Article
Oncology
Shunichiro Miki, Tomoyuki Koga, Andrew M. Mckinney, Alison D. Parisian, Takahiro Tadokoro, Raghavendra Vadla, Martin Masala, Robert F. Hevner, Joseph F. Costello, Frank Furnari
Summary: The researchers established a model to study the role of heterozygous TERT promoter mutations (TPMs) in glioblastoma initiation. They found that the mutation enhanced tumorigenesis and maintained short telomeres, providing insights into TERT promoter-specific vulnerabilities.
Article
Endocrinology & Metabolism
Michiko Matsuse, Norisato Mitsutake
Summary: TERT promoter mutations have been identified as crucial factors in tumor progression, as they upregulate TERT transcription and contribute to the unlimited proliferative capacity of tumor cells. In differentiated thyroid carcinoma, these mutations are associated with high-risk clinicopathological aggressiveness and worse prognosis, making them the best molecular marker for predicting tumor aggressiveness to date. This review provides a summary of recent findings regarding TERT promoter mutations and their functional/mechanistic aspects.
Review
Oncology
Xiaotian Yuan, Huiyang Yuan, Ning Zhang, Tiantian Liu, Dawei Xu
Summary: This article summarizes the mechanisms of telomerase activation and TERT gene induction in thyroid carcinomas, as well as their implications in thyroid cancer precision medicine.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Cleandra Gregorio, Shefali Thakur, Raquel Camara Rivero, Simone Marcia dos Santos Machado, Cyrille Cuenin, Christine Carreira, Valerie White, Ian A. Cree, Katarina Vukojevic, Merica Glavina Durdov, Alessandro Bersch Osvaldt, Patricia Ashton-Prolla, Zdenko Herceg, Fazlur Rahman Talukdar
Summary: This study found that periampullary carcinoma (PAC) tissues have shorter telomeres, lower TERT protein expression, and DNA hypermethylation in the TERT promoter. These findings are important for understanding the molecular pathology of PAC and developing therapeutic strategies.
Article
Medicine, General & Internal
Yun-Suk Choi, Seong-Woon Choi, Jin-Wook Yi
Summary: This study identified TERT promoter mutations in PTC and found that they are associated with more aggressive behavior. Patients with TERT promoter mutations were older, had larger tumors, and exhibited other adverse clinical features, resulting in a poorer prognosis compared to those with wild-type TERT gene status.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Jue Lin, Elissa Epel
Summary: Short telomeres may increase the risk of degenerative diseases, with stress-induced telomere damage being an important pathway. The initial setting point of telomere length at birth appears to be influential, possibly affected by stress. Intergenerational stress effects on telomeres include prenatal stress and direct inheritance of short telomeres.
AGEING RESEARCH REVIEWS
(2022)
Article
Biochemistry & Molecular Biology
Francois Hafezi, Lisa Jaxel, Morgane Lemaire, Jonathan D. Turner, Danielle Perez-Bercoff
Summary: TERT promoter mutations, especially the -124C>T mutation, play a crucial role in the reactivation of telomerase reverse transcriptase. The mutations generally lead to increased TERT transcription levels, with the double mutation showing the highest impact. Additionally, the presence of these mutations may unleash antisense transcription and lncRNA TAPAS might help balance the effects of TERT promoter mutations.
Review
Oncology
Sivaramakrishna Rachakonda, Jorg D. Hoheisel, Rajiv Kumar
Summary: Telomere shortening acts as a tumor suppressor by restricting replicative potential, while cancer cells evade this limitation through telomerase reactivation. Mutations in the TERT promoter increase TERT transcription, delaying senescence but not preventing telomere shortening. The scarcity of functional mutations outside coding sequences suggests evolutionary constraints on human genomes.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Jinglong Zhang, Fan Zhang, Kenneth I. Porter, Panshak P. Dakup, Shuwen Wang, Gavin P. Robertson, Shobhan Gaddameedhi, Jiyue Zhu
Summary: Telomerase activation is crucial for melanomagenesis, but is hindered by telomere dysfunction in mice. The study found that telomere dysfunction delays melanoma development and leads to DNA damage and genomic instability.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Noriaki Minami, Donghyun Hong, Celine Taglang, Georgios Batsios, Anne Marie Gillespie, Pavithra Viswanath, Nicholas Stevers, Carter J. Barger, Joseph F. Costello, Sabrina M. Ronen
Summary: The expression of TERT and GABPB1 modulates flux via the pentose phosphate pathway. Silencing of TERT or GABPB1 leads to a reduction in PPP flux, as demonstrated by C-13 magnetic resonance spectroscopy. This study suggests the potential of targeting TERT or GABPB1 as a therapeutic strategy.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Hugo Martin, Marie Doumic, Maria Teresa Teixeira, Zhou Xu
Summary: This study provides a mathematical description of the generation-dependent processes underlying non-terminal arrests in telomerase-negative cells. The research highlights differences in the mechanisms and states between non-terminal and terminal senescence arrests. The findings suggest that these two processes contribute to different consequences of senescence at the population level.
CELL AND BIOSCIENCE
(2021)
Article
Oncology
Julie Delyon, Anais Vallet, Melanie Bernard-Cacciarella, Isabelle Kuzniak, Coralie Reger de Moura, Baptiste Louveau, Fanelie Jouenne, Samia Mourah, Celeste Lebbe, Nicolas Dumaz
Summary: TERT promoter mutations are frequently found in melanoma and are associated with a poorer prognosis. Our data suggest that TERT mRNA level is a reliable marker for prognosis and is associated with resistance to targeted therapy in melanoma. We showed that TERT overexpression drives resistance to BRAF and MEK inhibitors, and inhibition of TERT can be a therapeutic option for melanoma with acquired resistance to BRAF inhibition.
Article
Multidisciplinary Sciences
Neeraj Agarwal, Sebastien Rinaldetti, Bassem B. Cheikh, Qiong Zhou, Evan P. Hass, Robert T. Jones, Molishree Joshi, Daniel V. LaBarbera, Simon R. V. Knott, Thomas R. Cech, Dan Theodorescu
Summary: The study identified TRIM28 and TRIM24 as regulators of hTERT expression in bladder cancer cells, with TRIM28 activating hTERT and TRIM24 suppressing its transcription. Phosphorylation of TRIM28 by mTORC1 releases it from TRIM24, inducing hTERT transcription. Additionally, TRIM28 expression promotes BC cell growth and stratifies patient outcomes, with mTORC1 inhibition suppressing TRIM28 phosphorylation and hTERT expression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Cell Biology
Ruozhu Yang, Yi Han, Xinyu Guan, Yue Hong, Jiahao Meng, Shirong Ding, Qian Long, Wenjun Yi
Summary: TERT is an essential enzyme responsible for telomere maintenance and genome stability. In breast cancer, the overactivation of hTERT plays a critical role in tumor initiation and progression. Understanding the mechanisms of hTERT activation in cancer could lead to improved understanding of the disease and the development of more effective treatment strategies.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Maaike van Gerwen, Janete Maria Cerutti, Thais Biude Mendes, Rachel Brody, Eric Genden, Gregory J. Riggins, Emanuela Taioli
Summary: The study found that TERT promoter mutations were more common in thyroid cancers of individuals exposed to the World Trade Center disaster, potentially explaining the increased risk of thyroid cancer in this population.
Article
Medicine, General & Internal
Igor Khomenko, Ievgen Tsema, Kostiantyn Humeniuk, Heorhii Makarov, Dmytro Rahushyn, Yurii Yarynych, Artur Sotnikov, Viktor Slobodianyk, Serhii Shypilov, Dmytro Dubenko, Olena Barabanchyk, Andrii Dinets
Summary: Combat penetrating gunshot injury often leads to liver damage and complications such as bile leak and external biliary fistula. Biliary decompression is a commonly used treatment approach. However, little is known about combat trauma and its management in ongoing hybrid warfare. This article presents a case of successful biliary decompression and closure of an external biliary fistula in a 23-year-old male with a thoracoabdominal penetrating gunshot wound.
Article
Biochemistry & Molecular Biology
Li-Na Wang, Li Wang, Guanghui Cheng, Mingkai Dai, Yunhai Yu, Guoxin Teng, Jingjie Zhao, Dawei Xu
Summary: The study found that TERT overexpression inhibits SDC-1 expression in cervical cancer cells, affecting HPV invasion. Additionally, in females without HPV infection, telomeres in cervical epithelial cells were longer, and there were significant differences in TERT gene SNPs compared to those in the hrHPV group.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Oncology
Xiangling Xing, Ninni Mu, Xiaotian Yuan, Na Wang, C. Christofer Juhlin, Klas Straat, Catharina Larsson, Shi Yong Neo, Dawei Xu
Summary: GABPB1 plays an oncogenic role in activating TERT gene expression, but also has tumor-suppressive functions in thyroid cancer. Targeting GABPB1 for cancer therapy should be cautious.
Article
Oncology
Jing Wang, Mingkai Dai, Xiangling Xing, Xing Wang, Xin Qin, Tao Huang, Zhiqing Fang, Yidong Fan, Dawei Xu
Summary: Research has shown a close connection between telomerase activity score and characteristics like tumor stemness, proliferation, and activation of oncogenic signaling pathways, revealing a potential biomarker for predicting patient outcomes and response to immunotherapy. Additionally, the telomerase component TCAB1 may act as a dispensable factor in telomerase function.
MOLECULAR ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Xin Qin, Jing Wang, Xing Wang, Tao Huang, Zhiqing Fang, Lei Yan, Yidong Fan, Dawei Xu
Summary: DNA helicases play a crucial role in maintaining genomic stability, and mutations in these genes can lead to genomic instability and cancer susceptibility. Interestingly, overexpression of DNA helicases is observed in certain cancers. In this study, genomic and molecular alterations in 12 important DNA helicases were analyzed across various types of cancers. The study revealed significant expression heterogeneity among these helicases, and tumors were classified into subtypes based on their DNA helicase score. The high DNA helicase score subtypes were associated with stemness, proliferation, oncogenic signaling, longer telomeres, more mutations, copy number alterations, and shorter survival. Furthermore, high DNA helicase scores were linked to sensitivity to chemo- and radio-therapies, as well as defects in DNA repair pathways like homologous recombination deficiency. Importantly, a potential DNA helicase inhibitor, Danusertib, was identified in this study. These findings highlight the dysregulation of DNA helicases in cancer and their potential as therapeutic targets.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Surgery
Kostiantyn Gumeniuk, Igor A. A. Lurin, Ievgen Tsema, Lesia Malynovska, Maksym Gorobeiko, Andrii Dinets
Summary: This study evaluated the clinical features of colon injuries in combat patients in East Ukraine and compared the differences between injuries caused by shape-stable and hollow-point bullets. The results showed that injuries caused by hollow-point bullets were more severe, with higher rates of hemorrhagic shock, left colon involvement, and larger areas of colon defects. The mortality rate was also higher in patients with hollow-point bullet injuries.
Review
Oncology
Xiaotian Yuan, Huiyang Yuan, Ning Zhang, Tiantian Liu, Dawei Xu
Summary: This article summarizes the mechanisms of telomerase activation and TERT gene induction in thyroid carcinomas, as well as their implications in thyroid cancer precision medicine.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Surgery
Volodymyr M. Rogovskyi, Boris Koval, Igor A. Lurin, Kostiantyn Gumeniuk, Maksym Gorobeiko, Andrii Dinets
Summary: Vascular injuries to extremities are common in armed conflicts and are associated with high risks. Managing such injuries in ongoing warfare is challenging due to limited medical resources. This case report demonstrates the utility of temporary arterial shunting in combat conditions and highlights its potential for limb salvage.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Medicine, General & Internal
V. Tsymbaliuk, I. Lurin, K. Gumeniuk, O. Herasymenko, S. Furkalo, D. Oklei, V. Negoduyko, M. Gorobeiko, A. Dinets
Summary: Modeling of wound ballistics in biological tissues simulators was conducted to study the pathological processes in gunshot wounds. The results will aid in surgical decision-making and treatment improvement.
MEDICNI PERSPEKTIVI
(2023)
Article
Emergency Medicine
Serhii V. Tertyshnyi, Igor Lurin, Igor P. Khomenko, Kostiantyn V. Gumeniuk, Volodymyr Yu. Shapovalov, Volodymyr V. Nehoduiko, Maksym Gorobeiko, Andrii Dinets
Summary: This study presents a case of distal phalanx reconstruction using a flap with distal transverse digital artery (DTDA) blood supply, as well as demonstrates the utility of audio Doppler application in the reconstruction stage for a combat patient injured in the Russo-Ukrainian war.
SCANDINAVIAN JOURNAL OF TRAUMA RESUSCITATION & EMERGENCY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Huiyang Yuan, Xin Qin, Qingya Yang, Li Liu, Zhiqing Fang, Yidong Fan, Dawei Xu
Summary: In clear cell renal cell carcinoma (ccRCC) patients, high expression of DKC1 is associated with shorter disease progression-free survival (PFS) in female but not male patients. In ccRCC patients treated with Sunitinib, female patients in the DKC1-high group have lower response rates and shorter PFS. DKC1 serves as an independent female-specific predictor for survival and Sunitinib efficacy.
BIOLOGY OF SEX DIFFERENCES
(2023)
Article
Anatomy & Morphology
Y. Y. Bursuk, A. M. Babko, S. Savosko, R. O. Serhiienko, O. Olifirenko, V. V. Lykhodii, A. Yu Kondaurova, T. Ya Raskaliei, A. Dinets, M. Yu Levkiv
Summary: Refixation of the damaged acetabular labrum is a surgical treatment that can promote joint function repair and prevent premature osteoarthritis. This study examined the condition of the hip joint in rabbits 4 months after labrum excision and after labral refixation. Various methods, including histological examination and measurement of cartilage thickness, were used to assess the condition of the articular cartilage. The results showed significant differences between the condition of the cartilage after excision and after refixation, suggesting that this surgical technique can delay or prevent progressive changes in the damaged hip joint cartilage.
INTERNATIONAL JOURNAL OF MORPHOLOGY
(2023)
Article
Emergency Medicine
Sergiy Golovko, Rostislav Gybalo, Igor Lurin, Igor Taraban, Artem Kobirnichenko, Vitalii Ganiuk, Maksym Gorobeiko, Andrii Dinets
Summary: This report presents a case of successful penile salvage in a combat patient with gunshot genitourinary trauma, despite the interrupted supply of medical equipment. The patient underwent primary surgical debridement and suturing of multiple injuries, leading to functional recovery. This case sheds light on the management of penile gunshot injuries in warfare with limited medical resources.
INTERNATIONAL JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Medicine, Research & Experimental
V. I. Tsymbaliuk, I. A. Lurin, K. V. Gumeniuk, O. F. Savitsky, O. M. Popova, M. B. Gorobeiko, A. V. Dinets
Summary: Gunshot injuries to the colon are common and severe in combat casualties. This study investigated colon wounds in 374 servicemen injured in East Ukraine and confirmed the impact of different types of wounding projectiles on colon injuries through experimental analysis. The severity of colon injuries varied depending on the type of projectile.
WORLD OF MEDICINE AND BIOLOGY
(2022)
Article
Medicine, General & Internal
Maksym Gorobeiko, Andrii Dinets, Denys Pominchuk, Karim Abdalla, Yuriy Prylutskyy, Viktoria Hoperia
Summary: This article presents a case of breast cancer with hypercalcemia initially diagnosed as bone metastases, but later found to have hyperparathyroidism. Postoperative treatment successfully normalized the patient's PTH and Ca2+ levels. The study highlights the importance of considering hyperparathyroidism in breast cancer patients with bone lesions.
CLINICAL MEDICINE INSIGHTS-CASE REPORTS
(2022)