Article
Environmental Sciences
Ezgi Nur Demirkapi, Sinan Ince, Hasan Huseyin Demirel, Damla Arslan-Acaroz, Ulas Acaroz
Summary: This study demonstrates the protective effect of polydatin (PD) against oxidative stress caused by aflatoxin B-1 (AFB(1)) in mice. PD administration at increasing doses effectively reduced oxidative stress, DNA damage, and inflammation induced by AFB(1). Furthermore, PD improved liver and kidney tissue damage caused by AFB(1). These findings highlight the potential of PD as a therapeutic agent against AFB(1)-induced toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Engineering, Environmental
Nan Jiang, Peipei Song, Xianxu Li, Lusheng Zhu, Jinhua Wang, Xianqiang Yin, Jun Wang
Summary: The study found that low concentrations of DBP can cause oxidative damage and genotoxicity in the zebrafish brain, demonstrating clear toxic effects. Assessment of DBP's toxic effects on zebrafish brain can be effectively evaluated by measuring biomarkers such as SOD and CAT activities.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Environmental Sciences
Javed Ahmad, Rubina Yasmeen, Mohammad Irfan, Asma A. Al-Huqail, Mohammad Irfan Qureshi
Summary: Traces of arsenic in vegetables and crops cultivated in arsenic-polluted soils are a global concern due to its carcinogenic properties and harmful effects on the food chain. This study focused on the accumulation and defense mechanisms of fenugreek plants exposed to arsenic stress. The findings showed increased oxidative stress and DNA damage at higher arsenic concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Lucia M. Odetti, Evelyn C. Lopez Gonzalez, Pablo A. Siroski, Ma. Fernanda Simoniello, Gisela L. Poletta
Summary: This study aimed to assess the molecular stress responses in blood of Caiman latirostris hatchlings exposed to pesticide formulations and found that the expression levels of catalase (cat), superoxide dismutase (sod), and heat shock protein 70 (hsp70) genes were altered, which were associated with oxidative damage and genotoxicity. The pesticides tested showed significant increase in DNA damage and micronucleus frequency, as well as oxidation. The expression levels of cat gene were significantly higher in the cypermethrin group, while the expression of hsp70 gene was significantly lower in glyphosate, cypermethrin, and the ternary mixture group compared to the negative control group.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Environmental Sciences
Paritosh Mondal, Pallab Shaw, Arpan Dey Bhowmik, Arindam Bandyopadhyay, Muthammal Sudarshan, Anindita Chakraborty, Ansuman Chattopadhyay
Summary: This study found that the combined exposure of arsenic and fluoride had minimal impact on the female zebrafish brain, with lower oxidative stress response and tissue damage, indicating an antagonistic effect between the two toxicants.
Article
Environmental Sciences
Priyanka Prasad, Sushant Kumar Singh, Sukanya Ghosh, Suchisnigdha Dutta, Dona Sinha
Summary: This study investigated the impact of different exposure levels of arsenic in groundwater on cellular redox status, DNA damage, and repair mechanisms in rural women of West Bengal. The results showed a dose-dependent relationship between arsenic exposure levels and oxidative stress, DNA damage, and suppression of DNA repair proteins. Additionally, the exposed population had a very high risk of cancer.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Nazim Husain, Samra Hasan, Aijaz Ahmed Khan, Riaz Mahmood
Summary: Oral administration of copper chloride in rats led to significant oxidative damage in the intestine, affecting cellular metabolism, cell membrane, and DNA damage, which in turn can impair digestive and absorptive functions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Galina N. Chelomina, Sergey P. Kukla, Viktor P. Chelomin, Pham N. Doanh
Summary: Parasite infection can lead to DNA damage, potentially involving oxidative stress and cancer development; these research findings are important for understanding the pathogenesis mechanisms of parasitic diseases.
Article
Biochemistry & Molecular Biology
Min Zhou, Youpu Cheng, Ying Zhang, Ziqi Liu, Minghao Zhang
Summary: The toxicity of flufiprole enantiomers to earthworms was evaluated by investigating the effect on antioxidative enzyme activity, DNA damage, and gene expression levels. The study found that different enantiomers had varying effects on the earthworms, with R-(+)-flufiprole showing the highest toxicity. Additionally, the antioxidative enzyme SOD could be an important biomarker for monitoring the risk of flufiprole enantiomers.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yang Li, Xiuli Lu, Zhihao Yu, Haozhen Wang, Bing Gao
Summary: In this study, it was found that ATP1A1 may be a key susceptibility gene involved in calcium stone formation. The down-regulation of ATP1A1 was associated with crystal deposition and activation of related signaling pathways. Overexpression of ATP1A1 or treatment with a specific inhibitor alleviated oxidative stress, inflammation, apoptosis, crystal-cell adhesion, and stone formation. These findings suggest that ATP1A1 could be a potential therapeutic target for treating calcium stones.
Article
Environmental Sciences
Aline G. G. Aun, Debora C. Damasceno, Yuri K. K. Sinzato, Flavia R. Nogueira, Katina M. Souza, Youssef S. A. Lawi, Julia L. Guedes, Mariane A. P. Silva, Lidia R. de Carvalho, Leandro G. G. Braz, Mariana G. G. Braz
Summary: Evaluation of the possible toxic effects of occupational exposure to anesthetics is limited. This cohort study assessed oxidative stress, DNA damage, and gene expression in physicians occupationally exposed to modern anesthetics during their residency period. The results showed induction of oxidative stress, gene expression modulation, and genotoxicity in physicians during their specialization period.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Hiba Hamdi, Imen Graiet, Salwa Abid-Essefi, Joel Eyer
Summary: This study revealed that oral exposure to EPX caused oxidative stress, lipid peroxidation, protein oxidation, DNA fragmentation, impaired antioxidant enzyme activities, and histological alterations in the brain of adult rats. In embryonic neural stem cells, EPX treatment reduced cell viability, proliferation, induced cell cycle arrest, and disrupted cytoskeleton, ultimately leading to apoptosis. Pretreatment with N-acetylcysteine attenuated the toxic effects of EPX on neural stem cells.
Review
Genetics & Heredity
Susana G. Martins, Rita Zilhao, Solveig Thorsteinsdottir, Ana Rita Carlos
Summary: Oxidative stress and DNA damage can disrupt the normal physiological equilibrium of cells and tissues, particularly in the process of ECM remodeling. Mutations in ECM genes have a significant impact on tissue homeostasis, leading to increased oxidative stress and potential accumulation of DNA damage, ultimately resulting in negative impacts on tissue and organ function.
FRONTIERS IN GENETICS
(2021)
Article
Medicine, Research & Experimental
Ghorbannejad Hadi, Tofighi Asghar, Tolouei Azar Javad, Razi Mazdak
Summary: Long-term consumption of tramadol negatively affects spermatogenesis development, while exercise training protocols (ETPs) can reduce the damage caused by tramadol on antioxidant and endocrine capacities, with low-intensity training showing the best results.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Umit Acar, Burak Evren Inanan, Fahriye Zemheri Navruz, Sevdan Yilmaz
Summary: The study investigated the effects of different concentrations of GBH on Nile tilapia, revealing alterations in blood parameters, oxidative stress in the liver, and DNA damage induced by GBH exposure. Antioxidant enzyme-related genes were up-regulated to counter oxidative stress, while the expression levels of immune-related genes decreased in fish exposed to high concentrations of GBH (>=20 mg/L).
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Veterinary Sciences
Ulas Acaroz, Sinan Ince, Damla Arslan Acaroz, Zeki Gurler, Recep Kara, Ismail Kucukkurt, Abdullah Eryavuz
Summary: Enrofloxacin (ENR) and its metabolite ciprofloxacin (CIP) excretion levels in Anatolian buffalo milk were determined using LC-MS/MS method. The concentrations were found to be below the maximum residue limit in all samples, and no antibiotics were detected in the marketed buffalo milk samples.
ANKARA UNIVERSITESI VETERINER FAKULTESI DERGISI
(2021)
Article
Biochemistry & Molecular Biology
Funda Karabag Coban, Sinan Isnce, Hasan Huseyin Demirel, Izzet Islam, Hande Aytug
Summary: This study investigated the effects of boric acid on acute renal toxicity induced by acetaminophen and compared them to N-acetyl cysteine. The results showed that boric acid had a protective effect against the negative effects of acetaminophen on the kidneys.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Environmental Sciences
Sinan Ince, Hasan Huseyin Demirel, Fahriye Zemheri-Navruz, Damla Arslan-Acaroz, Ismail Kucukkurt, Ulas Acaroz, Ali Tureyen, Ezgi Nur Demirkapi
Summary: This study investigated the synergistic toxic effects of ethanol and 2,4-D in male albino rats. Co-administration of ethanol and 2,4-D increased liver functional enzyme levels and lipid peroxidation while decreased glutathione and antioxidant enzyme activities. Furthermore, it caused DNA damage and the increase in apoptotic and proinflammatory cytokine gene expressions. Histopathological examination revealed that these substances induced more serious damage, especially in the liver and kidney.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Environmental Sciences
Fahriye Zemheri-Navruz, Sinan Ince, Damla Arslan-Acaroz, Ulas Acaroz, Hasan Huseyin Demirel, Ezgi Nur Demirkapi
Summary: This study aimed to determine the protective effect of Res against Pyra-induced lipid peroxidation, oxidative stress, and DNA damage in rats. Researchers found that Res administrations in a dose-dependent manner improved Pyra-induced lipid peroxidation, oxidative and DNA damages, gene expressions, and histopathological changes in the liver and kidney.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ismail Kucukkurt, Sinan Ince, Abdullah Eryavuz, Hasan H. Demirel, Damla Arslan-Acaroz, Fahriye Zemheri-Navruz, Ibrahim Durmus
Summary: Boron has a dose-dependent protective antioxidant and tissue regenerative effects on fatty liver syndrome caused by a high-fat diet in rats.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Veterinary Sciences
F. Avdatek, H. H. Demirel, I. Kucukkurt, D. A. Acaroz, S. Ince
Summary: The study found that boron can protect the spermatological parameters, repair DNA damage, and reduce cell and oxidative damage caused by a high-fat diet in rats.
JOURNAL OF THE HELLENIC VETERINARY MEDICAL SOCIETY
(2022)
Review
Oncology
Syeda Tasmia Asma, Ulas Acaroz, Kalman Imre, Adriana Morar, Syed Rizwan Ali Shah, Syed Zajif Hussain, Damla Arslan-Acaroz, Hayri Demirbas, Zehra Hajrulai-Musliu, Fatih Ramazan Istanbullugil, Ali Soleimanzadeh, Dmitry Morozov, Kui Zhu, Viorel Herman, Abdelhanine Ayad, Christos Athanassiou, Sinan Ince
Summary: Cancer is a deadly disease that has seen a significant rise in mortality rates globally. The search for potent anticancer agents has led to a focus on natural sources for novel and effective drugs. Plants and microbial species, chosen based on their composition, ecology, phytochemical, and ethnopharmacological properties, have played a crucial role in producing effective anticancer agents. The clinical development of various plant-derived bioactive compounds against cancer, as well as the conjugation of natural compounds with anti-cancerous drugs, show promise in generating targeted treatment therapies. Awareness from pharmaceutical research studies in this field could lead to alternative drug development strategies that are economical, reliable, and safe to use.
Article
Biochemistry & Molecular Biology
Serkan Karatekeli, Hasan Huseyin Demirel, Fahriye Zemheri-Navruz, Sinan Ince
Summary: This study reveals the protective effect of boron against AFB1-induced liver damage in rats. Boron reverses the negative changes caused by AFB1 and exhibits antioxidant, anti-inflammatory, and anti-apoptotic effects.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Cell Biology
Ali Tureyen, Hasan Huseyin Demirel, Ezgi Nur Demirkapi, Azra Mila Eryavuz, Sinan Ince
Summary: The protective effect of Tubuloside A (TA) against diclofenac-induced hepato-renal damage was evaluated in this study. The results demonstrated the toxic effects of diclofenac on the liver and kidney, while TA treatment protected these organs from diclofenac-induced damage.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Multidisciplinary Sciences
Funda Karabag, Sinan Ince, Hasan Hueseyin Demirel
Summary: This study investigated the effects of boron on paracetamol-induced liver damage. The results showed that boron can protect the liver from oxidative stress, inflammation, and ER stress/apoptosis through the augmentation of various biomarkers.
JOURNAL OF TAIBAH UNIVERSITY FOR SCIENCE
(2023)
Article
Toxicology
Hasan Huseyin Demirel, Fahriye Zemheri-Navruz, Ismail Kucukkurt, Damla Arslan-Acaroz, Ali Tureyen, Sinan Ince
Summary: In this study, the combined exposure of 2,4-D and arsenic resulted in abnormal biochemical and hormonal parameters, increased lipid peroxidation, decreased antioxidant status, severe DNA damage, elevated levels of apoptotic and inflammation indexes, and histopathological changes in tissues. These findings indicate that co-exposure to 2,4-D and arsenic can cause oxidative stress, DNA damage, apoptosis, and inflammation, posing toxicological risks for organisms.
TOXICOLOGY RESEARCH
(2023)
Article
Environmental Sciences
Ezgi Nur Demirkapi, Sinan Ince, Hasan Huseyin Demirel, Damla Arslan-Acaroz, Ulas Acaroz
Summary: This study demonstrates the protective effect of polydatin (PD) against oxidative stress caused by aflatoxin B-1 (AFB(1)) in mice. PD administration at increasing doses effectively reduced oxidative stress, DNA damage, and inflammation induced by AFB(1). Furthermore, PD improved liver and kidney tissue damage caused by AFB(1). These findings highlight the potential of PD as a therapeutic agent against AFB(1)-induced toxicity.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Orthopedics
Bilge Kagan Yilmaz, Mehmet Nuri Konya, Sinan Ince, Hasan Huseyin Demirel, Yuksel Cetin, Aysen Gungor
Summary: This study aimed to determine the bioefficacy of epidermal growth factor (EGF), boric acid (BA), and their combination on cartilage injury in rats. The results showed that EGF and low-dose BA application had a positive effect on cartilage healing in rats.
JOINT DISEASES AND RELATED SURGERY
(2023)
Article
Toxicology
Ismail Kucukkurt, Erten Akbel, Sinan Ince, Damla Arslan Acaroz, Hasan Huseyin Demirel, Fahriye Kan
Summary: Escin from the horse-chestnut plant has a protective effect against cyclophosphamide-induced tissue damage in rats due to its ability to decrease malondialdehyde levels and increase glutathione levels in the heart, brain, and lung.
TOXICOLOGY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Ali Tureyen, Sinan Ince
Summary: The study demonstrated that magnolin has a significant protective effect against acute gastric damage induced by ethanol, reducing inflammation and oxidative stress while increasing antioxidant activity.
INTERNATIONAL JOURNAL OF PHARMACOLOGY
(2021)
