Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis

Mechanical overloading causes mitochondrial superoxide and SOD2 imbalance in chondrocytes resulting in cartilage degeneration

(2015) Masato Koike et al.   Scientific Reports

Emerging regulators of the inflammatory process in osteoarthritis

(2014) Ru Liu-Bryan et al.   Nature Reviews Rheumatology

Metabolic enrichment of omega-3 polyunsaturated fatty acids does not reduce the onset of idiopathic knee osteoarthritis in mice

(2014) A. Cai et al.   OSTEOARTHRITIS AND CARTILAGE

Identification of ‘erasers’ for lysine crotonylated histone marks using a chemical proteomics approach

(2014) Xiucong Bao et al.   eLife

Peroxisome Proliferator-Activated Receptor γ Coactivator 1α and FoxO3A Mediate Chondroprotection by AMP-Activated Protein Kinase

(2014) Xianling Zhao et al.   Arthritis & Rheumatology

Regulation of MnSOD Enzymatic Activity by Sirt3 Connects the Mitochondrial Acetylome Signaling Networks to Aging and Carcinogenesis

(2013) Randa Tao et al.   ANTIOXIDANTS & REDOX SIGNALING

Strain-dependent oxidant release in articular cartilage originates from mitochondria

(2013) M. J. Brouillette et al.   Biomechanics and Modeling in Mechanobiology

SIRT3: As Simple As It Seems?

(2013) David B. Lombard et al.   GERONTOLOGY

Proinflammatory Cytokines Stimulate Mitochondrial Superoxide Flashes in Articular Chondrocytes In Vitro and In Situ

(2013) Yongxing Cao et al.   PLoS One

Heme Oxygenase-1 Regulates Matrix Metalloproteinase MMP-1 Secretion and Chondrocyte Cell Death via Nox4 NADPH Oxidase Activity in Chondrocytes

(2013) Francis Rousset et al.   PLoS One

Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways

(2013) M. J. Rardin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

(2013) Freyr Petursson et al.   ARTHRITIS RESEARCH & THERAPY

Mitochondrial dysfunction increases inflammatory responsiveness to cytokines in normal human chondrocytes

(2012) Carlos Vaamonde-García et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of Type 1 diabetes

(2012) Shraddha S. Vadvalkar et al.   BIOCHEMICAL JOURNAL

Epigenetics, sirtuins and osteoarthritis

(2012) Odile Gabay et al.   JOINT BONE SPINE

High Dietary Fat Selectively Increases Catalase Expression within Cardiac Mitochondria

(2012) Paul M. Rindler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Protein Acylation and Intermediary Metabolism: Regulation by Sirtuins and Implications for Metabolic Disease

(2012) John C. Newman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Protein Deacetylates Isocitrate Dehydrogenase 2 (IDH2) and Regulates Mitochondrial Redox Status

(2012) Wei Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene Expression

(2012) T. Iwahara et al.   MOLECULAR AND CELLULAR BIOLOGY

Histopathology of naturally occurring and surgically induced osteoarthritis in mice

(2012) M.A. McNulty et al.   OSTEOARTHRITIS AND CARTILAGE

Microarray analysis reveals age-related differences in gene expression during the development of osteoarthritis in mice

(2011) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Tumour suppressor SIRT3 deacetylates and activates manganese superoxide dismutase to scavenge ROS

(2011) Yaohui Chen et al.   EMBO REPORTS

The role of mitochondria in osteoarthritis

(2011) Francisco J. Blanco et al.   Nature Reviews Rheumatology

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Why is osteoarthritis an age-related disease?

(2010) A. Shane Anderson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions

(2010) Norifumi Fujita et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Mitochondrial DNA haplogroups modulate the serum levels of biomarkers in patients with osteoarthritis

(2009) I. Rego-Perez et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of superoxide dismutase genes: Implications in disease

(2009) Lu Miao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Subcellular localization of Nox4 and regulation in diabetes

(2009) K. Block et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial DNA haplogroups: Role in the prevalence and severity of knee osteoarthritis

(2008) Ignacio Rego-Pérez et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS

The selective detection of mitochondrial superoxide by live cell imaging

(2008) Kristine M Robinson et al.   Nature Protocols

Oxidative stress induces expression of osteoarthritis markers procollagen IIA and 3B3(−) in adult bovine articular cartilage

(2008) I.M. Khan et al.   OSTEOARTHRITIS AND CARTILAGE

Interleukin-1β and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: a possible explanation for oxidative stress generation

(2008) M. Mathy-Hartert et al.   OSTEOARTHRITIS AND CARTILAGE