Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

(2016) Annelies Quaegebeur et al.   Cell Metabolism

The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise

(2014) C. Reuther et al.   APOPTOSIS

Pifithrin-α provides neuroprotective effects at the level of mitochondria independently of p53 inhibition

(2014) Sandra Neitemeier et al.   APOPTOSIS

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

(2014) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Metabolic control of cell death

(2014) D. R. Green et al.   SCIENCE

3-Hydroxybutyrate methyl ester as a potential drug against Alzheimer's disease via mitochondria protection mechanism

(2013) Junyu Zhang et al.   BIOMATERIALS

Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition: Robust New Target or Another Big Bust for Stroke Therapeutics?

(2012) Saravanan S Karuppagounder et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Roles of individual prolyl-4-hydroxylase isoforms in the first 24 hours following transient focal cerebral ischaemia: insights from genetically modified mice

(2012) Ruo-Li Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

HIF-independent role of prolyl hydroxylases in the cellular response to amino acids

(2012) R V Durán et al.   ONCOGENE

Physical exercise as a possible strategy for brain protection: Evidence from mitochondrial-mediated mechanisms

(2012) Inês Marques-Aleixo et al.   PROGRESS IN NEUROBIOLOGY

Neuron-Specific Prolyl-4-Hydroxylase Domain 2 Knockout Reduces Brain Injury After Transient Cerebral Ischemia

(2012) Reiner Kunze et al.   STROKE

Mutation of ATF4 mediates resistance of neuronal cell lines against oxidative stress by inducing xCT expression

(2011) J Lewerenz et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective effects and mechanisms of exercise in a chronic mouse model of Parkinson’s disease with moderate neurodegeneration

(2011) Yuen-Sum Lau et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

PHD1 interacts with ATF4 and negatively regulates its transcriptional activity without prolyl hydroxylation

(2011) Yusuke Hiwatashi et al.   EXPERIMENTAL CELL RESEARCH

Adaptation to moderate hypoxia protects cortical neurons against ischemia–reperfusion injury and excitotoxicity independently of HIF-1α

(2011) Dongdong Li et al.   EXPERIMENTAL NEUROLOGY

Impedance measurement for real time detection of neuronal cell death

(2011) S. Diemert et al.   JOURNAL OF NEUROSCIENCE METHODS

Inhibition of prolyl hydroxylases by dimethyloxaloylglycine after stroke reduces ischemic brain injury and requires hypoxia inducible factor-1α

(2011) Molly E. Ogle et al.   NEUROBIOLOGY OF DISEASE

Bid-mediated mitochondrial damage is a key mechanism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons

(2010) S Tobaben et al.   CELL DEATH AND DIFFERENTIATION

Utilization of an In Vivo Reporter for High Throughput Identification of Branched Small Molecule Regulators of Hypoxic Adaptation

(2010) Natalya A. Smirnova et al.   CHEMISTRY & BIOLOGY

ROS leads to MnSOD upregulation through ERK2 translocation and p53 activation in selenite-induced apoptosis of NB4 cells

(2010) Zhushi Li et al.   FEBS LETTERS

Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells

(2010) Masayuki Fukui et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroprotection by Dimethyloxalylglycine following Permanent and Transient Focal Cerebral Ischemia in Rats

(2010) Simon Nagel et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

(2010) Vishal M Gohil et al.   NATURE BIOTECHNOLOGY

Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1α and induction of autophagy in SH-SY5Y cells

(2010) Yuncheng Wu et al.   NEUROCHEMISTRY INTERNATIONAL

Cell Death Mechanisms and Their Implications in Toxicology

(2010) Sten Orrenius et al.   TOXICOLOGICAL SCIENCES

HIF Prolyl Hydroxylase Inhibitors Prevent Neuronal Death Induced by Mitochondrial Toxins: Therapeutic Implications for Huntington's Disease and Alzheimer's Disease

(2009) Zoya Niatsetskaya et al.   ANTIOXIDANTS & REDOX SIGNALING

Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death

(2009) Julia Grohm et al.   BRAIN BEHAVIOR AND IMMUNITY

Control of Cyclin D1 and Breast Tumorigenesis by the EglN2 Prolyl Hydroxylase

(2009) Qing Zhang et al.   CANCER CELL

Inhibition of Prolyl Hydroxylase Protects against 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity

(2009) Donna W. Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress

(2009) Stefanie Pallast et al.   JOURNAL OF NEUROCHEMISTRY

Selective Inhibition of Hypoxia-Inducible Factor (HIF) Prolyl-Hydroxylase 1 Mediates Neuroprotection against Normoxic Oxidative Death via HIF- and CREB-Independent Pathways

(2009) A. Siddiq et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Oxygen-Regulated  2-Adrenergic Receptor Hydroxylation by EGLN3 and Ubiquitylation by pVHL

(2009) L. Xie et al.   Science Signaling

Bid-induced release of AIF from mitochondria causes immediate neuronal cell death

(2008) S Landshamer et al.   CELL DEATH AND DIFFERENTIATION

Basal Levels of eIF2α Phosphorylation Determine Cellular Antioxidant Status by Regulating ATF4 and xCT Expression

(2008) Jan Lewerenz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATF4 is an oxidative stress–inducible, prodeath transcription factor in neurons in vitro and in vivo

(2008) Philipp S. Lange et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The von Hippel-Lindau Tumor Suppressor Protein and Egl-9-Type Proline Hydroxylases Regulate the Large Subunit of RNA Polymerase II in Response to Oxidative Stress

(2008) O. Mikhaylova et al.   MOLECULAR AND CELLULAR BIOLOGY

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS