Simultaneous structure–activity studies and arming of natural products by C–H amination reveal cellular targets of eupalmerin acetate

A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products

(2013) Robert W. Huigens III et al.   Nature Chemistry

An Approach to the Site-Selective Deoxygenation of Hydroxy Groups Based on Catalytic Phosphoramidite Transfer

(2012) Peter A. Jordan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010

(2012) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Intermolecular Ritter-Type C–H Amination of Unactivated sp3 Carbons

(2012) Quentin Michaudel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fully Functionalized Small-Molecule Probes for Integrated Phenotypic Screening and Target Identification

(2012) Justin S. Cisar et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cyclopropanations of Olefin-Containing Natural Products for Simultaneous Arming and Structure Activity Studies

(2012) Omar Robles et al.   ORGANIC LETTERS

Diazo Reagents with Small Steric Footprints for Simultaneous Arming/SAR Studies of Alcohol-Containing Natural ProductsviaO–H Insertion

(2011) Supakarn Chamni et al.   ACS Chemical Biology

Development of a Flexible Strategy towards FR900482 and the Mitomycins

(2011) Barry M. Trost et al.   CHEMISTRY-A EUROPEAN JOURNAL

Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

(2011) Hui-Xiong Dai et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Examination of thromboxane synthase as a prognostic factor and therapeutic target in non-small cell lung cancer

(2011) Mary-Clare Cathcart et al.   Molecular Cancer

Remodelling of the natural product fumagillol employing a reaction discovery approach

(2011) Bradley R. Balthaser et al.   Nature Chemistry

Stereoselective Rhodium-Catalyzed Amination of Alkenes

(2011) Hélène Lebel et al.   ORGANIC LETTERS

Organic synthesis toward small-molecule probes and drugs

(2011) S. L. Schreiber   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Natural Products as Chemical Probes

(2010) Erin E. Carlson   ACS Chemical Biology

Proteomic Analysis Provides Insights on Venom Processing inConus textile

(2010) Lemmuel L. Tayo et al.   JOURNAL OF PROTEOME RESEARCH

Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)

(2010) Derek Murphy et al.   Molecular Cancer

Role of the 18:1 Lysophosphatidic Acid-Ovarian Cancer Immunoreactive Antigen Domain Containing 1 (OCIAD1)-Integrin Axis in Generating Late-Stage Ovarian Cancer

(2010) C. Wang et al.   MOLECULAR CANCER THERAPEUTICS

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

Mild Arming and Derivatization of Natural Products via an In(OTf)3-Catalyzed Arene Iodination

(2010) Cong-Ying Zhou et al.   ORGANIC LETTERS

The economies of synthesis

(2009) Timothy Newhouse et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of substitutedN-[4(5-methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene sulfonamides as anti-inflammatory and anti-cancer agents

(2009) Madhavi Gangapuram et al.   JOURNAL OF HETEROCYCLIC CHEMISTRY

Understanding the Differential Performance of Rh2(esp)2as a Catalyst for C−H Amination

(2009) David N. Zalatan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identifying the proteins to which small-molecule probes and drugs bind in cells

(2009) S.-E. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drug Discovery and Natural Products: End of an Era or an Endless Frontier?

(2009) J. W.-H. Li et al.   SCIENCE

Mitochondrial voltage-dependent anion channels (VDACs) as novel pharmacological targets for anti-cancer agents

(2008) Eriko Simamura et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion

(2008) Huw M. L. Davies et al.   NATURE