Article
Biochemistry & Molecular Biology
Zahra Masoumi, Lena Erlandsson, Eva Hansson, Mattias Magnusson, Eva Mezey, Stefan R. Hansson
Summary: The study found that in preeclampsia (PE) pregnancies, there was no impact on placental hematopoietic stem and progenitor cells homing and erythropoiesis. Non-erythroid alpha-globin mRNA and protein were detected in syncytiotrophoblasts and stroma of PE placenta samples, while normal placenta explants cultured in hypoxia showed upregulation of alpha-globin protein and mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lingyu Ye, Yujia Huang, Xueqing Liu, Xinyu Zhang, Yang Cao, Xiangju Kong, Xiaolei Yuan, Jie Xu, Hui Zhu
Summary: The study revealed that women with preeclampsia had increased maternal apelin concentration but reduced APJ expression in the placenta. Treatment with apelin-13 could attenuate oxidative stress injury in placental trophoblasts through the activation of the PI3K/AKT signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Cell Biology
Leonardo Ermini, Abby Farrell, Sruthi Alahari, Jonathan Ausman, Chanho Park, Julien Sallais, Megan Melland-Smith, Tyler Porter, Michael Edson, Ori Nevo, Michael Litvack, Martin Post, Isabella Caniggia
Summary: Aberrant ceramide build-up in preeclampsia leads to exuberant autophagy-mediated trophoblast cell death. Lysosome formation is markedly increased in trophoblast cells of early-onset preeclamptic placentae, accompanied by augmented levels of transcription factor EB. Ceramide-induced lysosomal biogenesis and exocytosis contribute to maternal endothelial dysfunction in preeclampsia.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Developmental Biology
Ivo Carrasco-Wong, Macarena Aguilera-Olguin, Rodrigo Escalona-Rivano, Delia I. Chiarello, L. Jazel Barragan-Zuniga, Martha Sosa-Macias, Carlos Galaviz-Hernandez, Sebastian San Martin, Jaime Gutierrez
Summary: Preeclampsia is a pregnancy-specific syndrome characterized by sudden increase in blood pressure and poor fetal outcomes. Syncytiotrophoblast stress in early-onset preeclampsia leads to characteristic symptoms, which can be targeted for therapeutic management aiming to improve maternal and fetal outcomes.
Article
Biochemistry & Molecular Biology
Alvaro Santana-Garrido, Claudia Reyes-Goya, Pablo Espinosa-Martin, Luis Sobrevia, Luis M. Beltran, Carmen M. Vazquez, Alfonso Mate
Summary: This study investigates the role of the NADPH oxidase system in a rodent model of preeclampsia. The results suggest that NADPH oxidase mediates oxidative stress and inflammation in the placenta and kidney, providing important insights into the pathogenesis and potential treatment of preeclampsia.
Article
Biochemistry & Molecular Biology
Anna Maria Nuzzo, Laura Moretti, Paolo Mele, Tullia Todros, Carola Eva, Alessandro Rolfo
Summary: The conditioned media derived from human placenta-derived mesenchymal stromal cells (hPDMSCs) has shown pro-angiogenic and anti-inflammatory effects on a mouse model of preeclampsia, a severe pregnancy-related syndrome characterized by hypertension, proteinuria, inflammation, and fetal growth restriction. It was found that the hPDMSCs-derived conditioned media could reverse the preeclampsia-like features, including reducing maternal blood pressure, proteinuria, and levels of inflammatory markers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Margarita L. Martinez-Fierro, Idalia Garza-Veloz, Maria Eugenia Castaneda-Lopez, Dorothy Wasike, Claudia Castruita-De la Rosa, Iram Pablo Rodriguez-Sanchez, Ivan Delgado-Enciso, Jose Flores-Mendoza
Summary: In this study, the administration of FGF2 in a rat model of preeclampsia reduced proteinuria and elevated blood pressure, as well as the expression of genes involved in angiogenesis, apoptosis, and oxidative stress. These results provide valuable insights into the molecular targets and pathogenesis of preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hamid-Reza Kohan-Ghadr, Brooke Armistead, Mikaela Berg, Sascha Drewlo
Summary: Irisin is a newly discovered exercise-mediated polypeptide hormone. Studies have shown that Irisin protects against cell death by reducing pro-apoptotic signaling cascades, inducing DNA repair pathways, and inhibiting Caspase 3 activity. Additionally, Irisin acts through the Akt signaling pathway to prevent apoptosis, increase levels of anti-apoptotic BCL2, and reduce ROS levels. These findings provide new insights into the role of Irisin in promoting cell survival and preventing apoptosis in the human placenta under pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Lucia Perez-Roque, Elena Nunez-Gomez, Alicia Rodriguez-Barbero, Carmelo Bernabeu, Jose M. Lopez-Novoa, Miguel Pericacho
Summary: Preeclampsia is a pregnancy-specific disease characterized by hypertension, with its etiopathogenesis related to abnormal placentation and the release of soluble factors. High plasma levels of soluble endoglin (sEng) may serve as an early diagnostic and prognostic biomarker for the disease, impacting the pathophysiology of preeclampsia significantly.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Obstetrics & Gynecology
Stefano Fruci, Silvia Salvi, Sascia Moresi, Francesca Gallini, Marco Dell 'Aquila, Vincenzo Arena, Enrico Di Stasio, Sergio Ferrazzani, Sara De Carolis, Antonio Lanzone
Summary: This study describes the perinatal outcomes and placental histopathological findings in a small series of pregnant women with severe preeclampsia (PE) and intrauterine growth restriction (IUGR) treated with pravastatin on compassionate grounds. The two-year follow-up of these infants did not show significant differences.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yourong Feng, Qi Chen, Sien Yee Lau, Bridget W. Tsai, Katie Groom, Carolyn J. Barrett, Lawrence W. Chamley
Summary: Placental extracellular vesicles (EVs) play a crucial role in feto-maternal communication and their uptake by recipient cells involves various mechanisms such as time, concentration, energy-dependence, as well as phagocytosis and endocytosis. The interaction between placental EVs and recipient cells is mediated by integrins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Sandra M. Blois, Paula D. Prince, Sophia Borowski, Monica Galleano, Gabriela Barrientos
Summary: Utilizing the SHRSP model, this study investigated placental mechanisms promoting superimposed preeclampsia in women with chronic hypertension. The findings revealed sustained activation of cellular stress response in SHRSP placentas, leading to redox imbalance and significant alterations in placental glycocode. The study highlights the potential role of glycoredox balance as a promising target for interventions in hypertensive disorders of pregnancy.
Article
Immunology
Xinjia Han, Wei Li, Ping Li, Zheng Zheng, Baohua Lin, Bei Zhou, Kaimin Guo, Ping He, Jinying Yang
Summary: The down-regulation of alpha 7nAChR in decidual macrophages is associated with changes in polarization towards a more pro-inflammatory phenotype in preeclampsia patients. Nicotine treatment reverses these changes, improving inflammation levels and placental structures in a PE-like mouse model. This suggests that alpha 7nAChR plays a crucial role in regulating maternal-fetal inflammation and placental remodeling in preeclampsia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Sayani Banerjee, Zheping Huang, Zhengke Wang, Akitoshi Nakashima, Shigeru Saito, Surendra Sharma, Shibin Cheng
Summary: The understanding of sterile inflammation and its effects on pregnancy complications such as preeclampsia is still in its early stages. Emerging evidence suggests that sterile inflammation regulated by pathways such as the inflammasome-gasdermins-caspase-1 axis may contribute to the development of preeclampsia. Further research is needed to elucidate the mechanisms underlying these inflammatory pathways and potential therapeutic strategies for treating these complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Reproductive Biology
Barbara Denkl, Nada Cordasic, Hanna Huebner, Carlos Menendez-Castro, Marius Schmidt, Alexander Mocker, Joachim Woelfle, Andrea Hartner, Fabian B. Fahlbusch
Summary: The study investigates the roles of placental UPR and oxidative stress in IUGR and PE, finding that placental ER stress is not induced in rat and mouse models, while oxidative stress is significantly increased in female IUGR rat placentas.
BIOLOGY OF REPRODUCTION
(2021)
Article
Obstetrics & Gynecology
Joe Eid, Talar Kechichian, Elisa Benavides, Lisa Thibodeaux, Ashley E. Salazar, George R. Saade, Antonio F. Saad
Summary: The objective of this study was to determine the validity of Quantose IR test in assessing insulin resistance in pregnant obese women, as compared with HOMA-IR, and its ability to predict GDM and NH. The results suggest that Quantose IR may be a valid measure of insulin resistance in obese pregnant women, and early Quantose IR is a predictor of GDM diagnosed in the second trimester and NH.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Article
Obstetrics & Gynecology
Antonio F. Saad, Ashley E. Salazar, Lindsey Allen, George R. Saade
Summary: This study evaluated the effect of a novel antimicrobial dressing on patient satisfaction and health-related quality of life (HRQoL) after cesarean delivery. The results showed that the dressing led to higher satisfaction and better HRQoL scores among patients and providers. Further research is needed to assess its impact on surgical site infection rates and wound complications.
AMERICAN JOURNAL OF PERINATOLOGY
(2022)
Letter
Obstetrics & Gynecology
Nicholas R. Spencer, Antonio Saad
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Editorial Material
Obstetrics & Gynecology
Luis D. Pacheco, Marissa Berry, Antonio F. Saad, Sean G. Yates, George R. Saade
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Genetics & Heredity
Christopher P. Moutos, William G. Kearns, Sarah E. Farmer, Jon P. Richards, Antonio F. Saad, John R. Crochet
Summary: Male and female embryos have similar grade and quality, but female embryos are more likely to be aneuploid. Ongoing pregnancy rates do not differ by embryo sex. Day 5 embryos have more favorable transfer outcomes compared to day 6 embryos.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Article
Obstetrics & Gynecology
Luis D. Pacheco, Antonio F. Saad, George R. Saade
Summary: In recent years, new antimicrobials that are safer and more effective have become available in obstetrics, emphasizing the importance of early and adequate antibiotic coverage for managing severe infections in pregnant individuals. Poor initial antibiotic selection can lead to higher mortality and significant side effects in critically ill pregnant patients with life-threatening infections. This guide aims to assist clinicians in selecting appropriate empirical antibiotic regimens for common severe infections affecting pregnant individuals.
OBSTETRICS AND GYNECOLOGY
(2021)
Review
Obstetrics & Gynecology
Antonio F. Saad, Luis D. Pacheco, Lucy Chappell, George R. Saade
Summary: ICP is associated with poor perinatal outcomes in some women, but recent evidence shows that UDCA may not have a significant impact on most perinatal outcomes, therefore a comprehensive approach is needed to manage ICP effectively.
REPRODUCTIVE SCIENCES
(2022)
Article
Obstetrics & Gynecology
Christopher P. Moutos, Daphne D. Arena Goncharov, Antonio F. Saad, Gwyn Richardson, Sangeeta Jain
Summary: This study investigated the views and influence of left-handedness among obstetrics and gynecology trainees and educators. It found that left-handed trainees face unique challenges during their training, such as a lack of left-handed surgical instruments and difficulty using right-handed tools. The majority of left-handed trainees did not consider their handedness to be a disadvantage, but noted added difficulty when training under right-handed mentors. RH educators also endorsed added difficulty in instructing operative procedures to LH trainees compared to LH educators.
AMERICAN JOURNAL OF PERINATOLOGY
(2023)
Review
Obstetrics & Gynecology
Samantha J. Mitchell, Georgia Ngo, Kimberly A. Maurel, Junichi Hasegawa, Tatsuya Arakaki, Yaakov Melcer, Ron Maymon, Francoise Vendittelli, Alireza A. Shamshirsaz, Hadi Erfani, Scott A. Shainker, Antonio F. Saad, Marjorie C. Treadwell, Ashley S. Roman, Joanne L. Stone, Daniel L. Rolnik
Summary: Prolonging pregnancies until 36 weeks' gestation seems to be safe and beneficial in otherwise uncomplicated pregnancies with antenatally diagnosed vasa previa.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Rachana Gavara, Antonio F. Saad, RonaldJ Wapner, George Saade, Anne Fu, Ruth Barrow, Swapna Nalgonda, Sabine Bousleiman, Cassandra Almonte, Sarah Alnafisee, Anita Holman, Anna Burgansky, Pekka Heikkila
Summary: The study compared the effectiveness of synthetic osmotic cervical dilators and oral misoprostol for cervical ripening. Randomized trial showed that the mechanical cervical dilation group had shorter time to vaginal delivery, better sleep, less discomfort, and lower pain scores.
OBSTETRICS AND GYNECOLOGY
(2022)
Letter
Obstetrics & Gynecology
Marissa Berry, Amanda M. Wang, Christopher P. Moutos, Lena Younes, Christopher Meilchen, Luis D. Pacheco, Geprge R. Saade, Antonio F. Saad
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2023)
Letter
Obstetrics & Gynecology
Chasey Omere, Daphne Arena Goncharov, Claudia Pedroza, Mauricio La Rosa, Mary Munn, Giuseppe Chiossi, Monica Longo, Antonio F. Saad
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2022)
Meeting Abstract
Obstetrics & Gynecology
Amanda Wang, Christopher Moutos, Phuong Ly, George R. Saade, Antonio F. Saad
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Meeting Abstract
Obstetrics & Gynecology
Amanda M. Wang, Sara Jacobs, George Saade, Antonio F. Saad
REPRODUCTIVE SCIENCES
(2021)
Meeting Abstract
Critical Care Medicine
Joshua Patino, Ariza Martinez, Yota Suzuki, Tom Croschere, Tris Miller, Beth Teegarden, Antonio Saad, William Whitehead
CRITICAL CARE MEDICINE
(2021)