Interplay of autophagy, receptor tyrosine kinase signalling and endocytic trafficking

Targeting Autophagy in Cancer: Update on Clinical Trials and Novel Inhibitors

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

FGF2/FGFR1 regulates autophagy in FGFR1-amplified non-small cell lung cancer cells

(2017) Hong Yuan et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Autophagy Inhibition Enhances Sunitinib Efficacy in Clear Cell Ovarian Carcinoma

(2017) Lindsay DeVorkin et al.   MOLECULAR CANCER RESEARCH

Autophagy-Dependent Shuttling of TBC1D5 Controls Plasma Membrane Translocation of GLUT1 and Glucose Uptake

(2017) Srirupa Roy et al.   MOLECULAR CELL

mTORC1-independent TFEB activation via Akt inhibition promotes cellular clearance in neurodegenerative storage diseases

(2017) Michela Palmieri et al.   Nature Communications

Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

(2017) Jessica T Chang et al.   eLife

Autophagy inhibitor facilitates gefitinib sensitivity in vitro and in vivo by activating mitochondrial apoptosis in triple negative breast cancer

(2017) Zhaoyun Liu et al.   PLoS One

Autophagy induced by AXL receptor tyrosine kinase alleviates acute liver injury via inhibition of NLRP3 inflammasome activation in mice

(2016) Jihye Han et al.   Autophagy

Suppression of autophagy impedes glioblastoma development and induces senescence

(2016) Noor Gammoh et al.   Autophagy

Tyrosine kinase receptor EGFR regulates the switch in cancer cells between cell survival and cell death induced by autophagy in hypoxia

(2016) Yongqiang Chen et al.   Autophagy

Regulation of mATG9 trafficking by Src- and ULK1-mediated phosphorylation in basal and starvation-induced autophagy

(2016) Changqian Zhou et al.   CELL RESEARCH

Beta 1-integrin–c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes

(2016) Rachel Barrow-McGee et al.   Nature Communications

ATG9A loss confers resistance to trastuzumab via c-Cbl mediated Her2 degradation

(2016) Joao Nunes et al.   Oncotarget

The role of STAT3 in autophagy

(2015) Liangkun You et al.   Autophagy

Proteasome inhibitors induce FLT3-ITD degradation through autophagy in AML cells

(2015) C. Larrue et al.   BLOOD

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases

(2015) Mei-Kuang Chen et al.   FEBS Journal

Autophagy and proteins involved in vesicular trafficking

(2015) Celina Amaya et al.   FEBS LETTERS

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

(2015) C. K. Domigan et al.   JOURNAL OF CELL SCIENCE

Therapeutic targeting of autophagy in neurodegenerative and infectious diseases

(2015) David C. Rubinsztein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Two sides of the same coin: tyrosine kinase inhibition in cancer and neurodegeneration

(2015) Charbel E-H Moussa et al.   Neural Regeneration Research

Beclin 1 regulates growth factor receptor signaling in breast cancer

(2015) R A Rohatgi et al.   ONCOGENE

Combating autophagy is a strategy to increase cytotoxic effects of novel ALK inhibitor entrectinib in neuroblastoma cells

(2015) Sanja Aveic et al.   Oncotarget

Mitochondrially localized EGFR is subjected to autophagic regulation and implicated in cell survival

(2014) Xiaojing Yue et al.   Autophagy

TBC1D5 and the AP2 complex regulate ATG9 trafficking and initiation of autophagy

(2014) D. Popovic et al.   EMBO REPORTS

Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma

(2014) Hideki Makinoshima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The non-receptor tyrosine kinase Ack1 regulates the fate of activated EGFR by inducing trafficking to the p62/NBR1 pre-autophagosome

(2014) S. Jones et al.   JOURNAL OF CELL SCIENCE

Autophagosome-Mediated EGFR Down-Regulation Induced by the CK2 Inhibitor Enhances the Efficacy of EGFR-TKI on EGFR-Mutant Lung Cancer Cells with Resistance by T790M

(2014) Kwang Sup So et al.   PLoS One

Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance

(2014) G. Karsli-Uzunbas et al.   Cancer Discovery

Identification of Host-Targeted Small Molecules That Restrict Intracellular Mycobacterium tuberculosis Growth

(2014) Sarah A. Stanley et al.   PLoS Pathogens

The ULK1 complex

(2013) Pui-Mun Wong et al.   Autophagy

EGFR-Mediated Beclin 1 Phosphorylation in Autophagy Suppression, Tumor Progression, and Tumor Chemoresistance

(2013) Yongjie Wei et al.   CELL

Diverse Autophagosome Membrane Sources Coalesce in Recycling Endosomes

(2013) Claudia Puri et al.   CELL

Autophagy and cell death

(2013) Tohru Yonekawa et al.   Essays in Biochemistry

Role of the EphB2 receptor in autophagy, apoptosis and invasion in human breast cancer cells

(2013) Sahiti Chukkapalli et al.   EXPERIMENTAL CELL RESEARCH

IGF-1 receptor antagonism inhibits autophagy

(2013) Maurizio Renna et al.   HUMAN MOLECULAR GENETICS

Nilotinib reverses loss of dopamine neurons and improves motor behavior via autophagic degradation of  -synuclein in Parkinson's disease models

(2013) M. L. Hebron et al.   HUMAN MOLECULAR GENETICS

Interaction between Her2 and Beclin-1 Proteins Underlies a New Mechanism of Reciprocal Regulation

(2013) Jie Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class IA PI3K p110β Subunit Promotes Autophagy through Rab5 Small GTPase in Response to Growth Factor Limitation

(2013) Zhixun Dou et al.   MOLECULAR CELL

mTOR inhibits autophagy by controlling ULK1 ubiquitylation, self-association and function through AMBRA1 and TRAF6

(2013) Francesca Nazio et al.   NATURE CELL BIOLOGY

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

(2013) Ryan C. Russell et al.   NATURE CELL BIOLOGY

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Induction of Autophagy Is an Early Response to Gefitinib and a Potential Therapeutic Target in Breast Cancer

(2013) Wieslawa H. Dragowska et al.   PLoS One

Autophagy proteins regulate ERK phosphorylation

(2013) Nuria Martinez-Lopez et al.   Nature Communications

Amplification of the MET Receptor Drives Resistance to Anti-EGFR Therapies in Colorectal Cancer

(2013) Alberto Bardelli et al.   Cancer Discovery

The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

(2013) Sílvia Cufí et al.   Scientific Reports

EGFR tyrosine kinase inhibition induces autophagy in cancer cells

(2012) Christopher Fung et al.   CANCER BIOLOGY & THERAPY

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

(2012) Carmine Settembre et al.   EMBO JOURNAL

FRS2α is Essential for the Fibroblast Growth Factor to Regulate the mTOR Pathway and Autophagy in Mouse Embryonic Fibroblasts

(2012) Xiang Lin et al.   International Journal of Biological Sciences

TBC1D14 regulates autophagosome formation via Rab11- and ULK1-positive recycling endosomes

(2012) Andrea Longatti et al.   JOURNAL OF CELL BIOLOGY

Rab GTPase-Activating Proteins in Autophagy: Regulation of Endocytic and Autophagy Pathways by Direct Binding to Human ATG8 Modifiers

(2012) D. Popovic et al.   MOLECULAR AND CELLULAR BIOLOGY

EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans

(2012) Annelies Van Hoecke et al.   NATURE MEDICINE

Involvement of Receptor Tyrosine Kinase Tyro3 in Amyloidogenic APP Processing and β-Amyloid Deposition in Alzheimer's Disease Models

(2012) Yan Zheng et al.   PLoS One

Neuregulin Promotes Incomplete Autophagy of Prostate Cancer Cells That Is Independent of mTOR Pathway Inhibition

(2012) Eran Schmukler et al.   PLoS One

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

(2012) R. C. Wang et al.   SCIENCE

Receptor Tyrosine Kinase Inhibitors That Block Replication of Influenza A and Other Viruses

(2011) Naveen Kumar et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Autophagy inhibition cooperates with erlotinib to induce glioblastoma cell death

(2011) Sandrine Eimer et al.   CANCER BIOLOGY & THERAPY

Energy-preserving effects of IGF-1 antagonize starvation-induced cardiac autophagy

(2011) Rodrigo Troncoso et al.   CARDIOVASCULAR RESEARCH

Imatinib-Sensitive Tyrosine Kinases Regulate Mycobacterial Pathogenesis and Represent Therapeutic Targets against Tuberculosis

(2011) Ruth J. Napier et al.   Cell Host & Microbe

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells

(2011) Weidong Han et al.   PLoS One

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Mechanisms of acquired resistance to tyrosine kinase inhibitors

(2011) Yi-fan Chen et al.   Acta Pharmaceutica Sinica B

Roles of autophagy in cetuximab-mediated cancer therapy against EGFR

(2010) Xinqun Li et al.   Autophagy

The Epidermal Growth Factor Receptor Antibody Cetuximab Induces Autophagy in Cancer Cells by Downregulating HIF-1  and Bcl-2 and Activating the Beclin 1/hVps34 Complex

(2010) X. Li et al.   CANCER RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

The EphB2 tumor suppressor induces autophagic cell death via concomitant activation of the ERK1/2 and PI3K pathways

(2010) Mustapha Kandouz et al.   CELL CYCLE

Plasma membrane contributes to the formation of pre-autophagosomal structures

(2010) Brinda Ravikumar et al.   NATURE CELL BIOLOGY

Rubicon controls endosome maturation as a Rab7 effector

(2010) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Non-canonical MEK/ERK Signaling Pathway Regulates Autophagy via Regulating Beclin 1

(2009) Jianrong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

(2008) Zhang Weihua et al.   CANCER CELL

Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG

(2008) Eisuke Itakura et al.   MOLECULAR BIOLOGY OF THE CELL

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

(2007) Christopher Fung et al.   MOLECULAR BIOLOGY OF THE CELL