Protein-observed 19F-NMR for fragment screening, affinity quantification and druggability assessment

Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain through Protein-Observed19F NMR Spectroscopy

(2015) Clifford T. Gee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Protein-Observed Fluorine NMR: A Bioorthogonal Approach for Small Molecule Discovery

(2015) Keith E. Arntson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fluorinated Aromatic Amino Acids Are Sensitive 19F NMR Probes for Bromodomain-Ligand Interactions

(2014) Neeraj K. Mishra et al.   ACS Chemical Biology

19F NMR as a Probe of Ligand Interactions with the iNOS Binding site of SPRY Domain-Containing SOCS Box Protein 2

(2014) Eleanor W. W. Leung et al.   Chemical Biology & Drug Design

Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using 19F NMR

(2014) Xiaopeng Ge et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

19F NMR spectroscopy monitors ligand binding to recombinantly fluorine-labelled b′x from human protein disulphide isomerase (hPDI)

(2014) Rose Curtis-Marof et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

FP tethering: a screening technique to rapidly identify compounds that disrupt protein–protein interactions

(2014) Jean M. Lodge et al.   MedChemComm

Cyclin-Dependent Kinase Inhibitor Dinaciclib Interacts with the Acetyl-Lysine Recognition Site of Bromodomains

(2013) Mathew P. Martin et al.   ACS Chemical Biology

Development of Inhibitors of Plasmodium falciparum Apical Membrane Antigen 1 Based on Fragment Screening

(2013) San Sui Lim et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Detection and Prevention of Aggregation-based False Positives in STD-NMR-based Fragment Screening

(2013) Amelia Vom et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Design and Evaluation of the Performance of an NMR Screening Fragment Library

(2013) Bradley C. Doak et al.   AUSTRALIAN JOURNAL OF CHEMISTRY

Resolution of Oligomeric Species during the Aggregation of Aβ1–40 Using 19F NMR

(2013) Yuta Suzuki et al.   BIOCHEMISTRY

HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery

(2013) Bainan Wu et al.   CHEMISTRY & BIOLOGY

Using chemical shift perturbation to characterise ligand binding

(2013) Mike P. Williamson   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Is NMR Fragment Screening Fine-Tuned to Assess Druggability of Protein–Protein Interactions?

(2013) David M. Dias et al.   ACS Medicinal Chemistry Letters

Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization

(2012) William C. Pomerantz et al.   ACS Chemical Biology

Simple and inexpensive incorporation of 19F-Tryptophan for protein NMR spectroscopy

(2012) Peter B. Crowley et al.   CHEMICAL COMMUNICATIONS

Role of Detergents in Conformational Exchange of a G Protein-coupled Receptor

(2012) Ka Young Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vemurafenib: the first drug approved for BRAF-mutant cancer

(2012) Gideon Bollag et al.   NATURE REVIEWS DRUG DISCOVERY

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Current applications of 19F NMR to studies of protein structure and dynamics

(2011) Julianne L. Kitevski-LeBlanc et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

(2010) Daisuke Tanaka et al.   JOURNAL OF MEDICINAL CHEMISTRY

Expansion of the genetic code: Site-directed p-fluoro-phenylalanine incorporation in Escherichia coli

(2010) Rolf Furter   PROTEIN SCIENCE

A Mutagenesis-Free Approach to Assignment of19F NMR Resonances in Biosynthetically Labeled Proteins

(2009) Julianne L. Kitevski-LeBlanc et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein19F NMR inEscherichia coli

(2009) Conggang Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY