A brush-polymer/exendin-4 conjugate reduces blood glucose levels for up to five days and eliminates poly(ethylene glycol) antigenicity

Pre-existing anti–polyethylene glycol antibody linked to first-exposure allergic reactions to pegnivacogin, a PEGylated RNA aptamer

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Macromolecular Engineering by Atom Transfer Radical Polymerization

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Induced and pre-existing anti-polyethylene glycol antibody in a trial of every 3-week dosing of pegloticase for refractory gout, including in organ transplant recipients

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Protein–polymer hybrids: Conducting ARGET ATRP from a genetically encoded cleavable ATRP initiator

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Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein

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Growing polymers from peptides and proteins: a biomedical perspective

(2013) Yizhi Qi et al.   Polymer Chemistry

Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control

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The Future of Peptide-based Drugs

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Antibodies against polyethylene glycol in healthy subjects and in patients treated with PEG-conjugated agents

(2012) Ricardo P Garay et al.   Expert Opinion on Drug Delivery

The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide

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FDA-approved poly(ethylene glycol)–protein conjugate drugs

(2011) Steevens N. S. Alconcel et al.   Polymer Chemistry

In Situ Growth of Side-Chain PEG Polymers from Functionalized Human Growth Hormone—A New Technique for Preparation of Enhanced Protein−Polymer Conjugates

(2010) Johannes Pall Magnusson et al.   BIOCONJUGATE CHEMISTRY

Recursive Directional Ligation by Plasmid Reconstruction Allows Rapid and Seamless Cloning of Oligomeric Genes

(2010) Jonathan R. McDaniel et al.   BIOMACROMOLECULES

PK/PD modelling of comb-shaped PEGylated salmon calcitonin conjugates of differing molecular weights

(2010) Sinéad M. Ryan et al.   JOURNAL OF CONTROLLED RELEASE

Genetically Encoded Initiator for Polymer Growth from Proteins

(2010) Jennifer C. Peeler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation

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A recombinant polypeptide extends the in vivo half-life of peptides and proteins in a tunable manner

(2009) Volker Schellenberger et al.   NATURE BIOTECHNOLOGY

Incretin-based therapies for type 2 diabetes mellitus

(2009) Julie A. Lovshin et al.   Nature Reviews Endocrinology

In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics

(2009) W. Gao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide/protein–polymer conjugates: synthetic strategies and design concepts

(2008) Marc A. Gauthier et al.   CHEMICAL COMMUNICATIONS

The Hill equation: a review of its capabilities in pharmacological modelling

(2008) Sylvain Goutelle et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Protein therapeutics: a summary and pharmacological classification

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