IgE-Related Chronic Diseases and Anti-IgE-Based Treatments

Elucidating asthma phenotypes and endotypes: progress towards personalized medicine

(2016) Mauli Desai et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Fifty years later: Emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases

(2016) Hans C. Oettgen   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A randomized trial of quilizumab in adults with refractory chronic spontaneous urticaria

(2016) Jeffrey M. Harris et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Structural basis of omalizumab therapy and omalizumab-mediated IgE exchange

(2016) Luke F. Pennington et al.   Nature Communications

Comparable actions of omalizumab on mast cells and basophils

(2015) E. Serrano-Candelas et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Increased phenotypic differentiation and reduced corticosteroid sensitivity of fibrocytes in severe asthma

(2015) Chun-Yu Lo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IgE-activated basophils regulate eosinophil tissue entry by modulating endothelial function

(2015) Laurence E. Cheng et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Omalizumab Induced Remission of Idiopathic Anaphylaxis in a Patient Suffering from Indolent Systemic Mastocytosis

(2014) L Kibsgaard et al.   ACTA DERMATO-VENEREOLOGICA

The EAACI/GA2LEN/EDF/WAO Guideline for the definition, classification, diagnosis, and management of urticaria: the 2013 revision and update

(2014) T. Zuberbier et al.   ALLERGY

Therapy of chronic urticaria: a simple, modern approach

(2014) Allen P. Kaplan   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Pharmacokinetics, pharmacodynamics and safety of QGE031 (ligelizumab), a novel high-affinity anti-IgE antibody, in atopic subjects

(2014) J. P. Arm et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Accelerated dissociation of IgE-FcεRI complexes by disruptive inhibitors actively desensitizes allergic effector cells

(2014) Alexander Eggel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Changes in blood eosinophilia during omalizumab therapy as a predictor of asthma exacerbation

(2014) Roman Skiepko et al.   Postepy Dermatologii i Alergologii

Omalizumab, an anti-immunoglobulin E antibody: state of the art

(2014) Cristoforo Incorvaia et al.   Drug Design Development and Therapy

Omalizumab: a new treatment option for allergic bronchopulmonary aspergillosis in patients with cystic fibrosis

(2014) Sylvia Lehmann et al.   Therapeutic Advances in Respiratory Disease

A Proof-of-Concept, Randomized, Controlled Trial of Omalizumab in Patients With Severe, Difficult-to-Control, Nonatopic Asthma

(2013) Gilles Garcia et al.   CHEST

International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

(2013) K. F. Chung et al.   EUROPEAN RESPIRATORY JOURNAL

Anti-IgE – emerging opportunities for Omalizumab

(2013) K Suresh Babu et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Omalizumab in patients with symptomatic chronic idiopathic/spontaneous urticaria despite standard combination therapy

(2013) Allen Kaplan et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria

(2013) Marcus Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Omalizumab therapy for allergic bronchopulmonary aspergillosis in children with cystic fibrosis: A synthesis of published evidence

(2013) Kalliopi Tanou et al.   PEDIATRIC PULMONOLOGY

Omalizumab may decrease IgE synthesis by targeting membrane IgE+ human B cells

(2013) Marcia A Chan et al.   Clinical and Translational Allergy

Successful Treatment of Bullous Pemphigoid With Omalizumab

(2012) Vanessa A. London et al.   ARCHIVES OF DERMATOLOGY

Kinetics of mast cell, basophil, and oral food challenge responses in omalizumab-treated adults with peanut allergy

(2012) Jessica H. Savage et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Omalizumab is effective in allergic and nonallergic patients with nasal polyps and asthma

(2012) Philippe Gevaert et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor

(2012) Beomkyu Kim et al.   NATURE

Asthma phenotypes: the evolution from clinical to molecular approaches

(2012) Sally E Wenzel   NATURE MEDICINE

Effects of Adding Omalizumab, an Anti-Immunoglobulin E Antibody, on Airway Wall Thickening in Asthma

(2012) Makoto Hoshino et al.   RESPIRATION

Inhibition of ongoing allergic reactions using a novel anti-IgE DARPin-Fc fusion protein

(2011) A. Eggel et al.   ALLERGY

Successful management of severe infant bullous pemphigoid with omalizumab

(2011) C. Dufour et al.   BRITISH JOURNAL OF DERMATOLOGY

IL-33 links tissue cells, dendritic cells and Th2 cell development in a mouse model of asthma

(2011) Thomas Eiwegger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Omalizumab Treatment of Systemic Mast Cell Activation Disease: Experiences from Four Cases

(2011) Gerhard J. Molderings et al.   INTERNAL MEDICINE

A randomized, placebo-controlled, dose-ranging study of single-dose omalizumab in patients with H1-antihistamine–refractory chronic idiopathic urticaria

(2011) Sarbjit Saini et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Efficacy and safety of omalizumab in patients with chronic urticaria who exhibit IgE against thyroperoxidase

(2011) Marcus Maurer et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Rapid oral desensitization in combination with omalizumab therapy in patients with cow’s milk allergy

(2011) Kari C. Nadeau et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Effects of omalizumab in Aspergillus-associated airway disease

(2011) L. A. Perez-de-Llano et al.   THORAX

Successful treatment of cholinergic urticaria with anti-immunoglobulin E therapy

(2010) M. Metz et al.   ALLERGY

Antihistamine-resistant urticaria factitia successfully treated with anti-immunoglobulin E therapy

(2010) K. Krause et al.   ALLERGY

Epidemiology of urticaria: a representative cross-sectional population survey

(2010) T. Zuberbier et al.   CLINICAL AND EXPERIMENTAL DERMATOLOGY

Unique Epitopes on CεmX in IgE–B Cell Receptors Are Potentially Applicable for Targeting IgE-Committed B Cells

(2010) Jiun-Bo Chen et al.   JOURNAL OF IMMUNOLOGY

Efficacy of omalizumab in the treatment of nasal polyps

(2010) M. d. C. Vennera et al.   THORAX

Omalizumab is effective in treating systemic mastocytosis in a nonatopic patient

(2009) J. A. Douglass et al.   ALLERGY

EAACI/GA2LEN task force consensus report: the autologous serum skin test in urticaria

(2009) G. N. Konstantinou et al.   ALLERGY

Efficacy of omalizumab in delayed pressure urticaria: a case report

(2009) C. Bindslev-Jensen et al.   ALLERGY

After 6 years with Xolair; a 3-year withdrawal follow-up

(2009) A. Nopp et al.   ALLERGY

T-helper Type 2–driven Inflammation Defines Major Subphenotypes of Asthma

(2009) Prescott G. Woodruff et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Pathogenesis of chronic urticaria

(2009) A. P. Kaplan et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Successful treatment of solar urticaria with anti-immunoglobulin E therapy

(2008) O. Güzelbey et al.   ALLERGY

Omalizumab therapy: patients who achieve greatest benefit for their asthma experience greatest benefit for rhinitis

(2008) M. Humbert et al.   ALLERGY

Efficacy of omalizumab in the treatment of atopic dermatitis: A pilot study

(2008) Lee E. Sheinkopf et al.   ALLERGY AND ASTHMA PROCEEDINGS

Chromosome 17q21 Gene Variants Are Associated with Asthma and Exacerbations but Not Atopy in Early Childhood

(2008) Hans Bisgaard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Current advances in the management of urticaria

(2008) Ahmad T. Khalaf et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Fine epitope mapping of humanized anti-IgE monoclonal antibody omalizumab

(2008) Lei Zheng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Immunomodulatory therapy of eosinophil-associated gastrointestinal diseases

(2008) K. D. Stone et al.   CLINICAL AND EXPERIMENTAL ALLERGY