Review
Biochemistry & Molecular Biology
Genieve Ee Chia Yeo, Min Hwei Ng, Fazlina Binti Nordin, Jia Xian Law
Summary: The rapid growth of the geriatric population is accompanied by an increased prevalence of age-associated diseases, leading to the deterioration of the immune system known as immunosenescence. This review highlights the characteristics of an aging immune system, such as dysregulation of immune cell production and functioning, and the potential of mesenchymal stem cell transplantation as a promising solution for halting immunosenescence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Yingqian Zhu, Jianli Ge, Ce Huang, Hailiang Liu, Hua Jiang
Summary: Aging frailty is a complex geriatric syndrome characterized by disruption of physiological homeostasis and declining health status. Factors such as genome instability, DNA damage, and stem cell exhaustion contribute to the development of frailty with advancing age. Effective interventions are needed to improve the health status of frail patients.
Review
Biochemistry & Molecular Biology
Elancheleyen Mahindran, Jia Xian Law, Min Hwei Ng, Fazlina Nordin
Summary: With the global increase in life expectancy, age-related musculoskeletal diseases are becoming more common, leading to severe disabilities, and impacting the quality of life. There is currently no treatment to prevent or reverse musculoskeletal frailty, with existing interventions focusing on slowing down and controlling symptoms. Mesenchymal stem cell transplantation shows promise as a regenerative therapy for age-related musculoskeletal frailty.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Jose Becerra, Ivan Duran
Summary: Frailty has emerged as a key concept in understanding the declining health and shortened lifespan of global populations, with factors like inflammation, cellular aging, and stem cell exhaustion contributing to its development. Interdisciplinary research is crucial to unraveling the complexities of frailty and developing advanced therapies, especially in the context of conditions like COVID19 where frail individuals are more vulnerable to complications.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Chenghai Li, Hua Zhao, Linna Cheng, Bin Wang
Summary: MSC-based therapeutics are available for a range of diseases, with autologous and allogeneic MSCs having their own advantages and disadvantages in medical practice. The interaction of transplanted MSCs with their microenvironment can be impacted by factors from different donors, potentially leading to uncertainty in safety and efficacy. Donor-controlled clinical practice is suggested to minimize potential harm in MSC-based therapies.
CELL AND BIOSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Mustafa Burak Acar, Serife Ayaz-Guner, Zeynep Gunaydin, Musa Karakukcu, Gianfranco Peluso, Giovanni Di Bernardo, Servet Ozcan, Umberto Galderisi
Summary: Senotherapeutics, including senolytics and senomorphics, can delay replicative senescence and cell death, improving cell function through specific pathways. Metformin, a potential senomorphic agent, may exert its effects by scavenging ROS and regulating key transcription factors involved in blocking oxidative stress.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Genetics & Heredity
Xianmei Zhong, Jie Chen, Bo Wen, Xu Wu, Mingxing Li, Fukuan Du, Yu Chen, Shuai Deng, Yueshui Zhao, Jing Shen, Zhangang Xiao
Summary: Immunosenescence, characterized by immunodeficiency and inflammation, occurs with age. This review explores the potential role of mesenchymal stem cells (MSCs) in protecting against T cell aging, providing new insights for intervening in immune system aging.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Review
Geriatrics & Gerontology
X. Lv, H. Niu
Summary: As life expectancy increases, frailty and cognitive impairment have become major factors influencing healthy aging in elderly individuals. Cognitive frailty, a subtype of frailty, has gained widespread attention due to its pathogenesis involving chronic inflammatory response, immunological hypofunction, and other factors. Stem cell technology shows promise for treating cognitive frailty, but further comprehensive research is needed to assess its potential effectiveness.
JOURNAL OF NUTRITION HEALTH & AGING
(2021)
Review
Cell & Tissue Engineering
Ameneh Shokati, Abdorreza Naser Moghadasi, Mohsen Nikbakht, Mohammad Ali Sahraian, Seyed Asadollah Mousavi, Jafar Ai
Summary: Multiple sclerosis (MS) is a chronic central nervous system disease with limited treatment options, leading researchers to explore new therapies such as mesenchymal stromal cell (MSC) transplantation. Allogeneic MSCs are suggested as a potential novel solution for MS therapy as an alternative to autologous MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Immunology
Hongxia Tao, Qianglin Liu, Anqi Zeng, Linjiang Song
Summary: Liver fibrosis is a chronic liver disease that can lead to cirrhosis or hepatocellular carcinoma. Mesenchymal stem cells (MSCs) have emerged as a promising therapeutic option for liver fibrosis due to their ability to modulate the immune response and promote liver regeneration. Recent studies have shown that the antifibrotic effects of MSCs involve autophagy and senescence. However, aging-related autophagic damage can affect the number and function of MSCs, which are crucial in liver fibrosis development.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Matthew L. Potter, William D. Hill, Carlos M. Isales, Mark W. Hamrick, Sadanand Fulzele
Summary: miRNAs and cellular senescence have been implicated in driving age-related diseases, particularly in mesenchymal stem cells. Differential expression of key miRNAs in MSCs and other musculoskeletal cells during senescence and aging, regulation of miRNAs via SASP cytokines, and targeting of components of cell cycle arrest pathways by miRNAs have been identified. Identifying potential miRNA targets may have implications for regenerative medicine applications in age-related musculoskeletal diseases.
Article
Biochemistry & Molecular Biology
Mengzhu Lv, Simeng Zhang, Bo Jiang, Sunrun Cao, Yuqing Dong, Liu Cao, Shu Guo
Summary: The study demonstrated that adipose-derived stem cell therapy can delay replicative senescence and shift metabolic homeostasis, ultimately delaying the aging process by promoting mitophagy and improving mitochondrial quality in cells. The research also showed that ADSC therapy can improve aging-related symptoms and phenotypes through mitochondrial quality control, offering significant potential for future applications in aging-related diseases.
Article
Oncology
Anu Suominen, Anu Haavisto, Sidsel Mathiesen, Malene Mejdahl Nielsen, Paivi M. Lahteenmaki, Kaspar Sorensen, Marianne Ifversen, Christian Molgaard, Anders Juul, Klaus Muller, Kirsi Jahnukainen
Summary: The prevalence of frailty is increased among young adult childhood cancer survivors and is associated with early morbidity and mortality. Our study found that male long-term survivors of pediatric allogeneic hematopoietic stem cell transplantation showed significantly lower muscle strength and muscle endurance compared to normal values. 30% of the survivors were considered pre-frail or frail. Common cardiovascular risk factors and chronic graft-versus-host disease were associated with poor physical fitness. These findings highlight the need for long-term cardiovascular and metabolic follow-up in survivors of pediatric HSCT.
Article
Cell Biology
Dong Hoon Kwak, Ji Hye Park, Eul Sig Choi, Seong Hyun Park, Seo-Yeon Lee, Seoul Lee
Summary: This study analyzed the role of gangliosides in the osteogenesis of Lmna dysfunctional MSCs. The results showed that ganglioside GD1a played an important role in enhancing osteogenic differentiation in Lmna-mutated MSCs.
Review
Medicine, Research & Experimental
Yogesh Sardana, Gurjit Kaur Bhatti, Charan Singh, Pushpender Kumar Sharma, P. Hemachandra Reddy, Jasvinder Singh Bhatti
Summary: Rheumatoid arthritis (RA) related autoimmunity develops at mucosal sites and is influenced by genetic risk factors and environmental triggers. The transition from systemic circulation to joint localization of autoimmunity is still poorly understood, resulting in unanswered questions about the timing and occurrence of clinical synovitis. This review focuses on the role of mesenchymal stem cells and associated exosomes in modulating the immune response and regeneration in RA pathology, as well as the impact of age-related dysregulations in mesenchymal stem cell activities on the homing of systemic autoimmunity to joints.
Article
Neurosciences
Michael A. Durante, Stefan Kurtenbach, Zoukaa B. Sargi, J. William Harbour, Rhea Choi, Sarah Kurtenbach, Garrett M. Goss, Hiroaki Matsunami, Bradley J. Goldstein
NATURE NEUROSCIENCE
(2020)
Article
Multidisciplinary Sciences
Angela C. Rieger, Luiza L. Bagno, Alessandro Salerno, Victoria Florea, Jose Rodriguez, Marcos Rosado, Darren Turner, Raul A. Dulce, Lauro M. Takeuchi, Rosemeire M. Kanashiro-Takeuchi, Peter Buchwald, Amerylis C. B. A. Wanschel, Wayne Balkan, Ivonne H. Schulman, Andrew Schally, Joshua M. Hare
Summary: Research on a large-animal model showed that GHRH-A has beneficial effects on HFpEF induced by CKD, improving the symptoms of heart failure.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Editorial Material
Urology & Nephrology
Kirsten L. Johansen, Glenn M. Chertow, Robert N. Foley, David T. Gilbertson, Charles A. Herzog, Areef Ishani, Ajay K. Israni, Elaine Ku, Manjula Kurella Tamura, Shuling Li, Suying Li, Jiannong Liu, Gregorio T. Obrador, Ann M. O'Hare, Yi Peng, Neil R. Powe, Nicholas S. Roetker, Wendy L. St Peter, Kevin C. Abbott, Kevin E. Chan, Ivonne H. Schulman, Jon Snyder, Craig Solid, Eric D. Weinhandl, Wolfgang C. Winkelmayer, James B. Wetmore
AMERICAN JOURNAL OF KIDNEY DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Roberto Bolli, Raul D. Mitrani, Joshua M. Hare, Carl J. Pepine, Emerson C. Perin, James T. Willerson, Jay H. Traverse, Timothy D. Henry, Phillip C. Yang, Michael P. Murphy, Keith L. March, Ivonne H. Schulman, Sohail Ikram, David P. Lee, Connor O'Brien, Joao A. Lima, Mohammad R. Ostovaneh, Bharath Ambale-Venkatesh, Gregory Lewis, Aisha Khan, Ketty Bacallao, Krystalenia Valasaki, Bangon Longsomboon, Adrian P. Gee, Sara Richman, Doris A. Taylor, Dejian Lai, Shelly L. Sayre, Judy Bettencourt, RachelW. Vojvodic, Michelle L. Cohen, Lara Simpson, David Aguilar, Catalin Loghin, Lem Moye, Ray F. Ebert, Barry R. Davis, Robert D. Simari
Summary: The CONCERT-HF trial demonstrated the safety and feasibility of CPCs and MSCs treatment in ischemic cardiomyopathy-induced heart failure patients, with CPCs reducing MACE and MSCs improving quality of life. Further investigation is warranted to explore the potential beneficial effects of these cell types in heart failure.
EUROPEAN JOURNAL OF HEART FAILURE
(2021)
Article
Emergency Medicine
Courtney Premer, Ivonne H. Schulman, Jennifer S. Jackson
Summary: MSCs show promising potential in treating acute diseases, with clinical trials demonstrating safety but inconsistent efficacy data, necessitating further research.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cell Biology
Aisha Khan, Michael A. Bellio, Ivonne H. Schulman, Allan D. Levi, Bangon Longsomboon, Adriana Brooks, Krystalenia Valasaki, Darcy L. DiFede, Marietsy V. Pujol, Dileep R. Yavagal, Karen E. Bates, Ming-Sing Si, Sunjay Kaushal, Barth A. Green, Kimberly D. Anderson, James D. Guest, Stephen Shelby Burks, Risset Silvera, Andrea J. Santamaria, Anil Lalwani, W. Dalton Dietrich, Joshua M. Hare
Summary: The FDA's guidance on expanded access to investigational new drugs is crucial for advancing cell-based therapy, especially in rare and emergency conditions where patients seek alternative treatments like cell-based therapies. In this study, the use of FDA-approved INDs for treating incurable diseases such as stiff-person syndrome and spinal cord injury is described, highlighting the importance of expanded access programs in providing potential treatment options for patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Urology & Nephrology
Adan Z. Becerra, Kevin E. Chan, Paul W. Eggers, Jenna Norton, Paul L. Kimmel, Ivonne H. Schulman, Susan R. Mendley
Summary: This study found that kidney transplantation can significantly improve the survival rate in Black and White children with childhood-onset kidney failure. Black patients had a higher risk of death, lower chances of receiving a transplant, and experienced earlier graft failure. By equalizing the time with a functioning transplant for Black patients, the excess mortality rate could be reduced.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Transplantation
Daniel Lazzareschi, Ravindra L. Mehta, Laura M. Dember, Juliane Bernholz, Alparslan Turan, Amit Sharma, Sachin Kheterpal, Chirag R. Parikh, Omar Ali, Ivonne H. Schulman, Abigail Ryan, Jean Feng, Noah Simon, Romain Pirracchio, Patrick Rossignol, Matthieu Legrand
Summary: Acute kidney injury is a growing epidemic that is associated with increased risk of death, chronic kidney disease, and cardiovascular events. Clinical trials in this field are challenging due to the heterogeneity of the disease. Identifying subphenotypes of acute kidney injury can help elucidate its diverse etiologies and enhance prevention and treatment strategies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Cell & Tissue Engineering
Angela C. Rieger, Bryon A. Tompkins, Makoto Natsumeda, Victoria Florea, Monisha N. Banerjee, Jose Rodriguez, Marcos Rosado, Valeria Porras, Krystalenia Valasaki, Lauro M. Takeuchi, Kevin Collon, Sohil Desai, Michael A. Bellio, Aisha Khan, Nilesh D. Kashikar, Ana Marie Landin, Darrell Hardin, Daniel A. Rodriguez, Wayne Balkan, Joshua M. Hare, Ivonne Hernandez Schulman
Summary: This study suggests that intra-renal artery allogeneic cell therapy can improve preserved ejection fraction abnormalities in patients with chronic kidney disease. The therapy has a positive impact on renal function and ventricular compliance, supporting further research on its application in cardiorenal syndrome.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Claudia A. Martinez, Rishi Rikhi, Mollie S. Pester, Meela Parker, Alex Gonzalez, Michaela Larson, Jennifer Chavez, Armando Mendez, Jeffrey K. Raines, Michael A. Kolber, Ivonne H. Schulman, Maria L. Alcaide, Barry E. Hurwitz
Summary: Findings suggest that ABC treatment is not likely to significantly increase cardiovascular disease risk in 30-50 year-old PWH on stable ART.
Article
Urology & Nephrology
Matthieu Legrand, Sean M. Bagshaw, Jay L. Koyner, Ivonne H. Schulman, Michael R. Mathis, Juliane Bernholz, Steven Coca, Martin Gallagher, Stephane Gaudry, Kathleen D. Liu, Ravindra L. Mehta, Romain Pirracchio, Abigail Ryan, Dominik Steubl, Norman Stockbridge, Fredrik Erlandsson, Alparslan Turan, F. Perry Wilson, Alexander Zarbock, Michael P. Bokoch, Jonathan D. Casey, Patrick Rossignol, Michael O. Harhay
Summary: This article reviews the barriers to and strategies for improving clinical trial design and implementation in AKI patients, proposing novel approaches such as adaptive trial designs, pragmatic trial designs, and platform trial designs. It also covers new approaches to clinical trial analysis and provides a roadmap for future trial planning.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Britney A. Stottlemyer, Kaleab Z. Abebe, Paul M. Palevsky, Linda Fried, Ivonne H. Schulman, Chirag R. Parikh, Emilio Poggio, Edward D. Siew, Orlando M. Gutierrez, Edward Horwitz, Matthew R. Weir, F. Perry Wilson, Sandra L. Kane-Gill
Summary: This study created a standardized list of nephrotoxic medications and their nephrotoxic potential in non-critically ill patients, providing a basis for future clinical evaluations and research.
Article
Urology & Nephrology
Ivonne H. Schulman, Kevin Chan, Jane S. Der, Kenneth J. Wilkins, Helen L. Corns, Bryan Sayer, Duc Anh Ngo, Paul Eggers, Jenna Norton, Neha Shah, Susan Mendley, Afshin Parsa, Robert A. Star, Paul L. Kimmel
Summary: This study retrospectively investigated the various short-term and long-term outcomes of patients hospitalized with acute kidney injury (AKI), and found that AKI patients had higher risks of rehospitalization and mortality within 90 and 365 days after discharge.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Meeting Abstract
Cardiac & Cardiovascular Systems
Russell G. Saltzman, Ivonne H. Schulman, Barry E. Hurwitz, Hua Li, Lina V. Caceres, Mayra Vidro-Casiano, Jairo A. Tovar, Yvenie Desire, Valeria Porras, Jeanette Soto, Aisha Khan
Article
Medicine, Research & Experimental
Russell G. Saltzman, Dushyantha T. Jayaweera, Lina Caceres, Jairo A. Tovar, Mayra Vidro-Casiano, Vela Karakeshishyan, Jeanette Soto, Aisha Khan, Raul D. Mitrani, Ivonne H. Schulman, Joshua M. Hare
Summary: The study examined the voluntary participation rates of different demographic groups in cell-based therapy clinical trials conducted by the University of Miami's ISCI. It found that some minorities and women were under-represented in the trials, highlighting the need for novel community engagement strategies to improve inclusion in clinical research.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS
(2021)