Genetic Modification of Human Peripheral Blood Aspirates Using Recombinant Adeno-Associated Viral Vectors for Articular Cartilage Repair with a Focus on Chondrogenic Transforming Growth Factor-β Gene Delivery

TGF-β gene transfer and overexpressionviarAAV vectors stimulates chondrogenic events in human bone marrow aspirates

(2016) Janina Frisch et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

(2016) Ke Tao et al.   Stem Cell Research & Therapy

Novel nano-composite biomimetic biomaterial allows chondrogenic and osteogenic differentiation of bone marrow concentrate derived cells

(2015) Brunella Grigolo et al.   JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE

Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I

(2015) Janina Frisch et al.   TISSUE ENGINEERING PART A

Overexpression of MMP13 in human osteoarthritic cartilage is associated with the SMAD-independent TGF-β signalling pathway

(2015) Erfan Aref-Eshghi et al.   ARTHRITIS RESEARCH & THERAPY

Current Progress in Stem Cell-Based Gene Therapy for Articular Cartilage Repair

(2015) Janina Frisch et al.   Current Stem Cell Research & Therapy

Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model

(2015) Niina Hopper et al.   PLoS One

Determination of effective rAAV-mediated gene transfer conditions to support chondrogenic differentiation processes in human primary bone marrow aspirates

(2014) A Rey-Rico et al.   GENE THERAPY

Determination of the Chondrogenic Differentiation Processes in Human Bone Marrow-Derived Mesenchymal Stem Cells Genetically Modified to Overexpress Transforming Growth Factor-β via Recombinant Adeno-Associated Viral Vectors

(2014) Janina Frisch et al.   HUMAN GENE THERAPY

Influence of insulin-like growth factor I overexpression via recombinant adeno-associated vector gene transfer upon the biological activities and differentiation potential of human bone marrow-derived mesenchymal stem cells

(2014) Janina Frisch et al.   Stem Cell Research & Therapy

A New Source of Mesenchymal Stem Cells for Articular Cartilage Repair

(2013) Wei-Li Fu et al.   AMERICAN JOURNAL OF SPORTS MEDICINE

Articular Cartilage Regeneration With Autologous Peripheral Blood Stem Cells Versus Hyaluronic Acid: A Randomized Controlled Trial

(2013) Khay-Yong Saw et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

rAAV-mediated overexpression of TGF-β stably restructures human osteoarthritic articular cartilage in situ

(2013) Jagadeesh K Venkatesan et al.   Journal of Translational Medicine

Chondrogenesis of Human Bone Marrow-Derived Mesenchymal Stem Cells Is Modulated by Complex Mechanical Stimulation and Adenoviral-Mediated Overexpression of Bone Morphogenetic Protein 2

(2013) Alexander J. Neumann et al.   TISSUE ENGINEERING PART A

Comparative analysis of gene transcripts for cell signaling receptors in bone marrow-derived hematopoietic stem/progenitor cell and mesenchymal stromal cell populations

(2013) Khairul Anam et al.   Stem Cell Research & Therapy

Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs

(2012) Su Yeon Jeon et al.   BIOMATERIALS

Intracellular transport of recombinant adeno-associated virus vectors

(2012) M Nonnenmacher et al.   GENE THERAPY

Chondrogenic differentiation of bone marrow concentrate grown onto a hylauronan scaffold: Rationale for its use in the treatment of cartilage lesions

(2012) Carola Cavallo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Direct rAAV SOX9 administration for durable articular cartilage repair with delayed terminal differentiation and hypertrophy in vivo

(2012) Magali Cucchiarini et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells

(2012) Andre F Steinert et al.   ARTHRITIS RESEARCH & THERAPY

SOX9 gene transfer via safe, stable, replication-defective recombinant adeno-associated virus vectors as a novel, powerful tool to enhance the chondrogenic potential of human mesenchymal stem cells

(2012) Jagadeesh K Venkatesan et al.   Stem Cell Research & Therapy

Zinc-finger protein 145, acting as an upstream regulator of SOX9, improves the differentiation potential of human mesenchymal stem cells for cartilage regeneration and repair

(2011) Tong Ming Liu et al.   ARTHRITIS AND RHEUMATISM

Articular Cartilage Regeneration With Autologous Peripheral Blood Progenitor Cells and Hyaluronic Acid After Arthroscopic Subchondral Drilling: A Report of 5 Cases With Histology

(2011) Khay-Yong Saw et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Cartilage oligomeric matrix protein enhances matrix assembly during chondrogenesis of human mesenchymal stem cells

(2011) Hana Haleem-Smith et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Human peripheral blood derived mesenchymal stem cells demonstrate similar characteristics and chondrogenic differentiation potential to bone marrow derived mesenchymal stem cells

(2011) Pan-Pan Chong et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Metabolic Activities and Chondrogenic Differentiation of Human Mesenchymal Stem Cells Following Recombinant Adeno-Associated Virus–Mediated Gene Transfer and Overexpression of Fibroblast Growth Factor 2

(2011) Magali Cucchiarini et al.   TISSUE ENGINEERING PART A

Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer

(2009) Andre F Steinert et al.   ARTHRITIS RESEARCH & THERAPY

The Basic Science of Articular Cartilage: Structure, Composition, and Function

(2009) Alice J. Sophia Fox et al.   Sports Health-A Multidisciplinary Approach

Genetic manipulation of human mesenchymal progenitors to promote chondrogenesis using “bead-in-bead” polysaccharide capsules

(2007) Jodie C. Babister et al.   BIOMATERIALS