Fragment Screening and Druggability Assessment for the CBP/p300 KIX Domain through Protein-Observed19F NMR Spectroscopy

Anatomy of β-Strands at Protein–Protein Interfaces

(2014) Andrew M. Watkins et al.   ACS Chemical Biology

Fluorinated Aromatic Amino Acids Are Sensitive 19F NMR Probes for Bromodomain-Ligand Interactions

(2014) Neeraj K. Mishra et al.   ACS Chemical Biology

Using 19F NMR to Probe Biological Interactions of Proteins and Peptides

(2014) E. Neil G. Marsh et al.   ACS Chemical Biology

Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality

(2014) Michelle R. Arkin et al.   CHEMISTRY & BIOLOGY

Fragment-Based Screening of the Bromodomain of ATAD2

(2014) Mary J. Harner et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ligand-Induced Conformational Change of Plasmodium falciparum AMA1 Detected Using 19F NMR

(2014) Xiaopeng Ge et al.   JOURNAL OF MEDICINAL CHEMISTRY

The role of ligand efficiency metrics in drug discovery

(2014) Andrew L. Hopkins et al.   NATURE REVIEWS DRUG DISCOVERY

FP tethering: a screening technique to rapidly identify compounds that disrupt protein–protein interactions

(2014) Jean M. Lodge et al.   MedChemComm

HTS by NMR of Combinatorial Libraries: A Fragment-Based Approach to Ligand Discovery

(2013) Bainan Wu et al.   CHEMISTRY & BIOLOGY

Discovery of Epigenetic Regulator I-BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains

(2013) Olivier Mirguet et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Profiling the Dynamic Interfaces of Fluorinated Transcription Complexes for Ligand Discovery and Characterization

(2012) William C. Pomerantz et al.   ACS Chemical Biology

Fine-Tuning Multiprotein Complexes Using Small Molecules

(2012) Andrea D. Thompson et al.   ACS Chemical Biology

Sekikaic Acid and Lobaric Acid Target a Dynamic Interface of the Coactivator CBP/p300

(2012) Chinmay Y. Majmudar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural basis of CBP/p300 recruitment in leukemia induction by E2A-PBX1

(2012) C. M. Denis et al.   BLOOD

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Current applications of 19F NMR to studies of protein structure and dynamics

(2011) Julianne L. Kitevski-LeBlanc et al.   PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY

Amphipathic Small Molecules Mimic the Binding Mode and Function of Endogenous Transcription Factors

(2009) Sara J. Buhrlage et al.   ACS Chemical Biology

Discovery of a Small-Molecule Inhibitor of the KIX–KID Interaction

(2009) Bingbing X. Li et al.   CHEMBIOCHEM