Review
Cell Biology
Kaitlin M. Love, Eugene J. Barrett, Steven K. Malin, Jane E. B. Reusch, Judith G. Regensteiner, Zhenqi Liu
Summary: Endothelial cells play a crucial role in the development of insulin resistance and type 2 diabetes, with their dysfunction contributing to various metabolic complications. Various therapeutic modalities can improve endothelial function, reducing the onset and complications of diabetes.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Review
Multidisciplinary Sciences
Belinda J. Wilkes, Wallace Tucker, Norbert Schartel, Maria Santos-Lleo
Summary: The Chandra X-ray Observatory and the X-ray Multi-Mirror Mission have made groundbreaking discoveries in understanding high-energy processes in the Universe, providing valuable insights into our place in the cosmos and the fundamental laws that govern our existence.
Editorial Material
Hematology
David B. Wilson, Melanie E. Fields
Summary: This study investigates the impact of fetal and neonatal alloimmune thrombocytopenia on the risk of intracranial hemorrhage using a mouse model. The authors not only identify critical platelet thresholds but also demonstrate the development of resilience to thrombocytopenia-associated intracranial hemorrhage in mice shortly after birth.
Review
Pharmacology & Pharmacy
Joao Pedro de Magalhaes
Summary: With a globally aging population, longevity has become a promising market in the biotech industry. The potential to slow down human aging has led to a race in discovering promising longevity drugs and translating them to humans. Investment in longevity biotech is booming, with several clinical trials expected to reveal drugs that extend healthy lives.
DRUG DISCOVERY TODAY
(2021)
Review
Plant Sciences
Li Lei, Eugene Goltsman, David Goodstein, Guohong AlbertWu, Daniel S. Rokhsar, John P. Vogel
Summary: A plant pan-genome is typically larger than the genome of any individual plant, with many genes present in only some genomes. Constructing and interpreting plant pan-genomes is challenging due to the large size and repetitive content of plant genomes. Focus is often on nontransposable element protein coding genes, but noncoding and repetitive DNA also play important roles in genome evolution and phenotype determination.
ANNUAL REVIEW OF PLANT BIOLOGY, VOL 72, 2021
(2021)
Article
Physiology
Griffin S. S. Hampton, Kai Bartlette, Kristen J. J. Nadeau, Melanie Cree-Green, Cecilia Diniz Behn
Summary: Insulin resistance occurs when more insulin is required to achieve the same effects, and this resistance may be tissue-specific. This study found that insulin acts more quickly on adipose tissue compared to muscle and liver, suggesting tissue-specific dynamics of insulin action in an insulin-resistant adolescent population.
FRONTIERS IN PHYSIOLOGY
(2022)
Editorial Material
Operations Research & Management Science
Yves Crama, Michel Grabisch, Silvano Martello
Summary: This editorial note provides an update on the past three years of publications for the traditional triennial note used by the Editors for 4OR, with volumes 16 (2018), 17 (2019), and 18 (2020) being published.
4OR-A QUARTERLY JOURNAL OF OPERATIONS RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yao He, Juli Feigon
Summary: Telomerase is an RNA-protein complex that synthesizes telomeric DNA at the ends of linear chromosomes. Recent structural studies have provided insights into telomerase assembly, mechanism, recruitment, and disease-related mutations.
CURRENT OPINION IN STRUCTURAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Prachi B. Walke, Sneha B. Bansode, Nikita P. More, Arvindkumar H. Chaurasiya, Rakesh S. Joshi, Mahesh J. Kulkarni
Summary: The study revealed that glycated insulin exacerbates insulin resistance not only by impairing insulin signaling, but also by activating the AGE-RAGE signaling pathway.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Horticulture
Sadaruddin Chachar, Muzafaruddin Chachar, Adeel Riaz, Aamir Ali Shaikh, Xiulan Li, Xiaoxue Li, Changfei Guan, Pingxian Zhang
Summary: Our era has witnessed significant advancements in plant epigenetics, with recent discoveries of RNA chemical modifications playing a role in gene translation efficiency. The application of epigenetic modifications in horticultural plants has shown promise in studying processes like fruit development, grafting, and bud dormancy. This review highlights the importance of understanding epigenetic regulation mechanisms in plants and the potential for future innovations in computational techniques for research in this field.
SCIENTIA HORTICULTURAE
(2022)
Article
Cell Biology
Yishu Wang, Jingxiang Liu, Boyan Huang, Xiaojun Long, Xiuyun Su, Deshun Sun
Summary: Mathematical models can provide a comprehensive understanding of the regulatory mechanisms of the TNF signaling pathway in chondrocyte apoptosis. A fractional-order differential equation model is proposed in this study to describe the dynamic behavior and mutual interaction of apoptosis-related genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Engineering, Multidisciplinary
Oluwasegun M. Ibrahim, Daniel Okuonghae, Monday N. O. Ikhile
Summary: This paper examines the impact of correctional intervention measures on the population dynamics of criminal gangs in Nigeria. The study finds that timely prosecution and correction can potentially eradicate adolescent delinquencies from the population and control the entire criminal gangs' population.
APPLIED MATHEMATICAL MODELLING
(2022)
Review
Biochemical Research Methods
Yang Wang, Wei Yang
Summary: Protein S-acylation, also known as palmitoylation, is a crucial reversible lipid modification that regulates protein functions. Recent advances in proteomic analysis of S-acylation have significantly improved our understanding of its biological processes. This research field is expected to play a key role in discovering new disease mechanisms and therapeutic targets.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zeba Sultana, Mathurin Dorel, Bertram Klinger, Anja Sieber, Ilona Dunkel, Nils Bluethgen, Edda G. Schulz
Summary: By combining systematic perturbation experiments with mathematical modeling, it was found that the number of active X chromosomes in mouse embryonic stem cells affects cell signaling and differentiation propensity. The presence of a single active X chromosome makes cells more sensitive to differentiation-promoting pathways and leads to a stronger negative feedback in the MAPK pathway. This may explain the delayed differentiation observed in female mouse embryonic stem cells.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Editorial Material
Chemistry, Medicinal
Veronica A. Jimenez
Summary: Dipeptidyl peptidase-like protein 9 (DPP9) is a promising drug target for hematological diseases. Two novel DPP9 inhibitors with nanomolar affinity and unprecedented selectivity over DPP8 have been discovered, opening the way for future DPP9-mediated treatments.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lena Berning, David Schluetermann, Annabelle Friedrich, Niklas Berleth, Yadong Sun, Wenxian Wu, Maria Jose Mendiburo, Jana Deitersen, Hannah U. C. Brass, Margaretha A. Skowron, Michele J. Hoffmann, Gunter Niegisch, Joerg Pietruszka, Bjorn Stork
Summary: Prodigiosin has been shown to block autophagy and sensitize cisplatin-resistant cells to apoptotic cell death in urothelial carcinoma cells. It exhibits potent anticancer activity with nanomolar IC50 values and synergistic effects when combined with cisplatin. The effects of prodigiosin are partially mediated by altering lysosomal function, making it a promising candidate for therapy of cisplatin-resistant urothelial carcinomas.
Article
Cell Biology
Wenxian Wu, Xiaojing Wang, Yadong Sun, Niklas Berleth, Jana Deitersen, David Schluetermann, Fabian Stuhldreier, Nora Wallot-Hieke, Maria Jose Mendiburo, Jan Cox, Christoph Peter, Ann Kathrin Bergmann, Bjoern Stork
Summary: This study identified RIPK3 as an AMPK-activating kinase, establishing a direct link between the kinases regulating autophagy and necroptosis.Activation of AMPK by RIPK3 leads to phosphorylation of autophagy-regulating proteins ULK1 and BECN1, while TNF-induced necroptosis blocks lysosomal degradation of autophagosomes. Dysregulation of SNARE complexes, including reduced levels of full-length STX17, was observed upon TNF treatment.
Article
Biochemistry & Molecular Biology
Hussam Ibrahim, Philipp Reus, Anna Katharina Mundorf, Anna-Lena Grothoff, Valerie Rudenko, Christina Buschhaus, Anja Stefanski, Niklas Berleth, Bjoern Stork, Kai Stuehler, Faiza Kalfalah, Hans Reinke
Summary: The cytoplasmic PER complex component GAPVD1 interacts with PER2 and is associated with CSNK1D, which regulates PER2 levels through phosphorylation. The phosphorylation of GAPVD1 determines its degradation kinetics and is controlled by PER2 and an autoinhibitory domain in CSNK1D, suggesting a novel function of cytoplasmic PER complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Katharina Schmitz, Jan Cox, Lea Marie Esser, Martin Voss, Katja Sander, Antje Loeffler, Frank Hillebrand, Steffen Erkelenz, Heiner Schaal, Thilo Kaehne, Stefan Klinker, Tao Zhang, Luitgard Nagel-Steger, Dieter Willbold, Sabine Seggewiss, David Schluetermann, Bjoern Stork, Matthias Grimmler, Sebastian Wesselborg, Christoph Peter
Summary: The biogenesis of UsnRNPs relies on the methylation of Sm proteins and the SMN complex. ULK1 functions as a key regulator in UsnRNP biogenesis by phosphorylating pICIn, affecting the precursor Sm ring structure and core assembly efficiency. ULK1 has different functions in autophagy or snRNP biosynthesis depending on its complex formation.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Cell Biology
Jana Deitersen, Lena Berning, Fabian Stuhldreier, Sara Ceccacci, David Schluetermann, Annabelle Friedrich, Wenxian Wu, Yadong Sun, Philip Boehler, Niklas Berleth, Maria Jose Mendiburo, Sabine Seggewiss, Ruchika Anand, Andreas S. Reichert, Maria Chiara Monti, Peter Proksch, Bjoern Stork
Summary: High-throughput screening identified arzanol as a novel autophagy-modulating drug that not only induces early autophagosome biogenesis but also inhibits later autophagy events. Arzanol sensitizes bladder cancer cells to cisplatin and induces mitochondrial fragmentation, suggesting its potential as a lead compound for cancer therapy. The compound targets proteins related to mitochondria-associated quinone-binding oxidoreductases, making it a valuable tool for autophagy research.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
David Schluetermann, Niklas Berleth, Jana Deitersen, Nora Wallot-Hieke, Olena Friesen, Wenxian Wu, Fabian Stuhldreier, Yadong Sun, Lena Berning, Annabelle Friedrich, Maria Jose Mendiburo, Christoph Peter, Constanze Wiek, Helmut Hanenberg, Anja Stefanski, Kai Stuehler, Bjoern Stork
Summary: TBK1 is recruited to SQSTM1/p62-containing aggregates via the autophagy receptor TAX1BP1, where it phosphorylates SQSTM1/p62 at serine 403 to regulate the clearance of these structures. Activation of TBK1 is significantly increased when autophagy-inducing component FIP200 is absent or unable to bind to TAX1BP1, suggesting FIP200 plays a role in the inducible activation of TBK1 at SQSTM1/p62 condensates.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
William Lovfors, Christian Simonsson, Ali M. Komai, Elin Nyman, Charlotta S. Olofsson, Gunnar Cedersund
Summary: The regulation of adiponectin exocytosis is important for understanding metabolic diseases associated with obesity. Mathematical modeling and simulation experiments have provided insights into the mechanisms of adiponectin exocytosis, particularly involving adrenergic signaling pathways. The model developed in this study successfully predicted adiponectin release dynamics and cAMP levels, contributing to a better understanding of the intricate regulation of adiponectin exocytosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Jan Cox, Lea Marie Esser, Maximilian Juedt, Katharina Schmitz, Kaja Reiffert, Matthias Grimmler, Bjorn Stork, Sebastian Wesselborg, Christoph Peter
Summary: Protein-arginine methylation is a common posttranslational modification essential to cellular processes, with PRMT5 playing a central role in mammals. The study explores the specific interaction of NF90 with the PRMT5-WD45-RioK1 complex and reveals the symmetrical dimethylation of NF90 by PRMT5. Understanding PRMT5 function and its modulation by commercial inhibitors in cancer cells could provide insight into its role in cancer.
BIOLOGICAL CHEMISTRY
(2022)
Article
Endocrinology & Metabolism
Marco Bauza-Thorbrugge, Elin Banke, Belen Chanclon, Eduard Peris, Yanling Wu, Saliha Musovic, Cecilia Jonsson, Peter Stralfors, Patrik Rorsman, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm
Summary: This study found that SERCA2 expression is downregulated in adipocytes from obese and type-2 diabetes patients, and ablation of SERCA2 leads to disturbed calcium homeostasis, impaired hormone secretion, and abnormal glucose metabolism in adipocytes. Furthermore, adipocyte-specific SERCA2 knockout also affects glucose uptake in white and brown adipose tissue, which is associated with regulated mitochondrial function.
MOLECULAR METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Giusy Ferraro, Raffaella Belvedere, Antonello Petrella, Alessandra Tosco, Bjoern Stork, Stefano Salamone, Alberto Minassi, Federica Pollastro, Elva Morretta, Maria Chiara Monti
Summary: Artemetin interacts directly with filamins A and B in HeLa cells, leading to the disruption of the cell cytoskeleton and actin filaments, and ultimately blocking cell migration. This compound has potential anti-cancer and anti-inflammatory effects.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Christian Simonsson, William Lovfors, Niclas Bergqvist, Elin Nyman, Peter Gennemark, Karin G. Stenkula, Gunnar Cedersund
Summary: Insulin resistance leads to excessive insulin secretion, which can eventually result in beta-cell failure and type 2 diabetes (T2D). In order to study the progression of T2D, a complex disease involving multiple processes on different scales, a mathematical model of mice with insulin resistance was developed. This model successfully explained multi-scale data on insulin resistance in mice and made predictions that were supported by new experimental data. Additionally, the model was extended to simulate scenarios of T2D progression, providing insights and predictions on non-measured processes. Overall, this in silico mouse model is a valuable tool for studying T2D and can help in simulating treatment strategies and translating findings to humans.
BIOCHEMICAL ENGINEERING JOURNAL
(2023)
Article
Cell Biology
Fabian Stuhldreier, Laura Schmitt, Thomas Lenz, Ilka Hinxlage, Marcel Zimmermann, Philipp Wollnitzke, Julian Schliehe-Diecks, Yang Liu, Paul Jaeger, Stefanie Geyh, Nicole Teusch, Christoph Peter, Sanil Bhatia, Rainer Haas, Bodo Levkau, Andreas S. Reichert, Kai Stuehler, Peter Proksch, Bjoern Stork, Sebastian Wesselborg
Summary: Viriditoxin (VDT), derived from Cladosporium cladosporioides, shows promising potential as a candidate for leukemia and lymphoma treatment. It exhibits high cytotoxicity in leukemia and lymphoma cells, while having minimal impact on solid tumor cells. Furthermore, VDT does not affect hematopoietic stem and progenitor cells, making it a potentially effective and safe therapeutic approach.
CELL DEATH & DISEASE
(2022)
Article
Mathematical & Computational Biology
William Loevfors, Rasmus Magnusson, Cecilia Joensson, Mika Gustafsson, Charlotta S. Olofsson, Gunnar Cedersund, Elin Nyman
Summary: We developed a method to establish a core model of adipocyte signaling by connecting existing models and using phosphoproteomic data and protein interaction knowledge. By adding validated phosphosites layer by layer, we can predict systems-wide alterations in adipocytes in type 2 diabetes.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Lea Marie Esser, Katharina Schmitz, Frank Hillebrand, Steffen Erkelenz, Heiner Schaal, Matthias Grimmler, Sebastian Wesselborg, Christoph Peter
Summary: The spliceosome, consisting of UsnRNPs, plays a crucial role in the production of mature protein-coding transcripts of eukaryotic intron-containing genes. The assembly of UsnRNPs depends on the arginine methylation of Sm proteins by the PRMT5 complex and the phosphorylation of the PRMT5 subunit pICln by ULK1. However, the detailed mechanisms of phosphorylation-dependent integrity and UsnRNP assembly of the 6 S complex have not been fully analyzed yet.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Cell Biology
Zehan Hu, Devanarayanan Siva Sankar, Bich Vu, Alexandre Leytens, Christine Vionnet, Wenxian Wu, Michael Stumpe, Esther Martinez-Martinez, Bjoern Stork, Joern Dengjel
Summary: ULK1 kinase complex is a key regulator of autophagy, phosphorylating autophagy-relevant proteins for autophagosome maturation and turnover. It also interacts closely with various phosphatase complexes, such as PP2A, to coordinate protein degradation through autophagy.
