A diversity-oriented synthesis of bioactive benzanilides via a regioselective C(sp2)–H hydroxylation strategy

Directortho-Hydroxylation of 2-Phenylpyridines using Palladium(II) Chloride and Hydrogen Peroxide

(2015) Tomoaki Yamaguchi et al.   ADVANCED SYNTHESIS & CATALYSIS

Palladium catalyzed Csp2–H activation for direct aryl hydroxylation: the unprecedented role of 1,4-dioxane as a source of hydroxyl radicals

(2015) Kapileswar Seth et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Aryl C(sp2)–H Bond Hydroxylation of 2-Arylpyridine Using TBHP as Oxidant

(2015) Jiawei Dong et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis and characterization of hexaarylbenzenes with five or six different substituents enabled by programmed synthesis

(2015) Shin Suzuki et al.   Nature Chemistry

Improving Physical Properties via CH Oxidation: Chemical and Enzymatic Approaches

(2014) Quentin Michaudel et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aldehyde-Assisted Ruthenium(II)-Catalyzed CH Oxygenations

(2014) Fanzhi Yang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Intramolecular Metal-Free Oxidative Aryl-Aryl Coupling: An Unusual Hypervalent-Iodine-Mediated Rearrangement of 2-SubstitutedN-Phenylbenzamides

(2014) Siyun Shang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ortho-Benzoxylation ofN-Alkyl Benzamides with Aromatic Acids Catalyzed by Ruthenium(II) Complex

(2014) Kishor Padala et al.   CHEMISTRY-A EUROPEAN JOURNAL

Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting

(2014) Major Gooyit et al.   JOURNAL OF MEDICINAL CHEMISTRY

Modified Salicylanilide and 3-Phenyl-2H-benzo[e][1,3]oxazine-2,4(3H)-dione Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption

(2014) Chun-Liang Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Combined Experimental and Computational Investigations of Rhodium- and Ruthenium-Catalyzed C–H Functionalization of Pyrazoles with Alkynes

(2014) Andrés G. Algarra et al.   JOURNAL OF ORGANIC CHEMISTRY

Two-Phase Synthesis of (−)-Taxuyunnanine D

(2014) Nathan C. Wilde et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Switching the Enantioselectivity in Catalytic [4 + 1] Cycloadditions by Changing the Metal Center: Principles of Inverting the Stereochemical Preference of an Asymmetric Catalysis Revealed by DFT Calculations

(2014) Shivnath Mazumder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Facile BPO-Mediated ortho-Hydroxylation and Benzoylation of N-Alkyl Anilines for Synthesis of 2-Benzamidophenols

(2014) Zhi-Jing Zhang et al.   ORGANIC LETTERS

Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary

(2014) Xin Li et al.   ORGANIC LETTERS

Diversity-oriented synthesis as a tool for identifying new modulators of mitosis

(2014) Brett M. Ibbeson et al.   Nature Communications

Regio- and Chemoselective CH Chlorination/Bromination of Electron-Deficient Arenes by Weak Coordination and Study of Relative Directing-Group Abilities

(2013) Xiuyun Sun et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

PdCl2andN-Hydroxyphthalimide Co-catalyzed C sp 2H Hydroxylation by Dioxygen Activation

(2013) Yuepeng Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ruthenium-catalyzed oxidative ortho-benzoxylation of acetanilides with aromatic acids

(2013) Kishor Padala et al.   CHEMICAL COMMUNICATIONS

C–H nitrogenation and oxygenation by ruthenium catalysis

(2013) Vedhagiri S. Thirunavukkarasu et al.   CHEMICAL COMMUNICATIONS

Palladium-Catalyzed Meta-Selective C–H Bond Activation with a Nitrile-Containing Template: Computational Study on Mechanism and Origins of Selectivity

(2013) Yun-Fang Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Role of N-Acyl Amino Acid Ligands in Pd(II)-Catalyzed Remote C–H Activation of Tethered Arenes

(2013) Gui-Juan Cheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling

(2013) Henning S. G. Beckmann et al.   Nature Chemistry

Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate

(2013) Jing Li et al.   Nature Chemistry

Broadening the catalyst and reaction scope of regio- and chemoselective C–H oxygenation: a convenient and scalable approach to 2-acylphenols by intriguing Rh(ii) and Ru(ii) catalysis

(2013) Gang Shan et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Ortho- and Para-Selective Ruthenium-Catalyzed C(sp2)–H Oxygenations of Phenol Derivatives

(2013) Weiping Liu et al.   ORGANIC LETTERS

Synthesis of 2-Aminophenols and Heterocycles by Ru-Catalyzed C–H Mono- and Dihydroxylation

(2013) Xinglin Yang et al.   ORGANIC LETTERS

Ruthenium-Catalyzed C–H Oxygenation on Aryl Weinreb Amides

(2013) Fanzhi Yang et al.   ORGANIC LETTERS

Palladium-Catalyzed ortho-CH-Bond Oxygenation of Aromatic Ketones

(2013) Pui Ying Choy et al.   ORGANIC LETTERS

Pd(II)-Catalyzed C(sp2)–H Hydroxylation with R2(O)P-Coordinating Group

(2013) Hong-Yu Zhang et al.   ORGANIC LETTERS

Methane CH Activation by Palladium Complexes with Chelating Bis(NHC) Ligands: A DFT Study

(2013) Dominik Munz et al.   ORGANOMETALLICS

Strategic Redox Relay Enables A Scalable Synthesis of Ouabagenin, A Bioactive Cardenolide

(2013) H. Renata et al.   SCIENCE

Regioselective ortho-hydroxylation of 2-arylbenzothiazole via substrate directed C–H activation

(2013) Arghya Banerjee et al.   TETRAHEDRON

Palladium-catalyzed C–H activation of anilides at room temperature: ortho-arylation and acetoxylation

(2013) Fan Yang et al.   RSC Advances

Pd-Catalyzed CH Oxygenation with TFA/TFAA: Expedient Access to Oxygen-Containing Heterocycles and Late-Stage Drug Modification

(2012) Gang Shan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis and Structure-Activity Relationship Studies of HIV-1 Virion Infectivity Factor (Vif) Inhibitors that Block Viral Replication

(2012) Akbar Ali et al.   ChemMedChem

Pharmacophore-Based Virtual Screening and Biological Evaluation of Small Molecule Inhibitors for Protein Arginine Methylation

(2012) Juxian Wang et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Substituted Phenoxazine and Acridone Derivatives: Structure–Activity Relationships of Potent P2X4 Receptor Antagonists

(2012) Victor Hernandez-Olmos et al.   JOURNAL OF MEDICINAL CHEMISTRY

Antimycobacterial Assessment of Salicylanilide Benzoates including Multidrug-Resistant Tuberculosis Strains

(2012) Martin Krátký et al.   MOLECULES

Biomimetic diversity-oriented synthesis of benzannulated medium rings via ring expansion

(2012) Renato A Bauer et al.   Nature Chemical Biology

A diversity-oriented synthesis approach to macrocycles via oxidative ring expansion

(2012) Felix Kopp et al.   Nature Chemical Biology

Ruthenium-Catalyzed Oxidative C(sp2)–H Bond Hydroxylation: Site-Selective C–O Bond Formation on Benzamides

(2012) Vedhagiri S. Thirunavukkarasu et al.   ORGANIC LETTERS

Ruthenium(II)-Catalyzed Synthesis of Hydroxylated Arenes with Ester as an Effective Directing Group

(2012) Yiqing Yang et al.   ORGANIC LETTERS

Ruthenium-Catalyzed C–H Bond Oxygenations with Weakly Coordinating Ketones

(2012) Vedhagiri S. Thirunavukkarasu et al.   ORGANIC LETTERS

Innate and Guided C–H Functionalization Logic

(2011) Tobias Brückl et al.   ACCOUNTS OF CHEMICAL RESEARCH

Weak Coordination as a Powerful Means for Developing Broadly Useful C–H Functionalization Reactions

(2011) Keary M. Engle et al.   ACCOUNTS OF CHEMICAL RESEARCH

Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope

(2011) Lutz Ackermann   CHEMICAL REVIEWS

Discovery ofN-[2-Hydroxy-6-(4-methoxybenzamido)phenyl]-4- (4-methyl-1,4-diazepan-1-yl)benzamide (Darexaban, YM150) as a Potent and Orally Available Factor Xa Inhibitor

(2011) Fukushi Hirayama et al.   JOURNAL OF MEDICINAL CHEMISTRY

Analysis of the Palladium-Catalyzed (Aromatic)C–H Bond Metalation–Deprotonation Mechanism Spanning the Entire Spectrum of Arenes

(2011) Serge I. Gorelsky et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium-Catalyzed Intermolecular Directed C−H Amidation of Aromatic Ketones

(2011) Bin Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Theoretical Analysis of the Mechanism of Palladium(II) Acetate-Catalyzed Oxidative Heck Coupling of Electron-Deficient Arenes with Alkenes: Effects of the Pyridine-Type Ancillary Ligand and Origins of themeta-Regioselectivity

(2011) Songlin Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Autocatalysis for C–H Bond Activation by Ruthenium(II) Complexes in Catalytic Arylation of Functional Arenes

(2011) Emmanuel Ferrer Flegeau et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Key Mechanistic Features of Enantioselective C–H Bond Activation Reactions Catalyzed by [(Chiral Mono-N-Protected Amino Acid)–Pd(II)] Complexes

(2011) Djamaladdin G. Musaev et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanistic Insight into Direct Arylations with Ruthenium(II) Carboxylate Catalysts

(2010) Lutz Ackermann et al.   ORGANIC LETTERS

Electrophilic, Ambiphilic, and Nucleophilic C−H Bond Activation: Understanding the Electronic Continuum of C−H Bond Activation Through Transition-State and Reaction Pathway Interaction Energy Decompositions

(2010) Daniel H. Ess et al.   ORGANOMETALLICS

Ligand Lone-Pair Influence on Hydrocarbon C−H Activation: A Computational Perspective△

(2010) Daniel H. Ess et al.   ORGANOMETALLICS

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

(2010) Warren R.J.D. Galloway et al.   Nature Communications

Discovery of a Small-Molecule Inhibitor of the KIX–KID Interaction

(2009) Bingbing X. Li et al.   CHEMBIOCHEM

C–H activation in strongly acidic media. The co-catalytic effect of the reaction medium

(2009) Mårten Ahlquist et al.   CHEMICAL COMMUNICATIONS

Mechanisms of C–H bond activation: rich synergy between computation and experiment

(2009) Youcef Boutadla et al.   DALTON TRANSACTIONS

Mechanistic Comparison between Pd-Catalyzed Ligand-Directed C−H Chlorination and C−H Acetoxylation

(2009) Kara J. Stowers et al.   ORGANIC LETTERS

Mechanism based QSAR studies of N-phenylbenzamides as antimicrobial agents

(2008) F.A. Pasha et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Direct Ortho-Acetoxylation of Anilides via Palladium-Catalyzed sp2C−H Bond Oxidative Activation

(2008) Guan-Wu Wang et al.   JOURNAL OF ORGANIC CHEMISTRY

Insights into Directing Group Ability in Palladium-Catalyzed C−H Bond Functionalization

(2008) Lopa V. Desai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of 1,2- and 1,3-Dicarboxylic Acids via Pd(II)-Catalyzed Carboxylation of Aryl and Vinyl C−H Bonds

(2008) Ramesh Giri et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Towards the Optimal Screening Collection: A Synthesis Strategy

(2007) Thomas E. Nielsen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION