Activation of LXR Nuclear Receptors Impairs the Anti-Inflammatory Gene and Functional Profile of M-CSF-Dependent Human Monocyte-Derived Macrophages

Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer

(2020) Min Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

LXR Activation Induces a Proinflammatory Trained Innate Immunity-Phenotype in Human Monocytes

(2020) Yahya Sohrabi et al.   Frontiers in Immunology

Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism

(2018) Cristina Municio et al.   ANNALS OF THE RHEUMATIC DISEASES

LXR/ApoE Activation Restricts Innate Immune Suppression in Cancer

(2018) Masoud F. Tavazoie et al.   CELL

Fetal monocytes and the origins of tissue-resident macrophages

(2018) Guillaume Hoeffel et al.   CELLULAR IMMUNOLOGY

Macrophages Switch Their Phenotype by Regulating Maf Expression during Different Phases of Inflammation

(2018) Kenta Kikuchi et al.   JOURNAL OF IMMUNOLOGY

Cell-specific discrimination of desmosterol and desmosterol mimetics confers selective regulation of LXR and SREBP in macrophages

(2018) Evan D. Muse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Activin A-Peroxisome Proliferator-Activated Receptor Gamma Axis Contributes to the Transcriptome of GM-CSF-Conditioned Human Macrophages

(2018) Concha Nieto et al.   Frontiers in Immunology

Liver X receptors link lipid metabolism and inflammation

(2017) Ira G. Schulman   FEBS LETTERS

MAFB Determines Human Macrophage Anti-Inflammatory Polarization: Relevance for the Pathogenic Mechanisms Operating in Multicentric Carpotarsal Osteolysis

(2017) Víctor D. Cuevas et al.   JOURNAL OF IMMUNOLOGY

The transcription factor MafB promotes anti-inflammatory M2 polarization and cholesterol efflux in macrophages

(2017) Hwijin Kim   Scientific Reports

Methotrexate selectively targets human proinflammatory macrophages through a thymidylate synthase/p53 axis

(2016) Cristina Municio et al.   ANNALS OF THE RHEUMATIC DISEASES

Atypical Activin A and IL-10 Production Impairs Human CD16+Monocyte Differentiation into Anti-Inflammatory Macrophages

(2016) Érika González-Domínguez et al.   JOURNAL OF IMMUNOLOGY

Biological role of granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) on cells of the myeloid lineage

(2016) Irina Ushach et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation

(2016) Daniel Savic et al.   Genome Medicine

Colony stimulating factor-1 receptor signaling networks inhibit mouse macrophage inflammatory responses by induction of microRNA-21

(2015) C. I. Caescu et al.   BLOOD

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

Retinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling

(2015) María P. Menéndez-Gutiérrez et al.   JOURNAL OF CLINICAL INVESTIGATION

CD163L1 and CLEC5A discriminate subsets of human resident and inflammatory macrophages in vivo

(2015) E. Gonzalez-Dominguez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile

(2014) Blanca Soler Palacios et al.   JOURNAL OF PATHOLOGY

The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release

(2013) Darren Lee Asquith et al.   ANNALS OF THE RHEUMATIC DISEASES

Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool

(2013) Edward Y Chen et al.   BMC BIOINFORMATICS

The role of lipid-activated nuclear receptors in shaping macrophage and dendritic cell function: From physiology to pathology

(2013) Mate Kiss et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Serotonin Skews Human Macrophage Polarization through HTR2B and HTR7

(2013) M. de las Casas-Engel et al.   JOURNAL OF IMMUNOLOGY

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

The nuclear receptor LXRα controls the functional specialization of splenic macrophages

(2013) Noelia A-Gonzalez et al.   NATURE IMMUNOLOGY

CSF-1R inhibition alters macrophage polarization and blocks glioma progression

(2013) Stephanie M Pyonteck et al.   NATURE MEDICINE

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

Defining GM-CSF- and Macrophage-CSF-Dependent Macrophage Responses by In Vitro Models

(2012) D. C. Lacey et al.   JOURNAL OF IMMUNOLOGY

Kupffer cells express a unique combination of phenotypic and functional characteristics compared with splenic and peritoneal macrophages

(2012) Dowty Movita et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

Simultaneous activation of the liver X receptors (LXR  and LXR ) drives murine collagen-induced arthritis disease pathology

(2011) D. L. Asquith et al.   ANNALS OF THE RHEUMATIC DISEASES

Liver X receptors, lipids and their reproductive secrets in the male

(2011) Fatim-Zorah El-Hajjaji et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activin A skews macrophage polarization by promoting a proinflammatory phenotype and inhibiting the acquisition of anti-inflammatory macrophage markers

(2011) E. Sierra-Filardi et al.   BLOOD

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development

(2011) S M Pyonteck et al.   ONCOGENE

Liver X receptors as regulators of macrophage inflammatory and metabolic pathways

(2010) Noelia A-González et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Characterization of two F4/80-positive Kupffer cell subsets by their function and phenotype in mice

(2010) Manabu Kinoshita et al.   JOURNAL OF HEPATOLOGY

Activation of Liver X Receptor Sensitizes Human Dendritic Cells to Inflammatory Stimuli

(2010) D. Torocsik et al.   JOURNAL OF IMMUNOLOGY

Discovery of Tertiary Sulfonamides as Potent Liver X Receptor Antagonists

(2010) William J. Zuercher et al.   JOURNAL OF MEDICINAL CHEMISTRY

Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis

(2009) Darren L. Asquith et al.   ARTHRITIS AND RHEUMATISM

Folate Receptor   Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages

(2009) A. Puig-Kroger et al.   CANCER RESEARCH

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF- and M-CSF-dependent macrophage phenotypes display differential dependence on Type I interferon signaling

(2009) Andrew J. Fleetwood et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Liver Regeneration is Impaired in Macrophage Colony Stimulating Factor Deficient Mice After Partial Hepatectomy: The Role of M-CSF-Induced Macrophages

(2009) Hidetake Amemiya et al.   JOURNAL OF SURGICAL RESEARCH

Macrophage colony-stimulating factor is indispensable for repopulation and differentiation of Kupffer cells but not for splenic red pulp macrophages in osteopetrotic (op/op) mice after macrophage depletion

(2008) Takashi Yamamoto et al.   CELL AND TISSUE RESEARCH

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY