Article
Biotechnology & Applied Microbiology
Mustafa Burak Acar, Serife Ayaz-Guner, Zeynep Gunaydin, Musa Karakukcu, Gianfranco Peluso, Giovanni Di Bernardo, Servet Ozcan, Umberto Galderisi
Summary: Senotherapeutics, including senolytics and senomorphics, can delay replicative senescence and cell death, improving cell function through specific pathways. Metformin, a potential senomorphic agent, may exert its effects by scavenging ROS and regulating key transcription factors involved in blocking oxidative stress.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Cell & Tissue Engineering
Yaping Wang, Tianyun Gao, Bin Wang
Summary: Senescence is a hot topic due to the accumulation of senescent cells and inflammatory factors, leading to various senescence-related diseases. Stem cell-based therapy, particularly using mesenchymal stromal cells (MSCs), is considered a promising strategy to alleviate or cure these diseases.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Cell & Tissue Engineering
Seiko Harada, Yo Mabuchi, Jun Kohyama, Daisuke Shimojo, Sadafumi Suzuki, Yoshimi Kawamura, Daisuke Araki, Takashi Suyama, Masunori Kajikawa, Chihiro Akazawa, Hideyuki Okano, Yumi Matsuzaki
Summary: The study compared gene expression profiles of immature hMSCs and less potent MSCs to explore the molecular mechanisms regulating senescence in hMSCs. It was found that FZD5, a transcription factor expressed specifically in immature hMSCs, plays a crucial role in regulating senescence by promoting proliferation and delaying cell cycle arrest. Controlling FZD5 signaling may offer potential to improve hMSC quality for cell-replacement therapies.
Article
Biochemistry & Molecular Biology
Rocio Mato-Basalo, Miriam Morente-Lopez, Onno J. Arntz, Fons A. J. van de Loo, Juan Fafian-Labora, Maria C. Arufe
Summary: Mesenchymal stem cells have potential in treating age-related diseases, and small extracellular vesicles derived from these cells have been proposed as therapies. The activation of p65 is found to be important in cellular senescence and inflammatory activation in mesenchymal stem cells. Inhibiting p65 can prevent cellular senescence and the activation of proinflammatory molecules, highlighting its role in restoring functionality and preventing inflamm-aging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Akaitz Dorronsoro, Fernando E. Santiago, Diego Grassi, Tianpeng Zhang, Ruenn Chai Lai, Sara J. McGowan, Luise Angelini, Mitra Lavasani, Lana Corbo, Aiping Lu, Robert W. Brooks, Marta Garcia-Contreras, Donna B. Stolz, Antonio Amelio, Siddaraju V. Boregowda, Mohammad Fallahi, Adrian Reich, Camillo Ricordi, Donald G. Phinney, Johnny Huard, Sai Kiang Lim, Laura J. Niedernhofer, Paul D. Robbins
Summary: The injection of BM-MSCs from young mice can prolong lifespan and healthspan, while conditioned media (CM) from young BM-MSCs can rescue the function of aged stem cells and senescent fibroblasts. Extracellular vesicles (EVs) from young BM-MSC CM can extend lifespan in mice, and EVs from MSCs generated from human ES cells can reduce senescence and improve healthspan.
Article
Biology
Diptiman Chanda, Mohammad Rehan, Samuel R. Smith, Kevin G. Dsouza, Yong Wang, Karen Bernard, Deepali Kurundkar, Vinayak Memula, Kyoko Kojima, James A. Mobley, Gloria A. Benavides, Victor Darley-Usmar, Young-iL Kim, Jaroslaw W. Zmijewski, Jessy S. Deshane, Stijn De Langhe, Victor J. Thannickal
Summary: This study revealed the impact of cellular aging on the ability of L-MSC and AEC2s cells to form three-dimensional organoids, and found that reducing Nox4 activity may reverse critical effects of cellular aging.
Article
Cell Biology
Jiaming Gao, Hao Wang, Junyan Shen, Xiaojing Liu, Xiaoqi Zhu, Ce Huang, Gongchen Li, Yao Sun, Zhongmin Liu, Yi Eve Sun, Hailiang Liu
Summary: This study reveals the mechanism by which GDF11 reverses aging of mesenchymal stem cells (MSCs) through the activation of the Smad2/3-PI3K-AKT-mTOR signaling pathway and upregulation of the DNA demethylase Tet2. The mutual regulatory relationship between GDF11 and Tet2 plays a crucial role in the anti-aging effects.
JOURNAL OF CELLULAR PHYSIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Mahmoud Al-Azab, Mohammed Safi, Elina Idiiatullina, Fadhl Al-Shaebi, Mohamed Y. Zaky
Summary: Human mesenchymal stem cells (MSCs) play important roles in tissue homeostasis, aging-related diseases, and cellular therapy. Understanding the mechanisms and signs of MSC cellular senescence is crucial for combating aging and cellular senescence. This review discusses the factors contributing to MSC senescence and strategies to reverse it.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Gabriella Teti, Eleonora Mazzotti, Valentina Gatta, Francesca Chiarini, Maria Laura Alfieri, Mirella Falconi
Summary: Osteoarthritis (OA) is a chronic degenerative disease characterized by the loss of articular cartilage. Senescent cells in mesenchymal stem/stromal cells (MSCs) isolated from OA joints have been shown to inhibit cartilage regeneration. However, the connection between cellular senescence in MSCs and OA progression is still debated. This study aimed to characterize and compare synovial fluid MSCs (sf-MSCs) from OA joints with healthy sf-MSCs, and investigate the influence of senescence on cartilage repair. The findings demonstrated the presence of senescent sf-MSCs in OA joints, impairing chondrogenic differentiation abilities and potentially impacting OA progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Nicola Alessio, Tiziana Squillaro, Ida Lettiero, Giovanni Galano, Roberto De Rosa, Gianfranco Peluso, Umberto Galderisi, Giovanni Di Bernardo
Summary: Polyphenols, such as piceatannol, show promise in counteracting senescence by reducing the number of senescent cells and promoting the recovery of cell proliferation and stemness properties of MSCs. The multiple mechanisms of piceatannol suggest its potential to combat various senescent phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Mingjia Cheng, Weihao Yuan, Alireza Moshaverinia, Bo Yu
Summary: Advanced age is a shared risk factor for chronic skeletal diseases. The senescence of mesenchymal stem cells (MSCs) exacerbates inflammatory microenvironment and disrupts bone remodeling, contributing to age-related bone diseases. Understanding the molecular and epigenetic mechanisms of MSC senescence, such as oxidative stress and mitochondrial dysfunction, could present rejuvenation strategies for skeletal aging restoration.
Review
Biochemistry & Molecular Biology
Quentin Alle, Enora Le Borgne, Ollivier Milhavet, Jean-Marc Lemaitre
Summary: Aging is traditionally seen as an unavoidable process, but new strategies have been developed to delay or reverse aging. Some of these approaches may have medical applications to improve healthspan and longevity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell & Tissue Engineering
Tatiana Sekelova, Lubos Danisovic, Michaela Cehakova
Summary: This review discusses the impact of aging on MSCs and their role in joint diseases. Aging decreases the reparative potential of MSCs and contributes to the accumulation of senescent cells, which affects joint health. The review also explores current approaches to delay/reverse age-related pathological changes.
CELL TRANSPLANTATION
(2023)
Review
Biotechnology & Applied Microbiology
Yesuf Siraj, Umberto Galderisi, Nicola Alessio
Summary: Mesenchymal stromal cells (MSCs) are a heterogeneous population of adult stem cells that can differentiate into mesodermal derivatives. MSCs have therapeutic effects due to their secretome, which has anti-inflammatory and regenerative properties. However, when MSCs become senescent, their secretome can acquire pro-inflammatory and pro-aging activities, which should be considered in therapeutic applications.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Cell Biology
Raquel M. Alves-Paiva, Sabrina do Nascimento, Denise De Oliveira, Larissa Coa, Kelen Alvarez, Nelson Hamerschlak, Oswaldo Keith Okamoto, Luciana C. Marti, Andrea T. Kondo, Jose Mauro Kutner, Maria Augusta Tezelli Bortolini, Rodrigo Castro, Juliana A. Preto de Godoy
Summary: This study reports a case where MSCs derived from an elderly donor entered a senescence state after three passages. MSCs cultured with AS displayed an early senescence state, and there were more senescence cells and altered gene expression compared to cells cultured with FBS.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Binnur Eroglu, Evan Genova, Quanguang Zhang, Yun Su, Xingming Shi, Carlos Isales, Ali Eroglu
Summary: As stem cells age, their plasticity and proliferative capacity decrease, but photobiomodulation therapy can reverse this process by restoring mitochondrial functionality. Research shows that young and aged stem cells respond differently to PBM treatment, with a lasting rejuvenating effect achieved through three consecutive treatments on aged cells.
SCIENTIFIC REPORTS
(2021)
Article
Endocrinology & Metabolism
Jessica L. Pierce, Anuj K. Sharma, Rachel L. Roberts, Kanglun Yu, Debra L. Irsik, Vivek Choudhary, Jennifer S. Dorn, Husam Bensreti, Reginald D. Benson, Helen Kaiser, Andrew Khayrullin, Colleen Davis, Chase J. Wehrle, Maribeth H. Johnson, Wendy B. Bollag, Mark W. Hamrick, Xingming Shi, Carlos M. Isales, Meghan E. McGee-Lawrence
Summary: Deficiency in glucocorticoid receptor (GR) in aging-associated osteoporosis leads to low bone mass and bone marrow adipose tissue accumulation, as well as alterations in muscle mass, metabolic rate, and blood pressure. The study suggests a role for GR in facilitating healthy bone maintenance with aging in females and highlights the importance of bone as an endocrine organ.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Physiology
Ling Ruan, Bharati Mendhe, Emily Parker, Andrew Kent, Carlos M. Isales, William D. Hill, Meghan McGee-Lawrence, Sadanand Fulzele, Mark W. Hamrick
Summary: This study discovered that the expression of lncRNA MALAT1 decreases with age in skeletal muscle, accompanied by an increase in miR-34a-5p expression. In vitro experiments showed that silencing MALAT1 increases miR-34a expression. Additionally, oxidative stress reduces MALAT1 expression, but this effect can be attenuated by p53 siRNA. Furthermore, MALAT1 silencing significantly increases TGF-beta 1 expression in C2C12 cells.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Emily J. Gallagher, Don C. Rockey, Christopher D. Kontos, Jatin M. Vyas, Lawrence F. Brass, Patrick J. Hu, Carlos M. Isales, Olujimi A. Ajijola, W. Kimryn Rathmell, Paul R. Conlin, Robert A. Baiocchi, Barbara Kazmierczak, Myles H. Akabas, Christopher S. Williams
Summary: Postgraduate physician-scientist training programs (PSTPs) are instrumental in enhancing the development of physician-scientist trainees. A survey of PSTP directors in the US revealed that having first-author publications and a strong recommendation from the thesis advisor were considered crucial components of a successful PSTP application. This highlights the importance of scientific productivity and commitment to research in the selection process, as opposed to traditional measures of medical school performance.
Article
Endocrinology & Metabolism
Yanyan Xu, Shaoyong Su, William McCall, Carlos Isales, Harold Snieder, Xiaoling Wang
Summary: Circadian rhythm disturbance is significantly associated with impaired glucose homeostasis in a general population of adults without diabetes, suggesting that circadian dysfunction may contribute to early disease pathogenesis. The study analyzed data from 2760 adults without diabetes from the NHANES 2011-2014, showing that increased circadian rhythmicity was associated with lower 2-hour glucose levels and decreased odds of IGT, while increased rhythm fragmentation was associated with higher 2-hour glucose levels and increased odds of IGT.
BMJ OPEN DIABETES RESEARCH & CARE
(2022)
Review
Geriatrics & Gerontology
Andrew Murphy, Sagar Vyavahare, Sandeep Kumar, Tae Jin Lee, Ashok Sharma, Satish Adusumilli, Mark Hamrick, Carlos M. Isales, Sadanand Fulzele
Summary: This study summarizes the research on age-associated diseases and the efforts to extend a healthy lifespan. It discusses the positive effects of dietary protocols such as caloric restriction and protein restriction on human longevity. The study also analyzes the impacts of these protocols on bone and muscle biology, identifying new genes and signaling pathways involved in musculoskeletal tissue.
Article
Geriatrics & Gerontology
Dhara Patel, Tae Jin Lee, Sandeep Kumar, Sagar Vyavahare, Alison Worth, William D. Hill, Mark Hamrick, Carlos M. Isales, Rahul S. Shinde, Sadanand Fulzele
Summary: Understanding the pathophysiology of age-related diseases is crucial as the elderly population grows. Metabolic changes play an important role in age-related degeneration, affecting musculoskeletal health. Gender-specific differences in metabolic signaling pathways may contribute to the manifestation of musculoskeletal diseases in males and females.
Article
Endocrinology & Metabolism
Yun Su, Xing Chen, Hongyan Zhou, Sean Shaw, Jie Chen, Carlos M. Isales, Jing Zhao, Xingming Shi
Summary: Glucocorticoids are potent drugs with anti-inflammatory and immunosuppressive effects, but their clinical use is limited due to severe side effects. The molecular mechanisms underlying glucocorticoid-induced bone loss are unclear. In this study, RNA sequencing analysis identified Xist as a glucocorticoid-regulated gene involved in glucocorticoid-induced osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Alexis M. Stranahan, De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Wenbo Zhi, Yun Lei, Xinyun Lu, Kehong Ding, Carlos M. Isales
Summary: Preferential energy storage in subcutaneous adipose tissue (SAT) provides protection against obesity-induced pathophysiology in females. Differences in adipose tissue distribution before obesity onset determine susceptibility to inflammation in males and females, independent of sex hormones.
Article
Biology
P. Robinson Muller, Tae Jin Lee, Wenbo Zhi, Sandeep Kumar, Sagar Vyavahare, Ashok Sharma, Vikas Kumar, Carlos M. Isales, Monte Hunter, Sadanand Fulzele
Summary: Osteoarthritis is a common degenerative joint disease that primarily affects females. Research has shown that the protein composition of synovial fluid in female osteoarthritis patients differs, which may provide insights into gender-specific pathophysiology.
Article
Endocrinology & Metabolism
Laura Carbone, Petra Buzkova, Howard A. Fink, John A. Robbins, Joshua Barzilay, Rachel E. Elam, Carlos Isales
Summary: Amino acids are important for skeletal health, and the relationship between tryptophan and its metabolites with hip fractures and mortality has been examined. Higher serum levels of tryptophan were associated with lower risk of hip fractures, but no significant associations were found with mortality or frailty status. Further randomized clinical trials are needed to investigate the potential benefits of increased tryptophan intake for osteoporosis.
Article
Neurosciences
Vivek Choudhary, Etsubdenk Ajebo, Rawipan Uaratanawong, Shinjini C. Spaulding, Sarah Hossack, Xunsheng Chen, Jianrui Xu, Mrunal Choudhary, Debra L. Irsik, Carlos M. Isales, Wendy B. Bollag
Summary: A study found that the lack of the IDO1 gene does not have a significant effect on the immune response and skin lesions in a psoriasis model.
INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH
(2022)
Article
Geriatrics & Gerontology
Nicholas Cantu, Sagar Vyavahare, Sandeep Kumar, Jie Chen, Ravindra Kolhe, Carlos M. Isales, Mark Hamrick, Sadanand Fulzele
Summary: The study investigated the molecular mechanisms underlying muscle loss in COVID-19 patients, finding that cytokines, glucocorticoids, and antiviral drugs may synergistically contribute to this outcome.
Review
Pharmacology & Pharmacy
Burton Dunlap, G. Taylor Patterson, Sandeep Kumar, Sagar Vyavahare, Samarth Mishra, Carlos Isales, Sadanand Fulzele
Summary: 14% of US adults have been diagnosed with or show symptoms of osteoarthritis, with incidence gradually increasing over the past 30 years. The aging population and obesity prevalence exacerbate the situation. Research on antioxidant supplementation, particularly vitamin C, for treating osteoarthritis is controversial and further randomized controlled trials in humans are urgently needed.
THERAPEUTIC ADVANCES IN CHRONIC DISEASE
(2021)
Review
Endocrinology & Metabolism
Debra L. Irsik, Wendy B. Bollag, Carlos M. Isales
Summary: Aging leads to a decline in organismal mineral homeostasis, particularly in the skeleton and renal systems. Tight coordination among the intestine, bone, parathyroid gland, and kidney is required for calcium and phosphate regulation.
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.
