Article
Biochemistry & Molecular Biology
Zahra Masoumi, Lena Erlandsson, Eva Hansson, Mattias Magnusson, Eva Mezey, Stefan R. Hansson
Summary: The study found that in preeclampsia (PE) pregnancies, there was no impact on placental hematopoietic stem and progenitor cells homing and erythropoiesis. Non-erythroid alpha-globin mRNA and protein were detected in syncytiotrophoblasts and stroma of PE placenta samples, while normal placenta explants cultured in hypoxia showed upregulation of alpha-globin protein and mRNA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Jing Ma, Haoyue Hu, Miaoling Lin, Lu Chen, Mian Liu, Hong Li, Song Quan
Summary: ELABELA was found to have decreased expression in severe preeclampsia, while promoting trophoblast proliferation. It also showed potential in improving symptoms in a preeclampsia mouse model.
Article
Developmental Biology
YuJia Wang, Yingye Zhang, Yongqi Wu, Yunbiao He, Jingwen Xiang, Jieqiong Huang, Gendie E. Lash, Ping Li
Summary: The downregulation of SIRT1 and the upregulation of senescence- and ECM-related proteins are observed in premature aging placenta with preeclampsia. Activation of SIRT1 can abolish senescence in syncytialized BeWo cells, while knockdown of SIRT1 restores these effects.
Article
Biochemistry & Molecular Biology
Srividya Ganapathy, Elisa R. Farrell, Simran Vaghela, Lucy Joshee, Earl G. Ford, Olga Uchakina, Robert J. McKallip, Jennifer L. Barkin, Christy C. Bridges
Summary: This study assessed the transport of MeHg into placental syncytiotrophoblasts and characterized the mechanisms by which it exerts toxic effects. MeHg compounds were found to be transported into cells primarily by sodium-independent amino acid carriers and organic anion transporters. MeHg altered mitochondrial function and viability, decreased mitophagy and autophagy, and increased oxidative stress. Exposure to higher concentrations of MeHg inhibited the ability of cells to protect against MeHg-induced injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Developmental Biology
Fatma Simsek, Ezgi Turunc, Elif Keskin-Arslan, Hilal Erol, Selin Acar, Bahar Konuralp Atakul, Serpil Aydogmus, Tijen Temiz
Summary: This study aimed to investigate the differences in endothelin-1 (ET-1) levels in placenta, umbilical cord, and maternal blood in patients with preeclampsia (PE) and to understand the changes in umbilical artery contraction response. The results showed higher levels of ET-1 expression and lower levels of miR-125b expression in the placenta of the PE group compared to the control group. Additionally, the PE group exhibited changes in the morphology of umbilical cord vessels. However, there were no significant differences in ET-1 responses between the groups in the tissue bath experiments.
Article
Biochemistry & Molecular Biology
Marei Sammar, Monika Siwetz, Hamutal Meiri, Adi Sharabi-Nov, Peter Altevogt, Berthold Huppertz
Summary: This study revealed lower expression of CD24 mRNA in early pregnancy stages compared to normal term delivery, with a further decrease in preterm PE cases, indicating a potential link to reduced immune tolerance in preeclampsia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Developmental Biology
Chang Cao, Mark D. Fleming
Summary: Fetal development relies on adequate iron supply by the placenta, and the iron transporter Fpn1 plays an essential role in this process. Using gene manipulation techniques, we created a specific Cre mouse model, which provides direct evidence for the essential role of Fpn1 in placental iron transport.
Article
Cardiac & Cardiovascular Systems
Toluwalase Awoyemi, Wei Zhang, Maryam Rahbar, Adam Cribbs, Prasanna Logenthiran, Shuhan Jiang, Gavin Collett, Ana Sofia Cerdeira, Manu Vatish
Summary: By studying the differences in transcriptome between placenta and STB-EVs in preeclampsia and normal pregnancy, we have identified potential biomarkers and mechanistic gene pathways that may play important roles in the pathophysiology of preeclampsia and could be further explored in future studies.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hamid-Reza Kohan-Ghadr, Brooke Armistead, Mikaela Berg, Sascha Drewlo
Summary: Irisin is a newly discovered exercise-mediated polypeptide hormone. Studies have shown that Irisin protects against cell death by reducing pro-apoptotic signaling cascades, inducing DNA repair pathways, and inhibiting Caspase 3 activity. Additionally, Irisin acts through the Akt signaling pathway to prevent apoptosis, increase levels of anti-apoptotic BCL2, and reduce ROS levels. These findings provide new insights into the role of Irisin in promoting cell survival and preventing apoptosis in the human placenta under pathological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Stephen J. Renaud, Mariyan J. Jeyarajah
Summary: In humans, cell fusion is restricted to only a few cell types under normal conditions. In the placenta, cell fusion is a critical process for generating syncytiotrophoblast and plays a crucial role in ensuring pregnancy health.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Cell Biology
Sandra M. Blois, Paula D. Prince, Sophia Borowski, Monica Galleano, Gabriela Barrientos
Summary: Utilizing the SHRSP model, this study investigated placental mechanisms promoting superimposed preeclampsia in women with chronic hypertension. The findings revealed sustained activation of cellular stress response in SHRSP placentas, leading to redox imbalance and significant alterations in placental glycocode. The study highlights the potential role of glycoredox balance as a promising target for interventions in hypertensive disorders of pregnancy.
Review
Cell Biology
Adam Jaremek, Mariyan J. Jeyarajah, Gargi Jaju Bhattad, Stephen J. Renaud
Summary: Proper development of the placenta, specifically the syncytiotrophoblast, is crucial for successful pregnancy as it regulates the exchange of nutrients and gases between maternal and fetal blood. Dysregulated formation of syncytiotrophoblast can have negative impacts on maternal and fetal health. 'Omics' approaches have been used to gain multidimensional insights into the formation and function of syncytiotrophoblast, but there are still limitations and future avenues for exploration in this area.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Immunology
Sayani Banerjee, Zheping Huang, Zhengke Wang, Akitoshi Nakashima, Shigeru Saito, Surendra Sharma, Shibin Cheng
Summary: The understanding of sterile inflammation and its effects on pregnancy complications such as preeclampsia is still in its early stages. Emerging evidence suggests that sterile inflammation regulated by pathways such as the inflammasome-gasdermins-caspase-1 axis may contribute to the development of preeclampsia. Further research is needed to elucidate the mechanisms underlying these inflammatory pathways and potential therapeutic strategies for treating these complications.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Reproductive Biology
Barbara Denkl, Nada Cordasic, Hanna Huebner, Carlos Menendez-Castro, Marius Schmidt, Alexander Mocker, Joachim Woelfle, Andrea Hartner, Fabian B. Fahlbusch
Summary: The study investigates the roles of placental UPR and oxidative stress in IUGR and PE, finding that placental ER stress is not induced in rat and mouse models, while oxidative stress is significantly increased in female IUGR rat placentas.
BIOLOGY OF REPRODUCTION
(2021)
Review
Medicine, General & Internal
Teresa M. MacDonald, Susan P. Walker, Natalie J. Hannan, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino
Summary: Preeclampsia is a pregnancy-specific disease that has a significant impact on maternal and perinatal morbidity and mortality worldwide. Currently, there are limited options for predicting and diagnosing preeclampsia, and further research is needed to identify effective tests and biomarkers.
Meeting Abstract
Developmental Biology
B. Krause, I. Carrasco-Wong, C. Hernandez, R. Uauy, P. Casanello
Article
Multidisciplinary Sciences
Bernardo J. Krause, Ivo Carrasco-Wong, Angelica Dominguez, Pilar Arnaiz, Marcelo Farias, Salesa Barja, Francisco Mardones, Paola Casanello
Article
Pharmacology & Pharmacy
Bernardo J. Krause, Cherie Hernandez, Andres Caniuguir, Paola Vasquez-Devaud, Ivo Carrasco-Wong, Ricardo Uauy, Paola Casanello
BIOCHEMICAL PHARMACOLOGY
(2016)
Meeting Abstract
Developmental Biology
P. Casanello, C. Hernandez, I. Carrasco-Wong, E. Munoz-Munoz, A. Jaramillo, G. Soto, K. Carrasco, J. A. Castro-Rodriguez, R. Uauy, B. Krause
Article
Biotechnology & Applied Microbiology
Rodrigo Ortiz, Hugo Navarrete, Jose Navarrete, Mario Parraga, Ivo Carrasco, Eduardo de la Vega, Manuel Ortiz, Paula Herrera, Robert A. Blanchette
INTERNATIONAL BIODETERIORATION & BIODEGRADATION
(2014)
Article
Chemistry, Medicinal
Nuria E. Rocha-Guzman, Luis E. Simental-Mendia, Laura J. Barragan-Zuniga, Julio C. Ramirez-Espana, J. Alberto Gallegos-Infante, Claudia I. Lujan-Mendoza, Claudia I. Gamboa-Gomez
MEDICINAL CHEMISTRY RESEARCH
(2018)
Article
Cell Biology
Ivo Carrasco-Wong, Cherie Hernandez, Carlos Jara-Gutierrez, Omar Porras, Paola Casanello
JOURNAL OF CELLULAR PHYSIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Ivo Carrasco-Wong, Alejandra Moller, Fernanda R. Giachini, Victor V. Lima, Fernando Toledo, Jana Stojanova, Luis Sobrevia, Sebastian San Martin
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2020)
Review
Pharmacology & Pharmacy
Ricardo Blanco-Castaneda, Carlos Galaviz-Hernandez, Paula C. S. Souto, Victor Vitorino Lima, Fernanda R. Giachini, Carlos Escudero, Alicia E. Damiano, L. Jazel Barragan-Zuniga, Gerardo Martinez-Aguilar, Martha Sosa-Macias
EXPERT REVIEW OF CLINICAL PHARMACOLOGY
(2020)
Article
Medicine, General & Internal
Laura Jazel Barragan-Zuniga, Laurence A. Marchat, Ivo Carrasco-Wong, Ricardo Blanco-Castaneda, Jose M. Salas-Pacheco, Luis Ernesto Simental-Mendia, Miguel Mauricio Correa-Ramirez, Martha Sosa-Macias, Jaime Gutierrez, Carlos Galaviz-Hernandez
Summary: Preeclampsia is a major cause of maternal-fetal mortality worldwide, and obesity is a significant risk factor. This study found an association between severe preeclampsia and obesity, as well as higher expression of the PLAC8 gene in preeclamptic placentas.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Camila Cardenas-Calderon, Valentina Veloso-Gimenez, Tamara Gonzalez, Aniela Wozniak, Patricia Garcia, Sebastian San Martin, Juan F. Varas, Ivo Carrasco-Wong, Mario Vera, Jose Tomas Egana
Summary: This study aims to study the functional biofilms in physiological conditions and their potential effects on health and regeneration. The results show that biofilm infection induces leucocyte infiltration, elevated interferon-gamma and interleukin-10, as well as high systemic pro-calcitonin concentrations, indicating significant effects of biofilm infection on the host.
SCIENTIFIC REPORTS
(2022)
Review
Endocrinology & Metabolism
Delia I. Chiarello, Javier Ustariz, Reinaldo Marin, Ivo Carrasco-Wong, Marcelo Farias, Ady Giordano, Felipe S. Gallardo, Sebastian E. Illanes, Jaime Gutierrez
Summary: Pregnancy is a critical period for environmental influences on both the mother and the offspring, with air pollution exposure being associated with adverse pregnancy outcomes. Particulate matter can trigger inflammation and reach the placenta, causing damage and impacting fetal health. A combination of strategies including risk assessment, education about environmental risks, nutritional interventions, and digital monitoring of air quality can help mitigate the effects of air pollution during pregnancy.
FRONTIERS IN ENDOCRINOLOGY
(2023)