Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways

Randomized trial of tofacitinib in active ulcerative colitis: analysis of efficacy based on patient-reported outcomes

(2015) Julián Panés et al.   BMC GASTROENTEROLOGY

Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-κB in HaCaT cells

(2015) Soo-Jin Jeong et al.   PHYTOMEDICINE

The role of the catecholic and the electrophilic moieties of caffeic acid in Nrf2/Keap1 pathway activation in ovarian carcinoma cell lines

(2015) R. Sirota et al.   Redox Biology

Grape Seed Proanthocyanidin Extract Ameliorates Diabetic Bladder Dysfunction via the Activation of the Nrf2 Pathway

(2015) Shouzhen Chen et al.   PLoS One

Tofacitinib

(2014) Deepti Vyas et al.   ANNALS OF PHARMACOTHERAPY

Oxidative Stress and Respiratory System: Pharmacological and Clinical Reappraisal of N-Acetylcysteine

(2014) Pierachille Santus et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Camel’s milk ameliorates TNBS-induced colitis in rats via downregulation of inflammatory cytokines and oxidative stress

(2014) Hany H. Arab et al.   FOOD AND CHEMICAL TOXICOLOGY

The Relationship Between Serum Bilirubin and Crohn’s Disease

(2014) Martin Leníček et al.   INFLAMMATORY BOWEL DISEASES

Fucoxanthin Enhances the Level of Reduced Glutathione via the Nrf2-Mediated Pathway in Human Keratinocytes

(2014) Jian Zheng et al.   Marine Drugs

Molecular and Chemical Regulation of the Keap1-Nrf2 Signaling Pathway

(2014) Young-Sam Keum et al.   MOLECULES

Telmisartan Attenuates Colon Inflammation, Oxidative Perturbations and Apoptosis in a Rat Model of Experimental Inflammatory Bowel Disease

(2014) Hany H. Arab et al.   PLoS One

Red wine extract decreases pro-inflammatory markers, nuclear factor-κB and inducible NOS, in experimental metabolic syndrome

(2014) Pavol Janega et al.   Food & Function

A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate–nitrite–nitric oxide pathway in the gut

(2014) Bárbara S. Rocha et al.   Food & Function

Glutathione: new roles in redox signaling for an old antioxidant

(2014) Katia Aquilano et al.   Frontiers in Pharmacology

Stilbenes and Anthocyanins Reduce Stress Signaling in BV-2 Mouse Microglia

(2013) Amanda N. Carey et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Involvement of JAK/STAT signaling in the pathogenesis of inflammatory bowel disease

(2013) Mehmet Coskun et al.   PHARMACOLOGICAL RESEARCH

Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages

(2013) Hong-Guang Chen et al.   International Journal of Surgery

Effect of high-dose N-acetylcysteine on airway geometry, inflammation, and oxidative stress in COPD patients

(2013) Jan De Backer et al.   International Journal of Chronic Obstructive Pulmonary Disease

The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

(2013) Mohammad A. Aminzadeh et al.   Redox Biology

Glutathione Efflux and Cell Death

(2012) Rodrigo Franco et al.   ANTIOXIDANTS & REDOX SIGNALING

The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation

(2012) Holly K. Bryan et al.   BIOCHEMICAL PHARMACOLOGY

Glutathione and modulation of cell apoptosis

(2012) Magdalena L. Circu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Inflammatory bowel disease pathogenesis

(2012) Michael Scharl et al.   CURRENT OPINION IN GASTROENTEROLOGY

Synergistic and suppressive effects of dietary phenolic acids and other phytochemicals from cereal extracts on nuclear factor kappa B activity

(2012) Anastasia S. Hole et al.   FOOD CHEMISTRY

Nadroparin Sodium Activates Nrf2/HO-1 Pathway in Acetic Acid-Induced Colitis in Rats

(2012) Mehmet Yalniz et al.   INFLAMMATION

Dangkwisoo-san, an herbal medicinal formula, ameliorates acute lung inflammation via activation of Nrf2 and suppression of NF-κB

(2012) Ji Hyo Lyu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Review of natural products actions on cytokines in inflammatory bowel disease

(2012) Sun Jin Hur et al.   NUTRITION RESEARCH

Synergism of plant-derived polyphenols in adipogenesis: Perspectives and implications

(2012) María Herranz-López et al.   PHYTOMEDICINE

N-acetylcysteine expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid-induced colitis in rats

(2012) Suleyman Uraz et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells

(2012) Carla Nunes et al.   Food & Function

Nuclear factor p65 interacts with Keap1 to repress the Nrf2-ARE pathway

(2011) Miao Yu et al.   CELLULAR SIGNALLING

Polyphenol Supplementation as a Complementary Medicinal Approach to Treating Inflammatory Bowel Disease

(2011) F. Biasi et al.   CURRENT MEDICINAL CHEMISTRY

Nutritional Antioxidants and Adaptive Cell Responses: An Update

(2011) A. Speciale et al.   CURRENT MOLECULAR MEDICINE

Polyphenols activate Nrf2 in astrocytes via H2O2, semiquinones, and quinones

(2011) Hilla Erlank et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impaired Integrity of DNA After Recovery From Inflammation Causes Persistent Dysfunction of Colonic Smooth Muscle

(2011) Kuicheon Choi et al.   GASTROENTEROLOGY

Inhibition of Ulcerative Colitis in Mice after Oral Administration of a Polyphenol-Enriched Cocoa Extract Is Mediated by the Inhibition of STAT1 and STAT3 Phosphorylation in Colon Cells

(2011) Isabel Andújar et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Involvement of oxidative stress and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in inflammatory bowel disease

(2011) Satoshi Tanida et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Nitric oxide and DOPAC-induced cell death: From GSH depletion to mitochondrial energy crisis

(2011) Carla Nunes et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Genetics and pathogenesis of inflammatory bowel disease

(2011) Bernard Khor et al.   NATURE

When NRF2 Talks, Who's Listening?

(2010) Nobunao Wakabayashi et al.   ANTIOXIDANTS & REDOX SIGNALING

Carbon Monoxide Liberated from Carbon Monoxide-Releasing Molecule Exerts an Anti-inflammatory Effect on Dextran Sulfate Sodium-Induced Colitis in Mice

(2010) Tomohisa Takagi et al.   DIGESTIVE DISEASES AND SCIENCES

Efficacy and safety of drugs for ulcerative colitis

(2010) Laura Noddin Rosenberg et al.   Expert Opinion On Drug Safety

Anthocyanins from purple sweet potato attenuate dimethylnitrosamine-induced liver injury in rats by inducing Nrf2-mediated antioxidant enzymes and reducing COX-2 and iNOS expression

(2010) Yong Pil Hwang et al.   FOOD AND CHEMICAL TOXICOLOGY

Analysis of phenolic compounds in cork from Quercus suber L. by HPLC–DAD/ESI–MS

(2010) Ana Fernandes et al.   FOOD CHEMISTRY

Luteolin inhibits cytokine expression in endotoxin/cytokine-stimulated microglia

(2010) Tsung-Kuei Kao et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Epigallocatechin-3-gallate activates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats

(2010) Kazim Sahin et al.   LIFE SCIENCES

Basic biochemical mechanisms behind the health benefits of polyphenols

(2010) Cesar G. Fraga et al.   MOLECULAR ASPECTS OF MEDICINE

Inhibition of inflammatory mediators by polyphenolic plant extracts in human intestinal Caco-2 cells

(2009) Béatrice Romier-Crouzet et al.   FOOD AND CHEMICAL TOXICOLOGY

Prohibitin Is a Novel Regulator of Antioxidant Response That Attenuates Colonic Inflammation in Mice

(2009) Arianne L. Theiss et al.   GASTROENTEROLOGY

Chitosan prevents oxidative stress-induced amyloid β formation and cytotoxicity in NT2 neurons: involvement of transcription factors Nrf2 and NF-κB

(2009) Fariba Khodagholi et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

(2009) Jiyoung Kim et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A molecular phylogeny of the benign Theileria parasites based on major piroplasm surface protein (MPSP) gene sequences

(2009) W. JEONG et al.   PARASITOLOGY

Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis

(2008) Wenge Li et al.   BIOCHEMICAL PHARMACOLOGY

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

(2008) Guang-Hui Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Polymeric black tea polyphenols induce phase II enzymes via Nrf2 in mouse liver and lungs

(2008) Rachana Patel et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein tyrosine phosphatases in the JAK/STAT pathway

(2008) Dan Xu   Frontiers in Bioscience-Landmark

Molecular mechanisms of Nrf2-mediated antioxidant response

(2008) Wenge Li et al.   MOLECULAR CARCINOGENESIS

A Review of Complementary and Alternative Approaches to Immunomodulation

(2008) John O. Clarke et al.   NUTRITION IN CLINICAL PRACTICE

Inteferons pen the JAK–STAT pathway

(2008) Christian Schindler et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Dietary factors, hormesis and health

(2007) Mark P. Mattson   AGEING RESEARCH REVIEWS