Article
Developmental Biology
Jose Esteban-Collado, Montserrat Corominas, Florenci Serras
Summary: The study showed that in Drosophila wing, PI3K Akt signaling is crucial for Ask1 to activate p38, but not JNK. Nutrient restriction or mutations targeting specific residues of Drosophila Ask1 protein can block regeneration, which can be reversed by ectopic activation of p38.
Article
Ecology
Denni Currin-Ross, Luke Husdell, Gregory K. Pierens, Nicholas E. Mok, Scott L. O'Neill, Horst Joachim Schirra, Jeremy C. Brownlie
Summary: The endosymbiotic bacteria Wolbachia manipulates insect-host reproduction systems and depends on host metabolism, with iron speculated to be a key aspect of their interplay. Metabolite profiles in Wolbachia-infected vs uninfected Drosophila flies raised on different iron diets showed significant differences, influencing lipid and carbohydrate metabolism. Wolbachia infection led to a reprogramming of mitochondrial metabolism in the host, with insulin pathways depressed and hypoxia signaling activated.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Multidisciplinary Sciences
Ibtesam Rajpar, Gaurav Kumar, Paolo Fortina, Ryan E. Tomlinson
Summary: In mature bone, NGF produced by osteoblasts following mechanical loading signals through TrkA receptor on sensory nerves to support bone formation. TLR4, a key receptor in NF-KB signaling pathway, is required for initiating NGF-TrkA signaling for load-induced bone formation. Loss of TLR4 signaling reduces lamellar bone formation and dysregulates inflammatory signaling after mechanical loading, revealing the important role of osteoblastic TLR4 in skeletal adaptation to mechanical forces.
Review
Biochemistry & Molecular Biology
Mariam Ahmed Galal, Samhar Samer Alouch, Buthainah Saad Alsultan, Huda Dahman, Nouf Abdullah Alyabis, Sarah Ammar Alammar, Ahmad Aljada
Summary: This comprehensive review thoroughly explores the intricate involvement of insulin receptor isoforms and insulin-like growth factor receptors in the insulin and insulin-like growth factor signaling pathway, emphasizing their crucial roles in cancer development and resistance to anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geriatrics & Gerontology
Hiroyasu Sakai, Maho Asami, Hiroaki Naito, Satoko Kitora, Yuta Suzuki, Yu Miyauchi, Rei Tachinooka, Satoshi Yoshida, Risako Kon, Nobutomo Ikarashi, Yoshihiko Chiba, Junzo Kamei
Summary: Exogenous recombinant human IGF-1 attenuated cisplatin-induced muscle atrophy by restoring IGF-1/PI3K/Akt signaling pathway activity, inhibiting muscle protein degradation, and reducing muscle atrophy.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Biochemistry & Molecular Biology
Can Zhang, Keon Mook Seong, Weilin Sun, Omprakash Mittapalli, Baoli Qiu, John M. Clark, Barry R. Pittendrigh
Summary: The study demonstrates a novel strategy to attenuate insecticide resistance by targeting fundamental energy-associated pathways, specifically focusing on PEPCK and GSK3β-PO proteins. Inhibitors for PEPCK and GSK3β-PO, hydrazine sulfate and lithium chloride respectively, have shown to decrease DDT resistance phenotype, with PEPCK inhibitor resulting in a more significant effect. This research reveals the potential role of IIS genes in DDT resistance and the discovery of a potential Achilles' heel against pesticide resistance in this pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Review
Endocrinology & Metabolism
Leonie Rieger, Rosemary O'Connor
Summary: The internalization and localization of the IGF-1 receptor play crucial roles in cell signaling and biological processes, with different cell types and cell adhesion receptors regulating this process. Further study on how IGF-1R intracellular trafficking and compartmentalized signaling is controlled, particularly in cancer, is needed.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yi-kuan Wu, Zheng-nan Ren, Sheng-long Zhu, Yun-zhou Wu, Gang Wang, Hao Zhang, Wei Chen, Zhao He, Xian-long Ye, Qi-xiao Zhai
Summary: Sulforaphane may ameliorate lipid metabolism disorders in NAFLD mice by upregulating the FGF21/FGFR1 pathway, making it a promising intervention to treat or relieve NAFLD.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cardiac & Cardiovascular Systems
Mahmoud Abdellatif, Viktoria Trummer-Herbst, Alexander Martin Heberle, Alina Humnig, Tobias Pendl, Sylvere Durand, Giulia Cerrato, Sebastian J. Hofer, Moydul Islam, Julia Voglhuber, Jose Miguel Ramos Pittol, Oliver Kepp, Gerald Hoefler, Albrecht Schmidt, Peter P. Rainer, Daniel Scherr, Dirk von Lewinski, Egbert Bisping, Julie R. McMullen, Abhinav Diwan, Tobias Eisenberg, Frank Madeo, Kathrin Thedieck, Guido Kroemer, Simon Sedej
Summary: This study suggests a biphasic relationship between insulin-like growth factor 1 receptor (IGF1R) signaling and cardiac health. Higher IGF1R signaling in young mice leads to declining cardiac function and shorter lifespan, while lower IGF1R signaling improves cardiac function and extends lifespan in aging mice.
Article
Biochemistry & Molecular Biology
Elisa Martin-Montanez, Nadia Valverde, David Ladron de Guevara-Miranda, Estrella Lara, Yanina S. Romero-Zerbo, Carmelo Millon, Federica Boraldi, Fabiola Avila-Gamiz, Ana M. Perez-Cano, Pablo Garrido-Gil, Jose Luis Labandeira-Garcia, Luis J. Santin, Jose Pavia, Maria Garcia-Fernandez
Summary: This study demonstrates the neuroprotective effects of IGF-II against MPP+-induced damage in neuronal dopaminergic cell cultures and a mouse model of PD, highlighting mechanisms such as improving mitochondrial function, upregulating antioxidative enzymes, and modulating the mTOR signaling pathway. The specific IGF-II receptor is crucial for IGF-II's neuroprotective effect, preventing behavioral dysfunction, dopaminergic degeneration, and neuroinflammation. Modulating the IGF-II/IGF-IIr signaling pathway may represent a promising therapeutic approach for PD prevention and treatment.
Article
Entomology
Yiyang Yuan, Yanyan Wang, Wanwan Ye, Erliang Yuan, Jian Di, Xin Chen, Yanling Xing, Yucheng Sun, Feng Ge
Summary: This study investigates the role of the insulin/insulin-like growth factor signaling (IIS) pathway in regulating transgenerational wing polyphenism in aphids. It is found that ILP5 and FoxO play important roles in controlling wing morph development in embryos. ILP4 and ILP11 are also associated with wing polyphenism, but the regulation may not involve the canonical IIS pathway.
Review
Chemistry, Medicinal
Fatemeh Meshkini, Nahid Ramezani-Jolfaie, Saman Sargazi, Cain C. T. Clark, Sepideh Soltani
Summary: A systematic review of the effects of lycopene on circulating IGF-1 and IGFBPs in adults found no consistent modifying effect of lycopene supplementation on IGF-1 and IGFBP levels. More research is needed to explore the effect of lycopene on the IGF-1 system.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yalei Liu, Zhenyu Zhou, Liufang Yin, Mengnan Zhu, Fei Wang, Lijun Zhang, Hongqing Wang, Zhiqin Zhou, Huanhu Zhu, Cheng Huang, Shengjie Fan
Summary: Tangeretin, a polymethoxylated flavonoid found in citrus fruits, has shown significant antiaging effects by extending the mean lifespan, slowing down aging-related functional declines, and enhancing heat stress tolerance in Caenorhabditis elegans. Its effects are dependent on the insulin/insulin-like growth factor signaling pathway.
Review
Endocrinology & Metabolism
Armel H. H. Nwabo Kamdje, Paul F. Seke Etet, Maulilio J. Kipanyula, Lorella Vecchio, Richard Tagne Simo, Alfred K. Njamnshi, Kiven E. Lukong, Patrice N. Mimche
Summary: The tumor microenvironment plays a role in tumorigenesis and drug resistance through the overexpression of insulin-like growth factor 1 (IGF-1). Anti-IGF therapies have shown potential in inhibiting cancer and overcoming chemotherapy drug resistance in preclinical studies, but toxicity and resistance are challenges in clinical trials.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Paula Juricic, Sebastian Groenke, Linda Partridge
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Cell Biology
Luke S. Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Groenke, Linda Partridge
Article
Biochemical Research Methods
Parisa Kakanj, Sabine A. Eming, Linda Partridge, Maria Leptin
Review
Biotechnology & Applied Microbiology
Linda Partridge, Matias Fuentealba, Brian K. Kennedy
NATURE REVIEWS DRUG DISCOVERY
(2020)
Review
Biotechnology & Applied Microbiology
Maarouf Baghdadi, Helena M. Hinterding, Linda Partridge, Joris Deelen
Summary: Leading causes of death in humans, such as cardiovascular disease, type 2 diabetes, and Alzheimer's disease, are influenced by aging-related biological mechanisms. Studying genetic variants associated with aging can help uncover aging mechanisms and guide targeted interventions to improve health in old age.
BRIEFINGS IN FUNCTIONAL GENOMICS
(2022)
Article
Cell Biology
Matias Fuentealba, Daniel K. Fabian, Handan Melike Donertas, Janet M. Thornton, Linda Partridge
Summary: Genetically modified mouse models of ageing provide evidence that lifespan and healthspan can be influenced, with mutations affecting lifespan inducing similar transcriptomic changes. The study identified consistent gene expression changes in long-lived and short-lived mice, particularly in energy and lipid metabolism genes, suggesting accelerated ageing models partially reproduce molecular changes of aging. New genetic interventions were identified that may ameliorate ageing, by comparing the transcriptomes of mouse mutants with expression signatures of long-lived and short-lived mice.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Biology
Yu-Xuan Lu, Jennifer C. Regan, Jacqueline Esser, Lisa F. Drews, Thomas Weinseis, Julia Stinn, Oliver Hahn, Richard A. Miller, Sebastian Gronke, Linda Partridge
Summary: Research shows that inhibition of mTORC1 by rapamycin increases the expression of histones H3 and H4 in intestinal enterocytes of Drosophila, leading to improved intestinal health and extended longevity. This finding suggests that the mTORC1-histone axis may be partially conserved in mammals, potentially offering new targets for anti-ageing interventions.
Article
Cell Biology
Tobias Nespital, Brit Neuhaus, Andrea Mesaros, Andre Pahl, Linda Partridge
Summary: Lithium shows a potential positive impact on health span in mice within a tolerable dose range, with caution needed for overdosing to avoid organ health issues.
Article
Cell Biology
Helen C. Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D. Hingorani, Andreas Beyer, Linda Partridge
Summary: This study found that interventions in the aging process can confer resistance to multiple age-related diseases in laboratory animals. By analyzing literature abstracts and clinical data, the researchers discovered associations between age-related diseases and aging mechanisms in humans. They also identified specific mechanisms that are associated with diverse age-related diseases. This suggests that targeting these mechanisms could potentially prevent multimorbidity.
Review
Cell Biology
Mihails Laskovs, Linda Partridge, Cathy Slack
Summary: The RAS/MAPK pathway plays a crucial role in cancer and is also associated with ageing. Decreasing RAS/MAPK signaling activity can extend lifespan, improve healthspan, and delay or prevent age-related functional decline. Evidence suggests that repurposing small molecule inhibitors of RAS/MAPK signaling can enhance health during ageing, but challenges need to be addressed before clinical implementation.
DISEASE MODELS & MECHANISMS
(2022)
Article
Multidisciplinary Sciences
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J. Withers, Sebastian Gronke, Linda Partridge
Summary: Reduced insulin/insulin-like growth factor signaling (IIS) extends health and lifespan, but the exact tissues involved are unknown. This study found that lack of IRS1 in liver, muscle, or fat does not increase lifespan or improve health, but neuronal loss of IRS1 specifically in old males leads to improved health and metabolic adaptations consistent with activated stress response.
Article
Biology
Javier Moron-Oset, Lilly K. S. Fischer, Mireia Carcole, Ashling Giblin, Pingze Zhang, Adrian M. Isaacs, Sebastian Groenke, Linda Partridge
Summary: Hexanucleotide repeat expansions in the C9orf72 gene are the most prevalent genetic cause of amyotrophic lateral sclerosis frontotemporal dementia. Transcripts of the expansions translated into toxic dipeptide repeat (DPR) proteins. This study investigated the effects of protein tags on DPR toxicity using Drosophila.
LIFE SCIENCE ALLIANCE
(2023)
Article
Cell Biology
Carolina Monzo, Lisonia Gkioni, Andreas Beyer, Dario Riccardo Valenzano, Sebastian Gronke, Linda Partridge
Summary: Aging impairs immune function, but dietary restriction (DR) can attenuate this decline. In this study, it was shown that DR preserves B cell receptor (BCR) repertoire diversity and reduces clonal expansions during aging in mice. Remarkably, mice starting DR in mid-life have similar BCR diversity and clonal expansion rates as mice on chronic DR. These findings suggest a potential role of B cell repertoire dynamics in age-related health.
Article
Cell Biology
Jennifer C. Regan, Yu-Xuan Lu, Enric Urena, Ralf L. Meilenbrock, James H. Catterson, Disna Kissler, Jenny Froehlich, Emilie Funk, Linda Partridge
Summary: Pharmacological attenuation of mTOR presents a promising route for delay of age-related disease. In this study, the researchers found that the mTOR inhibitor rapamycin extends lifespan in female Drosophila by slowing down age-related gut pathology through increased autophagy. The study also reveals sexual dimorphism in enterocyte autophagy and response to rapamycin, which is conserved in mice.