Review
Immunology
Thivya Balendran, Keith Lim, John A. Hamilton, Adrian A. Achuthan
Summary: Rheumatoid arthritis (RA) is an autoimmune disease that causes pain and disability. Current drugs for treating RA aim to halt the disease progression and reduce inflammation, but they have drawbacks. To address this, targeting transcription factors (TFs) has become a focus, as they play a vital role in RA pathogenesis. Synthetic drugs and natural compounds are being explored to target key TFs and their signaling pathways in RA. This review discusses the potential of targeting four key TFs, namely NF-?B, STATs, AP-1, and IRFs, for treating RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Jianjian Dong, Xun Wang, Chenchen Xu, Manli Gao, Shijing Wang, Jin Zhang, Haiyang Tong, Lulu Wang, Yongzhu Han, Nan Cheng, Yongsheng Han
Summary: The study demonstrates that copper-mediated neuroinflammation is associated with the activation of the NLRP3 inflammasome, contributing to progressive neuropathology in a murine model of WD. Blocking the activation of the NLRP3 inflammasome effectively mitigates cognitive decline, locomotor behavior impairment, and neurodegeneration in the mice.
CELL DEATH & DISEASE
(2021)
Article
Engineering, Chemical
Ji-Woong Park, Woong Kim, Chul Yung Choi, Seok-Jun Kim
Summary: The study found that RLE effectively suppressed the inflammatory response induced by LPS in BV-2 cells, suggesting its potential use as a preventive agent against diseases triggered by microglial inflammatory responses.
Article
Cell Biology
Ting Zuo, Yinzi Yue, Xiaohui Wang, Huan Li, Shuai Yan
Summary: The study demonstrated that luteolin effectively improved colon health indicators and reduced inflammation levels in the affected areas by regulating the signaling pathways in the intestine to alleviate colitis.
Review
Chemistry, Medicinal
Saeed Mohammadian Haftcheshmeh, Maliheh Abedi, Kazem Mashayekhi, Mohammad Javad Mousavi, Jamshid Gholizadeh Navashenaq, Asadollah Mohammadi, Amir Abbas Momtazi-Borojeni
Summary: This review discusses the modulatory effects of berberine (BBR) on various inflammatory signaling pathways in the immune system and explores its therapeutic efficacy and anti-inflammatory effects.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Medicinal
Yuyan Bai, Jin Zhou, Han Zhu, Yanlin Tao, Lupeng Wang, Liu Yang, Hui Wu, Fei Huang, Hailian Shi, Xiaojun Wu
Summary: This study found that Isoliquiritigenin (ISL) can inhibit microglia-mediated neuroinflammation in Parkinson's disease (PD) by deactivating JNK/AKT/NFκB signaling pathways. These findings suggest the therapeutic potential of ISL for microglia-mediated neuroinflammation in PD.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yongpeng Zou, Xing Luo, Yi Feng, Shaohong Fang, Jiangtian Tian, Bo Yu, Ji Li
Summary: Pyroptosis plays a crucial role in various diseases, and luteolin can prevent macrophage pyroptosis by inhibiting ROS production through Nrf2 activation and NF-κB inactivation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Zhanyou Cao, Chenghong Xing, Xinyi Cheng, Junrong Luo, Ruiming Hu, Huabin Cao, Xiaoquan Guo, Fan Yang, Yu Zhuang, Guoliang Hu
Summary: Avian colibacillosis is a major cause of animal death and egg-production decline in the poultry industry. Luteolin has been found to alleviate inflammation and oxidative stress caused by E. coli and may be used as an alternative to antibiotics for controlling avian colibacillosis.
Article
Neurosciences
Philippa Malko, Xiaoling Jia, Ian Wood, Lin-Hua Jiang
Summary: Microglial cell function and inflammation are regulated by the activation of Piezo1 channel. This study found that the activation of Piezo1 channel can inhibit the pro-inflammatory activation and production of pro-inflammatory cytokines in microglial cells by initiating intracellular Ca2+ signaling to inhibit the NF-kappa B inflammatory signaling pathway.
Article
Pharmacology & Pharmacy
Xue-Fei Wu, Chun Li, Guang Yang, Ying-Zi Wang, Yan Peng, Dan-Dan Zhu, Ao-Ran Sui, Qiong Wu, Qi-Fa Li, Bin Wang, Na Li, Yue Zhang, Bi-Ying Ge, Jie Zhao, Shao Li
Summary: The study demonstrates that SVHRP can inhibit neuroinflammation and microglia activation, potentially explaining the therapeutic effects of BmK-derived materials and suggesting that BmK venom could be a potential source for CNS drug development.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Immunology
Chenchen Liu, Wei Zhao, Jia Su, Xiaochun Chen, Feifan Zhao, Jindai Fan, Xiaowen Li, Xiaodi Liu, Linke Zou, Mengru Zhang, Zilin Zhang, Liangliang Zhang, Shuangqi Fan, Yuwan Li, Mingqiu Zhao, Jinding Chen, Lin Yi
Summary: Heat shock protein HSP90AA1 plays an important role in classical swine fever virus (CSFV) infection by inhibiting viral replication and activating JAK/STAT and NF-κB signaling pathways through interaction with NS5A protein.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Yoshinori Aoki, Hongmei Dai, Fumika Furuta, Tomohisa Akamatsu, Takuya Oshima, Naoto Takahashi, Yu-ichi Goto, Akira Oka, Masayuki Itoh
Summary: Microglial cells have an important role in the brain's immune system. LOX-1 expression was confirmed in microglial cells in the neonatal hypoxic-ischemic encephalopathy model brain. LOX-1 activates cytokines and chemokines through intracellular pathways. This study investigated the role and molecular mechanism of LOX-1 gene transcription in microglial cells under hypoxic and ischemic conditions.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Clinical Neurology
Sofia Ibarburu, Mariangeles Kovacs, Valentina Varela, Jorge Rodriguez-Duarte, Mariana Ingold, Paulina Invernizzi, Williams Porcal, Ana Paula Arevalo, Karen Perelmuter, Mariela Bollati-Fogolin, Carlos Escande, Gloria V. Lopez, Peter King, Ying Si, Yuri Kwon, Carlos Batthyany, Luis Barbeito, Emiliano Trias
Summary: These findings indicate a potential therapeutic effect of BANA in ALS patients, as it can slow down paralysis progression by inhibiting microglial NF-kappa B activation. Experimental results demonstrate that administration of BANA to SOD1(G93A) rats after paralysis onset can improve spinal motor neuron pathology and preserve neuromuscular junction innervation, thus prolonging post-paralysis survival.
Article
Biochemistry & Molecular Biology
So-Ra Kim, Kyung-Joo Seong, Won-Jae Kim, Ji-Yeon Jung
Summary: EGCG protects microglia from hypoxia-induced inflammation and oxidative stress through inhibition of the NF-κB pathway and activation of the Nrf-2/HO-1 pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jiayuan Wu, Xinqin Xu, Li Zheng, Juanfen Mo, Xiuhui Jin, Yi Bao
Summary: Nilotinib has been shown to suppress microglia-mediated neuroinflammatory response and protect DA neurons from inflammatory damage, suggesting its potential application in further clinical trials.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell & Tissue Engineering
Neng-Wen Lo, Payungsuk Intawicha, Yung-Tsung Chiu, Kun-Hsiung Lee, Hsi-Chi Lu, Chien-Hong Chen, Yong-Hsuan Chang, Chun-Da Chen, Jyh-Cherng Ju
CELL TRANSPLANTATION
(2015)
Article
Food Science & Technology
Ching-Wen Liu, Yi-Cheng Wang, Chang-Yi Huang, Hsi-Chi Lu, Wen-Dee Chang
FOOD SCIENCE AND TECHNOLOGY RESEARCH
(2015)
Article
Biochemistry & Molecular Biology
Ching-Wen Liu, Yi-Cheng Wang, Chang-Chi Hsieh, Hsi-Chi Lu, Wen-Dee Chiang
PROCESS BIOCHEMISTRY
(2015)
Article
Endocrinology & Metabolism
Chia-Chu Chang, Chen-Yu Chen, Hui-Chin Wen, Chih-Yang Huang, Ming-Shiu Hung, Hsi-Chi Lu, Woan-Ling Chen, Chung-Ho Chang
Article
Biochemistry & Molecular Biology
Yen-Chuan Ou, Jian-Ri Li, Jiaan-Der Wang, Wen-Ying Chen, Yu-Hsiang Kuan, Ching-Ping Yang, Su-Lan Liao, Hsi-Chi Lu, Chun-Jung Chen
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Biotechnology & Applied Microbiology
Fan-Chiang Yang, Yu-Hsuan Yang, Hsi-Chi Lu
BIOCHEMICAL ENGINEERING JOURNAL
(2013)
Article
Chemistry, Applied
May-June Tsou, Fuh-Juin Kao, Hsi-Chi Lu, Hao-Chun Kao, Wen-Dee Chiang
Article
Food Science & Technology
Yu-Cheng Chiang, Hsi-Chi Lu, Sheng-Chih Li, Yu-Hsin Chang, Hsin-Yen Chen, Chia-Wei Lin, Hau-Yang Tsen
FOODBORNE PATHOGENS AND DISEASE
(2012)
Article
Medicine, Research & Experimental
Yen-Chuan Ou, Jian-Ri Li, Yu-Hsiang Kuan, Shue-Ling Raung, Chung-Chiang Wang, Yu-Yeh Hung, Pin-Ho Pan, Hsi-Chi Lu, Chun-Jung Chen
Article
Plant Sciences
Hsi-Chi Lu, Jia-Hui Lin, Anna C. N. Chua, Tse-Yu Chung, I-Chun Tsai, Jason T. C. Tzen, Wing-Ming Chou
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2012)
Article
Biochemistry & Molecular Biology
Ching-Wen Liu, Yi-Cheng Wang, Hsi-Chi Lu, Wen-Dee Chiang
PROCESS BIOCHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Yen-Chuan Ou, Jian-Ri Li, Jiaan-Der Wang, Cheng-Yi Chang, Chih-Cheng Wu, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Hsi-Chi Lu, Chun-Jung Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Biochemistry & Molecular Biology
Mingli Hsieh, Pei-Ju Huang, Pei-Yu Chou, Shih-Wei Wang, Hsi-Chi Lu, Wei-Wen Su, Yuan-Chiang Chung, Min-Huan Wu
Summary: Research has shown that CAVIII is overexpressed in colorectal cancer tissues and more aggressive cancer cells. It may facilitate the release of VEGF by inhibiting miRNA16-5p. The CAVIII/miR-16-5p signaling pathway appears to function as a metastasis suppressor in CRC.
Article
Plant Sciences
Douglas J. H. Shyu, Yi-Mei Young, Hsi-Chi Lu, Yueh-Mei Cheng, Jason T. C. Tzen, Wing-Ming Chou
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)