Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington's disease

Regulation of TORC1 in Response to Amino Acid Starvation via Lysosomal Recruitment of TSC2

(2014) Constantinos Demetriades et al.   CELL

Where is mTOR and what is it doing there?

(2014) Charles Betz et al.   JOURNAL OF CELL BIOLOGY

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of mTORC1 by amino acids

(2014) Liron Bar-Peled et al.   TRENDS IN CELL BIOLOGY

Selective Activation of mTORC1 Signaling Recapitulates Microcephaly, Tuberous Sclerosis, and Neurodegenerative Diseases

(2014) Hidetoshi Kassai et al.   Cell Reports

A novel human embryonic stem cell-derived Huntington's disease neuronal model exhibits mutant huntingtin (mHTT) aggregates and soluble mHTT-dependent neurodegeneration

(2013) Boxun Lu et al.   FASEB JOURNAL

Rheb GTPase Regulates β-Secretase Levels and Amyloid β Generation

(2013) Neelam Shahani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rhes, a Striatal-selective Protein Implicated in Huntington Disease, Binds Beclin-1 and Activates Autophagy

(2013) Robert G. Mealer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin Mediates Anxiety/Depression-Related Behaviors and Hippocampal Neurogenesis

(2013) K. Ben M'Barek et al.   JOURNAL OF NEUROSCIENCE

Rhes Deletion Is Neuroprotective in the 3-Nitropropionic Acid Model of Huntington's Disease

(2013) R. G. Mealer et al.   JOURNAL OF NEUROSCIENCE

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Attenuation of Rhes Activity Significantly Delays the Appearance of Behavioral Symptoms in a Mouse Model of Huntington's Disease

(2013) Brandon A. Baiamonte et al.   PLoS One

Mammalian Target of Rapamycin Complex I (mTORC1) Activity in Ras Homologue Enriched in Brain (Rheb)-Deficient Mouse Embryonic Fibroblasts

(2013) Marlous J. Groenewoud et al.   PLoS One

Aberrant splicing of HTT generates the pathogenic exon 1 protein in Huntington disease

(2013) K. Sathasivam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

(2013) I. Ben-Sahra et al.   SCIENCE

Golgi Protein ACBD3 Mediates Neurotoxicity Associated with Huntington’s Disease

(2013) Juan I. Sbodio et al.   Cell Reports

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Multiple phenotypes in Huntington disease mouse neural stem cells

(2012) James J. Ritch et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation

(2012) Lin Qi et al.   PLoS One

Molecular characterization of skeletal muscle atrophy in the R6/2 mouse model of Huntington's disease

(2011) Pengxiang She et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

mTOR signaling in disease

(2011) Eva Dazert et al.   CURRENT OPINION IN CELL BIOLOGY

HD CAG-correlated gene expression changes support a simple dominant gain of function

(2011) Jessie C. Jacobsen et al.   HUMAN MOLECULAR GENETICS

Mechanisms Involved in the Coordinate Regulation of mTORC1 by Insulin and Amino Acids

(2011) Michael D. Dennis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

Rhes, a striatal-enriched small G protein, mediates mTOR signaling and L-DOPA–induced dyskinesia

(2011) Srinivasa Subramaniam et al.   NATURE NEUROSCIENCE

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

Regulation of mTORC1 Signaling by pH

(2011) Aruna D. Balgi et al.   PLoS One

Decreased Striatal RGS2 Expression Is Neuroprotective in Huntington's Disease (HD) and Exemplifies a Compensatory Aspect of HD-Induced Gene Regulation

(2011) Tamara Seredenina et al.   PLoS One

The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation

(2011) Michelle C. Mendoza et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Rhes, a Physiologic Regulator of Sumoylation, Enhances Cross-sumoylation between the Basic Sumoylation Enzymes E1 and Ubc9

(2010) Srinivasa Subramaniam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of mTORC1 by the Rab and Arf GTPases

(2010) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes

(2010) Juliane P. Caviston et al.   MOLECULAR BIOLOGY OF THE CELL

The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease

(2010) Jonathan H Fox et al.   Molecular Neurodegeneration

Termination of autophagy and reformation of lysosomes regulated by mTOR

(2010) Li Yu et al.   NATURE

Huntington’s Disease is a disorder of the corpus striatum: Focus on Rhes (Ras homologue enriched in the striatum)

(2010) Srinivasa Subramaniam et al.   NEUROPHARMACOLOGY

mTOR phosphorylated at S2448 binds to raptor and rictor

(2009) M. Rosner et al.   AMINO ACIDS

Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

(2009) X. Li et al.   MOLECULAR AND CELLULAR BIOLOGY

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin

(2009) Shu-ichi Okamoto et al.   NATURE MEDICINE

Mechanisms of amino acid sensing in mTOR signaling pathway

(2009) Eunjung Kim   Nutrition Research and Practice

Rheb controls misfolded protein metabolism by inhibiting aggresome formation and autophagy

(2009) X. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

(2009) S. Subramaniam et al.   SCIENCE

Huntingtin as an essential integrator of intracellular vesicular trafficking

(2009) Juliane P. Caviston et al.   TRENDS IN CELL BIOLOGY

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies

(2008) J. N. Savas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE