Neuroprotective effects of PPAR-γ agonist rosiglitazone in N171-82Q mouse model of Huntington's disease

Metabolic State Determines Sensitivity to Cellular Stress in Huntington Disease: Normalization by Activation of PPARγ

(2012) Youngnam N. Jin et al.   PLoS One

The dysfunction of hepatic transcriptional factors in mice with Huntington's Disease

(2011) Ming-Chang Chiang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Protective effect of pioglitazone, a PPARγ ligand, in a 3 nitropropionic acid model of Huntington's disease

(2011) Maddalena Napolitano et al.   BRAIN RESEARCH BULLETIN

Mutant Huntingtin Causes Metabolic Imbalance by Disruption of Hypothalamic Neurocircuits

(2011) Sofia Hult et al.   Cell Metabolism

Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter

(2011) Elodie Martin et al.   HUMAN MOLECULAR GENETICS

Pharmacologic activation of mitochondrial biogenesis exerts widespread beneficial effects in a transgenic mouse model of Huntington's disease

(2011) Ashu Johri et al.   HUMAN MOLECULAR GENETICS

Conditional BDNF release under pathological conditions improves Huntington's disease pathology by delaying neuronal dysfunction

(2011) Albert Giralt et al.   Molecular Neurodegeneration

Peroxisome proliferation–associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity

(2011) Sabrina Diano et al.   NATURE MEDICINE

Neuroprotective role of Sirt1 in mammalian models of Huntington's disease through activation of multiple Sirt1 targets

(2011) Mali Jiang et al.   NATURE MEDICINE

Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease

(2011) Rhîannan H. Williams et al.   NEUROBIOLOGY OF DISEASE

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

Rosiglitazone decreases peroxisome proliferator receptor-gamma levels in microglia and inhibits TNF-alpha production: new evidences on neuroprotection in a progressive Parkinson's disease model

(2011) A.R. Carta et al.   NEUROSCIENCE

Activation of Peroxisome Proliferator-Activated Receptor Gamma by Rosiglitazone Increases Sirt6 Expression and Ameliorates Hepatic Steatosis in Rats

(2011) Soo Jin Yang et al.   PLoS One

Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease

(2011) Chiara Zuccato et al.   PLoS One

The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α

(2010) Lei Zhong et al.   CELL

Full-length huntingtin levels modulate body weight by influencing insulin-like growth factor 1 expression

(2010) M. A. Pouladi et al.   HUMAN MOLECULAR GENETICS

Modulation of energy deficiency in Huntington's disease via activation of the peroxisome proliferator-activated receptor gamma

(2010) Ming-Chang Chiang et al.   HUMAN MOLECULAR GENETICS

Impairment of PGC-1alpha expression, neuropathology and hepatic steatosis in a transgenic mouse model of Huntington's disease following chronic energy deprivation

(2010) R. K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

Mitochondrial matters of the brain: the role in Huntington’s disease

(2010) C. Turner et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

The interrelationship between mitochondrial dysfunction and transcriptional dysregulation in Huntington disease

(2010) Youngnam N. Jin et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

SIRT6 Deficiency Results in Severe Hypoglycemia by Enhancing Both Basal and Insulin-stimulated Glucose Uptake in Mice

(2010) Cuiying Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT6 in DNA repair, metabolism and ageing

(2010) D. B. Lombard et al.   JOURNAL OF INTERNAL MEDICINE

BDNF Overexpression in the Forebrain Rescues Huntington's Disease Phenotypes in YAC128 Mice

(2010) Y. Xie et al.   JOURNAL OF NEUROSCIENCE

Huntington's disease

(2010) T Hoppitt et al.   LANCET

Huntington's disease: from molecular pathogenesis to clinical treatment

(2010) Christopher A Ross et al.   LANCET NEUROLOGY

Brief ampakine treatments slow the progression of Huntington's disease phenotypes in R6/2 mice

(2010) Danielle A. Simmons et al.   NEUROBIOLOGY OF DISEASE

Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ) Activation Confers Functional Neuroprotection in Global Ischemia

(2010) Zahra Fatehi-Hassanabad et al.   NEUROTOXICITY RESEARCH

PGC-1 , A Potential Therapeutic Target for Early Intervention in Parkinson's Disease

(2010) B. Zheng et al.   Science Translational Medicine

Transcriptional dysregulation of coding and non-coding genes in cellular models of Huntington's disease

(2009) Angela Bithell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Impaired mitochondrial trafficking in Huntington's disease

(2009) Xiao-Jiang Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

(2009) Rodrigo A. Quintanilla et al.   BRAIN RESEARCH BULLETIN

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

PPAR-gamma-mediated neuroprotection in a chronic mouse model of Parkinson’s disease

(2009) Nicoletta Schintu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Impaired PGC-1α function in muscle in Huntington's disease

(2009) Rajnish K. Chaturvedi et al.   HUMAN MOLECULAR GENETICS

Decreased BDNF Levels Are a Major Contributor to the Embryonic Phenotype of Huntingtin Knockdown Zebrafish

(2009) H. Diekmann et al.   JOURNAL OF NEUROSCIENCE

RETRACTED: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype

(2008) Tina Wenz et al.   Cell Metabolism

Rosiglitazone Treatment Prevents Mitochondrial Dysfunction in Mutant Huntingtin-expressing Cells

(2008) Rodrigo A. Quintanilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain-derived neurotrophic factor modulates the severity of cognitive alterations induced by mutant huntingtin: Involvement of phospholipaseCγ activity and glutamate receptor expression

(2008) A. Giralt et al.   NEUROSCIENCE

Peroxisome Proliferator-Activated Receptor-γin Amyotrophic Lateral Sclerosis and Huntington’s Disease

(2008) Mahmoud Kiaei   PPAR Research