Article
Radiology, Nuclear Medicine & Medical Imaging
Andrei Bradu, Mircea Penescu, Camille Pitrou, Jing Hao, Philippe Bourrinet
Summary: The study evaluated the pharmacokinetics of gadopiclenol in subjects with impaired renal function and assessed its dialysability in ESRD patients. Results showed that the impact of gadopiclenol on renal function varied depending on the severity of impairment, and it was effectively cleared after dialysis in ESRD patients.
INVESTIGATIVE RADIOLOGY
(2021)
Article
Anesthesiology
Thomas Stoehr, Pieter J. Colin, Joachim Ossig, Marija Pesic, Keith Borkett, Peter Winkle, Michel M. R. F. Struys, Frank Schippers
Summary: The study demonstrated that no dose adjustments are required in patients with hepatic or renal impairment when using remimazolam, and no unexpected adverse events related to remimazolam were observed in these patients.
BRITISH JOURNAL OF ANAESTHESIA
(2021)
Review
Oncology
Dehua Zhao, Xiaoqing Long, Hongying Fan, Jisheng Wang
Summary: ICIs are essential in the treatment of various cancers, but limited data is available regarding their efficacy and safety in patients with hepatic or renal impairment. This review characterizes the pharmacokinetics of ICIs and their interactions with hepatic and renal function, providing specific recommendations for clinicians when prescribing ICIs in these patients.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Multidisciplinary Sciences
Kang Min Park, Chang Min Heo, Dong Ah Lee, Yoo Jin Lee, Sihyung Park, Yang Wook Kim, Bong Soo Park
Summary: This study aimed to investigate the effect of hemodialysis on functional brain connectivity in patients with end-stage renal disease (ESRD) using functional near-infrared spectroscopy (fNIRS). The study found significant changes in functional brain connectivity measures between the pre- and post-hemodialysis periods, but no changes between the pre- and mid-hemodialysis periods or between the mid- and post-hemodialysis periods. These findings suggest that hemodialysis has a significant effect on functional brain connectivity in patients with ESRD.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Vivek Purohit, Yeamin Huh, Jessica Wojciechowski, Anna Plotka, Stephanie Salts, Jeremias Antinew, Angela Dimitrova, Timothy Nicholas
Summary: This article presents the pharmacokinetics and safety study of Ritlecitinib in participants with hepatic and renal impairment. Two innovative approaches, statistical analysis and in silico simulation, were used to analyze the data. The results show that patients with renal impairment do not require dose modification of Ritlecitinib. These analyses provide reference data and adequate pharmacokinetic models for drug development in special populations.
Article
Pharmacology & Pharmacy
Heidemarie Kletzl, Hassan Ajmi, Izabela Antys, Katja Heinig, Birgit Jaber, Thomas C. Marbury, Annie Young, Andreas Gunther
Summary: This study aimed to evaluate the effect of mild to moderate hepatic impairment on the pharmacokinetics, safety, and tolerability of a single oral dose of risdiplam. The results showed that mild or moderate hepatic impairment did not have a clinically relevant impact on the pharmacokinetics of risdiplam, indicating no dose adjustment is required for patients with mild or moderate hepatic impairment receiving risdiplam.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Richard A. Preston, Thomas Marbury, Ganesh Balaratnam, Michelle Green, Sandy Dixon, Josh Lehrer-Graiwer, Carla Washington
Summary: Two open-label studies investigated the safety, tolerability, and pharmacokinetics of Oxbryta (voxelotor) in patients with hepatic or renal impairment. Results showed that dose adjustment is not necessary for severe renal impairment or mild to moderate hepatic impairment, but a lower dose is recommended for patients with severe hepatic impairment. Voxelotor was well tolerated in all treatment groups.
JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Oncology
Michael Z. Liao, Hans Prenen, Sandeep Dutta, Vijay V. Upreti
Summary: The study demonstrated that mild-to-moderate hepatic or renal impairment had no clinically meaningful impact on the pharmacokinetics of panitumumab in patients with mCRC, indicating no need for dose adjustments.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xinhui Chen, Xiaoming Cui, Nathalie Pognan, Michelle Quinlan, Shruti Kapoor, Gholamreza Rahmanzadeh, Monica Giovannini, Thomas C. Marbury
Summary: This study compared the pharmacokinetics of a single oral dose of 200 mg capmatinib in participants with varying degrees of hepatic impairment and normal hepatic function. The results showed that mild, moderate, and severe hepatic impairment did not have a clinically relevant impact on capmatinib pharmacokinetics, and no new safety findings were reported.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Review
Chemistry, Medicinal
Dehua Zhao, Xiaoqing Long, Jisheng Wang
Summary: PARP inhibitors are a novel class of drugs that target tumor cells with DNA repair defects, and are particularly effective in patients with BRCA1/2 mutations. Impairment of liver or kidney function can affect the pharmacokinetics and safety of PARP inhibitors, therefore it is important to understand these effects and provide specific recommendations for clinicians.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Microbiology
Gina Patel, Keith A. Rodvold, Vipul K. Gupta, Jon Bruss, Leanne Gasink, Floni Bajraktari, Yang Lei, Akash Jain, Praveen Srivastava, Angela K. Talley
Summary: This study evaluated the safety, tolerability, and pharmacokinetics of Tebipenem pivoxil hydrobromide (TBP-PI-HBr) in healthy subjects and patients with renal impairment. The results showed that TBP-PI-HBr had higher plasma exposure in patients with renal impairment, highlighting the importance of the renal route in TBP elimination. Dose adjustment may be needed for patients with renal impairment. Overall, TBP-PI-HBr was well tolerated in different cohorts.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Jon B. Bruss, Justin Bader, Kamal A. Hamed
Summary: SPR206 is a novel drug that shows potent activity against multidrug-resistant bacteria. Its safety and pharmacokinetics have been evaluated in patients with varying degrees of renal impairment. The drug was found to be generally safe and well-tolerated, with predictable pharmacokinetic profile.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Oncology
Thomas Marbury, Mona El-Hashimy, Lars Blumenstein, Franck Letellier, Tirtha Sengupta, Sebastien Lorenzo, Richard Alfred Preston
Summary: The pharmacokinetics and safety of single-dose alpelisib (300 mg) were evaluated in participants with moderate to severe hepatic impairment. The results showed that there was no significant impact of hepatic impairment on the exposure of alpelisib, and the drug was well tolerated in the study population.
Article
Neurosciences
Ziyang Yu, Huize Pang, Yu Liu, Xiaolu Li, Shuting Bu, Juzhou Wang, Mengwan Zhao, Ke Ren
Summary: This study investigated the functional connectivity (FC) of resting-state networks (RSNs) in end-stage renal disease (ESRD) patients using resting state functional magnetic resonance imaging (MRI). The increased functional network connectivity between the default mode network (DMN) and the left frontoparietal network (LFPN) was found to be the most critical predictor for ESRD-associated mild cognitive impairment. The study provides noninvasive evidence of brain networks in ESRD and helps to understand the individual brain circuits.
Article
Pharmacology & Pharmacy
Sjoukje van Der Hoek, Antoon T. M. Willemsen, Ton Visser, Andre Heeres, Douwe J. Mulder, Reinoud P. H. Bokkers, Riemer H. J. A. Slart, Philip H. Elsinga, Hiddo J. L. Heerspink, Jasper Stevens
Summary: SGLT2 inhibitors reduce cardiovascular and kidney risks, but there is individual variation in response. The use of [F-18]canagliflozin PET imaging in this study helped determine the association between clinical canagliflozin doses and SGLT2 occupancy.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Mechanics
A. Al-Juboori, H. Zhu, D. Wexler, H. Li, C. Lu, A. McCusker, J. McLeod, S. Pannila, J. Barnes
ENGINEERING FRACTURE MECHANICS
(2019)
Article
Engineering, Mechanical
H. Zhu, H. Li, A. Al-Juboori, D. Wexler, C. Lu, A. McCusker, J. McLeod, S. Pannila, J. Barnes
Article
Materials Science, Multidisciplinary
Buraq Talib Shalash AL-Mosawi, David Wexler, Andrzej Calka
Summary: Al-matrix composites reinforced with varying amounts of milled carbon fibers were produced through uniball magneto milling and uniaxial hot pressing. The addition of 20% MCFs resulted in higher compressive strength and modulus of elasticity compared to other composites. Factors such as enhanced interface, porosity elimination, refined microstructure, and improved wetting contributed to the improved composite properties.
METALS AND MATERIALS INTERNATIONAL
(2021)
Article
Materials Science, Multidisciplinary
Zhijun Qiu, Bintao Wu, Hanliang Zhu, Zhiyang Wang, Alan Hellier, Yan Ma, Huijun Li, Ondrej Muransky, David Wexler
MATERIALS & DESIGN
(2020)
Article
Materials Science, Multidisciplinary
Navjeet Singh, Gilberto Casillas, David Wexler, Chris Killmore, Elena Pereloma
Article
Materials Science, Multidisciplinary
Zhijun Qiu, Bintao Wu, Zhiyang Wang, David Wexler, Kristin Carpenter, Hanliang Zhu, Ondrej Muransky, Jianrui Zhang, Huijun Li
Summary: This study investigates the influence of post-heat treatments on the microstructure and mechanical properties of a nickel-base Hastelloy C276 alloy. It shows that post-heat treatment at different temperatures can improve the strength and ductility of the alloy.
MATERIALS CHARACTERIZATION
(2021)
Article
Engineering, Mechanical
Tri Dinh Vo, Bach Tran, A. Kiet Tieu, David Wexler, Guanyu Deng, Cuong Nguyen
Summary: Dual phase high-entropy alloys formed by eutectic transformation from the melt exhibit a greater balance in strength and ductility compared to conventional single-phase HEAs. High-temperature oxidation behavior significantly influences the friction and wear properties of these alloys, with the development of oxide scale playing a major role in the transition from abrasive to adhesive wear mechanisms above 700 degrees C.
TRIBOLOGY INTERNATIONAL
(2021)
Article
Engineering, Manufacturing
Zhijun Qiu, Bosheng Dong, Bintao Wu, Zhiyang Wang, Kristin Carpenter, Tao Wu, Jianrui Zhang, David Wexler, Hanliang Zhu, Huijun Li
Summary: The study investigated the effects of magnetic arc oscillation (MAO) at different frequencies on the deposition of Hastelloy C276 alloy samples during wire arc additive manufacturing (WAAM). It was found that MAO could improve the surface accuracy and mechanical properties of the alloy by reducing arc density, decreasing solidification time, and enhancing dendrite growth orientations. Additionally, MAO at 5 Hz showed enhanced mechanical properties, while frequencies of 10 Hz and 20 Hz had less pronounced effects on mechanical performance improvement.
ADDITIVE MANUFACTURING
(2021)
Review
Chemistry, Multidisciplinary
Fangli Zhang, Wenchao Zhang, David Wexler, Zaiping Guo
Summary: Aqueous monovalent-ion batteries have advantages of fast charging capability and high power densities. Prussian blue analogues, polyanion-type compounds, and layered oxides are commonly used cathode materials with low cost and high theoretical capacity. Design strategies such as reducing free water molecules and introducing electrolyte additives have been proposed to expand the electrochemical stability window.
ADVANCED MATERIALS
(2022)
Article
Engineering, Mechanical
Cuong Nguyen, Anh Kiet Tieu, Guanyu Deng, David Wexler, Bach Tran, Tri Dinh Vo
Summary: This study investigates the sliding friction and wear performance of an economical Co-free CrFeNiAl0.4Ti0.2 high entropy alloy over a wide temperature range. The results show that sliding temperature has a significant influence on the friction coefficient, wear rate, and worn surface morphology. The maximum friction coefficient and minimum wear rate are achieved at 800 degrees C. The main wear mechanism is abrasion at 600 degrees C, but oxidation becomes more significant at higher temperatures.
TRIBOLOGY INTERNATIONAL
(2022)
Article
Engineering, Manufacturing
Bintao Wu, Zhijun Qiu, Bosheng Dong, David Wexler, Zengxi Pan, Kristin Carpenter, Diego Raimundi Corradi, Huijun Li
Summary: In this study, the microstructure and mechanical properties of wire arc additively manufactured Ti6Al4V alloy with/ without magnetic arc oscillation were investigated. The results showed that the addition of magnetic arc oscillation resulted in refinement of the microstructure, modification of texture orientation, and improvement of mechanical properties of the deposition.
ADDITIVE MANUFACTURING
(2022)
Article
Materials Science, Multidisciplinary
Navjeet Singh, David Wexler, Andrii Kostryzhev, Chris Killmore, Elena Pereloma
Summary: High yield strength ferritic microalloyed steels with the addition of Nb, Mo, V, and Cr microalloying elements and controlled thermomechanical treatment have been developed. The microstructures and mechanical properties are characterized using advanced microscopy techniques and uniaxial tensile testing. By adjusting the roughing strain in the recrystallization region, the grain size of the steel can be reduced, and the number density and size of NbV carbonitrides and VCr interphase precipitates can be increased. These finer grains and more nanosized interphase precipitates are key to achieving high yield strength.
ADVANCED ENGINEERING MATERIALS
(2022)
Article
Chemistry, Physical
Tong Wang, David Wexler, Liangliang Guo, Yangfan Wang, Huijun Li
Summary: The melting and solidification process of S32101 duplex stainless steel was investigated using high-temperature confocal microscopy. It was found that a higher cooling rate led to a finer microstructure and a change in solidification pattern from cellular to dendritic growth.
Article
Engineering, Mechanical
Cuong Nguyen, Anh Kiet Tieu, Guanyu Deng, David Wexler, Tri Dinh Vo, Long Wang, Jun Yang
Summary: A cost-effective self-lubricating composite material based on CrFeNiAl0.3Ti0.3 as the matrix and Ag as the solid lubricant has been fabricated. Tribological tests show that the presence of Ag tribo-film reduces the coefficient of friction and wear of the composites from room temperature to 600 degrees C. The wear mechanism changes from abrasive to oxidative wear at 750 degrees C.
TRIBOLOGY INTERNATIONAL
(2022)
Article
Chemistry, Physical
Tri Dinh Vo, Anh Kiet Tieu, David Wexler, Lihong Su, Cuong Nguyen, Guanyu Deng
Summary: This study investigates a novel solid self-lubricating composite, EHEA-Ag, which exhibits excellent mechanical properties and wear characteristics in the temperature range from room temperature to 600 degrees Celsius.
JOURNAL OF ALLOYS AND COMPOUNDS
(2022)