Review
Cell Biology
Selin Gencer, Bryce R. Evans, Emiel P. C. van der Vorst, Yvonne Doering, Christian Weber
Summary: Atherosclerosis is a chronic inflammatory disease of the vessel wall leading to occlusive lesions in large arteries. Chemokines and their receptors play a key role in the development of atherosclerotic lesions by orchestrating immune cell activation and recruitment. Recent research has focused on targeting these chemokines for potential treatment of atherosclerosis.
Article
Neurosciences
Adrian Jorda, Martin Aldasoro, Constanza Aldasoro, Soraya L. Valles
Summary: The study investigated the changes in chemokines and their receptor expression related to inflammation in Alzheimer's disease. Significant inflammatory changes were detected in APP/PS1 mice compared to wild type mice, which could explain the differences between AD patients and elderly individuals without the disease, providing a new strategy for AD treatment targeting specific inflammatory pathways.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Rachele Di Donato, Raffaella Bonecchi, Francesca Albano
Summary: Chemokines have local functions in controlling leukocyte extravasation and also play additional roles in regulating hematopoiesis and leukocyte differentiation at a systemic level. Atypical chemokine receptors (ACKRs) are regulators of the chemokine system and have a selective role in neutrophil production and differentiation. This review provides an overview of the role of chemokines and chemokine receptors in neutrophil biology with a focus on the regulation exerted by ACKRs.
Article
Immunology
Dominic D. Skinner, Amber R. Syage, Gema M. Olivarria, Colleen Stone, Bailey Hoglin, Thomas E. Lane
Summary: By characterizing the molecular and cellular changes in transgenic mice, this study reveals the changes in the profile of neutrophils associated with increased white matter damage in mice persistently infected with a neurotropic coronavirus.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Physiology
Zhiyuan Li, Shuyan Dong, Shichen Huang, Yuhan Sun, Yingzhi Sun, Beibei Zhao, Qiulan Qi, Lei Xiong, Feng Hong, Yuxin Jiang
Summary: Inflammatory bowel disease (IBD) is an autoimmune disease caused by chronic recurrent inflammation of the ileum, rectum, and colon. CD34 is involved in mediating the migration of various immune cells to the inflammatory site during IBD, and its interaction with adhesion molecules contributes to the occurrence and development of IBD. This article aims to explore the structure, biological function, and potential mechanism of CD34 in IBD.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Cameron R. Bastow, Mark D. Bunting, Ervin E. Kara, Duncan R. McKenzie, Adriana Caon, Sapna Devi, Lynn Tolley, Scott N. Mueller, Ian H. Frazer, Natasha Harvey, Mark R. Condina, Clifford Young, Peter Hoffmann, Shaun R. McColl, Iain Comerford
Summary: This study reveals the mechanism by which ACKR4 controls DC migration in barrier tissues, identifying the existence of two forms of CCL21 in steady-state conditions and their regulation by ACKR4. It enhances understanding of functional chemokine gradient formation by showing how ACKR4 affects CCL21 gradients in barrier tissues and downstream lymph nodes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Sofia R. Gardeta, Eva M. Garcia-Cuesta, Gianluca D'Agostino, Blanca Soler Palacios, Adriana Quijada-Freire, Pilar Lucas, Jorge Bernardino de la Serna, Carolina Gonzalez-Riano, Coral Barbas, Jose Miguel Rodriguez-Frade, Mario Mellado
Summary: The local lipid environment plays an important role in regulating CXCR4 organization and function, and modulating chemokine-triggered directed cell migration. Treatment of T cells with bacterial sphingomyelinase alters the lipid composition of the cell membrane, affecting membrane fluidity and CXCR4 nanoclustering and dynamics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Andrea Bonnin Marquez, Emiel P. C. van der Vorst, Sanne L. Maas
Summary: Atherosclerosis is a major cause of cardiovascular diseases, and chemokines and their receptors play a crucial role in its pathophysiological development. Targeting these factors through various methods shows promise in ameliorating atherosclerosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Juan Hernandez, Elodie Rouille, Florian Chocteau, Marie Allard, Karine Haurogne, Florence Lezin, Julie M. Herve, Jean-Marie Bach, Jerome Abadie, Blandine Lieubeau
Summary: The study revealed that dogs with inflammatory bowel disease (IBD) exhibited varying degrees of clinical disease, with no significant histopathological alterations in gut tissues compared to controls except in the colon. Dogs with IBD had decreased CD3(+) T lymphocyte numbers in the ileum and colon, while other cell populations were similar between the two groups. The levels of certain chemokines in the mucosa were affected by the disease to a limited extent.
INFLAMMATORY BOWEL DISEASES
(2021)
Review
Immunology
Teizo Yoshimura, Chunning Li, Yuze Wang, Akihiro Matsukawa
Summary: Breast cancer is a common cancer worldwide, and metastasis is the main cause of cancer-related death. Human monocyte chemoattractant protein-1 (MCP-1/CCL2) was identified as a chemotactic factor for monocytes, and its role in cancer development and progression was investigated. Studies showed positive correlations between MCP-1 production in tumors and TAM infiltration, as well as cancer progression. MCP-1 was found to promote breast cancer metastasis to the lung and brain, but not bone. The mechanisms of MCP-1 production in the breast cancer microenvironment were also reported.
CELLULAR & MOLECULAR IMMUNOLOGY
(2023)
Article
Medicine, General & Internal
Vanesa Seery, Silvina C. Raiden, Silvia C. Algieri, A. Grisolia, Daniela Filippo, Norberto De Carli, Sandra Di Lalla, Hector Cairoli, Maria J. Chiolo, Claudia N. Meregalli, Lorena I. Gimenez, Gabriela Gregorio, Mariam Sarli, Ana L. Alcalde, Carolina Davenport, Maria J. Bruera, Nancy Simaz, Mariela F. Perez, Valeria Nivela, Carola Bayle, Patricia Tuccillo, Maria T. Agosta, Hernan Perez, Susana Villa Nova, Patricia Suarez, Eugenia M. Takata, Mariela Garcia, Jorge Lattner, Maria J. Rolon, Patricia Coll, Ines Sananez, Maria P. Holgado, Fernando Ferrero, Jorge Geffner, Lourdes Arruvito
Summary: Neutrophils in children with COVID-19 exhibit a unique phenotype with high expression of inhibitory receptors and low expression of adhesion molecules, potentially preventing tissue infiltration. The expression of CD64 and serum IgG antibodies to the spike protein of SARS-CoV-2 can differentiate asymptomatic cases from mild and moderate cases of COVID-19.
Review
Oncology
Mudassier Ahmad, Anupam Dhasmana, Prateek Suresh Harne, Asif Zamir, Bilal Bin Hafeez
Summary: Tumor heterogeneity is a crucial factor in the resistance to chemotherapy and limited efficacy in hepatocellular carcinoma (HCC). Chemokines, a sub-family of cytokines, play a key role in HCC heterogeneity by affecting cell survival, growth, migration, and angiogenesis. Understanding the impact of chemokines on genetic, epigenetic, metabolic, immune cell composition, and tumor microenvironment levels can contribute to the development of personalized medicine strategies for HCC.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Cell Biology
Alessio Ardizzone, Rossella Basilotta, Alessia Filippone, Lelio Crupi, Marika Lanza, Sofia Paola Lombardo, Cristina Colarossi, Dorotea Sciacca, Salvatore Cuzzocrea, Emanuela Esposito, Michela Campolo
Summary: Primary brain tumors are highly heterogeneous and invasive, leading to high mortality rates worldwide. Current therapies have improved survival rates, but new therapeutic strategies are needed. Immunotherapy approaches, targeting the immunosuppressive microenvironment, have shown promise in CNS tumors. Chemokines, a group of proteins that regulate immune cell recruitment and tumor growth, are examined as potential targets for immunotherapy in primary brain tumors.
Review
Oncology
Jiakang Jin, Jinti Lin, Ankai Xu, Jianan Lou, Chao Qian, Xiumao Li, Yitian Wang, Wei Yu, Huimin Tao
Summary: CCL2 plays a crucial role in tumor microenvironment by recruiting macrophages and stromal cells, impacting tumor progression both negatively and positively by influencing the immune response.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Hunter G. Lindsay, Colby J. Hendrix, Josue D. Gonzalez Murcia, Christopher Haynie, K. Scott Weber
Summary: Neuroinflammation plays a significant role in neurodegenerative disorders, and the role of atypical chemokine receptors (ACKRs) in these conditions has been identified. ACKRs modulate inflammatory responses by regulating chemokine abundance, location, and availability. The ability of ACKRs to alter chemokine levels makes them an appealing therapeutic target for neurodegenerative conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
Nathalie Van Den Berghe, Bram Verstockt, Severine Vermeire, Debby Thomas, Paul Declerck
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Kevin L. Winthrop, Severine Vermeire, Millie D. Long, Julian Panes, Siew C. Ng, Nicole Kulisek, Rajiv Mundayat, Nervin Lawendy, Ivana Vranic, Irene Modesto, Chinyu Su, Gil Y. Melmed
Summary: The incidence rates of herpes zoster in patients with ulcerative colitis remained stable during 7.8 years of tofacitinib exposure. Older age, lower weight, geographic region, and prior tumor necrosis factor inhibitor failure were identified as significant risk factors for herpes zoster.
INFLAMMATORY BOWEL DISEASES
(2023)
Letter
Gastroenterology & Hepatology
Dahham Alsoud, Bram Verstockt, Severine Vermeire
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Walter Reinisch, Adrian Serone, Xavier Hebuterne, Tanja Kuehbacher, Maria Klopocka, Xavier Roblin, Jens Brodbeck, Kim Etchevers, Rene Galien, Ethan Grant, Chantal Tasset, Oh Kyu Yoon, Shiva Zaboli, Severine Vermeire
Summary: This study examines the relationship between endoscopic, histologic, and molecular activity in patients with Crohn's disease. The findings suggest that histologic activity should be considered when assessing inflammatory burden in CD patients.
Review
Gastroenterology & Hepatology
Pieter Sinonquel, Severine Vermeire, Frederik Maes, Raf Bisschops
Summary: This article reviews the latest developments in advanced GI endoscopy, focusing on screening, diagnosis, and surveillance of common upper and lower GI pathology. The importance of artificial intelligence in the field is emphasized, and the potential future impact of the literature is assessed.
GE PORTUGUESE JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Gary R. Lichtenstein, Brian Bressler, Carlos Francisconi, Severine Vermeire, Nervin Lawendy, Leonardo Salese, Gosford Sawyerr, Hongjiong Shi, Chinyu Su, Donna T. Judd, Thomas Jones, Edward V. Loftus
Summary: Age is considered a risk factor for adverse events in the tofacitinib ulcerative colitis clinical program, with older individuals potentially having a higher risk of herpes zoster, malignancies (excluding nonmelanoma skin cancer), and nonmelanoma skin cancer compared to younger patients.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Sara Deleu, Kaline Arnauts, Lowie Deprez, Kathleen Machiels, Marc Ferrante, Geert R. B. Huys, Johan M. M. Thevelein, Jeroen Raes, Severine Vermeire
Summary: Short-chain fatty acids and their bacterial producers are gaining increasing attention in inflammatory bowel diseases. Acetate, although less studied compared to butyrate, shows potential in being less toxic to epithelial cells, stimulating butyrate-producing bacteria, and having anti-inflammatory and barrier-protective properties. In a study using organoid-based monolayer cultures from ulcerative colitis patients, high acetate concentrations were found to improve epithelial resistance, decrease pro-inflammatory markers, and enhance barrier gene expression. These findings suggest that acetate may offer a promising approach for managing barrier defects and inflammation in IBD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Gastroenterology & Hepatology
Wannee Kantasiripitak, Sebastian G. Wicha, Debby Thomas, Ilse Hoffman, Marc Ferrante, Severine Vermeire, Karen van Hoeve, Erwin Dreesen
Summary: The study aimed to develop a multi-model model-based software tool for guiding personalized infliximab induction treatment in pediatric inflammatory bowel disease patients. The study found that using the tool for individualized dosing improved the chances for children to achieve deep remission at 6 months.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Loris Riccardo Lopetuso, Sara Deleu, Lihi Godny, Valentina Petito, Pierluigi Puca, Federica Facciotti, Harry Sokol, Gianluca Ianiro, Luca Masucci, Maria Abreu, Iris Dotan, Samuel Paul Costello, Ailsa Hart, Tariq H. Iqbal, Sudarshan Paramsothy, Maurizio Sanguinetti, Silvio Danese, Herbert Tilg, Fabio Cominelli, Theresa T. Pizarro, Alessandro Armuzzi, Giovanni Cammarota, Antonio Gasbarrini, Severine Vermeire, Franco Scaldaferri
Summary: An international panel of experts has generated evidence-based guidelines for the evaluation and management of inflammatory bowel disease (IBD) using faecal microbiota transplantation (FMT). The guidelines provide specific statements and recommendations to promote FMT as a recognized strategy for the treatment of IBD.
Article
Gastroenterology & Hepatology
Julian Panes, Severine R. Vermeire, Geert D'Haens, Silvio Danese, Fernando Magro, Maciej Nazar, Manuela Le Bars, Marjolein Lahaye, Lioudmila Ni, Ivana R. Bravata, Daniel Gaya, Laurent Peyrin-Biroulet, Axel Dignass
Summary: This study compared two treatment strategies for Crohn's disease patients and found that regardless of whether the treatment was "treat-to-target" or "standard of care", ustekinumab was effective in improving the health-related quality of life and work productivity of patients over a 2-year follow-up period.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Article
Immunology
Jeroen Geldof, Marie Truyens, Joao Sabino, Marc Ferrante, Jo Lambert, Hilde Lapeere, Tom Hillary, An Van Laethem, Kurt de Vlam, Patrick Verschueren, Elizaveta Padalko, Triana Lobaton, Severine Vermeire
Summary: The BELCOMID study confirms the benign course of COVID19 infection and vaccination in a large real-life population of patients with immune-mediated inflammatory diseases. However, the results emphasize the need for repeated vaccination and smoking cessation in IMID patients treated with immune-modulating therapies or systemic steroids during the pandemic.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Gabriele Bislenghi, Julie Van Den Bossch, Steffen Fieuws, Albert Wolthuis, Marc Ferrante, Gert de Hertogh, Severine Vermeire, Andre D'Hoore
Summary: The macroscopic appearance of the bowel and associated mesentery during surgery does not appear to be predictive of postoperative recurrence after ileocecal resection for Crohn's disease. Prospective studies investigating risk factors for Crohn's disease recurrence after surgery are scarce.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Remo Panaccione, Maria T. Abreu, David T. Rubin, Subrata Ghosh, Axel Dignass, Anita Afzali, Douglas C. Wolf, Michael Chiorean, Severine Vermeire, Anjali Jain, Lorna Charles, Garrett Lawlor, Mark T. Osterman, Hsiuanlin Wu, James B. Canavan, Annkatrin Petersen, Jean-Frederic Colombel, Miguel Regueiro
Summary: This interim analysis examines the efficacy and safety of ozanimod treatment in patients with ulcerative colitis over a period of approximately 3 years. The results show that a high percentage of patients maintain clinical and mucosal efficacy during the treatment. No new safety concerns arise from long-term use of ozanimod.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Biochemical Research Methods
Bryan Linggi, Jonathan Cremer, Zhongya Wang, Tanja Van Viegen, Severine Vermeire, Pavine Lefevre, Lisa M. Shackelton, Vipul Jairath, Wendy Teft, Niels Vande Casteele, Bram Verstockt
Summary: Clinical trials of novel therapies for ulcerative colitis may benefit from immune cell profiling, but implementation is limited by the necessity of timely isolation and processing of peripheral blood mononuclear cells (PBMC). The use of Becton Dickinson Vacutainer CPTTM Cell Preparation Tubes (CPTTM) allows for delayed processing of PBMC, with ideal processing within 48 hours. Delayed processing may be considered for cell types that are robust to these conditions.
JOURNAL OF IMMUNOLOGICAL METHODS
(2023)
Article
Gastroenterology & Hepatology
Severine Vermeire, Jurij Hanzel, Mark Lowenberg, Marc Ferrante, Peter Bossuyt, Frank Hoentjen, Denis Franchimont, Karoly Palatka, Harald Peeters, Aart Mookhoek, Gert de Hertogh, Tamas Molnar, Wouter van Moerkercke, Triana Lobaton, Esme Clasquin, Melanie S. Hulshoff, Filip Baert, Geert D'Haens
Summary: This study explored the differential efficacy of vedolizumab in early and late ulcerative colitis and evaluated clinical, endoscopic, and histological outcomes. The results showed no significant differences between early and late UC in terms of clinical, endoscopic, and histological improvement.
JOURNAL OF CROHNS & COLITIS
(2023)