Paramagnetic relaxation enhancement for protein-observed 19F NMR as an enabling approach for efficient fragment screening

NMR-based platform for fragment-based lead discovery used in screening BRD4-targeted compounds

(2016) Jun-lan Yu et al.   ACTA PHARMACOLOGICA SINICA

Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor

(2016) Laetitia J. Martin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paramagnetic fluorinated nanoemulsions for sensitive cellular fluorine-19 magnetic resonance imaging

(2016) Alexander A. Kislukhin et al.   NATURE MATERIALS

Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

(2016) Clifford T Gee et al.   Nature Protocols

Fragment-Based Discovery of a Selective and Cell-Active Benzodiazepinone CBP/EP300 Bromodomain Inhibitor (CPI-637)

(2016) Alexander M. Taylor et al.   ACS Medicinal Chemistry Letters

Dual Screening of BPTF and Brd4 Using Protein-Observed Fluorine NMR Uncovers New Bromodomain Probe Molecules

(2015) Andrew K. Urick et al.   ACS Chemical Biology

Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain through Protein-Observed19F NMR Spectroscopy

(2015) Clifford T. Gee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Increasing the sensitivity of NMR diffusion measurements by paramagnetic longitudinal relaxation enhancement, with application to ribosome–nascent chain complexes

(2015) Sammy H. S. Chan et al.   JOURNAL OF BIOMOLECULAR NMR

Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

(2015) Keith E. Arntson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anatomy of β-Strands at Protein–Protein Interfaces

(2014) Andrew M. Watkins et al.   ACS Chemical Biology

Fluorinated Aromatic Amino Acids Are Sensitive 19F NMR Probes for Bromodomain-Ligand Interactions

(2014) Neeraj K. Mishra et al.   ACS Chemical Biology

Using 19F NMR to Probe Biological Interactions of Proteins and Peptides

(2014) E. Neil G. Marsh et al.   ACS Chemical Biology

19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2

(2014) Eleanor W. W. Leung et al.   Chemical Biology & Drug Design

Fragment-Based Screening of the Bromodomain of ATAD2

(2014) Mary J. Harner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using 19F NMR

(2014) Xiaopeng Ge et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fragment-based drug discovery using NMR spectroscopy

(2013) Mary J. Harner et al.   JOURNAL OF BIOMOLECULAR NMR

Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization

(2012) William C. Pomerantz et al.   ACS Chemical Biology

The kinetics of lanthanide complexation by EDTA and DTPA in lactate media

(2012) K. L. Nash et al.   DALTON TRANSACTIONS

Leveraging kinase inhibitors to develop small molecule tools for imaging kinases by fluorescence microscopy

(2012) Zijuan Zhang et al.   Molecular BioSystems

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Place your BETs: the therapeutic potential of bromodomains

(2012) R.K. Prinjha et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fluorinated paramagnetic chelates as potential multi-chromic 19F tracer agents

(2011) Zhong-Xing Jiang et al.   CHEMICAL COMMUNICATIONS

Paramagnetic relaxation enhancement to improve sensitivity of fast NMR methods: application to intrinsically disordered proteins

(2011) François-Xavier Theillet et al.   JOURNAL OF BIOMOLECULAR NMR

Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-Abundance

(2011) Kazutoshi Yamamoto et al.   JOURNAL OF PHYSICAL CHEMISTRY B

High-Resolution 3D CANCA NMR Experiments for Complete Mainchain Assignments Using CαDirect Detection

(2010) Koh Takeuchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Suppression of inflammation by a synthetic histone mimic

(2010) Edwige Nicodeme et al.   NATURE

Approaches for the measurement of solvent exposure in proteins by 19F NMR

(2009) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF BIOMOLECULAR NMR

Perspectives on NMR in drug discovery: a technique comes of age

(2008) Maurizio Pellecchia et al.   NATURE REVIEWS DRUG DISCOVERY