Excess of Yra1 RNA-Binding Factor Causes Transcription-Dependent Genome Instability, Replication Impairment and Telomere Shortening

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair

(2015) Elodie Hatchi et al.   MOLECULAR CELL

The Fanconi Anemia Pathway Protects Genome Integrity from R-loops

(2015) María L. García-Rubio et al.   PLoS Genetics

BRCA2 prevents R-loop accumulation and associates with TREX-2 mRNA export factor PCID2

(2014) Vaibhav Bhatia et al.   NATURE

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Telomeric transcripts stimulate telomere recombination to suppress senescence in cells lacking telomerase

(2014) Tai-Yuan Yu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage Factor I Links Transcription Termination to DNA Damage Response and Genome Integrity Maintenance in Saccharomyces cerevisiae

(2014) Hélène Gaillard et al.   PLoS Genetics

Causes of Genome Instability

(2013) Andrés Aguilera et al.   Annual Review of Genetics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

The THO complex component Thp2 counteracts telomeric R-loops and telomere shortening

(2013) Verena Pfeiffer et al.   EMBO JOURNAL

The Npl3 hnRNP prevents R-loop-mediated transcription-replication conflicts and genome instability

(2013) J. M. Santos-Pereira et al.   GENES & DEVELOPMENT

Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence

(2013) Bettina Balk et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

R-Loop Mediated Transcription-Associated Recombination in trf4Δ Mutants Reveals New Links between RNA Surveillance and Genome Integrity

(2013) Sandra Gavaldá et al.   PLoS One

A new regulatory pathway of mRNA export by an F-box protein, Mdm30

(2013) G. Durairaj et al.   RNA

Making ends meet: coordination between RNA 3′-end processing and transcription initiation

(2013) Pia K. Andersen et al.   Wiley Interdisciplinary Reviews-RNA

Regulated pre-mRNA splicing: The ghostwriter of the eukaryotic genome

(2012) Tracy L. Johnson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Transcription-associated quality control of mRNP

(2012) Manfred Schmid et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

R-loops cause replication impairment and genome instability during meiosis

(2012) Maikel Castellano-Pozo et al.   EMBO REPORTS

R-loop-mediated genome instability in mRNA cleavage and polyadenylation mutants

(2012) P. C. Stirling et al.   GENES & DEVELOPMENT

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

Telomeres and disease: Enter TERRA

(2012) André Maicher et al.   RNA Biology

CTD Tyrosine Phosphorylation Impairs Termination Factor Recruitment to RNA Polymerase II

(2012) A. Mayer et al.   SCIENCE

Requirement of DDX39 DEAD box RNA helicase for genome integrity and telomere protection

(2011) Hyun Hee Yoo et al.   AGING CELL

Differential expression of THOC1 and ALY mRNP biogenesis/export factors in human cancers

(2011) María S Domínguez-Sánchez et al.   BMC CANCER

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles

(2011) Belén Gómez-González et al.   EMBO JOURNAL

Cotranscriptional Association of mRNA Export Factor Yra1 with C-terminal Domain of RNA Polymerase II

(2011) April L. MacKellar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nab2 functions in the metabolism of RNA driven by polymerases II and III

(2011) Cristina González-Aguilera et al.   MOLECULAR BIOLOGY OF THE CELL

RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

(2011) Lamia Wahba et al.   MOLECULAR CELL

Yeast Sen1 Helicase Protects the Genome from Transcription-Associated Instability

(2011) Hannah E. Mischo et al.   MOLECULAR CELL

Keeping mRNPs in check during assembly and nuclear export

(2011) Evelina Tutucci et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The export factor Yra1 modulates mRNA 3′ end processing

(2011) Sara A Johnson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

SUS1 introns are required for efficient mRNA nuclear export in yeast

(2011) Bernardo Cuenca-Bono et al.   NUCLEIC ACIDS RESEARCH

Genome Instability and Transcription Elongation Impairment in Human Cells Depleted of THO/TREX

(2011) María S. Domínguez-Sánchez et al.   PLoS Genetics

Activation-Induced Cytidine Deaminase Targets DNA at Sites of RNA Polymerase II Stalling by Interaction with Spt5

(2010) Rushad Pavri et al.   CELL

Ubiquitin-mediated mRNP dynamics and surveillance prior to budding yeast mRNA export

(2010) N. Iglesias et al.   GENES & DEVELOPMENT

Nuclear export of mRNA

(2010) Murray Stewart   TRENDS IN BIOCHEMICAL SCIENCES

A role for TREX components in the release of spliced mRNA from nuclear speckle domains

(2010) Anusha P. Dias et al.   Nature Communications

Degradation of YRA1 Pre-mRNA in the Cytoplasm Requires Translational Repression, Multiple Modular Intronic Elements, Edc3p, and Mex67p

(2010) Shuyun Dong et al.   PLOS BIOLOGY

A Genome-wide siRNA Screen Reveals Diverse Cellular Processes and Pathways that Mediate Genome Stability

(2009) Renee D. Paulsen et al.   MOLECULAR CELL

Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae

(2009) Anna Azvolinsky et al.   MOLECULAR CELL

Progression through the RNA Polymerase II CTD Cycle

(2009) Stephen Buratowski   MOLECULAR CELL

A genome-wide screen for essential yeast genes that affect telomere length maintenance

(2009) L. Ungar et al.   NUCLEIC ACIDS RESEARCH

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Biogenesis of mRNPs: integrating different processes in the eukaryotic nucleus

(2008) Rosa Luna et al.   CHROMOSOMA

The THP1-SAC3-SUS1-CDC31 Complex Works in Transcription Elongation-mRNA Export Preventing RNA-mediated Genome Instability

(2008) Cristina González-Aguilera et al.   MOLECULAR BIOLOGY OF THE CELL

Cotranscriptional Recruitment of the mRNA Export Factor Yra1 by Direct Interaction with the 3′ End Processing Factor Pcf11

(2008) Sara Ann Johnson et al.   MOLECULAR CELL