Mapping Protein–Protein Interactions of the Resistance-Related Bacterial Zeta Toxin–Epsilon Antitoxin Complex (ε2ζ2) with High Affinity Peptide Ligands Using Fluorescence Polarization

Novel Approaches Are Needed to Develop Tomorrow’s Antibacterial Therapies

(2015) Brad Spellberg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Structure-Based Design of Inhibitors of Protein-Protein Interactions: Mimicking Peptide Binding Epitopes

(2015) Marta Pelay-Gimeno et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

State-of-the-art strategies for targeting protein–protein interactions by small-molecule inhibitors

(2015) Chunquan Sheng et al.   CHEMICAL SOCIETY REVIEWS

Antibiotic resistance: are we all doomed?

(2015) P. Collignon   INTERNAL MEDICINE JOURNAL

Structural and functional studies of theMycobacterium tuberculosisVapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides

(2015) In-Gyun Lee et al.   NUCLEIC ACIDS RESEARCH

Antimicrobial Resistance: The Major Contribution of Poor Governance and Corruption to This Growing Problem

(2015) Peter Collignon et al.   PLoS One

Fluorescent Mimetics of CMP-Neu5Ac Are Highly Potent, Cell-Permeable Polarization Probes of Eukaryotic and Bacterial Sialyltransferases and Inhibit Cellular Sialylation

(2014) Johannes J. Preidl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Chemokine Receptor CCR5 Antagonist Maraviroc: Medicinal Chemistry and Clinical Applications

(2014) Guoyan Xu et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Clinical, economic and societal impact of antibiotic resistance

(2014) Steven L Barriere   EXPERT OPINION ON PHARMACOTHERAPY

The ClpXP Protease Is Responsible for the Degradation of the Epsilon Antidote to the Zeta Toxin of the Streptococcal pSM19035 Plasmid

(2014) Iwona Brzozowska et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Emergence and spread of antibiotic resistance: setting a parameter space

(2014) José Luis Martínez et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Toxin-Antitoxin Systems as Multilevel Interaction Systems

(2014) Nathalie Goeders et al.   Toxins

Highly Functionalized Terpyridines as Competitive Inhibitors of AKAP-PKA Interactions

(2013) Gesa Schäfer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Toxin-antitoxin systems are ubiquitous and versatile modulators of prokaryotic cell fate

(2013) Christopher F. Schuster et al.   FEMS MICROBIOLOGY LETTERS

Benzoylphosphonate-Based Photoactive Phosphopeptide Mimetics for Modulation of Protein Tyrosine Phosphatases and Highly Specific Labeling of SH2 Domains

(2012) André Horatscheck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artificial activation of toxin–antitoxin systems as an antibacterial strategy

(2012) Julia J. Williams et al.   TRENDS IN MICROBIOLOGY

Toxin-Antitoxin Systems in Bacteria and Archaea

(2011) Yoshihiro Yamaguchi et al.   Annual Review of Genetics

COCOMAPS: a web application to analyze and visualize contacts at the interface of biomolecular complexes

(2011) A. Vangone et al.   BIOINFORMATICS

Discovery, Structure-Activity Relationship Studies, and Crystal Structure of Nonpeptide Inhibitors Bound to the Shank3 PDZ Domain

(2011) Jörn Saupe et al.   ChemMedChem

ε/ζ systems: their role in resistance, virulence, and their potential for antibiotic development

(2011) Hannes Mutschler et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Analysis of protein-ligand interactions by fluorescence polarization

(2011) Ana M Rossi et al.   Nature Protocols

A Novel Mechanism of Programmed Cell Death in Bacteria by Toxin–Antitoxin Systems Corrupts Peptidoglycan Synthesis

(2011) Hannes Mutschler et al.   PLOS BIOLOGY

Antibiotic discovery in the twenty-first century: current trends and future perspectives

(2010) Stefano Donadio et al.   JOURNAL OF ANTIBIOTICS

Health-care-associated infections in developing countries

(2010) Victor D Rosenthal   LANCET

TADB: a web-based resource for Type 2 toxin–antitoxin loci in bacteria and archaea

(2010) Yucheng Shao et al.   NUCLEIC ACIDS RESEARCH

Conjugative Plasmids of Neisseria gonorrhoeae

(2010) Emilia Pachulec et al.   PLoS One

Amino Acid-Protecting Groups

(2009) Albert Isidro-Llobet et al.   CHEMICAL REVIEWS

Identification of the folding inhibitors of hen-egg lysozyme: gathering the right tools

(2009) Martina Caldarini et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

PemK Toxin ofBacillus anthracisIs a Ribonuclease

(2009) Shivangi Agarwal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A toxin–antitoxin module as a target for antimicrobial development

(2009) Virginia S. Lioy et al.   PLASMID

Rapid Evolution of Virulence and Drug Resistance in the Emerging Zoonotic Pathogen Streptococcus suis

(2009) Matthew T. G. Holden et al.   PLoS One

Bacterial Toxin–Antitoxin Systems: More Than Selfish Entities?

(2009) Laurence Van Melderen et al.   PLoS Genetics

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

Predicting druggable binding sites at the protein–protein interface

(2008) Jonathan C. Fuller et al.   DRUG DISCOVERY TODAY

Complete sequence of Enterococcus faecium pVEF3 and the detection of an ω-ε-ζ toxin–antitoxin module and an ABC transporter

(2008) H. Sletvold et al.   PLASMID

Identification and characterization of folding inhibitors of hen egg lysozyme: An example of a new paradigm of drug design

(2008) M. Caldarini et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

MICROBIOLOGY: Desperately Seeking New Antibiotics

(2008) D. J. Payne   SCIENCE