Article
Immunology
Arturo Gonzalez de la Aleja, Cristina Herrero, Monica Torres-Torresano, Juan Vladimir de la Rosa, Barbara Alonso, Enrique Capa-Sardon, Ittai B. Muller, Gerrit Jansen, Amaya Puig-Kroeger, Miguel A. Vega, Antonio Castrillo, Angel L. Corbi
Summary: LXR activation limits the anti-inflammatory polarization of human macrophages and promotes the acquisition of an inflammatory profile, which is associated with the expression of specific genes and the release of activin A.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Isidora Panez-Toro, Dominique Heymann, Francois Gouin, Jerome Amiaud, Marie-Francoise Heymann, Luis A. Cordova
Summary: This review discusses the role of non-myelomonocytic cells in periprosthetic tissues exposed to wear particles. T cells and B cells are found to coexist with multinucleated giant cells in periprosthetic membranes infiltrated by polyethylene and metallic particles.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Lauren Daniel, Marion Tassery, Clara Lateur, Antoine Thierry, Andre Herbelin, Jean-Marc Gombert, Alice Barbarin
Summary: Immunosenescence is a physiological process associated with changes in the immune system, particularly involving CD8 T cells. The newly described innate E(+) CD8 T cells may exhibit an exacerbated senescent phenotype in a chronic inflammatory environment, especially in kidney transplant and cytomegalovirus-infected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Angela Saez, Beatriz Herrero-Fernandez, Raquel Gomez-Bris, Hector Sanchez-Martinez, Jose M. M. Gonzalez-Granado
Summary: Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), is a chronic intestinal inflammation with an unknown cause. Innate immune cells (IICs), such as neutrophils, monocytes, macrophages, and dendritic cells, play a crucial role in defending against pathogens and maintaining immune tolerance. An imbalance in the innate immune response is closely linked to intestinal inflammation and IBD. Understanding the mechanisms and interactions of IICs with other immune cells is essential for developing effective therapies for IBD patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Miguel Reyes, Samantha M. Leff, Matteo Gentili, Nir Hacohen, Paul C. Blainey
Summary: Cells respond to various signals by adopting complex transcriptional states. Most single-cell profiling is done at baseline, ignoring cells' potential functional responses. Single-cell genomics combined with multiplexing techniques provide a useful tool for characterizing cell states across experimental conditions.
Article
Computer Science, Hardware & Architecture
Dongmei Wang, Yiwen Liang, Xinmin Yang
Summary: A novel natural killer cell algorithm (NKA) inspired by NK cells' mechanism constructs phenotype detectors based on pathogen dose. NKA optimizes the detectors and establishes k-d tree for the optimized phenotype, leading to the best performance with fewer detectors and higher efficiency in training and detection phases. Compared with three versions of distance-based NSA algorithms, NKA shows comparable results and efficiency, as well as performance compared with six popular machine learning algorithms.
JOURNAL OF SUPERCOMPUTING
(2022)
Article
Microbiology
Tiphaine M. N. Camarasa, Julia A. Torne, Christine Chevalier, Orhan A. Rasid, Melanie Hamon
Summary: NK cells have been found to exhibit memory properties, leading to a stronger secondary response upon reinfection. However, their memory functions in bacterial infections have not been fully understood. Using Streptococcus pneumoniae as a model bacterium, we show that NK cells develop specific and long-term memory, providing protection against lethal infection for at least 12 weeks. Memory NK cells produce more cytotoxic molecules upon secondary stimulation. These findings uncover a new role for NK cells in the context of bacterial infections, opening possibilities for therapeutic applications.
Review
Oncology
Alaa Kassim Ali, Mubin Tarannum, Rizwan Romee
Summary: The success of checkpoint blockade and adoptive cell therapy has brought new hope to cancer immunotherapy, but there are limitations and severe adverse effects that need to be addressed. Research on innate immune cells and their potential in therapy is crucial for further advancements in the field.
Article
Immunology
Xiaowu Bai, Weixin Liu, Hongxia Chen, Tao Zuo, Xiaojian Wu
Summary: By analyzing RNA-seq data from patients with IBD (including CD and UC) and healthy individuals, this study revealed increased numbers of immune cells in different intestinal regions and disease-specific immune features in CD and UC. These findings provide important insights into the pathogenesis of IBD and serve as a valuable resource for future targeted studies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Guzel Rafikova, Svetlana Piatnitskaia, Elena Shapovalova, Svyatoslav Chugunov, Victor Kireev, Daria Ialiukhova, Azat Bilyalov, Valentin Pavlov, Julia Kzhyshkowska
Summary: The immuno-compatibility of ceramic implants, which depends on the interaction with immune cells, is still insufficiently understood and requires intensive experimental research. This review summarizes the state of the art in ceramic implants, including their mechanical properties, chemical modifications, surface structures, and shapes. The gaps in knowledge are identified, and the possibilities for further research using advanced quantitative technologies are outlined.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Congmin Xu, Junkai Yang, Astrid Kosters, Benjamin R. Babcock, Peng Qiu, Eliver E. B. Ghosn
Summary: Single-cell transcriptomics allows for the identification of diverse human immune cell types and can be improved through integration of multiple single-cell omics. We developed SuPERR, an analysis workflow that enhances clustering resolution and accuracy, leading to the discovery of hidden cell subsets. By incorporating information from cell-surface proteins and immunoglobulin transcript counts, SuPERR effectively removes cell doublets and prevents misclassification of cell types, improving identification of heterogeneous cell types and states in the human immune system.
Article
Immunology
Sneha M. Pinto, Hera Kim, Yashwanth Subbannayya, Miriam S. Giambelluca, Korbinian Bosl, Liv Ryan, Animesh Sharma, Richard K. Kandasamy
Summary: The study demonstrated the impact of variations in PMA concentration and post-stimulation rest duration on the protein expression and cellular signaling processes in macrophage-like cells, leading to altered inflammatory responses and cytokine expression levels. This provides valuable insights into the dynamics of protein expression with common in vitro macrophage models, significantly expanding knowledge in immune and inflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biology
Marie Marotel, Marine Villard, Annabelle Drouillard, Issam Tout, Laurie Besson, Omran Allatif, Marine Pujol, Yamila Rocca, Michelle Ainouze, Guillaume Roblot, Sebastien Viel, Melissa Gomez, Veronique Loustaud, Sophie Alain, David Durantel, Thierry Walzer, Uzma Hasan, Antoine Marcais
Summary: Impaired function of NK cells in CHB patients may be associated with reduced expression of NKp30, CD16, and defective mTOR pathway activity. NK cell dysfunction and T cell exhaustion may share common mechanisms, including the impact of TOX transcription factor and NFAT on NK cell function.
Review
Cell Biology
Zhigang Guo, Lixue Wang, Hongjian Liu, Yuhuai Xie
Summary: Atherosclerosis is a metabolic disease characterized by lipid metabolism dysfunction and chronic inflammation. Recent studies have shown that monocytes and macrophages can establish innate immune memory, leading to a proinflammatory phenotype. These cells undergo changes in cellular metabolism and epigenetic modifications, contributing to the development of atherosclerosis.
Article
Immunology
Margaux Vienne, Marion Etiennot, Bertrand Escaliere, Justine Galluso, Lionel Spinelli, Sophie Guia, Aurore Fenis, Eric Vivier, Yann M. Kerdiles
Summary: NK cells are known to have cytotoxic effects on tumor cell lines, but their specific roles in primary tumor detection and elimination remain unclear. ILC1 play an active role in inhibiting the antitumoral immune response, suggesting the need to evaluate the tumor infiltration of ILC1 and NK cells to optimize immune harnessing in cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Katie L. O'Brien, Nadine Assmann, Eimear O'Connor, Cathal Keane, Jessica Walls, Chloe Choi, Peter J. Oefner, Clair M. Gardiner, Katja Dettmer, David K. Finlay
Summary: Cellular metabolism plays a crucial role in regulating NK cell responses, with SREBP and cMyc controlling metabolic and functional responses. Polyamine synthesis is essential for NK cell glycolytic and oxidative metabolism, while spermidine supports protein translation. Inhibition of hypusination impacts NK cell metabolism and effector functions.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Correction
Immunology
Mihai G. Netea, Frances Balkwill, Michel Chonchol, Fabio Cominelli, Marc Y. Donath, Evangelos J. Giamarellos-Bourboulis, Douglas Golenbock, Mark S. Gresnigt, Michael T. Heneka, Hal M. Hoffman, Richard Hotchkiss, Leo A. B. Joosten, Daniel L. Kastner, Martin Korte, Eicke Latz, Peter Libby, Thomas Mandrup-Poulsen, Alberto Mantovani, Kingston H. G. Mills, Kristen L. Nowak, Luke A. O'Neill, Peter Pickkers, Tom van der Poll, Paul M. Ridker, Joost Schalkwijk, David A. Schwartz, Britta Siegmund, Clifford J. Steer, Herbert Tilg, Jos W. M. van der Meer, Frank L. van de Veerdonk, Charles A. Dinarello
Article
Immunology
Kyle T. Cunningham, Conor M. Finlay, Kingston H. G. Mills
Summary: These findings demonstrate that helminth products can modulate HSCs to promote development of anti-inflammatory myeloid cells that attenuate T cell-mediated autoimmune disease.
JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Kyle T. Cunningham, Kingston H. G. Mills
Summary: Current therapeutics for preventing or treating allograft rejection in transplant patients mainly target T cells, but recent advances in transplant immunology have shown the importance of innate immune responses. Trained innate immunity, where innate immune cells undergo memory-like responses, could play a crucial role in transplantation rejection and tolerance. Targeting the mechanisms of training innate immune cells in the bone marrow may offer potential for long-term solid organ and HSC transplant tolerance.
Article
Oncology
Karen Slattery, Elena Woods, Vanessa Zaiatz-Bittencourt, Sam Marks, Sonya Chew, Michael Conroy, Caitriona Goggin, Colm MacEochagain, John Kennedy, Sophie Lucas, David K. Finlay, Clair M. Gardiner
Summary: Patients with metastatic breast cancer exhibit metabolic deficits in circulating NK cells, including reduced glycolysis and oxidative phosphorylation, as well as morphological alterations in mitochondria. Transforming growth factor-beta (TGFβ) is identified as a key driver of this phenotype. Blocking TGFβ and/or GARP can restore NK cell metabolism and function, presenting a novel target for improving NK cell-based immunotherapies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Immunology
Lisa Borkner, Lucy M. Curham, Mieszko M. Wilk, Barry Moran, Kingston H. G. Mills
Summary: Understanding the mechanism of protective immunity in the nasal mucosae is crucial for effective vaccine design against Bordetella pertussis. IL-17 plays a critical role in both natural and acquired immunity to pertussis in the nasal mucosae, mobilizing neutrophils, especially Siglec-F+ neutrophils. Depletion of CD4 T cells delays bacterial clearance, while IL-17-producing CD4(+) T-RM cells aid in rapid clearance of bacteria from the nasal cavity in re-infected mice.
MUCOSAL IMMUNOLOGY
(2021)
Correction
Immunology
Lisa Borkner, Lucy M. Curham, Mieszko M. Wilk, Barry Moran, Kingston H. G. Mills
MUCOSAL IMMUNOLOGY
(2021)
Review
Immunology
Dearbhla M. Murphy, Kingston H. G. Mills, Sharee A. Basdeo
Summary: Trained immunity, also known as innate immune training, involves the medium-term epigenetic and metabolic reprogramming of innate immune cells in response to an initial challenge, resulting in altered responses to subsequent challenges. It can lead to increased production of proinflammatory mediators, affect T cell responses, and create a new immune pattern that interacts with adaptive immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Lucy Ryan, Kingston H. G. Mills
Summary: Multiple sclerosis is an autoimmune disease of the central nervous system that affects over 2.5 million individuals worldwide, with striking sex differences in susceptibility and disease progression. Differences in immune responses between males and females may play a role in these disparities.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Infectious Diseases
Patrick Wg Mallon, Mary Horgan, Conor G. McAloon, Peter D. Lunn, Julian Little, Andrew Beck, Alexandria Bennett, Nicole Shaver, Aileen McConway, Rhea O'Regan, Barbara Whelan
Summary: This study describes the development of a risk assessment profile tool that utilizes data from various domains to identify activities and events where rapid antigen detection tests can be used to screen asymptomatic individuals and identify infectious cases, thus reducing the transmission of SARS-CoV-2.
Editorial Material
Oncology
Kingston H. G. Mills
Summary: In a recent study published in Nature Immunology, Bruchard et al. found that type 3 innate lymphoid cells, activated and recruited by cisplatin-induced chemokine ligand 20 (CCL20) and interleukin-1 beta (IL-1b), enhance CD4 and CD8 T cell infiltration in murine tumors, thus increasing responsiveness to immune checkpoint inhibitors.
Review
Immunology
Kyle T. Cunningham, Kingston H. G. Mills
Summary: During inflammation, haematopoietic stem cells (HSCs) rapidly expand in both the bone marrow (BM) and periphery, differentiating into myeloid cells to mediate innate immune responses. Parasite-induced haematopoiesis, which remains poorly understood, has recently been elucidated through advances in imaging, genomic sequencing, and mouse models. Parasites can modify the haematopoiesis in the BM and periphery, as well as induce long-lasting modifications to HSCs, affecting future immune responses and promoting chronic infections.
PARASITE IMMUNOLOGY
(2023)
Editorial Material
Immunology
Kingston H. G. Mills
Summary: Current acellular pertussis vaccines do not prevent nasal infection and transmission of Bordetella pertussis, but immunology is aiding in the design of new vaccines that induce sterilizing immunity.
Review
Immunology
Kingston H. G. Mills
Summary: IL-17 cytokines have both protective and pathological functions in the context of infection and autoimmunity. They promote protective immunity against pathogens but can also drive inflammatory pathology. Dysregulated IL-17 responses can contribute to immunopathology, and IL-17 is implicated in various inflammatory diseases.
NATURE REVIEWS IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Tristram A. J. Ryan, Alexander Hooftman, Aisling M. Rehill, Matt D. Johansen, Eoin C. O'Brien, Juliana E. Toller-Kawahisa, Mieszko M. Wilk, Emily A. Day, Hauke J. Weiss, Pourya Sarvari, Emilio G. Vozza, Fabian Schramm, Christian G. Peace, Alessia Zotta, Stefan Miemczyk, Christina Nalkurthi, Nicole G. Hansbro, Gavin McManus, Laura O'Doherty, Siobhan Gargan, Aideen Long, Jean Dunne, Cliona Ni Cheallaigh, Niall Conlon, Michael Carty, Padraic G. Fallon, Kingston H. G. Mills, Emma M. Creagh, James S. O'Donnell, Paul J. Hertzog, Philip M. Hansbro, Rachel M. McLoughlin, Malgorzata Wygrecka, Roger J. S. Preston, Zbigniew Zaslona, Luke A. J. O'Neill
Summary: Excessive inflammation-associated coagulation is a major cause of mortality in infectious diseases. Recent research has found that type I interferon signaling is necessary for the release of tissue factor, a critical initiator of coagulation, providing an important link between innate immunity and coagulation. DMF and 4-OI inhibit tissue factor-mediated coagulopathy through suppression of macrophage type I IFN-TF axis.
NATURE COMMUNICATIONS
(2023)
