Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries

The I-TASSER Suite: protein structure and function prediction

(2015) Jianyi Yang et al.   NATURE METHODS

Multiple hereditary exostoses (MHE): elucidating the pathogenesis of a rare skeletal disorder through interdisciplinary research

(2014) Kevin B. Jones et al.   CONNECTIVE TISSUE RESEARCH

Fell-Muir Lecture: Syndecans: from peripheral coreceptors to mainstream regulators of cell behaviour

(2014) John R. Couchman et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing

(2014) Eric Sterner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic View of Basement Membranes from Human Retinal Blood Vessels, Inner Limiting Membranes, and Lens Capsules

(2014) Guy Uechi et al.   JOURNAL OF PROTEOME RESEARCH

Simpson-Golabi-Behmel syndrome types I and II

(2014) Jair Tenorio et al.   Orphanet Journal of Rare Diseases

The Role of Heparanase and Sulfatases in the Modification of Heparan Sulfate Proteoglycans within the Tumor Microenvironment and Opportunities for Novel Cancer Therapeutics

(2014) Edward Hammond et al.   Frontiers in Oncology

Cooperation of binding sites at the hydrophilic domain of cell-surface sulfatase Sulf1 allows for dynamic interaction of the enzyme with its substrate heparan sulfate

(2013) Fabian Milz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Epiphyseal abnormalities, trabecular bone loss and articular chondrocyte hypertrophy develop in the long bones of postnatal Ext1-deficient mice

(2013) Federica Sgariglia et al.   BONE

Heparan sulfate in skeletal development, growth, and pathology: The case of hereditary multiple exostoses

(2013) Julianne Huegel et al.   DEVELOPMENTAL DYNAMICS

Glycosaminoglycans in the blood of hereditary multiple exostoses patients: Half reduction of heparan sulfate to chondroitin sulfate ratio and the possible diagnostic application

(2013) Md. Ferdous Anower-E-Khuda et al.   GLYCOBIOLOGY

Insights into the Mechanism by Which Interferon-γ Basic Amino Acid Clusters Mediate Protein Binding to Heparan Sulfate

(2013) Els Saesen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heparanase: Multiple functions in inflammation, diabetes and atherosclerosis

(2013) Israel Vlodavsky et al.   MATRIX BIOLOGY

Border patrol: Insights into the unique role of perlecan/heparan sulfate proteoglycan 2 at cell and tissue borders

(2013) Mary C. Farach-Carson et al.   MATRIX BIOLOGY

Heparan sulfate as a regulator of endochondral ossification and osteochondroma development

(2013) Katja Jochmann et al.   MATRIX BIOLOGY

Proline: The Distribution, Frequency, Positioning, and Common Functional Roles of Proline and Polyproline Sequences in the Human Proteome

(2013) Alexander A. Morgan et al.   PLoS One

Structural insights into proteoglycan-shaped Hedgehog signaling

(2013) D. M. Whalen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Interferon Gamma Signaling by Suppressors of Cytokine Signaling and Regulatory T Cells

(2013) Joseph Larkin et al.   Frontiers in Immunology

Hedgehog Secretion and Signal Transduction in Vertebrates

(2012) Kaitlyn E. Ryan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Roles of Heparan Sulfate Sulfation in Dentinogenesis

(2012) Satoru Hayano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Synovial Lubricin Expresses Sialyl Lewis x Determinant and Has L-selectin Ligand Activity

(2012) Chunsheng Jin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Introduction to Proteoglycans and Their Localization

(2012) John R. Couchman et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Heparan Sulfate Proteoglycans Mediate the Angiogenic Activity of the Vascular Endothelial Growth Factor Receptor-2 Agonist Gremlin

(2011) Paola Chiodelli et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Compound heterozygous loss of Ext1 and Ext2 is sufficient for formation of multiple exostoses in mouse ribs and long bones

(2011) Beverly M. Zak et al.   BONE

Two Distinct Sites in Sonic Hedgehog Combine for Heparan Sulfate Interactions and Cell Signaling Functions

(2011) Shu-Chun Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serglycin: A Structural and Functional Chameleon with Wide Impact on Immune Cells

(2011) Svein O. Kolset et al.   JOURNAL OF IMMUNOLOGY

Betaglycan: A multifunctional accessory

(2011) Maree Bilandzic et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Transmembrane Signaling Proteoglycans

(2010) John R. Couchman   Annual Review of Cell and Developmental Biology

Interactions between Hedgehog proteins and their binding partners come into view

(2010) P. A. Beachy et al.   GENES & DEVELOPMENT

Proteoglycans in cancer biology, tumour microenvironment and angiogenesis

(2010) Renato V. Iozzo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Syndecans as cell surface receptors: Unique structure equates with functional diversity

(2010) Youngsil Choi et al.   MATRIX BIOLOGY

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

Heparin binding domain peptides of antithrombin III: Analysis by isothermal titration calorimetry and circular dichroism spectroscopy

(2010) Ruth Tyler-Cross et al.   PROTEIN SCIENCE

Loss of glypican-3 function causes growth factor-dependent defects in cardiac and coronary vascular development

(2009) Ann Ng et al.   DEVELOPMENTAL BIOLOGY

Characterization of the Structural Features and Interactions of Sclerostin

(2009) Vaclav Veverka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the Human Sulfatase Sulf1 and Its High Affinity Heparin/Heparan Sulfate Interaction Domain

(2009) Marc-André Frese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Syndecan-1 Is Required for Robust Growth, Vascularization, and Metastasis of Myeloma Tumorsin Vivo

(2009) Yekaterina B. Khotskaya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses

(2009) Jennifer A Chan et al.   NATURE NEUROSCIENCE

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

I-TASSER server for protein 3D structure prediction

(2008) Yang Zhang   BMC BIOINFORMATICS

The Hedgehog protein family

(2008) Thomas R Bürglin   GENOME BIOLOGY