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate

(2015) Bo Liang et al.   JOURNAL OF VIROLOGY

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The first step of peptide selection in antigen presentation by MHC class I molecules

(2015) Malgorzata A. Garstka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Safety of vaccine adjuvants: Focus on autoimmunity

(2015) Jan Willem van der Laan et al.   VACCINE

Conformational instability governed by disulfide bonds partitions the dominant from subdominant helper T-cell responses specific for HIV-1 envelope glycoprotein gp120

(2015) Hong-Nam P. Nguyen et al.   VACCINE

A highly stable prefusion RSV F vaccine derived from structural analysis of the fusion mechanism

(2015) Anders Krarup et al.   Nature Communications

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

(2015) Young Do Kwon et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ligand Binding Modulates the Structural Dynamics and Compactness of the Major Birch Pollen Allergen

(2014) Sarina Grutsch et al.   BIOPHYSICAL JOURNAL

Bet v 1 - a Trojan horse for small ligands boosting allergic sensitization?

(2014) C. Asam et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Forces stabilizing proteins

(2014) C. Nick Pace et al.   FEBS LETTERS

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

(2014) Nicholas van Panhuys et al.   IMMUNITY

T Follicular Helper Cell Differentiation, Function, and Roles in Disease

(2014) Shane Crotty   IMMUNITY

Itk-mediated integration of T cell receptor and cytokine signaling regulates the balance between Th17 and regulatory T cells

(2014) Julio Gomez-Rodriguez et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Divergent paths for the selection of immunodominant epitopes from distinct antigenic sources

(2014) AeRyon Kim et al.   Nature Communications

Early signaling events that underlie fate decisions of naive CD4+T cells toward distinct T-helper cell subsets

(2013) Hidehiro Yamane et al.   IMMUNOLOGICAL REVIEWS

Key roles of adjuvants in modern vaccines

(2013) Steven G Reed et al.   NATURE MEDICINE

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

(2013) J. S. McLellan et al.   SCIENCE

Rational Engineering of Recombinant Picornavirus Capsids to Produce Safe, Protective Vaccine Antigen

(2013) Claudine Porta et al.   PLoS Pathogens

Generation and Function of Induced Regulatory T Cells

(2013) Erica G. Schmitt et al.   Frontiers in Immunology

Intracellular glutathione pools are heterogeneously concentrated

(2013) Davide Montero et al.   Redox Biology

Structural and Immunological Analysis of Anthrax Recombinant Protective Antigen Adsorbed to Aluminum Hydroxide Adjuvant

(2012) Leslie Wagner et al.   Clinical and Vaccine Immunology

Thermal, Chemical and pH Induced Denaturation of a Multimeric β-Galactosidase Reveals Multiple Unfolding Pathways

(2012) Devesh Kishore et al.   PLoS One

Distinct influences of peptide-MHC quality and quantity on in vivo T-cell responses

(2012) R. A. Gottschalk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutations for decreasing the immunogenicity and maintaining the function of core streptavidin

(2012) Kyohei Yumura et al.   PROTEIN SCIENCE

Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non-specific immunostimulatory effects

(2011) Sergio Arancibia et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Macropinocytosis: an endocytic pathway for internalising large gulps

(2011) Jet Phey Lim et al.   IMMUNOLOGY AND CELL BIOLOGY

A recombinant immunotoxin engineered for increased stability by adding a disulfide bond has decreased immunogenicity

(2011) W. Liu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Differentiation of Effector CD4 T Cell Populations

(2010) Jinfang Zhu et al.   Annual Review of Immunology

Designing hypoallergenic derivatives for allergy treatment by means of in silico mutation and screening

(2010) Theresa Thalhamer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TCR ligand density and affinity determine peripheral induction of Foxp3 in vivo

(2010) Rachel A. Gottschalk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Protein's Conformational Stability Is an Immunologically Dominant Factor: Evidence That Free-Energy Barriers for Protein Unfolding Limit the Immunogenicity of Foreign Proteins

(2010) T. Ohkuri et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: Lack of High Affinity Competition for Peptide in Polyclonal CD4+ Responses Unmasks IL-4 Production

(2010) J. D. Milner et al.   JOURNAL OF IMMUNOLOGY

Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

(2009) Daniel Finley   Annual Review of Biochemistry

IL-17 and Th17 Cells

(2009) Thomas Korn et al.   Annual Review of Immunology

Long-lasting cross-presentation of tumor antigen in human DC

(2009) Florence Faure et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding

(2009) Nicolas Fazilleau et al.   NATURE IMMUNOLOGY

Cynomolgus macaques immunized with two HIV-1 Tat stabilized proteins raise strong and long-lasting immune responses with a pattern of Th1/Th2 response differing from that in mice

(2009) Sabrina Turbant et al.   VACCINE

Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Increasing the humoral immunogenic properties of the HIV-1 Tat protein using a ligand-stabilizing strategy

(2008) Alain Lecoq et al.   VACCINE

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology