Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade

Randomized Trial of Benznidazole for Chronic Chagas’ Cardiomyopathy

(2015) Carlos A. Morillo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Overcoming neglect of kinetoplastid diseases

(2015) G. Bilbe   SCIENCE

New Compound Sets Identified from High Throughput Phenotypic Screening Against Three Kinetoplastid Parasites: An Open Resource

(2015) Imanol Peña et al.   Scientific Reports

Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

(2015) Jennifer Riley et al.   PLoS Neglected Tropical Diseases

Automated High-Content Assay for Compounds Selectively Toxic to Trypanosoma cruzi in a Myoblastic Cell Line

(2015) Julio Alonso-Padilla et al.   PLoS Neglected Tropical Diseases

Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity

(2015) Andrea Nühs et al.   PLoS Neglected Tropical Diseases

Susceptibilidad in vitro a hexadecilfosfocolina (miltefosina), nifurtimox y benznidazole de cepas de Trypanosoma cruzi aisladas en Santander, Colombia

(2014) Patricia Escobar et al.   Biomedica

Randomized Trial of Posaconazole and Benznidazole for Chronic Chagas' Disease

(2014) Israel Molina et al.   NEW ENGLAND JOURNAL OF MEDICINE

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

(2014) Joseph D. Planer et al.   PLoS Neglected Tropical Diseases

Potential new clinical therapies for Chagas disease

(2014) Juan M Bustamante et al.   Expert Review of Clinical Pharmacology

Comparison of a High-Throughput High-Content Intracellular Leishmania donovani Assay with an Axenic Amastigote Assay

(2013) Manu De Rycker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Selection and optimization of hits from a high-throughput phenotypic screen againstTrypanosoma cruzi

(2013) Martine Keenan et al.   Future Medicinal Chemistry

Benznidazole and Posaconazole in Experimental Chagas Disease: Positive Interaction in Concomitant and Sequential Treatments

(2013) Lívia de Figueiredo Diniz et al.   PLoS Neglected Tropical Diseases

Determination of ifenprodil by LC–MS/MS and its application to a pharmacokinetic study in healthy Chinese volunteers

(2013) Jing Yang et al.   Acta Pharmaceutica Sinica B

The promiscuous binding of pharmaceutical drugs and their transporter-mediated uptake into cells: what we (need to) know and how we can do so

(2012) Douglas B. Kell et al.   DRUG DISCOVERY TODAY

In vivosusceptibility to benznidazole ofTrypanosoma cruzistrains from the western Brazilian Amazon

(2012) Ana P. M. Teston et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

A Static-Cidal Assay for Trypanosoma brucei to Aid Hit Prioritisation for Progression into Drug Discovery Programmes

(2012) Manu De Rycker et al.   PLoS Neglected Tropical Diseases

Fexinidazole: A Potential New Drug Candidate for Chagas Disease

(2012) Maria Terezinha Bahia et al.   PLoS Neglected Tropical Diseases

Epidemiology of Mortality Related to Chagas' Disease in Brazil, 1999–2007

(2012) Francisco Rogerlândio Martins-Melo et al.   PLoS Neglected Tropical Diseases

Drug Developers Finally Take Aim at a Neglected Disease

(2011) M. Leslie   SCIENCE

Image-Based High-Throughput Drug Screening Targeting the Intracellular Stage of Trypanosoma cruzi, the Agent of Chagas' Disease

(2010) J. C. Engel et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Deconstructing the Drug Development Process: The New Face of Innovation

(2010) K I Kaitin   CLINICAL PHARMACOLOGY & THERAPEUTICS

Antitrypanosomal agents: treatment or threat?

(2010) Victor Sarli Issa et al.   LANCET

Chagas disease

(2010) Anis Rassi et al.   LANCET

Chagas disease: pushing through the pipeline

(2010) Julie Clayton   NATURE

High-content imaging for automated determination of host-cell infection rate by the intracellular parasite Trypanosoma cruzi

(2010) L.L. Nohara et al.   PARASITOLOGY INTERNATIONAL

In Vitro and In Vivo High-Throughput Assays for the Testing of Anti-Trypanosoma cruzi Compounds

(2010) Adriana M. C. Canavaci et al.   PLoS Neglected Tropical Diseases

Two approaches to discovering and developing new drugs for Chagas disease

(2009) JH McKerrow et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Identification of Three Classes of Heteroaromatic Compounds with Activity against Intracellular Trypanosoma cruzi by Chemical Library Screening

(2009) Esther Bettiol et al.   PLoS Neglected Tropical Diseases

Triatominae–Trypanosoma cruzi/T. rangeli: Vector–parasite interactions

(2008) G.A. Vallejo et al.   ACTA TROPICA

Differential Azole Antifungal Efficacies Contrasted Using a Saccharomyces cerevisiae Strain Humanized for Sterol 14 -Demethylase at the Homologous Locus

(2008) J. E. Parker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A mechanism for cross-resistance to nifurtimox and benznidazole in trypanosomes

(2008) Shane R. Wilkinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA