Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes
出版年份 2016 全文链接
标题
Requirements for multi-level systems pharmacology models to reach end-usage: the case of type 2 diabetes
作者
关键词
-
出版物
Interface Focus
Volume 6, Issue 2, Pages 20150075
出版商
The Royal Society
发表日期
2016-02-19
DOI
10.1098/rsfs.2015.0075
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- (2015) David Jullesson et al. FEBS Journal
- Mathematical modeling improves EC50estimations from classical dose-response curves
- (2015) Elin Nyman et al. FEBS Journal
- New perspectives in signaling mediated by receptors coupled to stimulatory G protein: the emerging significance of cAMP efflux and extracellular cAMP-adenosine pathway
- (2015) Rosely O. Godinho et al. Frontiers in Pharmacology
- A Single Mechanism Can Explain Network-wide Insulin Resistance in Adipocytes from Obese Patients with Type 2 Diabetes
- (2014) Elin Nyman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Insulin Signaling in Type 2 Diabetes
- (2013) Cecilia Brännmark et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Kinase Inhibitors: Adverse Effects Related to the Endocrine System
- (2013) Maya B. Lodish JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology
- (2013) Oliver J. Britton et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Parameter Trajectory Analysis to Identify Treatment Effects of Pharmacological Interventions
- (2013) Christian A. Tiemann et al. PLoS Computational Biology
- Evaluation of a mathematical model of diabetes progression against observations in the Diabetes Prevention Program
- (2012) Thomas Hardy et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Conclusions via unique predictions obtained despite unidentifiability - new definitions and a general method
- (2012) Gunnar Cedersund FEBS Journal
- Kinetic Modeling of Human Hepatic Glucose Metabolism in Type 2 Diabetes Mellitus Predicts Higher Risk of Hypoglycemic Events in Rigorous Insulin Therapy
- (2012) Matthias König et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project
- (2012) Denis Noble et al. JOURNAL OF PHYSIOLOGY-LONDON
- Insulin signaling – mathematical modeling comes of age
- (2012) Elin Nyman et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
- Quantifying the Contribution of the Liver to Glucose Homeostasis: A Detailed Kinetic Model of Human Hepatic Glucose Metabolism
- (2012) Matthias König et al. PLoS Computational Biology
- Parameter adaptations during phenotype transitions in progressive diseases
- (2011) Christian A Tiemann et al. BMC Systems Biology
- Set points, settling points and some alternative models: theoretical options to understand how genes and environments combine to regulate body adiposity
- (2011) J. R. Speakman et al. Disease Models & Mechanisms
- A Hierarchical Whole-body Modeling Approach Elucidates the Link betweenin VitroInsulin Signaling andin VivoGlucose Homeostasis
- (2011) Elin Nyman et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Quantification of the effect of energy imbalance on bodyweight
- (2011) Kevin D Hall et al. LANCET
- Systems Pharmacology: Bridging Systems Biology and Pharmacokinetics-Pharmacodynamics (PKPD) in Drug Discovery and Development
- (2011) Piet H. van der Graaf et al. PHARMACEUTICAL RESEARCH
- Conflicting Biomedical Assumptions for Mathematical Modeling: The Case of Cancer Metastasis
- (2011) Anna Divoli et al. PLoS Computational Biology
- A Biophysical Model of Electrical Activity in Human β -Cells
- (2010) Morten Gram Pedersen BIOPHYSICAL JOURNAL
- Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-free Modeling Framework
- (2010) Cecilia Brännmark et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Model for Glucose, Insulin, and Beta-Cell Dynamics in Subjects With Insulin Resistance and Patients With Type 2 Diabetes
- (2010) Jakob Ribbing et al. JOURNAL OF CLINICAL PHARMACOLOGY
- A Model of NEFA Dynamics with Focus on the Postprandial State
- (2009) Katarina Jelic et al. ANNALS OF BIOMEDICAL ENGINEERING
- An Integrated Model for the Glucose-Insulin System
- (2009) Hanna E. Silber et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- A Mathematical Model of Murine Metabolic Regulation by Leptin: Energy Balance and Defense of a Stable Body Weight
- (2009) Joshua Tam et al. Cell Metabolism
- Sustained Effects of Interleukin-1 Receptor Antagonist Treatment in Type 2 Diabetes
- (2009) C. M. Larsen et al. DIABETES CARE
- An Integrated Glucose-Insulin Model to Describe Oral Glucose Tolerance Test Data in Healthy Volunteers
- (2009) Hanna E. Silber et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Mathematical models of diabetes progression
- (2008) Andrea De Gaetano et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Bioinformatics, multiscale modeling and the IUPS Physiome Project
- (2008) P. J. Hunter et al. BRIEFINGS IN BIOINFORMATICS
- Pharmacokinetic/Pharmacodynamic Modelling in??Diabetes Mellitus
- (2008) Cornelia B Landersdorfer et al. CLINICAL PHARMACOKINETICS
- Putting the pieces together in diabetes research: Towards a hierarchical model of whole-body glucose homeostasis
- (2008) Gunnar Cedersund et al. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Central Control of Body Weight and Appetite
- (2008) Stephen C. Woods et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- Approaches to handling pharmacodynamic baseline responses
- (2008) Chantaratsamon Dansirikul et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Core Content for the Subspecialty of Clinical Informatics
- (2008) R. M. Gardner et al. JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION
- Patients’ use of digital pens for pain assessment in advanced palliative home healthcare
- (2007) L LIND et al. INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS
- The development of tolerance to drugs that suppress food intake
- (2007) John D. Fernstrom et al. PHARMACOLOGY & THERAPEUTICS
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