Article
Chemistry, Multidisciplinary
Bong Kyun Kim, Sang-A Lee, Minju Park, Eui Ju Jeon, Mi Jung Kim, Jung Min Kim, Heesuk Kim, Seungwon Jung, Sang Kyung Kim
Summary: This article introduces a photonic PCR platform using hydrogel microparticles, which utilizes photothermal nanomaterials as heating elements for rapid and portable POCT. The researchers successfully demonstrate the ability to perform multiplex assays by loading multiple encoded pPIN microparticles in a single reaction.
Article
Peripheral Vascular Disease
Mi-Kyung Shin, Roxana Mitrut, Chenjuan Gu, Lenise J. Kim, Bonnie H. Y. Yeung, Rachel Lee, Luu Pham, Wan-Yee Tang, James S. K. Sham, Honggang Cui, Vsevolod Y. Polotsky
Summary: The study demonstrates that inhibition of TRPM7 in carotid bodies abolishes leptin-induced hypertension in obese mice.
Article
Oncology
Aileen I. Fernandez, Niki Gavrielatou, Leena McCann, Saba Shafi, Myrto K. Moutafi, Sandra Martinez-Morilla, Ioannis A. Vathiotis, Thazin Nwe Aung, Vesal Yaghoobi, Yalai Bai, Yvonne G. Chan, Jodi Weidler, Roy Herbst, Michael Bates, David L. Rimm
Summary: This study investigates the use of PD-L1 mRNA level as a predictive biomarker for nonresponse to immune checkpoint inhibitors (ICIs) in lung cancer patients. The results show that high levels of PD-L1 and PD-L2 mRNA are associated with improved long-term benefit and overall survival, while low PD-L1 mRNA level has a high negative predictive value for absence of long-term benefit.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Endocrinology & Metabolism
Maggie C. Evans, Elliot G. Wallace, Caroline M. Ancel, Greg M. Anderson
Summary: The adipose-derived hormone leptin plays a critical role in reproductive function by modulating the neuroendocrine reproductive axis. Pituitary adenylate cyclase-activating polypeptide (PACAP)-expressing neurons are leptin-sensitive and involved in feeding behavior and reproductive function. This study investigates the role of PACAP neurons in mediating leptin's effects on reproductive function in mice. The results show that PACAP neurons are involved in the timing of female puberty onset but not fertility, and PACAP does not play a critical role in relaying leptin's effects in males or adult females.
Article
Multidisciplinary Sciences
Walid Hossain, Mohabbat Hossain, Khalid Arafath, Subarna Sayed Ety, Mahade Hasan Shetu, Mazbahul Kabir, Farjana Akther Noor, Kalissar Mannoor
Summary: The study aimed to reduce the run time of multiplex RT-PCR for detecting SARS CoV-2 N1 and N2 sequences and human RNase P (RP) sequence. By optimizing the Fast PCR protocol and comparing it with conventional PCR, the researchers found that Fast PCR significantly shortened the run time while yielding comparable results to conventional PCR.
Article
Zoology
HuaBin Zhang, YaSen Li, Tao Pan, Peng Yani, En Li, Hui Xue, XiaoBing Wu
Summary: The study revealed the presence and location of leptin and its receptor in different tissues of the Chinese alligator, suggesting a potential role of leptin in regulating nutrient storage, absorption and utilization, as well as reproductive behavior. Additionally, seasonal changes of leptin levels in plasma of Chinese alligators were observed, indicating a dynamic role of leptin in response to environmental factors.
PAKISTAN JOURNAL OF ZOOLOGY
(2021)
Article
Chemistry, Analytical
Yuwei Qiu, Kunlun Jiang, Jingrui Wu, Yung-Kang Peng, Jeong-Wook Oh, Jung- Hoon Lee
Summary: A plasmonic photothermal quantitative immuno-PCR (PPT-qiPCR) assay is developed for biomarker detection using multifunctional plasmonic immunomagnetic nanoparticles (PIMNs). This assay has real-time and end-point dual readout and is simple, time-saving, and inexpensive compared to conventional iPCR platforms. It can quickly discriminate target proteins and improve assay sensitivity with in-situ end-point fluorescence or colorimetric detection using only the human eye.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Multidisciplinary
Jing Tu, Yi Qiao, Yuhan Luo, Naiyun Long, Zuhong Lu
Summary: DNA quantification is crucial in life sciences research, and real-time MDA technology can provide template amount information during whole-genome amplification with a very low detection limit, offering a promising tool to quantify entire DNA without sacrificing sample completeness or introducing redundant steps.
Article
Chemistry, Multidisciplinary
Byoung-Hoon Kang, Youngseop Lee, Eun-Sil Yu, Hamin Na, Minhee Kang, Hee Jae Huh, Ki-Hun Jeong
Summary: The rapid and accurate molecular diagnostics are crucial in the face of pandemic diseases, and the nanoplasmonic PCR provides a new solution for rapid and quantitative molecular diagnostics at point-of-care level.
Review
Endocrinology & Metabolism
Milan Obradovic, Emina Sudar-Milovanovic, Sanja Soskic, Magbubah Essack, Swati Arya, Alan J. Stewart, Takashi Gojobori, Esma R. Isenovic
Summary: Leptin, a peptide hormone, regulates food intake, body mass, and reproductive function, playing a crucial role in fetal growth, immune responses, angiogenesis, and lipolysis. Leptin resistance can lead to reduced satiety, overconsumption of nutrients, and increased body mass, potentially causing obesity. Combining leptin therapies with sensitizers may help overcome resistance and treat obesity effectively.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Analytical
Liang Gong, Siyue Yao, Yidong He, Chengliang Liu
Summary: A new qPCR data analysis method called AERKM is proposed to achieve more accurate results by introducing amplification efficiency (AE) for error correction. It has been verified to have higher precision and stability in 5-point 10-fold gradient qPCR tests of 63 genes.
ANALYTICAL CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Polyxeni Bouna-Pyrrou, Christiane Muehle, Johannes Kornhuber, Christian Weinland, Bernd Lenz
Summary: This study found a correlation between higher BMI and binge drinking in men, and demonstrated for the first time a relationship between ObRe/BMI and binge drinking in women. These results highlight the potential role of metabolic markers in binge drinking behavior.
PSYCHONEUROENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Byoung-Hoon Kang, Kyung-Won Jang, Eun-Sil Yu, Hamin Na, Yun-Jae Lee, Woong-Yeol Ko, NamHo Bae, Donggee Rho, Ki -Hun Jeong
Summary: This study presents a rapid and compact real-time RT-PCR system for decentralized molecular diagnostics. It utilizes plasmonic nucleic acid amplification and quantification, and features an ultrafast plasmonic thermocycler, a disposable plastic-on-metal cartridge, and a compact fluorescence microscope. The system successfully enables 10-minute diagnosis of COVID-19 with high amplification efficiency, classification accuracy, and total percent agreement for clinical diagnostic tests.
Article
Chemistry, Multidisciplinary
Byoung-Hoon Kang, Kyung-Won Jang, Eun-Sil Yu, Hamin Na, Yun-Jae Lee, Woong-Yeol Ko, NamHo Bae, Donggee Rho, Ki-Hun Jeong
Summary: This study presents an ultrafast plasmonic nucleic acid amplification and real-time quantification system for decentralized molecular diagnostics. The system features ultrafast photothermal cycling, rapid heat transfer, and efficient PCR quantification, along with high-contrast fluorescence microscopic imaging. It enables decentralized point-of-care molecular diagnostic testing in primary care and developing countries.
Article
Chemistry, Analytical
Kazuyuki Nobusawa, Huan-Wen Han, Fumie Takei, Ting-Chieh Chu, Noriyasu Hashida, Ichiro Yamashita
Summary: We developed a new electrochemical method for real-time detection of polymerase chain reactions, using a DNA intercalator to enhance charge transfer and monitoring the changes in charge transfer resistance. This simple method has the potential to be a cost-effective and portable PCR device.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Silvia Barbon, Elena Stocco, Senthilkumar Rajendran, Lorena Zardo, Veronica Macchi, Claudio Grandi, Giuseppe Tagariello, Andrea Porzionato, Paolo Radossi, Raffaele De Caro, Pier Paolo Parnigotto
Summary: Research shows that adipose-derived mesenchymal stem cells stimulated towards the endothelial lineage have the capacity to produce coagulation factor VIII and can contribute to the improvement of Haemophilia A through acceleration of clot formation and enhancement of FVIII activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Carmelo Pirri, Nina Pirri, Diego Guidolin, Veronica Macchi, Raffaele De Caro, Carla Stecco
Summary: This study used ultrasound imaging to measure the thickness of superficial fascia in different regions of the arm and forearm. The results showed that the superficial fascia in the posterior region of the arm was thicker than in the forearm, while there was no significant difference between the anterior regions of the arm and forearm. This study highlights the importance of understanding the distribution and thickness differences of the superficial fascia.
Article
Biochemistry & Molecular Biology
Chiara Giulia Fontanella, Elisa Belluzzi, Assunta Pozzuoli, Manuela Scioni, Eleonora Olivotto, Davide Reale, Pietro Ruggieri, Raffaele De Caro, Roberta Ramonda, Emanuele Luigi Carniel, Marta Favero, Veronica Macchi
Summary: This study analyzed the role of infrapatellar fat pad (IFP) and suprapatellar fat pad (SFP) in knee osteoarthritis (OA) using magnetic resonance (MR) imaging. The results showed differences in the characteristics of these tissues among different patient groups, supporting their importance in the pathology and progression of OA.
Article
Biochemistry & Molecular Biology
Elena Stocco, Silvia Barbon, Elena Zeni, Leonardo Cassari, Annj Zamuner, Antonio Gloria, Teresa Russo, Rafael Boscolo-Berto, Maria Martina Sfriso, Veronica Macchi, Raffaele De Caro, Monica Dettin, Andrea Porzionato
Summary: The OxPVA/chitosan sponges as hybrid scaffolds for nerve conduits were investigated. The scaffolds showed good mechanical properties, ultrastructure, bioactivity, and biocompatibility. The combination of ChS and OxPVA with functionalized peptides can enhance cell interaction and promote cell adhesion/proliferation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Caterina Fede, Chenglei Fan, Carmelo Pirri, Lucia Petrelli, Carlo Biz, Andrea Porzionato, Veronica Macchi, Raffaele De Caro, Carla Stecco
Summary: The intramuscular connective tissue plays a critical role in maintaining muscle integrity and providing mechanical support. This study found age-related changes in collagen accumulation, decreased elastic fibers and hyaluronan content in the muscle, which may lead to muscle stiffening and reduced adaptability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Katarzyna Stefanska, Lucie Nemcova, Malgorzata Blatkiewicz, Wojciech Pienkowski, Marcin Rucinski, Maciej Zabel, Paul Mozdziak, Marzenna Podhorska-Okolow, Piotr Dziegiel, Bartosz Kempisty
Summary: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) possess multilineage differentiation potential and specific surface markers. In this study, RNA sequencing analysis revealed differentially expressed genes associated with apoptosis and identified upregulation of ZBTB16 and FOXO1, as well as downregulation of TGFA, in all differentiated groups. Additionally, several novel marker genes related to WJ-MSCs differentiation were identified. This study sheds light on the molecular mechanisms involved in long-term culture and differentiation of WJ-MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Elena Stocco, Silvia Barbon, Aron Emmi, Cesare Tiengo, Veronica Macchi, Raffaele De Caro, Andrea Porzionato
Summary: In peripheral nerve injuries with substance loss, graft positioning is required. The available options include autografts, allografts, and hollow nerve conduits. However, none of the current alternatives fully satisfy the anatomical and functional nerve regeneration requirements, and future research should focus on wall and/or inner lumen organization/functionalization. This review aims to describe common alternatives for severe peripheral nerve injury recovery, highlighting future conduits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Elena Stocco, Silvia Barbon, Marco Mammana, Diletta Trojan, Alice Bianchin, Francesca Favaretto, Martina Contran, Giovanni Zambello, Andrea Vogliardi, Marta Confalonieri, Silvia Todros, Piero G. Pavan, Filippo Romanato, Maria Teresa Conconi, Veronica Macchi, Raffaele De Caro, Federico Rea, Andrea Porzionato
Summary: The study aimed to develop a new decellularized trachea from pig tissue and compare it with cryopreserved trachea for predictive analysis. The decellularization effectively removed Alpha-Gal epitopes, while cryopreserved samples retained some respiratory epithelial cells. Despite some limitations, both cryopreserved and decellularized trachea are viable options that require further investigation in comparative animal studies.
Article
Medicine, General & Internal
Carmelo Pirri, Nina Pirri, Diego Guidolin, Veronica Macchi, Andrea Porzionato, Raffaele De Caro, Carla Stecco
Summary: Recent studies have found an association between thoracolumbar fascia thickness and reduced gliding in patients with lower back pain. This study aimed to measure and compare the thickness of thoracolumbar fascia in chronic non-specific lower back pain patients and healthy individuals using ultrasound imaging. The results showed that lower back pain patients had a loss of anisotropy in the thoracolumbar fascia, with a homogeneous increase in thickness and a loss of adaptability in the transverse direction.
Article
Biochemistry & Molecular Biology
Malgorzata Blatkiewicz, Kacper Kaminski, Marta Szyszka, Zaid Al-Shakarchi, Anna Olechnowicz, Ewelina Stelcer, Hanna Komarowska, Marianna Tyczewska, Anna Klimont, Marek Karczewski, Tomasz Wierzbicki, Joanna Mikolajczyk-Stecyna, Marek Ruchala, Ludwik K. Malendowicz, Marcin Rucinski
Summary: The study examines the association of ZWILCH gene with adrenocortical carcinoma (ACC). The higher expression of ZWILCH gene was found in ACC tissue compared to normal adrenal glands. Upregulation of ZWILCH is correlated with tumor mitotic rate and patient survival. The enhanced ZWILCH level is also associated with activation of genes involved in cell proliferation and inhibition of genes related to the immune system.
Article
Biochemistry & Molecular Biology
Remigiusz Domin, Michal Pytka, Mikolaj Zolynski, Jan Nizinski, Marcin Rucinski, Przemyslaw Guzik, Jacek Zielinski, Marek Ruchala
Summary: This study aimed to investigate the relationship between serum MOTS-c concentration and muscle strength parameters, as well as oxygen consumption, in physically active individuals. The results showed that higher serum MOTS-c concentration was associated with greater muscle mass, force, and power, but not with exercise capacity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Carmelo Pirri, Carlo Biz, Nina Pirri, Veronica Macchi, Andrea Porzionato, Raffaele De Caro, Pietro Ruggieri, Carla Stecco
Summary: This study measured and compared the thickness of the crural fascia (CF) and plantar fascia (PF) in chronic Charcot diabetic foot patients and healthy volunteers using ultrasound imaging. The results showed that CF and PF thickness were significantly greater in diabetic foot patients compared to healthy volunteers.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Carmelo Pirri, Nina Pirri, Carla Stecco, Veronica Macchi, Andrea Porzionato, Raffaele De Caro, Levent Ozcakar
Summary: Ultrasound imaging of the musculoskeletal system is essential and has become an extension of physical examinations. The combination of classical physical examination and static/dynamic ultrasound imaging provides valuable insights and research opportunities. This study aimed to analyze the global/research status of ultrasound examination of the musculoskeletal system through bibliometric and visualized analysis.
Article
Biochemistry & Molecular Biology
Natalia Izycka, Marcin Rucinski, Malgorzata Andrzejewska, Sebastian Szubert, Ewa Nowak-Markwitz, Karolina Sterzynska
Summary: Recurrent disease and treatment-associated chemoresistance are major contributors to poor clinical outcomes in ovarian cancer patients. This study investigated the expression of CSC-associated markers ALDH1A, CD44, and CD133 to predict patient prognosis. ALDH1A1-positive patients had significantly shorter overall survival (OS) and progression-free survival (PFS). Multivariate analysis revealed that ALDH1A1 expression, FIGO stage III-IV, and residual disease were associated with shorter OS. Targeting ALDH1A1-positive cancer cells may be a promising therapeutic strategy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Agnieszka Anna Rawluszko-Wieczorek, Julia Lipowicz, Marta Nowacka, Kamila Ostrowska, Paulina Pietras, Malgorzata Blatkiewicz, Marcin Rucinski, Pawel Piotr Jagodzinski, Michal Nowicki
Summary: The presence of estrogen receptor beta (ER beta) is inversely correlated with the occurrence of colorectal cancer (CRC), and low expression of ER beta is associated with poorer overall survival of CRC patients. ER beta can inhibit tumorigenesis through various molecular pathways and also has an impact on the hypoxic response in CRC cells.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2024)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.