Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications

Randomised clinical trial: a phase 1, dose-ranging study of the anti-matrix metalloproteinase-9 monoclonal antibody GS-5745 versus placebo for ulcerative colitis

(2016) W. J. Sandborn et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

ASCA, ANCA, ALCA and Many More: Are They Useful in the Diagnosis of Inflammatory Bowel Disease?

(2016) Guangxi Zhou et al.   DIGESTIVE DISEASES

Protease inhibition as new therapeutic strategy for GI diseases

(2016) Nathalie Vergnolle   GUT

Neutrophil extracellular traps — the dark side of neutrophils

(2016) Ole E. Sørensen et al.   JOURNAL OF CLINICAL INVESTIGATION

A Meta-Analysis of the Utility of C-Reactive Protein, Erythrocyte Sedimentation Rate, Fecal Calprotectin and Fecal Lactoferrin to Exclude Inflammatory Bowel Disease in Adults With IBS

(2015) Stacy B Menees et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

C-Reactive Protein, Fecal Calprotectin and Stool Lactoferrin for Detection of Endoscopic Activity in Symptomatic Inflammatory Bowel Disease Patients: A Systematic Review and Meta-Analysis

(2015) Mahmoud H Mosli et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Evaluation of Mucosal Healing in Ulcerative Colitis by Fecal Calprotectin Vs. Fecal Immunochemical Test

(2015) Shiho Takashima et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

CXCR2 Antagonist MK-7123. A Phase 2 Proof-of-Concept Trial for Chronic Obstructive Pulmonary Disease

(2015) Stephen I. Rennard et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

The effect of a selective CXCR2 antagonist (AZD5069) on human blood neutrophil count and innate immune functions

(2015) Stipo Jurcevic et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Anrukinzumab, an anti-interleukin 13 monoclonal antibody, in active UC: efficacy and safety from a phase IIa randomised multicentre study

(2015) Walter Reinisch et al.   GUT

High Within-day Variability of Fecal Calprotectin Levels in Patients with Active Ulcerative Colitis

(2015) Margalida Calafat et al.   INFLAMMATORY BOWEL DISEASES

Serum Neutrophil Gelatinase B-associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Marker for Mucosal Healing in Patients with Crohn’s Disease

(2015) Magali de Bruyn et al.   Journal of Crohns & Colitis

The epidemiology of inflammatory bowel disease

(2015) Johan Burisch et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Mesalamine Dose Escalation Reduces Fecal Calprotectin in Patients With Quiescent Ulcerative Colitis

(2014) Mark T. Osterman et al.   Clinical Gastroenterology and Hepatology

Matrix Metalloproteinase-9: Its Interplay with Angiogenic Factors in Inflammatory Bowel Diseases

(2014) Malgorzata Matusiewicz et al.   DISEASE MARKERS

Comparing histological activity indexes in UC

(2014) Aude Bressenot et al.   GUT

Outcome measures for clinical trials in paediatric IBD: an evidence-based, expert-driven practical statement paper of the paediatric ECCO committee

(2014) Frank M Ruemmele et al.   GUT

Histologic Evaluation of Ulcerative Colitis

(2014) Mahmoud H. Mosli et al.   INFLAMMATORY BOWEL DISEASES

Neutrophil Gelatinase B–associated Lipocalin and Matrix Metalloproteinase-9 Complex as a Surrogate Serum Marker of Mucosal Healing in Ulcerative Colitis

(2014) Magali de Bruyn et al.   INFLAMMATORY BOWEL DISEASES

Comparison of Proteins Expressed on Secretory Vesicle Membranes and Plasma Membranes of Human Neutrophils

(2014) S. M. Uriarte et al.   JOURNAL OF IMMUNOLOGY

Neutrophils at work

(2014) William M Nauseef et al.   NATURE IMMUNOLOGY

The multifactorial role of neutrophils in rheumatoid arthritis

(2014) Helen L. Wright et al.   Nature Reviews Rheumatology

The role and utility of faecal markers in inflammatory bowel disease

(2014) Frank S. Lehmann et al.   Therapeutic Advances in Gastroenterology

EMerging BiomARKers in Inflammatory Bowel Disease (EMBARK) Study Identifies Fecal Calprotectin, Serum MMP9 and Serum IL-22 as a Novel Combination of Biomarkers for Crohn's Disease Activity: Role of Cross-Sectional Imaging

(2013) William A Faubion et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Inflammatory bowel diseases: from pathogenesis to laboratory testing

(2013) Daniela Basso et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Histologic Markers of Inflammation in Patients With Ulcerative Colitis in Clinical Remission

(2013) Laura Rosenberg et al.   Clinical Gastroenterology and Hepatology

Histologic Remission: The Ultimate Therapeutic Goal in Ulcerative Colitis?

(2013) Laurent Peyrin–Biroulet et al.   Clinical Gastroenterology and Hepatology

The potential of neutrophil elastase inhibitors as anti-inflammatory therapies

(2013) Peter A. Henriksen   CURRENT OPINION IN HEMATOLOGY

Relationship Between Neutrophil Gelatinase-Associated Lipocalin (NGAL) Levels and Inflammatory Bowel Disease Type and Activity

(2013) Atakan Yeşil et al.   DIGESTIVE DISEASES AND SCIENCES

Once-daily budesonide MMX in active, mild-to-moderate ulcerative colitis: results from the randomised CORE II study

(2013) Simon P L Travis et al.   GUT

Fecal calprotectin and lactoferrin as predictors of relapse in patients with quiescent ulcerative colitis during maintenance therapy

(2013) Takayuki Yamamoto et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

Gene expression profiling of whole blood in ipilimumab-treated patients for identification of potential biomarkers of immune-related gastrointestinal adverse events

(2013) Vafa Shahabi et al.   Journal of Translational Medicine

EGF-Induced Bronchial Epithelial Cells Drive Neutrophil Chemotactic and Anti-Apoptotic Activity in Asthma

(2013) Mohib Uddin et al.   PLoS One

Disease associations in alpha-1-antitrypsin deficiency

(2013) H. Stone et al.   RESPIRATORY MEDICINE

Lactoferrin, a key molecule in immune and inflammatory processes1This article is part of Special Issue entitled Lactoferrin and has undergone the Journal’s usual peer review process.

(2012) Dominique Legrand   Biochemistry and Cell Biology

Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebo-controlled clinical trial

(2012) P. Nair et al.   CLINICAL AND EXPERIMENTAL ALLERGY

The Impact of Matrix Metalloproteinases and Their Tissue Inhibitors in Inflammatory Bowel Diseases

(2012) Gábor Lakatos et al.   DIGESTIVE DISEASES

Fecal calprotectin concentration predicts outcome in inflammatory bowel disease after induction therapy with TNFα blocking agents

(2012) Pauliina Molander et al.   INFLAMMATORY BOWEL DISEASES

Fecal MMP-9

(2012) Anita Annaházi et al.   INFLAMMATORY BOWEL DISEASES

Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature

(2012) Shaji Sebastian et al.   Journal of Crohns & Colitis

Achievement of deep remission during scheduled maintenance therapy with TNFα-blocking agents in IBD

(2012) Pauliina Molander et al.   Journal of Crohns & Colitis

Safety and early treatment effects of the CXCR2 antagonist SB-656933 in patients with cystic fibrosis

(2012) Richard B. Moss et al.   Journal of Cystic Fibrosis

The role of neutrophils during intestinal inflammation

(2012) B M Fournier et al.   Mucosal Immunology

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fc Gamma Receptor CD64 Modulates the Inhibitory Activity of Infliximab

(2012) Kacper A. Wojtal et al.   PLoS One

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity

(2012) M. Beyrau et al.   Open Biology

Mucosal Gene Expression of Cell Adhesion Molecules, Chemokines and Chemokine Receptors in Patients With Inflammatory Bowel Disease Before and After Infliximab Treatment

(2011) Ingrid Arijs et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Late Intervention with a Myeloperoxidase Inhibitor Stops Progression of Experimental Chronic Obstructive Pulmonary Disease

(2011) Andrew Churg et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands

(2011) A. Kohler et al.   BLOOD

SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans

(2011) Aili L. Lazaar et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor

(2011) R. Virtala et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Long pentraxin 3 (PTX3) expression and release by neutrophils in vitro and in ulcerative colitis

(2011) Alexander S. Savchenko et al.   PATHOLOGY INTERNATIONAL

Faecal calprotectin, lactoferrin, M2-pyruvate kinase and S100A12 in severe ulcerative colitis: a prospective multicentre comparison of predicting outcomes and monitoring response

(2010) D. Turner et al.   GUT

Neutrophil Transmigration Mediated by the Neutrophil-Specific Antigen CD177 Is Influenced by the Endothelial S536N Dimorphism of Platelet Endothelial Cell Adhesion Molecule-1

(2010) B. Bayat et al.   JOURNAL OF IMMUNOLOGY

Gene Expression Changes Associated with Resistance to Intravenous Corticosteroid Therapy in Children with Severe Ulcerative Colitis

(2010) Boyko Kabakchiev et al.   PLoS One

Prosurvival activity for airway neutrophils in severe asthma

(2010) M. Uddin et al.   THORAX

Luminal Cathepsin G and Protease-Activated Receptor 4

(2009) Marta Dabek et al.   AMERICAN JOURNAL OF PATHOLOGY

Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN

(2009) Zvi G. Fridlender et al.   CANCER CELL

SCH527123, a novel CXCR2 antagonist, inhibits ozone-induced neutrophilia in healthy subjects

(2009) O. Holz et al.   EUROPEAN RESPIRATORY JOURNAL

The functional significance behind expressing two IL-8 receptor types on PMN

(2009) RoseMarie Stillie et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neutrophil Extracellular Traps Contain Calprotectin, a Cytosolic Protein Complex Involved in Host Defense against Candida albicans

(2009) Constantin F. Urban et al.   PLoS Pathogens

Expression of the High-Affinity IgG Receptor FcRI (CD64) in Patients With Inflammatory Bowel Disease: A New Biomarker for Gastroenterologic Diagnostics

(2008) Wolfgang Tillinger et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Can Calprotectin Predict Relapse Risk in Inflammatory Bowel Disease?

(2008) Renata D'Incà et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

A Randomized, Double-Blind, Sham-Controlled Study of Granulocyte/Monocyte Apheresis for Active Ulcerative Colitis

(2008) Bruce E. Sands et al.   GASTROENTEROLOGY

Accumulation, activation, and survival of neutrophils in ulcerative colitis: regulation by locally produced factors in the colon and impact of steroid treatment

(2008) Maria Lampinen et al.   INTERNATIONAL JOURNAL OF COLORECTAL DISEASE

CXCR2 antagonists for the treatment of pulmonary disease

(2008) R.W. Chapman et al.   PHARMACOLOGY & THERAPEUTICS

Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses

(2008) Brian D. Corbin et al.   SCIENCE

Noninvasive Markers in the Assessment of Intestinal Inflammation in Inflammatory Bowel Diseases: Performance of Fecal Lactoferrin, Calprotectin, and PMN-Elastase, CRP, and Clinical Indices

(2007) Jost Langhorst et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Discriminating IBD from IBS: Comparison of the test performance of fecal markers, blood leukocytes, CRP, and IBD antibodies

(2007) Alain M. Schoepfer et al.   INFLAMMATORY BOWEL DISEASES