Classification of in vitro genotoxicants using a novel multiplexed biomarker assay compared to the flow cytometric micronucleus test
出版年份 2017 全文链接
标题
Classification of in vitro genotoxicants using a novel multiplexed biomarker assay compared to the flow cytometric micronucleus test
作者
关键词
-
出版物
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
Volume 58, Issue 9, Pages 662-677
出版商
Wiley
发表日期
2017-09-21
DOI
10.1002/em.22130
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay
- (2017) Steven M. Bryce et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Threshold and non-threshold chemical carcinogens: A survey of the present regulatory landscape
- (2017) Ruth J. Bevan et al. REGULATORY TOXICOLOGY AND PHARMACOLOGY
- Genotoxic mode of action predictions from a multiplexed flow cytometric assay and a machine learning approach
- (2016) Steven M. Bryce et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Dopamine induces mitochondrial depolarization without activating PINK1-mediated mitophagy
- (2016) Heather Bondi et al. JOURNAL OF NEUROCHEMISTRY
- Relationships between p53 status, apoptosis and induction of micronuclei in different human and mouse cell lines in vitro: Implications for improving existing assays
- (2015) James Whitwell et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Histone markers identify the mode of action for compounds positive in the TK6 micronucleus assay
- (2015) Jennifer R. Cheung et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Assessment of mechanisms driving non-linear dose–response relationships in genotoxicity testing
- (2015) M. Guérard et al. MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
- The Extended ToxTracker Assay Discriminates Between Induction of DNA Damage, Oxidative Stress, and Protein Misfolding
- (2015) Giel Hendriks et al. TOXICOLOGICAL SCIENCES
- The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events
- (2014) Ted W. Simon et al. CRITICAL REVIEWS IN TOXICOLOGY
- Interpreting in vitro micronucleus positive results: Simple biomarker matrix discriminates clastogens, aneugens, and misleading positive agents
- (2014) Steven M. Bryce et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- AMG 900, a potent inhibitor of aurora kinases causes pharmacodynamic changes in p-Histone H3 immunoreactivity in human tumor xenografts and proliferating mouse tissues
- (2014) Gloria Juan et al. Journal of Translational Medicine
- Cyclin-Dependent Kinase Inhibitors as Marketed Anticancer Drugs: Where Are We Now? A Short Survey
- (2014) Gaëlle Mariaule et al. MOLECULES
- Benzo[a]pyrene-induced cell cycle arrest in HepG2 cells is associated with delayed induction of mitotic instability
- (2014) Dimitris Stellas et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- The predominant role of apoptosis in γH2AX formation induced by aneugens is useful for distinguishing aneugens from clastogens
- (2014) Asako Harada et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- A comparative study of the aneugenic and polyploidy-inducing effects of fisetin and two model Aurora kinase inhibitors
- (2014) P. Gollapudi et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- An update on PARP inhibitors—moving to the adjuvant setting
- (2014) Amir Sonnenblick et al. Nature Reviews Clinical Oncology
- PARP-2 and PARP-3 are selectively activated by 5′ phosphorylated DNA breaks through an allosteric regulatory mechanism shared with PARP-1
- (2014) Marie-France Langelier et al. NUCLEIC ACIDS RESEARCH
- The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response
- (2014) Teodora Nikolova et al. TOXICOLOGICAL SCIENCES
- A combination of in vitro comet assay and micronucleus test using human lymphoblastoid TK6 cells
- (2013) A. Kimura et al. MUTAGENESIS
- Way forward in case of a false positive in vitro genotoxicity result for a cosmetic substance?
- (2013) Tatyana Y. Doktorova et al. TOXICOLOGY IN VITRO
- Nongenotoxic Apoptosis Inducers Do Not Produce Misleading Positive Results in the TK6 Cell-Based GADD45a-GFP Genotoxicity Assay
- (2012) Caroline H. Topham et al. TOXICOLOGICAL SCIENCES
- Efficient Monitoring of In Vivo Pig-a Gene Mutation and Chromosomal Damage: Summary of 7 Published Studies and Results From 11 New Reference Compounds
- (2012) Stephen D. Dertinger et al. TOXICOLOGICAL SCIENCES
- Regulation of brefeldin A-induced ER stress and apoptosis by mitochondrial NADP+-dependent isocitrate dehydrogenase
- (2011) Jung Lee Moon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Use of threshold and mode of action in risk assessment
- (2011) Kenny S. Crump CRITICAL REVIEWS IN TOXICOLOGY
- Molecular cytogenetic evaluation of the mechanism of genotoxic potential of amsacrine and nocodazole in mouse bone marrow cells
- (2011) Sabry M. Attia JOURNAL OF APPLIED TOXICOLOGY
- The incidence of positive results in the mouse lymphoma TK assay (MLA) in pharmaceutical screening and their prediction by MultiCase MC4PC
- (2011) M. D. Fellows et al. MUTAGENESIS
- Genotoxicity screening via the γH2AX by flow assay
- (2011) D.J. Smart et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Workshop summary: Top concentration for in vitro mammalian cell genotoxicity assays; and report from working group on toxicity measures and top concentration for in vitro cytogenetics assays (chromosome aberrations and micronucleus)
- (2011) Sheila Galloway et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Reduction of misleading (“false”) positive results in mammalian cell genotoxicity assays. I. Choice of cell type
- (2011) Paul Fowler et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- How accurate is in vitro prediction of carcinogenicity?
- (2010) Richard Maurice Walmsley et al. BRITISH JOURNAL OF PHARMACOLOGY
- Preclinical Evaluation of AMG 900, a Novel Potent and Highly Selective Pan-Aurora Kinase Inhibitor with Activity in Taxane-Resistant Tumor Cell Lines
- (2010) M. Payton et al. CANCER RESEARCH
- Miniaturized flow cytometry-based CHO-K1 micronucleus assay discriminates aneugenic and clastogenic modes of action
- (2010) Steven M. Bryce et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Comparison of in vitro micronucleus and gene mutation assay results for p53-competent versus p53-deficient human lymphoblastoid cells
- (2010) Masamitsu Honma et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Potential thresholds for genotoxic effects by micronucleus scoring
- (2010) A. Elhajouji et al. MUTAGENESIS
- Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test without cytokinesis block
- (2010) Leigh Hynes MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Nonlinear Cancer Response at Ultralow Dose: A 40800-Animal ED001Tumor and Biomarker Study
- (2009) George S. Bailey et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Molecular cytogenetic evaluation of the mechanism of micronuclei formation induced by camptothecin, topotecan, and irinotecan
- (2009) Sabry M. Attia et al. ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
- Further evaluation of a flow cytometric in vitro micronucleus assay in CHO-K1 cells: a reliable platform that detects micronuclei and discriminates apoptotic bodies
- (2009) Jing Shi et al. MUTAGENESIS
- H2AX phosphorylation as a genotoxicity endpoint
- (2009) Gary Peter Watters et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- GADD45a-GFP GreenScreen HC assay results for the ECVAM recommended lists of genotoxic and non-genotoxic chemicals for assessment of new genotoxicity tests
- (2009) Louise Birrell et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Literature review on the genotoxicity, reproductive toxicity, and carcinogenicity of ethyl methanesulfonate
- (2009) Elmar Gocke et al. TOXICOLOGY LETTERS
- Cytotoxic and genotoxic effects of matrices for cartilage tissue engineering
- (2009) Amelie S. Lotz et al. TOXICOLOGY LETTERS
- TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use
- (2009) M. Olivier et al. Cold Spring Harbor Perspectives in Biology
- Caffeine Induces Cell Death via Activation of Apoptotic Signal and Inactivation of Survival Signal in Human Osteoblasts
- (2008) Pin-Zhen Lu et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Antitumor effect of dsRNA-induced p21WAF1/CIP1 gene activation in human bladder cancer cells
- (2008) Z. Chen et al. MOLECULAR CANCER THERAPEUTICS
- Assessment of DNA double-strand breaks and γH2AX induced by the topoisomerase II poisons etoposide and mitoxantrone
- (2008) Daniel J. Smart et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test
- (2008) Michael D. Fellows et al. MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS
- Executioner caspase-3 and caspase-7 are functionally distinct proteases
- (2008) J. G. Walsh et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Application of toxicogenomics to study mechanisms of genotoxicity and carcinogenicity
- (2008) Heidrun Ellinger-Ziegelbauer et al. TOXICOLOGY LETTERS
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started