RasGRP1 promotes amphetamine-induced motor behavior through a Rhes interaction network ("Rhesactome") in the striatum

Investigating complex basal ganglia circuitry in the regulation of motor behaviour, with particular focus on orofacial movement

(2015) Hiroko Ikeda et al.   BEHAVIOURAL PHARMACOLOGY

Fronto-striatal circuits in response-inhibition: Relevance to addiction

(2015) Sharon Morein-Zamir et al.   BRAIN RESEARCH

The BioPlex Network: A Systematic Exploration of the Human Interactome

(2015) Edward L. Huttlin et al.   CELL

Sex differences in monoamines following amphetamine and social reward in adolescent rats.

(2015) Virginia G. Weiss et al.   EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY

Ectopic expression of the striatal-enriched GTPase Rhes elicits cerebellar degeneration and an ataxia phenotype in Huntington's disease

(2015) Supriya Swarnkar et al.   NEUROBIOLOGY OF DISEASE

Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor

(2015) Sean M. Peterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amphetamine self-administration and dopamine function: assessment of gene × environment interactions in Lewis and Fischer 344 rats

(2015) Andrew C. Meyer et al.   PSYCHOPHARMACOLOGY

The Striatum: Where Skills and Habits Meet

(2015) Ann M. Graybiel et al.   Cold Spring Harbor Perspectives in Biology

Rhes influences striatal cAMP/PKA-dependent signaling and synaptic plasticity in a gender-sensitive fashion

(2015) Veronica Ghiglieri et al.   Scientific Reports

Genetic variation associated with euphorigenic effects of d-amphetamine is associated with diminished risk for schizophrenia and attention deficit hyperactivity disorder

(2014) A. B. Hart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

(2014) W. M. Pryor et al.   Science Signaling

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation

(2013) Neelam Shahani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multiple Checkpoint Breach of B Cell Tolerance in Rasgrp1-Deficient Mice

(2013) A. Bartlett et al.   JOURNAL OF IMMUNOLOGY

Rhes Deletion Is Neuroprotective in the 3-Nitropropionic Acid Model of Huntington's Disease

(2013) R. G. Mealer et al.   JOURNAL OF NEUROSCIENCE

SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties

(2013) Kihoon Han et al.   NATURE

Effects of the Ras homolog Rhes on Akt/protein kinase B and glycogen synthase kinase 3 phosphorylation in striatum

(2013) L.M. Harrison et al.   NEUROSCIENCE

Investigating the molecular mechanisms of L-DOPA-induced dyskinesia in the mouse

(2013) Veronica Francardo et al.   PARKINSONISM & RELATED DISORDERS

Role of Phospholipids in Endocytosis, Phagocytosis, and Macropinocytosis

(2013) Michal Bohdanowicz et al.   PHYSIOLOGICAL REVIEWS

The DAO Gene Is Associated with Schizophrenia and Interacts with Other Genes in the Taiwan Han Chinese Population

(2013) Hsin-Chou Yang et al.   PLoS One

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

(2013) Brandon A. Baiamonte et al.   PLoS One

Dysregulated RasGRP1 Responds to Cytokine Receptor Input in T Cell Leukemogenesis

(2013) C. Hartzell et al.   Science Signaling

Golgi Protein ACBD3 Mediates Neurotoxicity Associated with Huntington’s Disease

(2013) Juan I. Sbodio et al.   Cell Reports

Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1

(2013) Jeffrey S Iwig et al.   eLife

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

Rhes: A GTP-Binding Protein Integral to Striatal Physiology and Pathology

(2012) Laura M. Harrison   CELLULAR AND MOLECULAR NEUROBIOLOGY

Characterization of dopamine D1 and D2 receptor-expressing neurons in the mouse hippocampus

(2012) Giuseppe Gangarossa et al.   HIPPOCAMPUS

Functional roles of neurotransmitters and neuromodulators in the dorsal striatum

(2012) J. Do et al.   LEARNING & MEMORY

Striatum specific protein, Rhes regulates AKT pathway

(2012) Sookhee Bang et al.   NEUROSCIENCE LETTERS

Striatal Mechanisms Underlying Movement, Reinforcement, and Punishment

(2012) Alexxai V. Kravitz et al.   PHYSIOLOGY

Striatal dysfunction during failed motor inhibition in children at risk for bipolar disorder

(2012) Christen M. Deveney et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Striatal signaling: two decades of progress

(2012) Emmanuel Valjent   Frontiers in Neuroanatomy

Constitutive abnormal expression of RasGRP-1 isoforms and low expression of PARP-1 in patients with systemic lupus erythematosus

(2011) MJ Rapoport et al.   LUPUS

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

How Addictive Drugs Disrupt Presynaptic Dopamine Neurotransmission

(2011) David Sulzer   NEURON

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

(2011) J.-M. Beaulieu et al.   PHARMACOLOGICAL REVIEWS

Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

(2011) Tamara Seredenina et al.   PLoS One

Exploration of sex differences in Rhes effects in dopamine mediated behaviors

(2011) Gabriel Quintero et al.   Neuropsychiatric Disease and Treatment

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mice lacking rhes show altered morphine analgesia, tolerance, and dependence

(2010) Franklin A. Lee et al.   NEUROSCIENCE LETTERS

Abuse of Amphetamines and Structural Abnormalities in the Brain

(2009) Steven Berman et al.   Annals of the New York Academy of Sciences

The Cationic Region of Rhes Mediates its Interactions with Specific Gβ Subunits

(2009) Claire Hill et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Detection, Validation, and Downstream Analysis of Allelic Variation in Gene Expression

(2009) D. C. Ciobanu et al.   GENETICS

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Dysregulation of CalDAG-GEFI and CalDAG-GEFII predicts the severity of motor side-effects induced by anti-parkinsonian therapy

(2009) Jill R. Crittenden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Focusing on clathrin-mediated endocytosis

(2008) Joshua Z. Rappoport   BIOCHEMICAL JOURNAL

RASD2, MYH9, and CACNG2 Genes at Chromosome 22q12 Associated with the Subgroup of Schizophrenia with Non-Deficit in Sustained Attention and Executive Function

(2008) Yu-Li Liu et al.   BIOLOGICAL PSYCHIATRY

Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder

(2008) Manuel A R Ferreira et al.   NATURE GENETICS

An empirical framework for binary interactome mapping

(2008) Kavitha Venkatesan et al.   NATURE METHODS

The Ras homolog Rhes affects dopamine D1 and D2 receptor-mediated behavior in mice

(2008) Gabriel C. Quintero et al.   NEUROREPORT

Increased amphetamine-induced hyperactivity and reward in mice overexpressing the dopamine transporter

(2008) A. Salahpour et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The GTP-binding protein Rhes modulates dopamine signalling in striatal medium spiny neurons

(2007) Francesco Errico et al.   MOLECULAR AND CELLULAR NEUROSCIENCE