New 3D-Culture Approaches to Study Interactions of Bone Marrow Adipocytes with Metastatic Prostate Cancer Cells

Photoactivated inhibition of cathepsin K in a 3D tumor model

(2016) Mackenzie K. Herroon et al.   BIOLOGICAL CHEMISTRY

A 3D in vitro model of patient-derived prostate cancer xenograft for controlled interrogation of in vivo tumor-stromal interactions

(2016) Eliza L.S. Fong et al.   BIOMATERIALS

Interactions between Adipocytes and Breast Cancer Cells Stimulate Cytokine Production and Drive Src/Sox2/miR-302b–Mediated Malignant Progression

(2016) Manuel Picon-Ruiz et al.   CANCER RESEARCH

The next level of 3D tumour models: immunocompetence

(2016) Agata Nyga et al.   DRUG DISCOVERY TODAY

Marrow Adipose Tissue: Trimming the Fat

(2016) Erica L. Scheller et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

High fat diet increases melanoma cell growth in the bone marrow by inducing osteopontin and interleukin 6

(2016) Guang-Liang Chen et al.   Oncotarget

A systematic review on in vitro 3D bone metastases models: A new horizon to recapitulate the native clinical scenario?

(2016) Francesca Salamanna et al.   Oncotarget

The use of collagen-based scaffolds to simulate prostate cancer bone metastases with potential for evaluating delivery of nanoparticulate gene therapeutics

(2015) Kathleen A. Fitzgerald et al.   BIOMATERIALS

3D culture broadly regulates tumor cell hypoxia response and angiogenesis via pro-inflammatory pathways

(2015) Peter DelNero et al.   BIOMATERIALS

Human breast cancer bone metastasis in vitro and in vivo: a novel 3D model system for studies of tumour cell-bone cell interactions

(2015) I. Holen et al.   CLINICAL & EXPERIMENTAL METASTASIS

Marrow adipocyte-derived CXCL1 and CXCL2 contribute to osteolysis in metastatic prostate cancer

(2015) Aimalie L. Hardaway et al.   CLINICAL & EXPERIMENTAL METASTASIS

Detecting cathepsin activity in human osteoarthritis via activity-based probes

(2015) Louisa Ben-Aderet et al.   ARTHRITIS RESEARCH & THERAPY

Mature adipocytes in bone marrow protect myeloma cells against chemotherapy through autophagy activation

(2015) Zhiqiang Liu et al.   Oncotarget

Effect of Dietaryω-3 Polyunsaturated Fatty Acid DHA on Glycolytic Enzymes and Warburg Phenotypes in Cancer

(2015) Laura Manzi et al.   Biomed Research International

Breast Cancer Cell Colonization of the Human Bone Marrow Adipose Tissue Niche

(2015) Zach S. Templeton et al.   NEOPLASIA

Spherical Cancer Models in Tumor Biology

(2015) Louis-Bastien Weiswald et al.   NEOPLASIA

Paracrine Interactions between Adipocytes and Tumor Cells Recruit and Modify Macrophages to the Mammary Tumor Microenvironment: The Role of Obesity and Inflammation in Breast Adipose Tissue

(2015) Ana Santander et al.   Cancers

Human Adipocytes Stimulate Invasion of Breast Cancer MCF-7 Cells by Secreting IGFBP-2

(2015) Chen Wang et al.   PLoS One

Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

(2015) Mackenzie Herroon et al.   Oncotarget

Three-dimensional in vitro tumor models for cancer research and drug evaluation

(2014) Xian Xu et al.   BIOTECHNOLOGY ADVANCES

Bone marrow fat: linking adipocyte-induced inflammation with skeletal metastases

(2014) Aimalie L. Hardaway et al.   CANCER AND METASTASIS REVIEWS

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Three-dimensional organotypic culture: experimental models of mammalian biology and disease

(2014) Eliah R. Shamir et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

3D Cultures of Prostate Cancer Cells Cultured in a Novel High-Throughput Culture Platform Are More Resistant to Chemotherapeutics Compared to Cells Cultured in Monolayer

(2014) Karen F. Chambers et al.   PLoS One

Putative Role of Adipose Tissue in Growth and Metabolism of Colon Cancer Cells

(2014) Betty Schwartz et al.   Frontiers in Oncology

Adipose tissue and adipocytes support tumorigenesis and metastasis

(2013) Kristin M. Nieman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells

(2013) David G. Watson et al.   CELLULAR SIGNALLING

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Development of small-molecule inhibitors targeting adipose triglyceride lipase

(2013) Nicole Mayer et al.   Nature Chemical Biology

Power Surge: Supporting Cells “Fuel” Cancer Cell Mitochondria

(2012) Ubaldo E. Martinez-Outschoorn et al.   Cell Metabolism

Anex vivoco-culture model system to evaluate stromal-epithelial interactions in breast cancer

(2012) T.S. Salameh et al.   INTERNATIONAL JOURNAL OF CANCER

Imaging interactions between macrophages and tumour cells that are involved in metastasisin vivoandin vitro

(2012) A. DOVAS et al.   JOURNAL OF MICROSCOPY

Macrophage cathepsin K promotes prostate tumor progression in bone

(2012) M K Herroon et al.   ONCOGENE

MAME Models for 4D Live-cell Imaging of Tumor: Microenvironment Interactions that Impact Malignant Progression

(2012) Mansoureh Sameni et al.   Jove-Journal of Visualized Experiments

Cancer-Associated Adipocytes Exhibit an Activated Phenotype and Contribute to Breast Cancer Invasion

(2011) B. Dirat et al.   CANCER RESEARCH

Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

(2010) Johanna Chiche et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Bone Marrow-Derived Cathepsin K Cleaves SPARC in Bone Metastasis

(2009) Izabela Podgorski et al.   AMERICAN JOURNAL OF PATHOLOGY

Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer

(2009) M D Brown et al.   BRITISH JOURNAL OF CANCER

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Metabolic impact of adipose and hepatic glycerol channels aquaporin 7 and aquaporin 9

(2008) Norikazu Maeda et al.   Nature clinical practice. Endocrinology & metabolism