VCE-003.2, a novel cannabigerol derivative, enhances neuronal progenitor cell survival and alleviates symptomatology in murine models of Huntington’s disease

A double-blind, randomized, cross-over, placebo-controlled, pilot trial with Sativex in Huntington’s disease

(2016) Jose Luis López-Sendón Moreno et al.   JOURNAL OF NEUROLOGY

The CB1 cannabinoid receptor signals striatal neuroprotection via a PI3K/Akt/mTORC1/BDNF pathway

(2015) C Blázquez et al.   CELL DEATH AND DIFFERENTIATION

Rosiglitazone activation of PPARγ-dependent signaling is neuroprotective in mutant huntingtin expressing cells

(2015) Ming-Chang Chiang et al.   EXPERIMENTAL CELL RESEARCH

Endocannabinoid signalling and the deteriorating brain

(2015) Vincenzo Di Marzo et al.   NATURE REVIEWS NEUROSCIENCE

Cannabidiol Exposure During Neuronal Differentiation Sensitizes Cells Against Redox-Active Neurotoxins

(2014) Patrícia Schönhofen et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice

(2014) Sara Valdeolivas et al.   Neurotherapeutics

A Cannabigerol Derivative Suppresses Immune Responses and Protects Mice from Experimental Autoimmune Encephalomyelitis

(2014) Francisco J. Carrillo-Salinas et al.   PLoS One

A restricted population of CB1 cannabinoid receptors with neuroprotective activity

(2014) A. Chiarlone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PGC-1α, mitochondrial dysfunction, and Huntington's disease

(2013) Ashu Johri et al.   FREE RADICAL BIOLOGY AND MEDICINE

Reprint of: Nrf2/ARE-mediated antioxidant actions of pro-electrophilic drugs

(2013) Takumi Satoh et al.   FREE RADICAL BIOLOGY AND MEDICINE

The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

(2013) Alline C. Campos et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease

(2013) Jing Jin et al.   JOURNAL OF NEUROCHEMISTRY

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

(2013) Ismael Galve-Roperh et al.   PROGRESS IN LIPID RESEARCH

The role of nuclear receptors in controlling the fine balance between proliferation and differentiation of neural stem cells

(2012) Athanasios Stergiopoulos et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Pharmacological manipulation of peroxisome proliferator-activated receptor γ (PPARγ) reveals a role for anti-oxidant protection in a model of Parkinson's disease

(2012) Heather L. Martin et al.   EXPERIMENTAL NEUROLOGY

A Cannabigerol Quinone Alleviates Neuroinflammation in a Chronic Model of Multiple Sclerosis

(2012) Aitor G. Granja et al.   Journal of Neuroimmune Pharmacology

Cannabinoid Receptor 2 Signaling in Peripheral Immune Cells Modulates Disease Onset and Severity in Mouse Models of Huntington's Disease

(2012) J. Bouchard et al.   JOURNAL OF NEUROSCIENCE

CB2Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling

(2011) Javier Palazuelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease

(2011) Onintza Sagredo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Pioglitazone Reduces Secondary Brain Damage after Experimental Brain Trauma by PPAR-γ-Independent Mechanisms

(2011) Serge C. Thal et al.   JOURNAL OF NEUROTRAUMA

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

Cannabidiol Reduces Aβ-Induced Neuroinflammation and Promotes Hippocampal Neurogenesis through PPARγ Involvement

(2011) Giuseppe Esposito et al.   PLoS One

An NMR Spectroscopic Method to Identify and Classify Thiol-Trapping Agents: Revival of Michael Acceptors for Drug Discovery?

(2010) Cristina Avonto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Cancer Chemoprevention Mechanisms Mediated Through the Keap1–Nrf2 Pathway

(2010) John D. Hayes et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington’s disease

(2010) Cristina Blázquez et al.   BRAIN

Behavioural and molecular consequences of chronic cannabinoid treatment in Huntington's disease transgenic mice

(2010) M.J. Dowie et al.   NEUROSCIENCE

Revisiting the Rosiglitazone Story — Lessons Learned

(2010) Clifford J. Rosen   NEW ENGLAND JOURNAL OF MEDICINE

Oleuropein enhances osteoblastogenesis and inhibits adipogenesis: the effect on differentiation in stem cells derived from bone marrow

(2010) R. Santiago-Mora et al.   OSTEOPOROSIS INTERNATIONAL

When neurogenesis encounters aging and disease

(2010) Orly Lazarov et al.   TRENDS IN NEUROSCIENCES

Bone Loss in Diabetes: Use of Antidiabetic Thiazolidinediones and Secondary Osteoporosis

(2010) Beata Lecka-Czernik   Current Osteoporosis Reports

Microglial CB2 cannabinoid receptors are neuroprotective in Huntington's disease excitotoxicity

(2009) Javier Palazuelos et al.   BRAIN

Altered CB1 receptor and endocannabinoid levels precede motor symptom onset in a transgenic mouse model of Huntington's disease

(2009) M.J. Dowie et al.   NEUROSCIENCE

Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb

(2009) Angelo A. Izzo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Simple ortho- and para-hydroquinones as compounds neuroprotective against oxidative stress in a manner associated with specific transcriptional activation

(2008) Takumi Satoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging

(2008) R. I. Morimoto   GENES & DEVELOPMENT

The Development of INT131 as a Selective PPAR Modulator: Approach to a Safer Insulin Sensitizer

(2008) Linda S. Higgins et al.   PPAR Research