Human Mesenchymal Stem Cells Impact Th17 and Th1 Responses Through a Prostaglandin E2 and Myeloid-Dependent Mechanism

The immunomodulatory function of mesenchymal stem cells: mode of action and pathways

(2015) Antonio Uccelli et al.   Annals of the New York Academy of Sciences

Immunomodulatory characteristics of mesenchymal stem cells and their role in the treatment of Multiple Sclerosis

(2015) Tohid Gharibi et al.   CELLULAR IMMUNOLOGY

Role of the innate and adaptive immune responses in the course of multiple sclerosis

(2015) Bernhard Hemmer et al.   LANCET NEUROLOGY

Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy

(2015) Rui Li et al.   Science Translational Medicine

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

(2015) Yonghao Cao et al.   Science Translational Medicine

Mesenchymal Stem Cell-Derived Interleukin 1 Receptor Antagonist Promotes Macrophage Polarization and Inhibits B Cell Differentiation

(2015) Patricia Luz-Crawford et al.   STEM CELLS

Inhibition of B-Cell Proliferation and Antibody Production by Mesenchymal Stromal Cells Is Mediated by T Cells

(2015) Maria Manuela Rosado et al.   STEM CELLS AND DEVELOPMENT

Upregulation of BMSCs Osteogenesis by Positively-Charged Tertiary Amines on Polymeric Implants via Charge/iNOS Signaling Pathway

(2015) Wei Zhang et al.   Scientific Reports

Intravenous Administration of Bone Marrow-Derived Mesenchymal Stem Cells Induces a Switch from Classical to Atypical Symptoms in Experimental Autoimmune Encephalomyelitis

(2015) Mónica Kurte et al.   Stem Cells International

Regulatory T cells in autoimmune neuroinflammation

(2014) Markus Kleinewietfeld et al.   IMMUNOLOGICAL REVIEWS

Conversion of Th17 into IL-17AnegRegulatory T Cells: A Novel Mechanism in Prolonged Allograft Survival Promoted by Mesenchymal Stem Cell–Supported Minimized Immunosuppressive Therapy

(2014) Nataša Obermajer et al.   JOURNAL OF IMMUNOLOGY

IDO-Independent Suppression of T Cell Effector Function by IFN- -Licensed Human Mesenchymal Stromal Cells

(2014) R. Chinnadurai et al.   JOURNAL OF IMMUNOLOGY

SOCS1 Regulates the Immune Modulatory Properties of Mesenchymal Stem Cells by Inhibiting Nitric Oxide Production

(2014) Lei Zhang et al.   PLoS One

Randomized Placebo-Controlled Phase II Trial of Autologous Mesenchymal Stem Cells in Multiple Sclerosis

(2014) Sara Llufriu et al.   PLoS One

Mesenchymal Stem Cell Paracrine Activity Is Modulated by Platelet Lysate: Induction of an Inflammatory Response and Secretion of Factors Maintaining Macrophages in a Proinflammatory Phenotype

(2014) Valentina Ulivi et al.   STEM CELLS AND DEVELOPMENT

Phylogenetic distinction of iNOS and IDO function in mesenchymal stem cell-mediated immunosuppression in mammalian species

(2013) J Su et al.   CELL DEATH AND DIFFERENTIATION

Human adipose-tissue derived mesenchymal stem cells induce functionalde-novoregulatory T cells with methylatedFOXP3gene DNA

(2013) A. U. Engela et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Mechanisms of Immune Modulation by Mesenchymal Stromal Cells and Clinical Translation

(2013) J. Stagg et al.   CURRENT MOLECULAR MEDICINE

Mesenchymal stem cell transplantation in multiple sclerosis

(2013) Jeffrey A. Cohen   JOURNAL OF THE NEUROLOGICAL SCIENCES

PGE2Contributes toIn vitroMSC-Mediated Inhibition of Non-Specific and Antigen-Specific T Cell Proliferation in MS Patients

(2013) M. Zafranskaya et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Mesenchymal Stem Cells Induce an Inflammatory Response After Intravenous Infusion

(2013) Martin J. Hoogduijn et al.   STEM CELLS AND DEVELOPMENT

Mesenchymal stem cells generate a CD4+CD25+Foxp3+ regulatory T cell population during the differentiation process of Th1 and Th17 cells

(2013) Patricia Luz-Crawford et al.   Stem Cell Research & Therapy

Localization of Mesenchymal Stromal Cells Dictates Their Immune or Proinflammatory Effects in Kidney Transplantation

(2012) F. Casiraghi et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes

(2012) I. Hof-Nahor et al.   JOURNAL OF CELL SCIENCE

Mesenchymal Stem Cells Repress Th17 Molecular Program through the PD-1 Pathway

(2012) Patricia Luz-Crawford et al.   PLoS One

Human Mesenchymal Stem/Stromal Cells Cultured as Spheroids are Self-activated to Produce Prostaglandin E2 that Directs Stimulated Macrophages into an Anti-inflammatory Phenotype

(2012) Joni H. YlÖstalo et al.   STEM CELLS

The therapeutic effect of mesenchymal stem cell transplantation in experimental autoimmune encephalomyelitis is mediated by peripheral and central mechanisms

(2012) Sara Morando et al.   Stem Cell Research & Therapy

Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor

(2011) Michelle M. Duffy et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells

(2011) S. Chiesa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Mouse Mesenchymal Stem Cells in Differentiation of Naive T-Cells into Anti-Inflammatory Regulatory T-Cell or Proinflammatory Helper T-Cell 17 Population

(2011) Eliska Svobodova et al.   STEM CELLS AND DEVELOPMENT

Reciprocal Th1 and Th17 regulation by mesenchymal stem cells: Implication for multiple sclerosis

(2010) Peter J. Darlington et al.   ANNALS OF NEUROLOGY

Mesenchymal Stem Cells Inhibit Human Th17 Cell Differentiation and Function and Induce a T Regulatory Cell Phenotype

(2010) S. Ghannam et al.   JOURNAL OF IMMUNOLOGY

The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group

(2010) Mark S Freedman et al.   Multiple Sclerosis Journal

MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2

(2009) G. M. Spaggiari et al.   BLOOD

Prostaglandin E2 enhances Th17 responses via modulation of IL-17 and IFN-γ production by memory CD4+ T cells

(2009) Giorgio Napolitani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Human bone marrow-derived mesenchymal stem cells induce Th2-polarized immune response and promote endogenous repair in animal models of multiple sclerosis

(2009) Lianhua Bai et al.   GLIA

Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling

(2009) Katia Boniface et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mesenchymal Stromal Cells Ameliorate Experimental Autoimmune Encephalomyelitis by Inhibiting CD4 Th17 T Cells in a CC Chemokine Ligand 2-Dependent Manner

(2009) Moutih Rafei et al.   JOURNAL OF IMMUNOLOGY

Cytokine Modulation of TLR Expression and Activation in Mesenchymal Stromal Cells Leads to a Proinflammatory Phenotype

(2009) R. Romieu-Mourez et al.   JOURNAL OF IMMUNOLOGY

Human mesenchymal stem cells abrogate experimental allergic encephalomyelitis after intraperitoneal injection, and with sparse CNS infiltration

(2008) David Gordon et al.   NEUROSCIENCE LETTERS

Reciprocal Interactions Between Human Mesenchymal Stem Cells and γδ T Cells Or Invariant Natural Killer T Cells

(2008) Ignazia Prigione et al.   STEM CELLS

Bone Marrow-Derived Mesenchymal Stem Cells Induce Both Polyclonal Expansion and Differentiation of B Cells Isolated from Healthy Donors and Systemic Lupus Erythematosus Patients

(2007) Elisabetta Traggiai et al.   STEM CELLS