Transcriptomic profiling of long- and short-lived mutant mice implicates mitochondrial metabolism in ageing and shows signatures of normal ageing in progeroid mice

All of gene expression (AOE): An integrated index for public gene expression databases

(2020) Hidemasa Bono   PLoS One

The quest to slow ageing through drug discovery

(2020) Linda Partridge et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and Application of Gene Expression Signatures Associated with Lifespan Extension

(2019) Alexander Tyshkovskiy et al.   Cell Metabolism

Dietary restriction improves proteostasis and increases life span through endoplasmic reticulum hormesis

(2019) Latika Matai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Murine single-cell RNA-seq reveals cell-identity- and tissue-specific trajectories of aging

(2019) Jacob C. Kimmel et al.   GENOME RESEARCH

Mouse Models to Disentangle the Hallmarks of Human Aging

(2018) Alicia R. Folgueras et al.   CIRCULATION RESEARCH

Mouse Genome Database (MGD) 2019

(2018) Carol J Bult et al.   NUCLEIC ACIDS RESEARCH

Transcriptional Signatures of Aging

(2017) R. Stegeman et al.   JOURNAL OF MOLECULAR BIOLOGY

Discovering and linking public omics data sets using the Omics Discovery Index

(2017) Yasset Perez-Riverol et al.   NATURE BIOTECHNOLOGY

Drosophila as a model for ageing

(2017) Matthew D.W. Piper et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

Deleting IGF-1 receptor from forebrain neurons confers neuroprotection during stroke and upregulates endocrine somatotropin

(2016) C Daniel De Magalhaes Filho et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The aryl hydrocarbon receptor promotes aging phenotypes across species

(2016) Anna Eckers et al.   Scientific Reports

Mitochondrial electron transport chain functions in long-lived Ames dwarf mice

(2016) Kashyap B. Choksi et al.   Aging-US

Gene expression defines natural changes in mammalian lifespan

(2015) Alexey A. Fushan et al.   AGING CELL

Reduced Expression of MYC Increases Longevity and Enhances Healthspan

(2015) Jeffrey W. Hofmann et al.   CELL

Idh1 protects murine hepatocytes from endotoxin-induced oxidative stress by regulating the intracellular NADP+/NADPH ratio

(2015) M Itsumi et al.   CELL DEATH AND DIFFERENTIATION

Comparison of mice with accelerated aging caused by distinct mechanisms

(2015) Aditi U. Gurkar et al.   EXPERIMENTAL GERONTOLOGY

A weekly alternating diet between caloric restriction and medium fat protects the liver from fatty liver development in middle-aged C57BL/6J mice

(2015) Fenni Rusli et al.   MOLECULAR NUTRITION & FOOD RESEARCH

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Ageing and the border between health and disease

(2014) W. MacNee et al.   EUROPEAN RESPIRATORY JOURNAL

Mice Fed Rapamycin Have an Increase in Lifespan Associated with Major Changes in the Liver Transcriptome

(2014) Wilson C. Fok et al.   PLoS One

Combined treatment of rapamycin and dietary restriction has a larger effect on the transcriptome and metabolome of liver

(2013) Wilson C. Fok et al.   AGING CELL

Life spanning murine gene expression profiles in relation to chronological and pathological aging in multiple organs

(2013) Martijs J. Jonker et al.   AGING CELL

Effect of Calcium on the Oxidative Phosphorylation Cascade in Skeletal Muscle Mitochondria

(2013) Brian Glancy et al.   BIOCHEMISTRY

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Mitonuclear protein imbalance as a conserved longevity mechanism

(2013) Riekelt H. Houtkooper et al.   NATURE

Metformin improves healthspan and lifespan in mice

(2013) Alejandro Martin-Montalvo et al.   Nature Communications

Deciphering the effects of gene deletion on yeast longevity using network and machine learning approaches

(2012) Tao Huang et al.   BIOCHIMIE

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

Regulation of ATP production by mitochondrial Ca2+

(2012) Andrei I. Tarasov et al.   CELL CALCIUM

Role of MicroRNA Processing in Adipose Tissue in Stress Defense and Longevity

(2012) Marcelo A. Mori et al.   Cell Metabolism

Ageing as a Risk Factor for Disease

(2012) Teresa Niccoli et al.   CURRENT BIOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria

(2012) I. Kamileri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The starvation hormone, fibroblast growth factor-21, extends lifespan in mice

(2012) Yuan Zhang et al.   eLife

Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice

(2011) Holly M. Brown-Borg et al.   AGE

The microRNA-Processing Enzyme Dicer Is Essential for Thyroid Function

(2011) Daniela Frezzetti et al.   PLoS One

Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1

(2011) W. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Splicing-Directed Therapy in a New Mouse Model of Human Accelerated Aging

(2011) F. G. Osorio et al.   Science Translational Medicine

A framework for oligonucleotide microarray preprocessing

(2010) Benilton S. Carvalho et al.   BIOINFORMATICS

The Sequence Read Archive

(2010) R. Leinonen et al.   NUCLEIC ACIDS RESEARCH

Single-gene mutations and healthy ageing in mammals

(2010) A. Bartke   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial calcium as a key regulator of mitochondrial ATP production in mammalian cells

(2009) Elinor J. Griffiths et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Importing ArrayExpress datasets into R/Bioconductor

(2009) Audrey Kauffmann et al.   BIOINFORMATICS

Genes and gene expression modules associated with caloric restriction and aging in the laboratory mouse

(2009) William R Swindell   BMC GENOMICS

Alterations in Oxygen Consumption, Respiratory Quotient, and Heat Production in Long-Lived GHRKO and Ames Dwarf Mice, and Short-Lived bGH Transgenic Mice

(2009) Reyhan Westbrook et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

(2009) C. Selman et al.   SCIENCE

Inhibition of Growth Hormone Signaling by the Fasting-Induced Hormone FGF21

(2008) Takeshi Inagaki et al.   Cell Metabolism

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

S6K Directly Phosphorylates IRS-1 on Ser-270 to Promote Insulin Resistance in Response to TNF-α Signaling through IKK2

(2008) Jin Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Caloric Restriction and Aging: Studies in Mice and Monkeys

(2008) Rozalyn M. Anderson et al.   TOXICOLOGIC PATHOLOGY

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics