Transcription Regulation of the Human Telomerase Reverse Transcriptase (hTERT) Gene

Recurrent TERT promoter mutations in urothelial carcinoma and potential clinical applications

(2016) Boaz Kurtis et al.   Annals of Diagnostic Pathology

Triptolide inhibits transcription of hTERT through down-regulation of transcription factor specificity protein 1 in primary effusion lymphoma cells

(2016) Cong Long et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Prognostic effects ofTERTpromoter mutations are enhanced by coexistence withBRAForRASmutations and strengthen the risk prediction by the ATA or TNM staging system in differentiated thyroid cancer patients

(2016) Young Shin Song et al.   CANCER

TERTpromoter mutations are a major indicator of recurrence and death due to papillary thyroid carcinomas

(2016) Martyn Bullock et al.   CLINICAL ENDOCRINOLOGY

Clinical utility of TERT promoter mutations and ALK rearrangement in thyroid cancer patients with a high prevalence of the BRAF V600E mutation

(2016) Ja Seong Bae et al.   Diagnostic Pathology

The Sensitive Detection of Telomerase Reverse Transcriptase Promoter Mutation by Amplification Refractory Mutation System-PCR

(2016) Jinbo Liu et al.   Genetic Testing and Molecular Biomarkers

Telomerase reverse transcriptase (TERT) promoter mutation analysis of benign, malignant and reactive urothelial lesions reveals a subpopulation of inverted papilloma with immortalizing genetic change

(2016) Liang Cheng et al.   HISTOPATHOLOGY

The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism

(2016) Rui Batista et al.   INTERNATIONAL JOURNAL OF CANCER

Inactivating ARID1A Tumor Suppressor EnhancesTERTTranscription and Maintains Telomere Length in Cancer Cells

(2016) Yohan Suryo Rahmanto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic and transcriptomic hallmarks of poorly differentiated and anaplastic thyroid cancers

(2016) Iñigo Landa et al.   JOURNAL OF CLINICAL INVESTIGATION

TGF-β/β2-spectrin/CTCF-regulated tumor suppression in human stem cell disorder Beckwith-Wiedemann syndrome

(2016) Jian Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Radiotherapy plus concomitant temozolomide in primary gliosarcoma

(2016) Sebastian Adeberg et al.   JOURNAL OF NEURO-ONCOLOGY

Lack of TERT promoter mutations in melanomas with extensive regression

(2016) Blanca de Unamuno Bustos et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The genetic difference between Western and Chinese urothelial cell carcinomas: infrequent FGFR3 mutation in Han Chinese patients

(2016) Xiaotian Yuan et al.   Oncotarget

BRAF and TERT promoter mutations in the aggressiveness of papillary thyroid carcinoma: a study of 653 patients

(2016) Langping Jin et al.   Oncotarget

Telomerase reverse transcriptase promoter mutations in hepatitis B virus-associated hepatocellular carcinoma

(2016) Xunjun Yang et al.   Oncotarget

TERT Promoter Mutations and Tumor Persistence/Recurrence in Papillary Thyroid Cancer

(2016) Jae Kyung Myung et al.   Cancer Research and Treatment

Leptin as a critical regulator of hepatocellular carcinoma development through modulation of human telomerase reverse transcriptase

(2016) Nikolaos Stefanou et al.   BMC CANCER

TERT promoter mutations in primary central nervous system lymphoma are associated with spatial distribution in the splenium

(2015) Aurélie Bruno et al.   ACTA NEUROPATHOLOGICA

Distinguishing Nested Variants of Urothelial Carcinoma From Benign Mimickers by TERT Promoter Mutation

(2015) Minghao Zhong et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Telomerase reverse transcriptase promoter mutations in glandular lesions of the urinary bladder

(2015) Eric Vail et al.   Annals of Diagnostic Pathology

Heterogeneity of TERT promoter mutations status in squamous cell carcinomas of different anatomical sites

(2015) Katherine A. Cheng et al.   Annals of Diagnostic Pathology

Involvement of transcription repressor Snail in the regulation of human telomerase reverse transcriptase (hTERT) by transforming growth factor-β

(2015) Young-Sun Yoo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Alterations in Gliosarcoma and Giant Cell Glioblastoma

(2015) Ji Eun Oh et al.   BRAIN PATHOLOGY

TERTpromoter mutations in periocular carcinomas: implications of ultraviolet light in pathogenesis

(2015) Shih-Yao Lin et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Down regulation of miR-202 modulates Mxd1 and Sin3A repressor complexes to induce apoptosis of pancreatic cancer cells

(2015) Lulu Farhana et al.   CANCER BIOLOGY & THERAPY

TERTpromoter mutations in thyroid cancer: a report from a Middle Eastern population

(2015) Ebtesam Qasem et al.   ENDOCRINE-RELATED CANCER

Tall cell papillary thyroid carcinoma: new diagnostic criteria and mutations in BRAF and TERT

(2015) M. S Dettmer et al.   ENDOCRINE-RELATED CANCER

Recurrent TERT promoter mutations identified in a large-scale study of multiple tumour types are associated with increased TERT expression and telomerase activation

(2015) Dong-Sheng Huang et al.   EUROPEAN JOURNAL OF CANCER

Mutation of theTERTpromoter, switch to active chromatin, and monoallelicTERTexpression in multiple cancers

(2015) Josh Lewis Stern et al.   GENES & DEVELOPMENT

Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential

(2015) Keisuke Akaike et al.   HUMAN PATHOLOGY

Mutations inTERTpromoter andFGFR3and telomere length in bladder cancer

(2015) Ismail Hosen et al.   INTERNATIONAL JOURNAL OF CANCER

Human Telomerase Reverse Transcriptase (hTERT) Transcription Requires Sp1/Sp3 Binding to the Promoter and a Permissive Chromatin Environment

(2015) De Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Krüppel-like Factor 2 Represses Transcription of the Telomerase Catalytic Subunit Human Telomerase Reverse Transcriptase (hTERT) in Human T Cells

(2015) Toshifumi Hara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cordyceptin induces apoptosis through repressing hTERT expression and inducing extranuclear export of hTERT

(2015) Kyung-Jun Jang et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Association of TERT Promoter Mutation, But Not BRAF Mutation, With Increased Mortality in PTC

(2015) Jonathan R. George et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Association ofTERTPromoter Mutation 1,295,228 C>T WithBRAFV600E Mutation, Older Patient Age, and Distant Metastasis in Anaplastic Thyroid Cancer

(2015) Xiaoguang Shi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Clinical and Molecular Features of Hürthle Cell Carcinoma of the Thyroid

(2015) Ana-Maria Chindris et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT promoter mutations and rs2853669 polymorphism: prognostic impact and interactions with common alterations in glioblastomas

(2015) Umberto Nencha et al.   JOURNAL OF NEURO-ONCOLOGY

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

TERT promoter mutations in sinonasal malignant melanoma

(2015) Mattias Jangard et al.   MELANOMA RESEARCH

Telomerase in differentiated thyroid cancer: Promoter mutations, expression and localization

(2015) Marina Muzza et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

(2015) Martin Peifer et al.   NATURE

Non-canonical NF-κB signalling and ETS1/2 cooperatively drive C250T mutant TERT promoter activation

(2015) Yinghui Li et al.   NATURE CELL BIOLOGY

Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis

(2015) Sabine Spiegl-Kreinecker et al.   NEURO-ONCOLOGY

Role of diallyl disulfide-mediated cleavage of c-Myc and Sp-1 in the regulation of telomerase activity in human lymphoma cell line U937

(2015) Pritha Dasgupta et al.   NUTRITION

TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer

(2015) K. Wang et al.   ONCOLOGIST

Acidified bile acids increase hTERT expression via c-myc activation in human gastric cancer cells

(2015) XIAOLONG WANG et al.   ONCOLOGY REPORTS

TERTpromoter mutations and telomerase reactivation in urothelial cancer

(2015) Sumit Borah et al.   SCIENCE

Arsenic trioxide suppresses transcription of hTERT through down-regulation of multiple transcription factors in HL-60 leukemia cells

(2015) Yao Zhang et al.   TOXICOLOGY LETTERS

Epidermal growth factor activates telomerase activity by direct binding of Ets-2 to hTERT promoter in lung cancer cells

(2015) Chung-Ping Hsu et al.   TUMOR BIOLOGY

Hotspot TERT promoter mutations are rare events in testicular germ cell tumors

(2015) Flavio Mavignier Cárcano et al.   TUMOR BIOLOGY

Coexistence of TERT promoter and BRAF mutations in cutaneous melanoma is associated with more clinicopathological features of aggressiveness

(2015) Elisabetta Macerola et al.   VIRCHOWS ARCHIV

Common telomerase reverse transcriptase promoter mutations in hepatocellular carcinomas from different geographical locations

(2015) Dilek Cevik   WORLD JOURNAL OF GASTROENTEROLOGY

TERT promoter mutations and polymorphisms as prognostic factors in primary glioblastoma

(2015) Mohamed Ali Mosrati et al.   Oncotarget

RFPL3 and CBP synergistically upregulate hTERT activity and promote lung cancer growth

(2015) Yu Qin et al.   Oncotarget

TERT promoter mutations and telomere length in adult malignant gliomas and recurrences

(2015) Barbara Heidenreich et al.   Oncotarget

TERT Promoter Mutations Are Predictive of Aggressive Clinical Behavior in Patients with Spitzoid Melanocytic Neoplasms

(2015) Seungjae Lee et al.   Scientific Reports

miR-19b regulates hTERT mRNA expression through targeting PITX1 mRNA in melanoma cells

(2015) Takahito Ohira et al.   Scientific Reports

TERT Promoter Mutations and Risk of Recurrence in Meningioma

(2015) Felix Sahm et al.   JNCI-Journal of the National Cancer Institute

TERT promoter mutations are a rare event in gastrointestinal stromal tumors

(2015) Keisuke Akaike et al.   SpringerPlus

Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas

(2015) Patrick J. Killela et al.   Oncotarget

TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas

(2015) Kun Wang et al.   Oncotarget

Ret finger protein-like 3 promotes tumor cell growth by activating telomerase reverse transcriptase expression in human lung cancer cells

(2015) Wangbing Chen et al.   Oncotarget

Gastrokine 1 induces senescence and apoptosis through regulating telomere length in gastric cancer

(2015) Jung Hwan Yoon et al.   Oncotarget

Transcriptional coactivator CBP upregulates hTERT expression and tumor growth and predicts poor prognosis in human lung cancers

(2015) Wei Guo et al.   Oncotarget

TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR

(2015) Kun Wang et al.   Oncotarget

Chromatin Redistribution of the DEK Oncoprotein Represses hTERT Transcription in Leukemias

(2015) Maroun Karam et al.   NEOPLASIA

Mutation frequencies of GNAQ, GNA11, BAP1, SF3B1, EIF1AX and TERT in uveal melanoma: detection of an activating mutation in the TERT gene promoter in a single case of uveal melanoma

(2014) M Dono et al.   BRITISH JOURNAL OF CANCER

TERT promoter mutations in gliomas, genetic associations and clinico-pathological correlations

(2014) M Labussière et al.   BRITISH JOURNAL OF CANCER

TERTpromoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA

(2014) Na Wang et al.   CANCER

Vitamin D Suppresses Leptin Stimulation of Cancer Growth through microRNA

(2014) R. Kasiappan et al.   CANCER RESEARCH

Diagnostic and prognostic TERT promoter mutations in thyroid fine-needle aspiration biopsy

(2014) R. Liu et al.   ENDOCRINE-RELATED CANCER

The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors

(2014) Tiantian Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase reverse transcriptase promoter mutations in tumors originating from the adrenal gland and extra-adrenal paraganglia

(2014) Thomas G Papathomas et al.   ENDOCRINE-RELATED CANCER

Low frequency of TERT promoter mutations in gastrointestinal stromal tumors (GISTs)

(2014) Nathália C Campanella et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Global expression profile of telomerase-associated genes in HeLa cells

(2014) Akhil Varshney et al.   GENE

TERTpromoter mutations predict worse survival in laryngeal cancer patients

(2014) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

Telomeropathies: An emerging spectrum disorder

(2014) Brody Holohan et al.   JOURNAL OF CELL BIOLOGY

TERTPromoter Mutations and Their Association withBRAFV600E Mutation and Aggressive Clinicopathological Characteristics of Thyroid Cancer

(2014) Xiaoli Liu et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

(2014) Miguel Melo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

BRAF V600E and TERT Promoter Mutations Cooperatively Identify the Most Aggressive Papillary Thyroid Cancer With Highest Recurrence

(2014) Mingzhao Xing et al.   JOURNAL OF CLINICAL ONCOLOGY

TERTpromoter mutation is uncommon in acral lentiginous melanoma

(2014) Jau-Yu Liau et al.   JOURNAL OF CUTANEOUS PATHOLOGY

TERT promoter hotspot mutations are recurrent in myxoid liposarcomas but rare in other soft tissue sarcoma entities

(2014) Christian Koelsche et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

TERT Promoter Mutations in Skin Cancer: The Effects of Sun Exposure and X-Irradiation

(2014) Helena Pópulo et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Alterations of theRRASandERCC1Genes at 19q13 in Gemistocytic Astrocytomas

(2014) Takashi Ohta et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

TERT Promoter Mutation Status as an Independent Prognostic Factor in Cutaneous Melanoma

(2014) Klaus G. Griewank et al.   JNCI-Journal of the National Cancer Institute

Melanomas of unknown primary frequently harbor TERT-promoter mutations

(2014) Friederike Egberts et al.   MELANOMA RESEARCH

Molecular alterations in endometrial and ovarian clear cell carcinomas: clinical impacts of telomerase reverse transcriptase promoter mutation

(2014) Hsien-Neng Huang et al.   MODERN PATHOLOGY

TERT promoter mutations contribute to subset prognostication of lower-grade gliomas

(2014) Aden Ka-Yin Chan et al.   MODERN PATHOLOGY

CPSF4 activates telomerase reverse transcriptase and predicts poor prognosis in human lung adenocarcinomas

(2014) Wangbing Chen et al.   Molecular Oncology

Genome-wide analysis of noncoding regulatory mutations in cancer

(2014) Nils Weinhold et al.   NATURE GENETICS

Trans-ancestry mutational landscape of hepatocellular carcinoma genomes

(2014) Yasushi Totoki et al.   NATURE GENETICS

Systematic analysis of noncoding somatic mutations and gene expression alterations across 14 tumor types

(2014) Nils J Fredriksson et al.   NATURE GENETICS

TERT promoter mutations: a novel independent prognostic factor in primary glioblastomas

(2014) Matthias Simon et al.   NEURO-ONCOLOGY

Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes

(2014) M. Labussiere et al.   NEUROLOGY

E2F1 acts as a negative feedback regulator of c-Myc-induced hTERT transcription during tumorigenesis

(2014) YAFEI ZHANG et al.   ONCOLOGY REPORTS

Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Modifications of Telomerase (TERT) Gene in Hepatocellular Carcinoma Cells

(2014) Bin Zhang et al.   PLoS One

FOXO3a Potentiates hTERT Gene Expression by Activating c-MYC and Extends the Replicative Life-Span of Human Fibroblast

(2014) Shuntaro Yamashita et al.   PLoS One

Frequency of TERT promoter mutations in primary tumors of the liver

(2014) Alexander Quaas et al.   VIRCHOWS ARCHIV

Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma

(2014) Barbara Heidenreich et al.   Nature Communications

TERT promoter mutation in resectable hepatocellular carcinomas: A strong association with hepatitis C infection and absence of hepatitis B infection

(2014) Yu-Ling Chen et al.   International Journal of Surgery

5-aza-2′-deoxycytidine-mediated c-myc Down-regulation Triggers Telomere-dependent Senescence by Regulating Human Telomerase Reverse Transcriptase in Chronic Myeloid Leukemia

(2014) Cindy Grandjenette et al.   NEOPLASIA

TERT promoter mutation and aberrant hypermethylation are associated with elevated expression in medulloblastoma and characterise the majority of non-infant SHH subgroup tumours

(2013) Janet C. Lindsey et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations in primary and secondary glioblastomas

(2013) Naosuke Nonoguchi et al.   ACTA NEUROPATHOLOGICA

Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss

(2013) Hideyuki Arita et al.   ACTA NEUROPATHOLOGICA

Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system

(2013) Christian Koelsche et al.   ACTA NEUROPATHOLOGICA

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

(2013) Marc Remke et al.   ACTA NEUROPATHOLOGICA

The 58-kDa microspherule protein (MSP58) represses human telomerase reverse transcriptase (hTERT) gene expression and cell proliferation by interacting with telomerase transcriptional element-interacting factor (TEIF)

(2013) Che-Chia Hsu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

High Incidence of ActivatingTERTPromoter Mutations in Meningiomas Undergoing Malignant Progression

(2013) Stéphane Goutagny et al.   BRAIN PATHOLOGY

TERT promoter mutations in ocular melanoma distinguish between conjunctival and uveal tumours

(2013) K G Griewank et al.   BRITISH JOURNAL OF CANCER

TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine

(2013) I. Kinde et al.   CANCER RESEARCH

HTLV-1 bZIP factor impedes the menin tumor suppressor and upregulates JunD-mediated transcription of the hTERT gene

(2013) Malgorzata Borowiak et al.   CARCINOGENESIS

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Highly prevalentTERTpromoter mutations in bladder cancer and glioblastoma

(2013) Xiaoli Liu et al.   CELL CYCLE

Highly prevalent TERT promoter mutations in aggressive thyroid cancers

(2013) Xiaoli Liu et al.   ENDOCRINE-RELATED CANCER

Telomerase Reverse Transcriptase Gene Promoter Mutations Help Discern the Origin of Urogenital Tumors: A Genomic and Molecular Study

(2013) Song Wu et al.   EUROPEAN UROLOGY

Telomerase Reverse Transcriptase Promoter Mutations in Bladder Cancer: High Frequency Across Stages, Detection in Urine, and Lack of Association with Outcome

(2013) Yves Allory et al.   EUROPEAN UROLOGY

Comprehensive Mutation Analysis of the TERT Promoter in Bladder Cancer and Detection of Mutations in Voided Urine

(2013) Carolyn D. Hurst et al.   EUROPEAN UROLOGY

Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus leavis oocytes

(2013) Therese Wahlström et al.   EXPERIMENTAL CELL RESEARCH

Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription

(2013) Deqiang Ding et al.   FASEB JOURNAL

Low frequency of TERT promoter somatic mutation in 313 sporadic esophageal squamous cell carcinomas

(2013) Yuda Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Low frequency ofTERTpromoter mutations in a large cohort of gallbladder and gastric cancers

(2013) Yiping Qu et al.   INTERNATIONAL JOURNAL OF CANCER

CTCF mediates theTERTenhancer-promoter interactions in lung cancer cells: Identification of a novel enhancer region involved in the regulation ofTERTgene

(2013) Vegard Eldholm et al.   INTERNATIONAL JOURNAL OF CANCER

Role of histone deacetylase inhibitors in the aging of human umbilical cord mesenchymal stem cells

(2013) Yunshuai Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Frequent SomaticTERTPromoter Mutations in Thyroid Cancer: Higher Prevalence in Advanced Forms of the Disease

(2013) Iñigo Landa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The antiretroviral agent saquinavir enhances hTERT expression and telomerase activity in human T leukaemia cells in vitro

(2013) Riccardo Adamo et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy

(2013) Ren-Chin Wu et al.   JOURNAL OF PATHOLOGY

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study

(2013) Pedro Castelo-Branco et al.   LANCET ONCOLOGY

Mutations of the TERT promoter are common in basal cell carcinoma and squamous cell carcinoma

(2013) Glynis A Scott et al.   MODERN PATHOLOGY

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas

(2013) Klaus G Griewank et al.   MODERN PATHOLOGY

Landscape of genomic alterations in cervical carcinomas

(2013) Akinyemi I. Ojesina et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

Overexpression and promoter mutation of the TERT gene in malignant pleural mesothelioma

(2013) A Tallet et al.   ONCOGENE

The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas

(2013) T Liu et al.   ONCOGENE

Hedgehog Signaling Regulates Telomerase Reverse Transcriptase in Human Cancer Cells

(2013) Tapati Mazumdar et al.   PLoS One

Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth

(2013) Lingyi Fu et al.   PLoS One

TERT Promoter Mutations Are Frequent in Cutaneous Basal Cell Carcinoma and Squamous Cell Carcinoma

(2013) Klaus G. Griewank et al.   PLoS One

Constitutive Activation of STAT3 Signaling Regulates hTERT and Promotes Stem Cell-Like Traits in Human Breast Cancer Cells

(2013) Seyung S. Chung et al.   PLoS One

TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism

(2013) P. S. Rachakonda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

EGFR Tyrosine Kinase Inhibitor Pelitinib Regulates Radiation-Induced p65-Dependent Telomerase Activation in Squamous Cell Carcinoma

(2013) Natarajan Aravindan et al.   RADIATION RESEARCH

TERT Promoter Mutations in Familial and Sporadic Melanoma

(2013) S. Horn et al.   SCIENCE

Highly Recurrent TERT Promoter Mutations in Human Melanoma

(2013) F. W. Huang et al.   SCIENCE

An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes

(2013) Mei Xu et al.   VIROLOGY

Frequency of TERT promoter mutations in human cancers

(2013) João Vinagre et al.   Nature Communications

High frequency of telomerase reverse-transcriptase promoter somatic mutations in hepatocellular carcinoma and preneoplastic lesions

(2013) Jean Charles Nault et al.   Nature Communications

Selective death of cancer cells by preferential induction of reactive oxygen species in response to (-)-epigallocatechin-3-gallate

(2012) Na Young Min et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Second-generation tyrosine kinase inhibitors reduce telomerase activity in K562 cells

(2012) Saar Shapira et al.   CANCER LETTERS

Novel anticancer therapeutics targeting telomerase

(2012) Maria Ruden et al.   CANCER TREATMENT REVIEWS

MiR-21 Modulates hTERT Through a STAT3-Dependent Manner on Glioblastoma Cell Growth

(2012) Ying-Yi Wang et al.   CNS Neuroscience & Therapeutics

MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene

(2012) Lei Shi et al.   GENE

Differential TERT promoter methylation and response to 5-aza-2′-deoxycytidine in acute myeloid leukemia cell lines: TERT expression, telomerase activity, telomere length, and cell death

(2012) Kerry A. Pettigrew et al.   GENES CHROMOSOMES & CANCER

Tumor Suppressors p53, p63TAα, p63TAy, p73α, and p73β Use Distinct Pathways to Repress Telomerase Expression

(2012) Yuan Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human Cancer

(2012) Yong Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498

(2012) Ravi Kasiappan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transfection of HCVc improves hTERT expression through STAT3 pathway by epigenetic regulation in Huh7 cells

(2012) Ning Guo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

JAK-STAT and JAK-PI3K-mTORC1 Pathways Regulate Telomerase Transcriptionally and Posttranslationally in ATL Cells

(2012) O. Yamada et al.   MOLECULAR CANCER THERAPEUTICS

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

DNA Methylation and Its Basic Function

(2012) Lisa D Moore et al.   NEUROPSYCHOPHARMACOLOGY

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Butylidenephthalide Suppresses Human Telomerase Reverse Transcriptase (TERT) in Human Glioblastomas

(2011) Po-Cheng Lin et al.   ANNALS OF SURGICAL ONCOLOGY

SIRT1 Promotes Tumorigenesis and Resistance to Chemotherapy in Hepatocellular Carcinoma and its Expression Predicts Poor Prognosis

(2011) Hsieh-Cheng Chen et al.   ANNALS OF SURGICAL ONCOLOGY

SIRT1 prevents replicative senescence of normal human umbilical cord fibroblast through potentiating the transcription of human telomerase reverse transcriptase gene

(2011) Shuntaro Yamashita et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Novel Prodrug of Epigallocatechin-3-gallate: Differential Epigenetic hTERT Repression in Human Breast Cancer Cells

(2011) S. M. Meeran et al.   Cancer Prevention Research

Sirtuin 1 Is Upregulated in a Subset of Hepatocellular Carcinomas where It Is Essential for Telomere Maintenance and Tumor Cell Growth

(2011) J. Chen et al.   CANCER RESEARCH

Indole-3-carbinol downregulation of telomerase gene expression requires the inhibition of estrogen receptor-alpha and Sp1 transcription factor interactions within the hTERT promoter and mediates the G1 cell cycle arrest of human breast cancer cells

(2011) C. N. Marconett et al.   CARCINOGENESIS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MMP-9 silencing regulates hTERT expression via β1 integrin-mediated FAK signaling and induces senescence in glioma xenograft cells

(2011) Shivani Ponnala et al.   CELLULAR SIGNALLING

Activation of STAT5 confers imatinib resistance on leukemic cells through the transcription of TERT and MDR1

(2011) Osamu Yamada et al.   CELLULAR SIGNALLING

Five dysfunctional telomeres predict onset of senescence in human cells

(2011) Zeenia Kaul et al.   EMBO REPORTS

Sirt1 deacetylates c-Myc and promotes c-Myc/Max association

(2011) Beibei Mao et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Curcumin Regulates Low-Linear Energy Transfer γ-Radiation-Induced NFκB-Dependent Telomerase Activity in Human Neuroblastoma Cells

(2011) Natarajan Aravindan et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Neuroprotective Signaling Mechanisms of Telomerase Are Regulated by Brain-Derived Neurotrophic Factor in Rat Spinal Cord Motor Neurons

(2011) Chenchen Niu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Identification of PITX1 as a TERT Suppressor Gene Located on Human Chromosome 5

(2011) D.-L. Qi et al.   MOLECULAR AND CELLULAR BIOLOGY

High-Mobility Group A2 Protein Modulates hTERT Transcription To Promote Tumorigenesis

(2011) A. Y.-J. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Silencing STAT3 may inhibit cell growth through regulating signaling pathway, telomerase, cell cycle, apoptosis and angiogenesis in hepatocellular carcinoma: potential uses for gene therapy

(2011) X. WANG et al.   NEOPLASMA

Nuclear Factor κB–Mediated Transactivation of Telomerase Prevents Intimal Smooth Muscle Cell From Replicative Senescence During Vascular Repair

(2010) De-xiu Bu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages

(2010) Florence Gizard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells

(2010) He Ren et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways

(2010) R T Sitaram et al.   BRITISH JOURNAL OF CANCER

Increase of telomerase activity and hTERT expression in myelodysplastic syndromes

(2010) Federica Briatore et al.   CANCER BIOLOGY & THERAPY

Grainyhead-like 2 Enhances the Human Telomerase Reverse Transcriptase Gene Expression by Inhibiting DNA Methylation at the 5′-CpG Island in Normal Human Keratinocytes

(2010) Wei Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Erythropoietin activates telomerase through transcriptional and posttranscriptional regulation in human erythroleukemic JAS-REN-A cells

(2010) Masaharu Akiyama et al.   LEUKEMIA RESEARCH

Reptin is required for the transcription of telomerase reverse transcriptase and over-expressed in gastric cancer

(2010) Wenjuan Li et al.   Molecular Cancer

Sulforaphane Causes Epigenetic Repression of hTERT Expression in Human Breast Cancer Cell Lines

(2010) Syed M. Meeran et al.   PLoS One

Krüppel-Like Transcription Factor 4 Contributes to Maintenance of Telomerase Activity in Stem Cells

(2010) Chui-Wei Wong et al.   STEM CELLS

Hepatitis B virus X protein upregulates transcriptional activation of human telomerase reverse transcriptase

(2010) Hua Liu et al.   VIRUS GENES

Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells

(2009) Dong-Oh Moon et al.   CANCER LETTERS

Telomeres and telomerase in cancer

(2009) S. E. Artandi et al.   CARCINOGENESIS

Telomeres and disease

(2009) Peter M Lansdorp   EMBO JOURNAL

Hepatitis B virus protein preS2 potentially promotes HCC development via its transcriptional activation of hTERT

(2009) F Luan et al.   GUT

The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma

(2009) Raviprakash T. Sitaram et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptional Activation ofhTERT, the Human Telomerase Reverse Transcriptase, by Nuclear Factor of Activated T Cells

(2009) Amel Chebel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PPARγ ligands inhibit telomerase activity and hTERT expression through modulation of the Myc/Mad/Max network in colon cancer cells

(2009) Cristina Toaldo et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

PAX5 activates the transcription of the human telomerase reverse transcriptase gene in B cells

(2009) Stéphanie Bougel et al.   JOURNAL OF PATHOLOGY

Inhibition of the hTERT promoter by the proto-oncogenic protein TAL1

(2009) J-M Terme et al.   LEUKEMIA

Wogonin, an active compound in Scutellaria baicalensis, induces apoptosis and reduces telomerase activity in the HL-60 leukemia cells

(2009) Sheng-Teng Huang et al.   PHYTOMEDICINE

Dynamic Telomerase Gene Suppression via Network Effects of GSK3 Inhibition

(2009) Alan E. Bilsland et al.   PLoS One

HPV E6 protein interacts physically and functionally with the cellular telomerase complex

(2009) X. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells

(2008) M. Bellon et al.   BLOOD

Induced telomerase activity in primary aortic endothelial cells by low-LET γ-radiation is mediated through NF-κB activation

(2008) M NATARAJAN et al.   BRITISH JOURNAL OF RADIOLOGY

PAX8 Regulates Telomerase Reverse Transcriptase and Telomerase RNA Component in Glioma

(2008) Y.-J. Chen et al.   CANCER RESEARCH

Early growth response-1 mediates downregulation of telomerase in cervical cancer

(2008) Osamu Akutagawa et al.   CANCER SCIENCE

Association of hsp90 to the hTERT promoter is necessary for hTERT expression in human oral cancer cells

(2008) R. H. Kim et al.   CARCINOGENESIS

Estrogen Receptor-α and Endothelial Nitric Oxide Synthase Nuclear Complex Regulates Transcription of Human Telomerase

(2008) Annalisa Grasselli et al.   CIRCULATION RESEARCH

The PPARα/p16 INK4a Pathway Inhibits Vascular Smooth Muscle Cell Proliferation by Repressing Cell Cycle–Dependent Telomerase Activation

(2008) Florence Gizard et al.   CIRCULATION RESEARCH

The longest telomeres: a general signature of adult stem cell compartments

(2008) I. Flores et al.   GENES & DEVELOPMENT

Pyk2/ERK 1/2 mediate Sp1- and c-Myc-dependent induction of telomerase activity by epidermal growth factor

(2008) Yira Bermudez et al.   GROWTH FACTORS

MCAF1/AM Is Involved in Sp1-mediated Maintenance of Cancer-associated Telomerase Activity

(2008) Lifeng Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ets2 Maintains hTERT Gene Expression and Breast Cancer Cell Proliferation by Interacting with c-Myc

(2008) Dakang Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysophosphatidic acid activates telomerase in ovarian cancer cells through hypoxia-inducible factor-1α and the PI3K pathway

(2008) Kun Yang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Regulation of Telomerase Activity by Interferon Regulatory Factors 4 and 8 in Immune Cells

(2008) R. Hrdlickova et al.   MOLECULAR AND CELLULAR BIOLOGY

Regulation of the hTERT promoter activity by MSH2, the hnRNPs K and D and GRHL2 in human oral squamous cell carcinoma cells

(2008) X Kang et al.   ONCOGENE

A novel function of colony-stimulating factor 1 receptor in hTERT immortalization of human epithelial cells

(2008) N F Li et al.   ONCOGENE

Lysine-Specific Demethylase 1 (LSD1) Is Required for the Transcriptional Repression of the Telomerase Reverse Transcriptase (hTERT) Gene

(2008) Qingjun Zhu et al.   PLoS One

Transforming growth factor-β inhibits telomerase through SMAD3 and E2F transcription factors

(2007) Annie Lacerte et al.   CELLULAR SIGNALLING

Wild-type but not mutant androgen receptor inhibits expression of the hTERT telomerase subunit: a novel role of AR mutation for prostate cancer development

(2007) Udo Moehren et al.   FASEB JOURNAL